LOCUS       NM_001550               3269 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens interferon related developmental regulator 1 (IFRD1),
            transcript variant 1, mRNA.
ACCESSION   NM_001550
VERSION     NM_001550.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3269)
  AUTHORS   Mondal,P., Roy,K.S., Bhagat,S.V., Singh,S., Chattopadhyay,A.,
            Ghosh,D.D., Kundu,T.K., Roychoudhury,S. and Roy,S.
  TITLE     Disrupting the interaction between a p53 gain-of-function mutant
            and the transcriptional co-activator PC4 reverses drug resistance
            in cancer cells
  JOURNAL   FEBS Lett 598 (12), 1532-1542 (2024)
   PUBMED   38664232
  REMARK    GeneRIF: Disrupting the interaction between a p53 gain-of-function
            mutant and the transcriptional co-activator PC4 reverses drug
            resistance in cancer cells.
REFERENCE   2  (bases 1 to 3269)
  AUTHORS   Pandey,B., Dev,A., Chakravorty,D., Bhandare,V.V., Polley,S., Roy,S.
            and Basu,G.
  TITLE     Insights on the disruption of the complex between human positive
            coactivator 4 and p53 by small molecules
  JOURNAL   Biochem Biophys Res Commun 578, 15-20 (2021)
   PUBMED   34534740
  REMARK    GeneRIF: Insights on the disruption of the complex between human
            positive coactivator 4 and p53 by small molecules.
REFERENCE   3  (bases 1 to 3269)
  AUTHORS   Chang,M., Zhang,Y., Hui,Z., Wang,D. and Guo,H.
  TITLE     IFRD1 regulates the asthmatic responses of airway via NF-kappaB
            pathway
  JOURNAL   Mol Immunol 127, 186-192 (2020)
   PUBMED   32992150
  REMARK    GeneRIF: IFRD1 regulates the asthmatic responses of airway via
            NF-kappaB pathway.
REFERENCE   4  (bases 1 to 3269)
  AUTHORS   Andreev,D.E., O'Connor,P.B., Fahey,C., Kenny,E.M., Terenin,I.M.,
            Dmitriev,S.E., Cormican,P., Morris,D.W., Shatsky,I.N. and
            Baranov,P.V.
  TITLE     Translation of 5' leaders is pervasive in genes resistant to eIF2
            repression
  JOURNAL   Elife 4, e03971 (2015)
   PUBMED   25621764
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3269)
  AUTHORS   Zhao,C., Datta,S., Mandal,P., Xu,S. and Hamilton,T.
  TITLE     Stress-sensitive regulation of IFRD1 mRNA decay is mediated by an
            upstream open reading frame
  JOURNAL   J Biol Chem 285 (12), 8552-8562 (2010)
   PUBMED   20080976
  REMARK    GeneRIF: IFRD1 mRNA decay stress-sensitive regulation is mediated
            by an upstream open reading frame
REFERENCE   6  (bases 1 to 3269)
  AUTHORS   Brkanac,Z., Spencer,D., Shendure,J., Robertson,P.D., Matsushita,M.,
            Vu,T., Bird,T.D., Olson,M.V. and Raskind,W.H.
  TITLE     IFRD1 is a candidate gene for SMNA on chromosome 7q22-q23
  JOURNAL   Am J Hum Genet 84 (5), 692-697 (2009)
   PUBMED   19409521
  REMARK    GeneRIF: Sequence conservation, animal models, and protein
            structure evaluation support the involvement of IFRD1 in SMNA
REFERENCE   7  (bases 1 to 3269)
  AUTHORS   Buanne,P., Incerti,B., Guardavaccaro,D., Avvantaggiato,V.,
            Simeone,A. and Tirone,F.
  TITLE     Cloning of the human interferon-related developmental regulator
            (IFRD1) gene coding for the PC4 protein, a member of a novel family
            of developmentally regulated genes
  JOURNAL   Genomics 51 (2), 233-242 (1998)
   PUBMED   9722946
  REMARK    GeneRIF: Identification of the IFRD gene family, comprising the two
            genes PC4 / Tis7 / IFRD1 and SKMc15 / IFRD2, and in
            situ-hybridization analysis of their expression during developments
REFERENCE   8  (bases 1 to 3269)
  AUTHORS   Guardavaccaro,D., Ciotti,M.T., Schafer,B.W., Montagnoli,A. and
            Tirone,F.
