LOCUS       NM_052989               4075 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens intraflagellar transport 122 (IFT122), transcript
            variant 2, mRNA.
ACCESSION   NM_052989
VERSION     NM_052989.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4075)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4075)
  AUTHORS   Takahara,M., Kunii,M., Nakamura,K., Harada,A., Hirano,T., Katoh,Y.
            and Nakayama,K.
  TITLE     C11ORF74 interacts with the IFT-A complex and participates in
            ciliary BBSome localization
  JOURNAL   J Biochem 165 (3), 257-267 (2019)
   PUBMED   30476139
  REMARK    GeneRIF: The C11ORF74, interacts with the IFT-A complex via the
            IFT122 subunit and is accumulated at the distal tip in the absence
            of an IFT-A subunit IFT139, suggesting that at least a fraction of
            C11ORF74 molecules can be transported towards the ciliary tip by
            associating with the IFT-A complex, although its majority might be
            out of cilia at steady state.
REFERENCE   3  (bases 1 to 4075)
  AUTHORS   Takahara,M., Katoh,Y., Nakamura,K., Hirano,T., Sugawa,M.,
            Tsurumi,Y. and Nakayama,K.
  TITLE     Ciliopathy-associated mutations of IFT122 impair ciliary protein
            trafficking but not ciliogenesis
  JOURNAL   Hum Mol Genet 27 (3), 516-528 (2018)
   PUBMED   29220510
  REMARK    GeneRIF: IFT122 mutations associated with cranioectodermal
            dysplasia 1 cause defects in ciliary protein trafficking, but not
            ciliogenesis when expressed in cells lacking endogenous IFT122
            (IFT122 KO).
REFERENCE   4  (bases 1 to 4075)
  AUTHORS   Bhattacharjee,S., Beauchamp,N., Murray,B.E. and Lynch,T.
  TITLE     Case series of autosomal recessive hereditary spastic paraparesis
            with novel mutation in SPG 7 gene
  JOURNAL   Neurosciences (Riyadh) 22 (4), 303-307 (2017)
   PUBMED   29057857
  REMARK    GeneRIF: This study demonstrated that the mutation in SPG 7 gene
            caused autosomal recessive hereditary spastic paraparesis.
REFERENCE   5  (bases 1 to 4075)
  AUTHORS   Walczak-Sztulpa,J., Eggenschwiler,J., Osborn,D., Brown,D.A.,
            Emma,F., Klingenberg,C., Hennekam,R.C., Torre,G., Garshasbi,M.,
            Tzschach,A., Szczepanska,M., Krawczynski,M., Zachwieja,J.,
            Zwolinska,D., Beales,P.L., Ropers,H.H., Latos-Bielenska,A. and
            Kuss,A.W.
  TITLE     Cranioectodermal Dysplasia, Sensenbrenner syndrome, is a ciliopathy
            caused by mutations in the IFT122 gene
  JOURNAL   Am J Hum Genet 86 (6), 949-956 (2010)
   PUBMED   20493458
  REMARK    GeneRIF: we found a homozygous missense mutation in the IFT122
            (WDR10) gene that cosegregated with Sensenbrenner syndrome
REFERENCE   6  (bases 1 to 4075)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 4075)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 4075)
  AUTHORS   Gross,C., De Baere,E., Lo,A., Chang,W. and Messiaen,L.
  TITLE     Cloning and characterization of human WDR10, a novel gene located
            at 3q21 encoding a WD-repeat protein that is highly expressed in
            pituitary and testis
  JOURNAL   DNA Cell Biol 20 (1), 41-52 (2001)
   PUBMED   11242542
REFERENCE   9  (bases 1 to 4075)
  AUTHORS   Tan,W., Lin,A. and Keppler-Noreuil,K.
