LOCUS       NM_001177701            1073 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens intraflagellar transport 27 (IFT27), transcript
            variant 1, mRNA.
ACCESSION   NM_001177701
VERSION     NM_001177701.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1073)
  AUTHORS   Zhou,Z., Qiu,H., Castro-Araya,R.F., Takei,R., Nakayama,K. and
            Katoh,Y.
  TITLE     Impaired cooperation between IFT74/BBS22-IFT81 and
            IFT25-IFT27/BBS19 causes Bardet-Biedl syndrome
  JOURNAL   Hum Mol Genet 31 (10), 1681-1693 (2022)
   PUBMED   34888642
  REMARK    GeneRIF: Impaired cooperation between IFT74/BBS22-IFT81 and
            IFT25-IFT27/BBS19 causes Bardet-Biedl syndrome.
REFERENCE   2  (bases 1 to 1073)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1073)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1073)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1073)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   6  (bases 1 to 1073)
  AUTHORS   Liew,G.M., Ye,F., Nager,A.R., Murphy,J.P., Lee,J.S., Aguiar,M.,
            Breslow,D.K., Gygi,S.P. and Nachury,M.V.
  TITLE     The intraflagellar transport protein IFT27 promotes BBSome exit
            from cilia through the GTPase ARL6/BBS3
  JOURNAL   Dev Cell 31 (3), 265-278 (2014)
   PUBMED   25443296
REFERENCE   7  (bases 1 to 1073)
  AUTHORS   Aldahmesh,M.A., Li,Y., Alhashem,A., Anazi,S., Alkuraya,H.,
            Hashem,M., Awaji,A.A., Sogaty,S., Alkharashi,A., Alzahrani,S., Al
            Hazzaa,S.A., Xiong,Y., Kong,S., Sun,Z. and Alkuraya,F.S.
  TITLE     IFT27, encoding a small GTPase component of IFT particles, is
            mutated in a consanguineous family with Bardet-Biedl syndrome
  JOURNAL   Hum Mol Genet 23 (12), 3307-3315 (2014)
   PUBMED   24488770
  REMARK    GeneRIF: Study coupled human genetics with functional validation in
            zebrafish and identified IFT27 as a novel BBS gene (BBS19).
REFERENCE   8  (bases 1 to 1073)
  AUTHORS   Diekmann,Y., Seixas,E., Gouw,M., Tavares-Cadete,F., Seabra,M.C. and
            Pereira-Leal,J.B.
  TITLE     Thousands of rab GTPases for the cell biologist
  JOURNAL   PLoS Comput Biol 7 (10), e1002217 (2011)
   PUBMED   22022256
REFERENCE   9  (bases 1 to 1073)
  AUTHORS   Qin,H., Wang,Z., Diener,D. and Rosenbaum,J.
  TITLE     Intraflagellar transport protein 27 is a small G protein involved
            in cell-cycle control
  JOURNAL   Curr Biol 17 (3), 193-202 (2007)
   PUBMED   17276912
REFERENCE   10 (bases 1 to 1073)
  AUTHORS   Forsyth,R. and Gunay-Aygun,M.
  TITLE     Bardet-Biedl Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301537
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB457924.1 and BC000566.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001177701.2.
            
            Summary: This gene encodes a GTP-binding protein that is a core
            component of the intraflagellar transport complex B.
