LOCUS       NM_016126                685 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens intraflagellar transport 25 (IFT25), transcript
            variant 1, mRNA.
ACCESSION   NM_016126
VERSION     NM_016126.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 685)
  AUTHORS   Zhou,Z., Qiu,H., Castro-Araya,R.F., Takei,R., Nakayama,K. and
            Katoh,Y.
  TITLE     Impaired cooperation between IFT74/BBS22-IFT81 and
            IFT25-IFT27/BBS19 causes Bardet-Biedl syndrome
  JOURNAL   Hum Mol Genet 31 (10), 1681-1693 (2022)
   PUBMED   34888642
  REMARK    GeneRIF: Impaired cooperation between IFT74/BBS22-IFT81 and
            IFT25-IFT27/BBS19 causes Bardet-Biedl syndrome.
REFERENCE   2  (bases 1 to 685)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 685)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 685)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 685)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 685)
  AUTHORS   Follit,J.A., Xu,F., Keady,B.T. and Pazour,G.J.
  TITLE     Characterization of mouse IFT complex B
  JOURNAL   Cell Motil Cytoskeleton 66 (8), 457-468 (2009)
   PUBMED   19253336
REFERENCE   7  (bases 1 to 685)
  AUTHORS   Pozsgai,E., Gomori,E., Szigeti,A., Boronkai,A., Gallyas,F. Jr.,
            Sumegi,B. and Bellyei,S.
  TITLE     Correlation between the progressive cytoplasmic expression of a
            novel small heat shock protein (Hsp16.2) and malignancy in brain
            tumors
  JOURNAL   BMC Cancer 7, 233 (2007)
   PUBMED   18154656
  REMARK    GeneRIF: Hsp16.2 expression is directly correlated with the
            histological grade of brain tumors.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 685)
  AUTHORS   Bellyei,S., Szigeti,A., Pozsgai,E., Boronkai,A., Gomori,E.,
            Hocsak,E., Farkas,R., Sumegi,B. and Gallyas,F. Jr.
  TITLE     Preventing apoptotic cell death by a novel small heat shock protein
  JOURNAL   Eur J Cell Biol 86 (3), 161-171 (2007)
   PUBMED   17275951
  REMARK    GeneRIF: These data suggest that Hsp16.2 can prevent the
            destabilization of mitochondrial membrane systems and could
            represent a suitable target for modulating cell death pathways.
REFERENCE   9  (bases 1 to 685)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   10 (bases 1 to 685)
  AUTHORS   Bohn,H. and Winckler,W.
  TITLE     Isolation and characterization of five new soluble placental tissue
            proteins (PP22, PP23, PP24, PP25, PP26)
  JOURNAL   Arch Gynecol Obstet 248 (3), 111-115 (1991)
   PUBMED   2018407
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031427.15.
            
            On Apr 24, 2020 this sequence version replaced NM_016126.3.
