LOCUS       NM_006764               1943 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens interferon related developmental regulator 2 (IFRD2),
            mRNA.
ACCESSION   NM_006764
VERSION     NM_006764.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1943)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1943)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1943)
  AUTHORS   Brown,A., Baird,M.R., Yip,M.C., Murray,J. and Shao,S.
  TITLE     Structures of translationally inactive mammalian ribosomes
  JOURNAL   Elife 7, e40486 (2018)
   PUBMED   30355441
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1943)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1943)
  AUTHORS   Li,S., Wang,L., Berman,M., Kong,Y.Y. and Dorf,M.E.
  TITLE     Mapping a dynamic innate immunity protein interaction network
            regulating type I interferon production
  JOURNAL   Immunity 35 (3), 426-440 (2011)
   PUBMED   21903422
  REMARK    Erratum:[Immunity. 2011 Oct 28;35(4):647-8]
REFERENCE   6  (bases 1 to 1943)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   7  (bases 1 to 1943)
  AUTHORS   Wang,X., Chorley,B.N., Pittman,G.S., Kleeberger,S.R., Brothers,J.
            2nd, Liu,G., Spira,A. and Bell,D.A.
  TITLE     Genetic variation and antioxidant response gene expression in the
            bronchial airway epithelium of smokers at risk for lung cancer
  JOURNAL   PLoS One 5 (8), e11934 (2010)
   PUBMED   20689807
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1943)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res 60 (21), 6116-6133 (2000)
   PUBMED   11085536
REFERENCE   9  (bases 1 to 1943)
  AUTHORS   Buanne,P., Incerti,B., Guardavaccaro,D., Avvantaggiato,V.,
            Simeone,A. and Tirone,F.
  TITLE     Cloning of the human interferon-related developmental regulator
            (IFRD1) gene coding for the PC4 protein, a member of a novel family
            of developmentally regulated genes
  JOURNAL   Genomics 51 (2), 233-242 (1998)
   PUBMED   9722946
  REMARK    GeneRIF: This publication discusses both IFRD1 and IFRD2.
            GeneRIF: Identification of the IFRD gene family, comprising the two
            genes PC4 / Tis7 / IFRD1 and SKMc15 / IFRD2, and in
            situ-hybridization analysis of their expression during developments
            GeneRIF: Identification of a new family of IFRD (interferon
            developmental regulator) genes, of which SkMC15 is part, being
            named IFDR2
REFERENCE   10 (bases 1 to 1943)
  AUTHORS   Latif,F., Duh,F.M., Bader,S., Sekido,Y., Li,H., Geil,L., Zbar,B.,
            Minna,J.D. and Lerman,M.I.
  TITLE     The human homolog of the rodent immediate early response genes, PC4
            and TIS7, resides in the lung cancer tumor suppressor gene region
            on chromosome 3p21
  JOURNAL   Hum Genet 99 (3), 334-341 (1997)
   PUBMED   9050919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U90094.1.
            
            On Jul 8, 2020 this sequence version replaced NM_006764.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007437.2, AK074763.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000417626.8/ ENSP00000402849.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               U90094.1           27020-27232         c
            214-333             U90094.1           25363-25482         c
            334-418             U90094.1           25191-25275         c
            419-543             U90094.1           24973-25097         c
            544-701             U90094.1           24732-24889         c
            702-752             U90094.1           24515-24565         c
            753-934             U90094.1           24250-24431         c
            935-1040            U90094.1           24058-24163         c
            1041-1178           U90094.1           23603-23740         c
            1179-1307           U90094.1           23386-23514         c
            1308-1403           U90094.1           23212-23307         c
            1404-1943           U90094.1           22535-23074         c
FEATURES             Location/Qualifiers
     source          1..1943
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1943
                     /gene="IFRD2"
                     /gene_synonym="IFNRP; SKMc15; SM15"
                     /note="interferon related developmental regulator 2"
                     /db_xref="GeneID:7866"
                     /db_xref="HGNC:HGNC:5457"
                     /db_xref="MIM:602725"
     exon            1..213
                     /gene="IFRD2"
                     /gene_synonym="IFNRP; SKMc15; SM15"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1484
                     /gene="IFRD2"
                     /gene_synonym="IFNRP; SKMc15; SM15"
                     /note="interferon-related protein"
                     /codon_start=1
                     /product="interferon-related developmental regulator 2"
                     /protein_id="NP_006755.5"
                     /db_xref="CCDS:CCDS77746.2"
                     /db_xref="GeneID:7866"
                     /db_xref="HGNC:HGNC:5457"
                     /db_xref="MIM:602725"