  TITLE     Inhibition of differentiation in myoblasts deprived of the
            interferon-related protein PC4
  JOURNAL   Cell Growth Differ 6 (2), 159-169 (1995)
   PUBMED   7756174
  REMARK    GeneRIF: Functional ablation of PC4/IFRD1 in myoblast cells by
            sense and antisense strategies as well as by microinjection of
            PC4/IFRD1 antibodies, inhibits differentiation.
            GeneRIF: In the absence of PC4/IFRD1 skeletal muscle
            differentiation is defective.
REFERENCE   9  (bases 1 to 3269)
  AUTHORS   Varnum,B.C., Lim,R.W. and Herschman,H.R.
  TITLE     Characterization of TIS7, a gene induced in Swiss 3T3 cells by the
            tumor promoter tetradecanoyl phorbol acetate
  JOURNAL   Oncogene 4 (10), 1263-1265 (1989)
   PUBMED   2797820
  REMARK    GeneRIF: This reference shows the cloning and the sequence of the
            original IFRD1 homolog isolated in mouse as TPA-inducible immediate
            early gene (named Tis7).
REFERENCE   10 (bases 1 to 3269)
  AUTHORS   Tirone,F. and Shooter,E.M.
  TITLE     Early gene regulation by nerve growth factor in PC12 cells:
            induction of an interferon-related gene
  JOURNAL   Proc Natl Acad Sci U S A 86 (6), 2088-2092 (1989)
   PUBMED   2467301
  REMARK    GeneRIF: This reference (Tirone and Shooter 1989) shows the cloning
            and the sequence of the original IFRD1 homolog, isolated in rat as
            NGF-inducible immediate early gene (named PC4).
            GeneRIF: This reference shows the cloning and the sequence of the
            original IFRD1 homolog isolated in rat as nerve growth
            factor-inducible immediate early gene (named PC4).
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079741.5 and AC005192.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 21, 2020 this sequence version replaced NM_001550.3.
            
            Summary: This gene is an immediate early gene that encodes a
            protein related to interferon-gamma. This protein may function as a
            transcriptional co-activator/repressor that controls the growth and
            differentiation of specific cell types during embryonic development
            and tissue regeneration. Mutations in this gene are associated with
            sensory/motor neuropathy with ataxia. This gene may also be
            involved in modulating the pathogenesis of cystic fibrosis lung
            disease. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Both variants 1 and 2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.219857.1,
                                           SRR11853562.29468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403825.8/ ENSP00000384477.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 20080976
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               AC079741.5         23792-24114
            324-428             AC079741.5         29095-29199
            429-513             AC079741.5         29334-29418
            514-638             AC079741.5         30246-30370
            639-796             AC079741.5         32193-32350
            797-847             AC005192.1         476-526
            848-1026            AC005192.1         611-789
            1027-1135           AC005192.1         880-988
            1136-1270           AC005192.1         6591-6725
            1271-1399           AC005192.1         10829-10957
            1400-1495           AC005192.1         11376-11471
            1496-3269           AC005192.1         14040-15813
FEATURES             Location/Qualifiers
     source          1..3269
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.1"
     gene            1..3269
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /note="interferon related developmental regulator 1"
