LOCUS       NM_022777               4881 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens intraflagellar transport 22 (IFT22), transcript
            variant 1, mRNA.
ACCESSION   NM_022777
VERSION     NM_022777.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4881)
  AUTHORS   Katoh,Y., Terada,M., Nishijima,Y., Takei,R., Nozaki,S., Hamada,H.
            and Nakayama,K.
  TITLE     Overall Architecture of the Intraflagellar Transport (IFT)-B
            Complex Containing Cluap1/IFT38 as an Essential Component of the
            IFT-B Peripheral Subcomplex
  JOURNAL   J Biol Chem 291 (21), 10962-10975 (2016)
   PUBMED   26980730
REFERENCE   2  (bases 1 to 4881)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4881)
  AUTHORS   Silva,D.A., Huang,X., Behal,R.H., Cole,D.G. and Qin,H.
  TITLE     The RABL5 homolog IFT22 regulates the cellular pool size and the
            amount of IFT particles partitioned to the flagellar compartment in
            Chlamydomonas reinhardtii
  JOURNAL   Cytoskeleton (Hoboken) 69 (1), 33-48 (2012)
   PUBMED   22076686
REFERENCE   4  (bases 1 to 4881)
  AUTHORS   Adhiambo,C., Blisnick,T., Toutirais,G., Delannoy,E. and Bastin,P.
  TITLE     A novel function for the atypical small G protein Rab-like 5 in the
            assembly of the trypanosome flagellum
  JOURNAL   J Cell Sci 122 (Pt 6), 834-841 (2009)
   PUBMED   19240117
REFERENCE   5  (bases 1 to 4881)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA709553.1, BC009823.2, AC006329.5 and CA841889.1.
            
            On May 17, 2019 this sequence version replaced NM_022777.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.252743.1,
                                           SRR1803612.264476.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315322.10/ ENSP00000320359.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DA709553.1         13-28
            17-805              BC009823.2         1-789
            806-1887            AC006329.5         83182-84263         c
            1888-2428           CA841889.1         1-541               c
            2429-4881           AC006329.5         80188-82640         c
FEATURES             Location/Qualifiers
     source          1..4881
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..4881
                     /gene="IFT22"
                     /gene_synonym="CFAP9; FAP9; RABL5"
                     /note="intraflagellar transport 22"
                     /db_xref="GeneID:64792"
                     /db_xref="HGNC:HGNC:21895"
                     /db_xref="MIM:620505"
     exon            1..142
                     /gene="IFT22"
                     /gene_synonym="CFAP9; FAP9; RABL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..661
                     /gene="IFT22"
                     /gene_synonym="CFAP9; FAP9; RABL5"
                     /note="isoform a is encoded by transcript variant 1; RAB,
                     member of RAS oncogene family-like 5; rab-like protein 5;
                     RAB, member RAS oncogene family-like 5; intraflagellar
                     transport protein 22 homolog; intraflagellar transport 22
                     homolog"
                     /codon_start=1
                     /product="intraflagellar transport protein 22 homolog
                     isoform a"
                     /protein_id="NP_073614.1"
                     /db_xref="CCDS:CCDS5719.1"
                     /db_xref="GeneID:64792"
                     /db_xref="HGNC:HGNC:21895"
                     /db_xref="MIM:620505"
                     /translation="MLKAKILFVGPCESGKTVLANFLTESSDITEYSPTQGVRILEFE
                     NPHVTSNNKGTGCEFELWDCGGDAKFESCWPALMKDAHGVVIVFNADIPSHRKEMEMW
                     YSCFVQQPSLQDTQCMLIAHHKPGSGDDKGSLSLSPPLNKLKLVHSNLEDDPEEIRME
                     FIKYLKSIINSMSESRDREEMSIMT"
     exon            143..219
                     /gene="IFT22"