            
            Transcript Variant: This variant (1), as well as variant 2, encodes
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU183088.1, BC005245.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267756 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000194214.10/ ENSP00000194214.5
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AL031427.15        91784-91928         c
            146-258             AL031427.15        86214-86326         c
            259-365             AL031427.15        76268-76374         c
            366-434             AL031427.15        74601-74669         c
            435-478             AL031427.15        70133-70176         c
            479-685             AL031427.15        67790-67996         c
FEATURES             Location/Qualifiers
     source          1..685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..685
                     /gene="IFT25"
                     /gene_synonym="C1orf41; CFAP232; FAP232; HSPB11; HSPCO34;
                     PP25"
                     /note="intraflagellar transport 25"
                     /db_xref="GeneID:51668"
                     /db_xref="HGNC:HGNC:25019"
                     /db_xref="MIM:620841"
     exon            1..145
                     /gene="IFT25"
                     /gene_synonym="C1orf41; CFAP232; FAP232; HSPB11; HSPCO34;
                     PP25"
                     /inference="alignment:Splign:2.1.0"
     exon            146..258
                     /gene="IFT25"
                     /gene_synonym="C1orf41; CFAP232; FAP232; HSPB11; HSPCO34;
                     PP25"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..595
                     /gene="IFT25"
                     /gene_synonym="C1orf41; CFAP232; FAP232; HSPB11; HSPCO34;
                     PP25"
                     /note="isoform a is encoded by transcript variant 1;
                     intraflagellar transport 25 homolog; heat shock protein
                     beta-11; placental protein 25; intraflagellar transport
                     protein 25 homolog; heat shock protein family B (small),
                     member 11; heat shock protein family B member 11; heat
                     shock protein family B (small) member 11"
                     /codon_start=1
                     /product="intraflagellar transport protein 25 homolog
                     isoform a"
                     /protein_id="NP_057210.2"
                     /db_xref="CCDS:CCDS41341.1"
                     /db_xref="GeneID:51668"
                     /db_xref="HGNC:HGNC:25019"
                     /db_xref="MIM:620841"
                     /translation="MRKIDLCLSSEGSEVILATSSDEKHPPENIIDGNPETFWTTTGM
                     FPQEFIICFHKHVRIERLVIQSYFVQTLKIEKSTSKEPVDFEQWIEKDLVHTEGQLQN
                     EEIVAHDGSATYLRFIIVSAFDHFASVHSVSAEGTVVSNLSS"
     exon            259..365
                     /gene="IFT25"
                     /gene_synonym="C1orf41; CFAP232; FAP232; HSPB11; HSPCO34;
                     PP25"
                     /inference="alignment:Splign:2.1.0"
     exon            366..434
                     /gene="IFT25"
                     /gene_synonym="C1orf41; CFAP232; FAP232; HSPB11; HSPCO34;
                     PP25"
                     /inference="alignment:Splign:2.1.0"
     exon            435..478
                     /gene="IFT25"
                     /gene_synonym="C1orf41; CFAP232; FAP232; HSPB11; HSPCO34;
                     PP25"
                     /inference="alignment:Splign:2.1.0"
     exon            479..685
                     /gene="IFT25"
                     /gene_synonym="C1orf41; CFAP232; FAP232; HSPB11; HSPCO34;
                     PP25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      666..671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT25"
                     /gene_synonym="C1orf41; CFAP232; FAP232; HSPB11; HSPCO34;
                     PP25"
                     /note="hexamer: ATTAAA"
     polyA_site      685
                     /gene="IFT25"
                     /gene_synonym="C1orf41; CFAP232; FAP232; HSPB11; HSPCO34;
                     PP25"
                     /note="major polyA site"
ORIGIN      
        1 agagttggag cgcgcgcgac cccggactcc acggaggccg cggcgagcag gcggagctgc
       61 gggtcgggac gctctgcgtg gggcggggcg caagggaggt ttcgagcccg gaaggtccgg
      121 cgcccagagc taacgggagt cccaggttaa acactttaag atgagaaaaa ttgatctctg
      181 tctgagctct gaagggtccg aagtgatttt agctacatca agtgatgaaa aacacccacc
      241 tgaaaatatc attgatggga atccagaaac gttttggacc accacaggaa tgtttcccca
      301 ggaattcatt atttgtttcc acaaacatgt aaggattgaa aggcttgtaa tccaaagtta
      361 ctttgtacag accttgaaga ttgaaaaaag cacgtctaaa gagccagttg attttgagca
      421 atggattgaa aaagatttgg tacacacaga ggggcagctt caaaatgaag aaattgtggc
      481 acatgatggc tccgctactt acttgagatt cattattgta tcagcctttg atcattttgc
      541 atctgtgcat agcgtttctg cagaaggaac agtagtctca aatctttcct cataatgata
      601 acaaaatgct cttgcatgat tttttaacaa tatatttaaa caggaagttg tcactgatat
      661 actttattaa aaggattttt atcaa
//