  TITLE     Cranioectodermal Dysplasia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24027799
REFERENCE   10 (bases 1 to 4075)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB099554.1, AF244931.1,
            AF302154.1, DB516647.1 and BF941125.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_052989.2.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. This cytoplasmic
            protein contains seven WD repeats and an AF-2 domain which function
            by recruiting coregulatory molecules and in transcriptional
            activation. Mutations in this gene cause cranioectodermal
            dysplasia-1. A related pseudogene is located on chromosome 3.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. It encodes
            isoform 2, which lacks an internal segment and is shorter that
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF302154.1, BC028353.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348417.7/ ENSP00000324005.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DB099554.1         189-197
            10-30               AF244931.1         95-115
            31-3907             AF302154.1         1-3877
            3908-4072           DB516647.1         256-420
            4073-4075           BF941125.1         2-4                 c
FEATURES             Location/Qualifiers
     source          1..4075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3-q22.1"
     gene            1..4075
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /note="intraflagellar transport 122"
                     /db_xref="GeneID:55764"
                     /db_xref="HGNC:HGNC:13556"
                     /db_xref="MIM:606045"
     exon            1..148
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..3833
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /note="isoform 2 is encoded by transcript variant 2; WD
                     repeat domain 10; WD repeat-containing protein 140; WD
                     repeat-containing protein 10; intraflagellar transport 122
                     homolog"
                     /codon_start=1
                     /product="intraflagellar transport protein 122 homolog
                     isoform 2"
                     /protein_id="NP_443715.1"
                     /db_xref="CCDS:CCDS3061.1"
                     /db_xref="GeneID:55764"
                     /db_xref="HGNC:HGNC:13556"
                     /db_xref="MIM:606045"
                     /translation="MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGT
                     LLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYN
                     PITHQLASCSSSDFGLWSPEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRN
                     KNGEEKVKIERPGGSLSPIWSICWNPSSRWESFWMNRENEDAEDVIVNRYIQEIPSTL
                     KSAVYSSQGSEAEEEEPEEEDDSPRDDNLEERNDILAVADWGQKVSFYQLSGKQIGKD
                     RALNFDPCCISYFTKGEYILLGGSDKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSN
                     YVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCKELVK
                     KIAIYRNRLAIQLPEKILIYELYSEDLSDMHYRVKEKIIKKFECNLLVVCANHIILCQ
                     EKRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAI
                     VLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCED
                     MLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFSISAVEVPQSAPMYQY
                     LDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIE
                     ERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLG
                     SGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLIDIAR
                     KLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALGEK
                     HPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTNNAVAESRFNDA
                     AYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHRHTEDPFSVHRPE
                     TLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYDKLRGLYIPAR
                     FQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSY
                     DVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVETKDSIGD
                     EDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLPDASI
                     TMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP"
     exon            149..215
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            216..300
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            301..379
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            380..456
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            457..523
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            524..670
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            671..847
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            848..923
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1115
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1254
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1457
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1595
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1760
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1958
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2099
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2153
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2315
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2482
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2654
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2757
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2898
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..2993
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3094
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3260
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3372