                     /gene_synonym="CFAP9; FAP9; RABL5"
                     /inference="alignment:Splign:2.1.0"
     exon            220..309
                     /gene="IFT22"
                     /gene_synonym="CFAP9; FAP9; RABL5"
                     /inference="alignment:Splign:2.1.0"
     exon            310..512
                     /gene="IFT22"
                     /gene_synonym="CFAP9; FAP9; RABL5"
                     /inference="alignment:Splign:2.1.0"
     exon            513..4881
                     /gene="IFT22"
                     /gene_synonym="CFAP9; FAP9; RABL5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1007
                     /gene="IFT22"
                     /gene_synonym="CFAP9; FAP9; RABL5"
                     /note="major polyA site"
     regulatory      1928..1933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT22"
                     /gene_synonym="CFAP9; FAP9; RABL5"
                     /note="hexamer: ATTACA"
     polyA_site      1945
                     /gene="IFT22"
                     /gene_synonym="CFAP9; FAP9; RABL5"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT22"
                     /gene_synonym="CFAP9; FAP9; RABL5"
                     /note="hexamer: ACTAAA"
     polyA_site      2101
                     /gene="IFT22"
                     /gene_synonym="CFAP9; FAP9; RABL5"
     regulatory      4851..4856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT22"
                     /gene_synonym="CFAP9; FAP9; RABL5"
                     /note="hexamer: ATTAAA"
     polyA_site      4881
                     /gene="IFT22"
                     /gene_synonym="CFAP9; FAP9; RABL5"
ORIGIN      
        1 gggcctctct ccgtcgccat ggaaacgaaa gcggccaagt agagctccgt cctgacgcgc
       61 cgcctcccgt gggctccggc cggctaagcc gcggcggaca actatgctga aagccaagat
      121 cctcttcgtg gggccttgcg agagtggaaa aactgttttg gccaactttc tgacagaatc
      181 ttctgacatc actgaataca gcccaaccca aggagtgagg atcctagaat ttgagaaccc
      241 gcatgttacc agcaacaaca aaggcacggg ctgtgaattc gagctatggg actgtggtgg
      301 cgatgctaag tttgagtcct gctggccggc cctgatgaag gatgctcatg gagtggtgat
      361 cgtcttcaat gctgacatcc caagccaccg gaaggaaatg gagatgtggt attcctgctt
      421 tgtccaacag ccgtccttac aggacacaca gtgtatgcta attgcacacc acaaaccagg
      481 ctctggagat gataaaggaa gcctgtcttt gtcgccaccc ttgaacaagc tgaagctggt
      541 gcactcaaac ctggaagatg accctgagga gatccggatg gaattcataa agtatttaaa
      601 aagcataatc aactccatgt ctgagagcag agacagggag gagatgtcaa ttatgaccta
      661 gccagccttc acctgggact gccacatccc cagtgaaatc agcatgtttc tcggtgcaga
      721 tctgaaatca catccagctc ctgatgtttt cttctccctc tgactgcaga ggaagtgttc
      781 ctacctgcag gaaggcacct gtcacacagg gcgttcactc agaccatctg tgctctgccc
      841 tgagttcagt tgagaaaatc ctattatcaa atttggattt cctggcccca gaacttccca
      901 aagacctgta aaatggaggg atttaccacc tcacatatgt ccagttaaac agtttgtgga
      961 cttgtaaccg tcgcagccca atgatacaac agtagtttaa tcacgtgtat tggcttgaat
     1021 gtgattttca ttccttgatt cacccaacaa ataccgactg gctgagcacc tgctgtgtgt
     1081 gcactgctgt tctagctgct gaccatagac agcataaatg aaaaagacag aaattcccac
     1141 cttcgtggaa ctctccattt tcctaaatgt taggttggtg caaaactaat cgtggttttt
     1201 gccattttta atttttaatg gcaaaagcca ctattacttt tgcaccaacc taataggccg
     1261 attcagaaac ttgagtgcaa tgtcttggat atgcaaaaaa gaaaatcaaa acgcattctt
     1321 cattctctat aagagttcta ggcggggcgt ggtggctcac acttgtaatc ccagcacttt
     1381 gggaggccaa ggtgggcgga tcatgaggtc aggagatcga gaccatcctg accaacgtgg
     1441 tgaaacccca tctctactaa aaatagaaaa atcagctggg tgtggtgccg cgtgcctgta
     1501 atcccagcta cttgggaggc tgaggcataa gaattgtttg agcccgggag acagaggttg
     1561 cagtgagcca agattgcgcc actgtactcc agcttgggca acagagcaag actccatctc
     1621 aaaaaaaaaa gagttctagc ccaggagcgg tggctcacac ttgtaatccc agcactttgg
     1681 gatgctaagg caggcggatc acttgaggcc aggagttcaa gaccagcctg gccaacatgg
     1741 caaaatccca tctctactaa aaatacaaaa attcacaggg tgtgttggca cacgcctgta