                     /translation="MPRARKGNTLRKGGQRRGGGARSSAQADSGSSDDEAASEARSTA
                     SECPSLLSTTAEDSLGGDVVDEQGQQEDLEEKLKEYVDCLTDKSAKTRQGALESLRLA
                     LASRLLPDFLLERRLTLADALEKCLKKGKGEEQALAAAVLGLLCVQLGPGPKGEELFH
                     SLQPLLVSVLSDSTASPAARLHCASALGLGCYVAAADIQDLVSCLACLESVFSRFYGL
                     GGSSTSPVVPASLHGLLSAALQAWALLLTICPSTQISHILDRQLPRLPQLLSSESVNL
                     RIAAGETIALLFELARDLEEEFVYEDMEALCSVLRTLATDSNKYRAKADRRRQRSTFR
                     AVLHSVEGGECEEEIVRFGFEVLYMDSWARHRIYAAFKEVLGSGMHHHLQNNELLRDI
                     FGLGPVLLLDATALKACKVPRFEKHLYNAAAFKARTKARSRVRDKRADIL"
     exon            214..333
                     /gene="IFRD2"
                     /gene_synonym="IFNRP; SKMc15; SM15"
                     /inference="alignment:Splign:2.1.0"
     exon            334..418
                     /gene="IFRD2"
                     /gene_synonym="IFNRP; SKMc15; SM15"
                     /inference="alignment:Splign:2.1.0"
     exon            419..543
                     /gene="IFRD2"
                     /gene_synonym="IFNRP; SKMc15; SM15"
                     /inference="alignment:Splign:2.1.0"
     exon            544..701
                     /gene="IFRD2"
                     /gene_synonym="IFNRP; SKMc15; SM15"
                     /inference="alignment:Splign:2.1.0"
     exon            702..752
                     /gene="IFRD2"
                     /gene_synonym="IFNRP; SKMc15; SM15"
                     /inference="alignment:Splign:2.1.0"
     exon            753..934
                     /gene="IFRD2"
                     /gene_synonym="IFNRP; SKMc15; SM15"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1040
                     /gene="IFRD2"
                     /gene_synonym="IFNRP; SKMc15; SM15"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1178
                     /gene="IFRD2"
                     /gene_synonym="IFNRP; SKMc15; SM15"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1307
                     /gene="IFRD2"
                     /gene_synonym="IFNRP; SKMc15; SM15"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1403
                     /gene="IFRD2"
                     /gene_synonym="IFNRP; SKMc15; SM15"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1943
                     /gene="IFRD2"
                     /gene_synonym="IFNRP; SKMc15; SM15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1910..1915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFRD2"
                     /gene_synonym="IFNRP; SKMc15; SM15"
                     /note="hexamer: ATTAAA"
     polyA_site      1943
                     /gene="IFRD2"
                     /gene_synonym="IFNRP; SKMc15; SM15"
                     /note="major polyA site"
ORIGIN      
        1 agggcggggc gcctcgcgaa gatggtggcg cgcgtggcgt gtggctcccg tcgtctggcc
       61 aagtctcagc gcagcgcacc ggccggcgtc tcgttggcct ggagcccaca cccaccgggt
      121 ccctgacccc gcgccccccg cgcccggttc ccggcatgcc tcgcgcccgt aagggcaaca
      181 cgctccggaa gggtggtcag cgccgtggag gaggtgcccg gagcagtgcc caagctgact
      241 cgggttccag tgacgatgag gcagccagtg aggcccgcag caccgccagt gaatgcccca
      301 gccttctcag caccactgca gaggacagcc ttggggggga tgtcgtggat gagcagggcc
      361 agcaggaaga ccttgaggaa aagctgaagg agtatgtgga ctgtctcaca gacaagagtg
      421 ccaagacccg gcagggtgct cttgagagcc tgcgcctggc cctagcgtcc cgcctactcc
      481 ccgacttctt gctggagcgc cgcctcacgc tagccgatgc cctggaaaag tgcctcaaga
      541 aagggaaggg cgaggaacaa gccctggctg ctgctgtgct aggcctgctc tgcgtgcagc
      601 tgggccctgg acctaagggt gaggagctgt ttcacagcct gcagcctctg ctggtctctg
      661 tgctcagtga cagcacagct agccctgctg cccggctcca ctgtgcttct gcccttggcc
      721 tgggctgcta cgtggctgcc gctgacatcc aggacctggt ctcttgcctt gcctgcttag
      781 aaagtgtttt cagccggttc tatggcttgg ggggcagctc cacaagtcct gtggttcctg
      841 ccagcctgca cggcctgctc tctgctgccc tgcaggcctg ggcattgctg ctcaccatct
      901 gccctagcac ccaaatcagc cacatccttg acaggcagct gccccggctg ccccagctct
      961 tgtccagtga aagtgtgaac ctgcggatcg ctgccggtga aaccattgca ctgctctttg
     1021 agcttgcccg ggaccttgag gaggagtttg tttacgagga catggaggcc ctctgcagtg
     1081 tcctgcgcac tctggccact gacagtaaca agtaccgtgc caaggctgat cgtcggcgcc
     1141 agcgctctac tttccgcgcc gtgctgcact ccgtggaggg cggtgaatgc gaagaagaga
     1201 tagtgcgctt cggctttgag gtgctctaca tggacagctg ggctcggcac cggatctacg
     1261 ctgccttcaa ggaagtgctg ggttcgggca tgcaccacca cctccagaac aatgagctac
     1321 tccgtgacat ctttggcctg ggccctgtgc tgttgctgga tgccactgcc ctgaaggcct
     1381 gcaaggttcc acgctttgag aagcacctgt acaatgctgc tgccttcaaa gcccggacca
     1441 aggctcgaag ccgtgtgcgg gacaagcggg cagacatcct gtgaagcagg acctgctgaa
     1501 gaggagactt tctatgccct tggtccgtat ttttaacaga agacagtgca acaactggtc
     1561 tccaccagta tttgtcactt tatttttttt aatgacaaaa ccaaaaacag acatggggtg
     1621 ggtagctggg ggcccggaca cttgggaccc tgaccccttt gtccctgcac tcagccctgt
     1681 ggccccttcc tgtcctgtct caggccaggc taaatatgtg ccttcctcag ggctgtgggg
     1741 caggcactag ggggcctttc ccttcctttc ctttctcagg ccttgctccc ccaggatgac
     1801 ccactcttag gggggtggtg gcatctggac aaatgccacc acagcaggtg gggtggcaaa
     1861 gctacctgga atggatttgt gtgctgattt ttaaggatta ttacagataa ttaaacagaa
     1921 cggtcagcct tctgtggtct taa
//