                     /db_xref="GeneID:3475"
                     /db_xref="HGNC:HGNC:5456"
                     /db_xref="MIM:603502"
     exon            1..323
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      28..186
                     /regulatory_class="uORF"
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:20080976]"
                     /note="this uORF is predicted to encode a 52 aa peptide
                     (PMID:20080976)"
     CDS             230..1585
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /note="isoform 1 is encoded by transcript variant 1; nerve
                     growth factor-inducible protein PC4; pheochromocytoma
                     cell-4; TPA induced sequence 7;
                     12-O-tetradecanoylphorbol-13-acetate-induced sequence 7"
                     /codon_start=1
                     /product="interferon-related developmental regulator 1
                     isoform 1"
                     /protein_id="NP_001541.2"
                     /db_xref="CCDS:CCDS34736.1"
                     /db_xref="GeneID:3475"
                     /db_xref="HGNC:HGNC:5456"
                     /db_xref="MIM:603502"
                     /translation="MPKNKKRNTPHRGSSAGGGGSGAAAATAATAGGQHRNVQPFSDE
                     DASIETMSHCSGYSDPSSFAEDGPEVLDEEGTQEDLEYKLKGLIDLTLDKSAKTRQAA
                     LEGIKNALASKMLYEFILERRMTLTDSIERCLKKGKSDEQRAAAALASVLCIQLGPGI
                     ESEEILKTLGPILKKIICDGSASMQARQTCATCFGVCCFIATDDITELYSTLECLENI
                     FTKSYLKEKDTTVICSTPNTVLHISSLLAWTLLLTICPINEVKKKLEMHFHKLPSLLS
                     CDDVNMRIAAGESLALLFELARGIESDFFYEDMESLTQMLRALATDGNKHRAKVDKRK
                     QRSVFRDVLRAVEERDFPTETIKFGPERMYIDCWVKKHTYDTFKEVLGSGMQYHLQSN
                     EFLRNVFELGPPVMLDAATLKTMKISRFERHLYNSAAFKARTKARSKCRDKRADVGEF
                     F"
     exon            324..428
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /inference="alignment:Splign:2.1.0"
     exon            429..513
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /inference="alignment:Splign:2.1.0"
     exon            514..638
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /inference="alignment:Splign:2.1.0"
     exon            639..796
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /inference="alignment:Splign:2.1.0"
     exon            797..847
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1026
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1135
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1270
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1399
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1495
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..3269
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2233..2238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /note="hexamer: AATAAA"
     polyA_site      2258
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /note="major polyA site"
     regulatory      3237..3242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /note="hexamer: AATGAA"
     regulatory      3248..3253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
                     /note="hexamer: ATTAAA"
     polyA_site      3253
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
     polyA_site      3269
                     /gene="IFRD1"
                     /gene_synonym="PC4; TIS7"
ORIGIN      
        1 gccttagctc ccgcgctaga gagaaacatg tatcgttttc gatcacagct cttcacgggg
       61 atttctgctg ccgccaccgc ccactcttac ccccgccgct tctcgactct gttgttagcc
      121 gaagactcgc ctctcagccg cccgccgcac agacgcacga gtaaaaagtg cagctccatc
      181 ggctgatcct cgctaagctc cgactctggg cggcaccggg cgtcccacga tgccgaagaa
      241 caagaagcgg aacactcccc accgcggtag cagtgctggc ggcggcgggt caggagcagc