     1801 ataccagcta ctcaggtggc tgaggcataa gaattgcttg agcctgggag gcagagattg
     1861 cactgagccg agatcgcgcc actatactcc agcctgggca acagacatcc tgtctcaaat
     1921 aaattaaatt acattaaatg tttaagaaga agtctaaata agtttcatat gctgccctcc
     1981 ctcagataat gagggaacct ggggtactta aaatgccaaa tgaacgtata cttgatcctt
     2041 attcatagat tttgtatttg agaatttgcc tactcactaa aatatgtttg taacccccaa
     2101 atcaatactg tggcactttc tcagttattc gcagacacac agagacaaaa aatttgaagt
     2161 gcctggctgg gcgtggtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcagg
     2221 cggatcacaa ggtccagaga tcgagaccat cctggccaac atggtgaaac cccgtctcta
     2281 ctaaaaatac aaaaattagc tgggcatggt ggggcatgcc tgtagtccca gctactcaga
     2341 agggtgaggc agaattgcct gaacccgcga ggcggagact gcagtgagcc gagatcgcac
     2401 cactgcactc cagcctggtg acagagcaaa aaaaaaaaaa ttgaagtgcc tggccagttg
     2461 cagtgggtca cacctgtaat cccaacactt tgggaggcta agatgggaga actgatggaa
     2521 gccaggagtt caagaacagc ctggccaaca tggcgaaacc ccatctctac taaaaataca
     2581 aaaattcgcc aggcatgttg gcacacacct gtaataccag ctactcatgt ggctgaggca
     2641 taagaattgc ttgagcctgg aggccgggtg cagtggctta cgcctgtaat cccaacactt
     2701 tgggagtctg agacgggtgg aaatcctgag gtcaggagtt caagaccagc ctgtccaaca
     2761 tggtgaaacc ccgtctctac taaaaataca aaaattagct gggcgtggta gcacgtgcct
     2821 gtaatcccag ctacctggga agctgaggca ggagaatcgc ttgaacctgg gaggcggagg
     2881 ttgcagtaag ccgagattgt gccattgcac tccagcctgg gcaacaagag caaaactcca
     2941 tctcaaaaaa aagaaaaaag tgccgagtgg agtggctcac acctgtaatc ccagcacttt
     3001 gggaggccaa ggcaggtaaa tcacaaggtc aggagttcga gaccagcctg tccaacatgg
     3061 tgaaaccccg actctactaa aaacacaaaa aattagctgg gcctggtggc gggtacctgt
     3121 aatcccagct actcaggaag ctgagggagg agaatcactt gaacccagga ggcagaggtt
     3181 gcagtgagcc aagatcgcgc cactgctctc cagcctcggc aacatagcga gactccgtca
     3241 caaaaaaaaa aaaaaaaaaa acaactctct ccaaaacatt atatttattt agatgacctt
     3301 gatatggaca ctatatccag ttggaaagtg gagtacagac acaatttttt gttttttgtt
     3361 tttttgagac acggtgtcac tctgtcatcc cggctggagt gcagtggcat gaccacagct
     3421 cacagcagcc tcaatctcct gggctccact gatctcgcca gctcagcctc tgagtagttg
     3481 agactagaga tacacacacc agtaatggtc cagcccacta attagtgcac gcctggctaa
     3541 tttttgtact ttttgtagag atggggtttt gccatgttgc cccagctgat ctcgaactcc
     3601 tgtccttgag tgatccgccc gtctcagcct cccaaagtgg tgggattaca ggcatgagtc
     3661 attgtgccca gcccatacac aacctctaaa aaatttttca taacaccaaa ttggtaaaca
     3721 tgttcaaaag atttaatgta cagaatcact agatacggtg agtttacggt ttattgtaga
     3781 agcaagtttg ttttaatcat cttaggagat ttttttgtgt tgttttgttt ttttgagagt
     3841 ctcactgcaa tctccaccct ccgggttcaa ctgattctcc tccctcagcc tcccaagcag
     3901 ctgggattac aggtgcctgc cactgcaccc ggctaatttt tgtattttta gtagagacgg
     3961 tttcaccatc ttggccaggc tggtcttgaa ctcctgacct tgtggtctac ccgcctcagc
     4021 ctcccaaagt gctgggatta caggtgtgag ccactgcacc cagccatgga gttatttttc
     4081 attcataatt gttatgtttg taatttttta acatagccaa taagaaaata cactaagtag
     4141 atgaaatggt agatgtagct cttttcagct gagagtggga gaaaaagttg aggcacctaa
     4201 gggagatgaa taaaaatgct agggtgtctg tcactttcac agtgaggagg gctgacatgt
     4261 agctgtgtga gcagtctact ggagagagtg gcttttctag accatgacaa ttccctggca
     4321 atttagtttg aaccacattc acctgttagg attaccatgc gtattattaa tgtcaactga
     4381 actaaatcat ctttccatga cagctgccta acaagaatcc atctcacaaa attgaccacc
     4441 tcaaaaggaa attattttca tttcaccttt aatgattatt caagacccca gtataacaac
     4501 ccaaggccag gcgcagtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcggg
     4561 tggattacga ggttaagaga tcgagaccat cctggctaac agtgaaaccc cacctctact
     4621 aaaaatacaa aaaataagcc gggtgtggtg gcgggcacct gtagtcccag ctactcagga
     4681 ggctgaggca ggagaatggc gtgaacctgg gaggcggagc ttgcagtgag ccgaggtccc
     4741 gccactgcac tccagcctgg gcgacagagc gagactccat ctcaaaaaaa aaaaaaaaaa
     4801 aaaaattaac ccagcagatt ttgttcacct gaatggccag agtacaaccc attaaatatt
     4861 tgaattgagt aaaagccttc a
//