            Characterization of the similar Chlamydomonas protein indicates a
            function in cell cycle control. Alternative splicing of this gene
            results in multiple transcript variants. [provided by RefSeq, Jan
            2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            5 encode isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000566.2, SRR1163655.290013.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000433985.7/ ENSP00000393541.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               DB457924.1         16-235
            221-1073            BC000566.2         213-1065
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..1073
                     /gene="IFT27"
                     /gene_synonym="BBS19; CFAP156; FAP156; RABL4; RAYL"
                     /note="intraflagellar transport 27"
                     /db_xref="GeneID:11020"
                     /db_xref="HGNC:HGNC:18626"
                     /db_xref="MIM:615870"
     exon            1..446
                     /gene="IFT27"
                     /gene_synonym="BBS19; CFAP156; FAP156; RABL4; RAYL"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..973
                     /gene="IFT27"
                     /gene_synonym="BBS19; CFAP156; FAP156; RABL4; RAYL"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1; RAB,
                     member of RAS oncogene family-like 4; intraflagellar
                     transport protein 27 homolog; rab-like protein 4"
                     /codon_start=1
                     /product="intraflagellar transport protein 27 homolog
                     isoform 1"
                     /protein_id="NP_001171172.1"
                     /db_xref="CCDS:CCDS54523.1"
                     /db_xref="GeneID:11020"
                     /db_xref="HGNC:HGNC:18626"
                     /db_xref="MIM:615870"
                     /translation="MVKLAAKCILAGDPAVGKTALAQIFRSDGAHFQKSYTLTTGMDL
                     VVKTVPVPDTGDSVELFIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSK
                     WLEKARSQAPGISLPGVLVGNKTDLAGRRAVDSAEARAWALGQGLECFETSVKEMENF
                     EAPFHCLAKQFHQLYREKVEVFRALA"
     exon            447..526
                     /gene="IFT27"
                     /gene_synonym="BBS19; CFAP156; FAP156; RABL4; RAYL"
                     /inference="alignment:Splign:2.1.0"
     exon            527..586
                     /gene="IFT27"
                     /gene_synonym="BBS19; CFAP156; FAP156; RABL4; RAYL"
                     /inference="alignment:Splign:2.1.0"
     exon            587..646
                     /gene="IFT27"
                     /gene_synonym="BBS19; CFAP156; FAP156; RABL4; RAYL"
                     /inference="alignment:Splign:2.1.0"
     exon            647..764
                     /gene="IFT27"
                     /gene_synonym="BBS19; CFAP156; FAP156; RABL4; RAYL"
                     /inference="alignment:Splign:2.1.0"
     exon            765..874
                     /gene="IFT27"
                     /gene_synonym="BBS19; CFAP156; FAP156; RABL4; RAYL"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1073
                     /gene="IFT27"
                     /gene_synonym="BBS19; CFAP156; FAP156; RABL4; RAYL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1052..1057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT27"
                     /gene_synonym="BBS19; CFAP156; FAP156; RABL4; RAYL"
                     /note="hexamer: AATAAA"
     polyA_site      1073
                     /gene="IFT27"
                     /gene_synonym="BBS19; CFAP156; FAP156; RABL4; RAYL"
                     /note="major polyA site"
ORIGIN      
        1 gcaggtgggc tatggttgct tggagagtgc atccggcccg gtacttgtga tcggaggaga
       61 gccggatcgt ccttccttga accctctggg tagggctgtg ctgaggggct gggcggggag
      121 cacaggccgt gtccgctcgc ttgcaccttt tcagactgcc gtgtcaggcc tcgagccggg
      181 cccacctgga gccctcccct gcccacccgc ccccagcgcc cgatatccgc ccccggccca
      241 gaagggccgg gctcggtcat ccccagtccc gtcgcggcca ctgacccttg agatcagccc
      301 tcccctcccc accttcccgt cccaggccag cccagggccc gaagcccacc cactcgcgtc
      361 tctagcagcc gctcttgtcc tctgggtacg gctcgcggga gtgttggtta ccatggtgaa
      421 gctggcagcc aaatgcatcc tggcaggaga cccagcagtg ggcaagaccg ccctggcaca
      481 gatcttccgc agtgatggag cccatttcca gaaaagctac accctgacaa caggaatgga
      541 tttggtggtg aagacagtgc cagttcctga cacgggagac agtgtggaac tcttcatttt
      601 tgactctgct ggcaaggagc tgttttcgga aatgctggat aaattgtggg agagtcccaa
      661 tgtcttatgt ctcgtctatg atgtgaccaa tgaagaatcc ttcaacaact gcagcaagtg
      721 gctggagaag gctcggtcac aggctccagg catctctctc ccaggtgttt tagttgggaa
      781 caagacagac ctggccggca gacgagcagt ggactcagct gaggcccggg catgggcgct
      841 gggccagggc ctggaatgtt ttgaaacatc cgtgaaagag atggaaaact tcgaagcccc
      901 tttccactgc cttgccaagc agttccacca gctgtaccgg gagaaggtgg aggttttccg
      961 ggccctggca tgacgagctg gagcagatcg tgctgcacaa ccggagaaga cagaattacc
     1021 tctgctcttt taatatataa tgatggcttt aaataaaatt aggagaaaat gtc
//