      301 cgcagcgacg gcggcgacag caggtggcca gcatcgaaat gttcagcctt ttagtgatga
      361 agatgcatca attgaaacaa tgagccattg cagtggttat agcgatcctt ccagttttgc
      421 tgaagatgga ccagaagtcc ttgatgagga aggaactcaa gaagacctag agtacaagtt
      481 gaagggatta attgacctaa ccctggataa gagtgcgaag acaaggcaag cagctcttga
      541 aggtattaaa aatgcactgg cttcaaaaat gctgtatgaa tttattctgg aaaggagaat
      601 gactttaact gatagcattg aacgctgcct gaaaaaaggt aagagtgatg agcaacgtgc
      661 agctgcagcg ttagcatctg ttctttgtat tcagctgggc cctggaattg aaagtgaaga
      721 gattttgaaa actcttggac caatcctaaa gaaaatcatt tgtgatgggt cagctagtat
      781 gcaggctagg caaacttgtg caacttgctt tggtgtttgc tgttttattg ccacagatga
      841 cattactgaa ctatactcaa ctctggaatg tttggaaaat atcttcacta aatcctatct
      901 caaagagaaa gacactactg ttatttgcag cactcctaat acagtgcttc atatcagctc
      961 tcttcttgca tggacactac tgctgaccat atgcccaatc aatgaagtga agaaaaagct
     1021 tgagatgcat ttccataagc ttccaagcct cctctcttgt gatgatgtaa acatgagaat
     1081 agctgctggt gaatctttgg cacttctctt tgaattggcc agaggaatag agagtgactt
     1141 tttttatgaa gacatggagt ccttgacgca gatgcttagg gccttggcaa cagatggaaa
     1201 taaacaccgg gccaaagtgg acaagagaaa gcagcggtca gttttcagag atgtcctgag
     1261 ggcagtggag gaacgggatt ttccaacaga aaccattaaa tttggtcctg aacgcatgta
     1321 tattgattgc tgggtaaaaa aacacaccta tgacaccttt aaggaggttc ttggatcagg
     1381 gatgcagtac cacttgcagt caaatgaatt ccttcgaaat gtatttgaac ttggaccccc
     1441 agtgatgctt gatgctgcaa cgcttaaaac gatgaagatt tctcgtttcg aaaggcattt
     1501 atataactct gcagccttca aagctcgaac caaagctaga agcaaatgtc gagataagag
     1561 agcagatgtt ggagaattct tctagatttt cagaacttga agactatttt ctaatttcta
     1621 tttttttttc tatttcaatg tatttaaact ctagacacag tttttatcct ggattaactt
     1681 agataacttt tgtagcagtg gttatattgc ttataattta atgtacaata ctattgaaac
     1741 tggtgagttc tgattattaa atattctctg taaatcagta aacatgtata aagtatttgt
     1801 aatgtttggt cataatttat ttatgaagac agcaaaagac tgatttcatg atggggaaaa
     1861 caattagcca aagtttaatt tcttacactg tggttgtcaa gaatactgat ttactataat
     1921 gatatataca tgcaagatat ttaacttaat atcttagaca agagttctgg gtacaatttt
     1981 gggatctagt tcccctggaa aagctgctgt atttttaatt tttaatggaa tgtagctttt
     2041 aaaatcctgt cactggcatc aacaaaagga attataccat gagaccttat agctgtactt
     2101 aaaagccatt cagttcagct attgggagtt catgatgaat tagcatatgc cagaaaggtt
     2161 gctaacctta acatctgaga gcagtaacac tgattttatc tgctgtatga gactttgtgc
     2221 attttacttt gaaataaaga tttttttcca cactgaaagt gcttctcttc taatagaaga
     2281 aatattattt atggctttga ggtacagagt ccaaaatgac taggccaggt gggcagggag
     2341 acaaagcttt atgtgtatat ttacaaacat taaagtagat gaaaagaatg tagcaataca
     2401 taattgggat taaggtttct gactttcaag aatatttctg cttggcaaca tgcagtgtgg
     2461 ctcatgccta taatcagcac tctggggagg ctgaggcggg aggatggcat gagcccagtt
     2521 tgagaccagc ctgggcaaca tagcgagacc ctgtctctac cagaaattta aaaaatgagt
     2581 gtggtggtgt gtgcttctac tctttatcta cttgggtgct gaggcaagag ggtaacttga
     2641 gcccaggagg tcaaagctgc agtgagccgt gattgtgcca ctccagcctg ggtgacgagt
     2701 gagaccttgt ctcaaaagca aaacaaaaaa gaatattgct gcttgtttgc ccatgaggta
     2761 tatttctttc attttatgaa aagcattttg acaacacgtt aacatttaat aaactttaga
     2821 ttaaaatata tagtgcaagc aacatgccat ttcaaatccg tagacttgtt tctttgatac
     2881 tcttgctgta ggtcgccgtg aggggtaggg aagcatatat actgtaggga gaagtatcaa
     2941 aatcatttaa ggtctttttt ccaaactagt gttcccctcc cacatcccaa caactcttgg
     3001 aagtctggtg ctccctctag gtgaaaatca tttgctggct tatggagtca ctgttgctga
     3061 gtcccatccc ccagttacag tgcagtggaa aacaggttta gaatctagaa cttgtttgta
     3121 tgttgtcact tggttatgtt ccaagtaggt tagaaccatg gaaaagagat tgcaaatggt
     3181 agtttcttct agatattcaa atgcatatat gtatgtacat gtaattataa ataaataatg
     3241 aatttttatt aaagtgttgt atgaacata
//