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            3373..3498
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            3499..3578
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3743
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..4075
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3897..3902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /note="hexamer: AATAAA"
     polyA_site      3916
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
                     /note="major polyA site"
     polyA_site      4075
                     /gene="IFT122"
                     /gene_synonym="CED; CED1; CFAP80; FAP80; SPG; WDR10;
                     WDR10p; WDR140"
ORIGIN      
        1 aacgcaggta gccaaagtgg cttgtggagt ggcgaccgtt agtgaggcgg ttgctgagac
       61 agacgctgag gcgggtagga ggagcccgag ccgtaaggga agccgtgatg agggccgtgt
      121 tgacgtggag agataaagcc gagcactgta taaatgacat cgcatttaag cctgatggaa
      181 ctcaactgat tttggctgcc ggaagcagat tactggttta tgacacctct gatggcacct
      241 tacttcagcc cctcaaggga cacaaagaca ctgtgtactg tgtggcatat gcgaaggatg
      301 gcaagcgctt tgcttctgga tcagctgaca aaagcgttat tatctggaca tcaaaactgg
      361 aaggcattct gaagtacacg cacaatgatg ctatacaatg tgtctcctac aatcctatta
      421 ctcatcaact ggcatcttgt tcctccagtg actttgggtt gtggtctcct gaacagaagt
      481 ctgtctccaa acacaaatca agcagcaaga tcatctgctg cagctggaca aatgatggtc
      541 agtacctggc gctggggatg ttcaatggga tcatcagcat acggaacaaa aatggcgagg
      601 agaaagtaaa gatcgagcgg ccggggggct ccctctcgcc aatatggtcc atctgctgga
      661 acccttcaag ccgatgggag agtttctgga tgaacagaga gaatgaggat gccgaggatg
      721 tcattgtcaa cagatatatt caggaaatcc cttccactct gaagtcagca gtgtacagta
      781 gtcagggtag tgaggcagag gaggaagaac cagaggaaga ggacgacagt cccagggacg
      841 acaacttaga ggaacgtaat gacatcctgg ctgtggctga ctggggacag aaagtttcct
      901 tctaccagct gagtggaaaa cagattggaa aggatcgggc actgaacttt gacccctgct
      961 gcatcagcta ctttactaaa ggcgagtaca ttttgctggg gggttcagac aagcaagtat
     1021 ctcttttcac caaggatgga gtgcggcttg ggactgttgg ggagcagaac tcctgggtgt
     1081 ggacgtgtca agcgaaaccg gattccaact atgtggtggt cggctgccag gacggcacca
     1141 tttccttcta ccagcttatt ttcagcacag tccatgggct ttacaaggac cgctatgcct
     1201 acagggatag catgactgac gtcattgtgc agcacctgat cactgagcag aaagttcgga
     1261 ttaaatgcaa agagcttgtc aagaagattg ccatctacag aaatcgattg gctatccaac
     1321 tgccagagaa aatcctcatc tatgagttgt attcagagga cttatcagac atgcattacc
     1381 gggtaaagga gaagattatc aagaagtttg agtgcaacct cctggtggtg tgtgccaatc
     1441 acatcatcct gtgccaggag aaacggctgc agtgcctgtc cttcagcgga gtgaaggagc
     1501 gggagtggca gatggagtct ctcattcgtt acatcaaggt gatcggtggc cctcctggaa
     1561 gagaaggcct cttagtgggg ctgaagaatg gacagatcct gaagatcttc gtggacaatc
     1621 tctttgctat cgtcctgctg aagcaggcca cagctgtgcg ctgcttggac atgagtgcct
     1681 cccgtaagaa gctggccgtg gtagatgaaa atgacacttg cctggtgtat gacatcgaca
     1741 ccaaggagct gctttttcag gaaccaaacg ccaacagtgt agcttggaac acccagtgtg
     1801 aggacatgct ctgcttctcg ggaggaggct acctcaacat caaagccagc accttccctg
     1861 tgcaccggca gaagctgcag ggctttgtgg tcggctacaa tggctccaag atcttctgcc
     1921 tccatgtctt ctccatttct gccgtggagg tgccgcagtc cgctcccatg taccagtacc
     1981 tggataggaa actgttcaag gaagcctacc agattgcttg cttgggtgtc acagacactg
     2041 attggcgtga actggccatg gaagcgctag aaggtttaga ttttgaaaca gcaaagaagg
     2101 ccttcatcag agtacaagac ctccgatatt tagagctcat cagcagcatt gaggagagga
     2161 agaagcgggg agagaccaac aatgacctgt ttctggcaga tgtgttttcc taccagggga
     2221 agttccatga ggccgccaaa ctgtacaaga ggagtgggca cgagaacctc gcgcttgaaa
     2281 tgtacaccga cctctgcatg tttgagtatg ccaaggattt ccttggatct ggagacccca
     2341 aagaaacaaa gatgctaatc accaaacagg ctgactgggc cagaaatatc aaggagccca
     2401 aagccgccgt ggagatgtac atctcagcag gagagcacgt caaggccatc gagatctgtg
     2461 gtgaccatgg ctgggttgac atgttgatcg acatcgcccg caaactggac aaggctgagc
     2521 gcgagcccct gctgctgtgc gctacctacc tcaagaagct ggacagccct ggctatgctg
     2581 ctgagaccta cctgaagatg ggtgacctca agtccctggt gcagctgcac gtggagaccc
     2641 agcgctggga tgaggccttt gctttgggtg agaagcatcc tgagtttaag gatgacatct
     2701 acatgccgta tgctcagtgg ctagcagaga acgatcgctt tgaggaagcc cagaaagcgt
     2761 tccacaaggc tgggcgacag agagaagcgg tccaggtgct ggagcagctc acaaacaatg
     2821 ccgtggcgga gagcaggttt aatgatgctg cctattatta ctggatgctg tccatgcagt
     2881 gcctcgatat agctcaagat cctgcccaga aggacacaat gcttggcaag ttctaccact
     2941 tccagcgttt ggcagagctg taccatggtt accatgccat ccatcgccac acggaagatc
     3001 cgttcagtgt ccatcgtcct gaaactcttt tcaacatctc caggttcctg ctgcacagcc
     3061 tgcccaagga caccccctcg ggcatctcta aagtgaaaat actcttcacc ttggccaagc
     3121 agagcaaggc cctcggtgcc tacaggctgg cccggcacgc ctatgacaag ctgcgtggcc
     3181 tgtacatccc tgccagattc caaaagtcca ttgagctggg taccctgacc atccgcgcca
     3241 agcccttcca cgacagtgag gagttggtgc ccttgtgcta ccgctgctcc accaacaacc
     3301 cgctgctcaa caacctgggc aacgtctgca tcaactgccg ccagcccttc atcttctccg
     3361 cctcttccta cgacgtgcta cacctggttg agttctacct ggaggaaggg atcactgatg
     3421 aagaagccat ctccctcatc gacctggagg tgctgagacc caagcgggat gacagacagc
     3481 tagagattgc aaacaacagc tcccagattc tgcggctagt ggagaccaag gactccatcg
     3541 gagatgagga cccgttcaca gctaagctga gctttgagca aggtggctca gagttcgtgc
     3601 cagtggtggt gagccggctg gtgctgcgct ccatgagccg ccgggatgtc ctcatcaagc
     3661 gatggccccc acccctgagg tggcaatact tccgctcact gctgcctgac gcctccatta
     3721 ccatgtgccc ctcctgcttc cagatgttcc attctgagga ctatgagttg ctggtgcttc
     3781 agcatggctg ctgcccctac tgccgcaggt gcaaggatga ccctggccca tgaccagcat
     3841 cctggggacg gcctgcaccc tctgcccgcc ttggggtctg ctgggctgtg aaggagaata
     3901 aagagttaaa ctgtcagaat gtgtttcttg cccagatgaa gtttgtgttt tgtggggggg
     3961 gccttgtgta accacggaat tcctatttat ggcatttcat gccttgtaaa tagcaccagg
     4021 agatgaggaa gagaatgtac atatattttc taaggaaaaa aatctgttac tttca
//
