LOCUS       NM_002177               1201 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens interferon omega 1 (IFNW1), mRNA.
ACCESSION   NM_002177
VERSION     NM_002177.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1201)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1201)
  AUTHORS   Mesev,E.V., LeDesma,R.A. and Ploss,A.
  TITLE     Decoding type I and III interferon signalling during viral
            infection
  JOURNAL   Nat Microbiol 4 (6), 914-924 (2019)
   PUBMED   30936491
  REMARK    Review article
REFERENCE   3  (bases 1 to 1201)
  AUTHORS   Li,S.F., Zhao,F.R., Shao,J.J., Xie,Y.L., Chang,H.Y. and Zhang,Y.G.
  TITLE     Interferon-omega: Current status in clinical applications
  JOURNAL   Int Immunopharmacol 52, 253-260 (2017)
   PUBMED   28957693
  REMARK    GeneRIF: a review on current status in clinical applications of
            interferon-omega
            Review article
REFERENCE   4  (bases 1 to 1201)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1201)
  AUTHORS   Baechler,E.C., Bilgic,H. and Reed,A.M.
  TITLE     Type I interferon pathway in adult and juvenile dermatomyositis
  JOURNAL   Arthritis Res Ther 13 (6), 249 (2011)
   PUBMED   22192711
  REMARK    GeneRIF: Studies indicate that upregulation of the type I
            interferon protein signature has added additional markers of
            disease activity and insight into the pathogenesis of the disease.
            Review article
REFERENCE   6  (bases 1 to 1201)
  AUTHORS   Olopade,O.I., Bohlander,S.K., Pomykala,H., Maltepe,E., Van
            Melle,E., Le Beau,M.M. and Diaz,M.O.
  TITLE     Mapping of the shortest region of overlap of deletions of the short
            arm of chromosome 9 associated with human neoplasia
  JOURNAL   Genomics 14 (2), 437-443 (1992)
   PUBMED   1385305
REFERENCE   7  (bases 1 to 1201)
  AUTHORS   Flores,I., Mariano,T.M. and Pestka,S.
  TITLE     Human interferon omega (omega) binds to the alpha/beta receptor
  JOURNAL   J Biol Chem 266 (30), 19875-19877 (1991)
   PUBMED   1834641
REFERENCE   8  (bases 1 to 1201)
  AUTHORS   Adolf,G.R., Fruhbeis,B., Hauptmann,R., Kalsner,I., Maurer-Fogy,I.,
            Ostermann,E., Patzelt,E., Schwendenwein,R., Sommergruber,W. and
            Zophel,A.
  TITLE     Human interferon omega 1: isolation of the gene, expression in
            Chinese hamster ovary cells and characterization of the recombinant
            protein
  JOURNAL   Biochim Biophys Acta 1089 (2), 167-174 (1991)
   PUBMED   1647209
REFERENCE   9  (bases 1 to 1201)
  AUTHORS   Adolf,G.R., Maurer-Fogy,I., Kalsner,I. and Cantell,K.
  TITLE     Purification and characterization of natural human interferon omega
            1. Two alternative cleavage sites for the signal peptidase
  JOURNAL   J Biol Chem 265 (16), 9290-9295 (1990)
   PUBMED   1693148
REFERENCE   10 (bases 1 to 1201)
  AUTHORS   Capon,D.J., Shepard,H.M. and Goeddel,D.V.
  TITLE     Two distinct families of human and bovine interferon-alpha genes
            are coordinately expressed and encode functional polypeptides
  JOURNAL   Mol Cell Biol 5 (4), 768-779 (1985)
   PUBMED   2985969
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI860608.1 and X02669.1.
            
            On Nov 19, 2020 this sequence version replaced NM_002177.2.
            
            Summary: The protein encoded by this gene is an interferon and
            possesses antiviral activity. The encoded protein binds to the
            interferon alpha/beta receptor but not to the interferon gamma
            receptor. This intronless gene has several pseudogenes spread
            throughout the genome. [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC117290.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380229.4/ ENSP00000369578.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               AI860608.1         1-324
            325-1201            X02669.1           1-877
FEATURES             Location/Qualifiers
     source          1..1201
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..1201
                     /gene="IFNW1"
                     /note="interferon omega 1"
                     /db_xref="GeneID:3467"
                     /db_xref="HGNC:HGNC:5448"
                     /db_xref="MIM:147553"
     exon            1..1201
                     /gene="IFNW1"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..850
                     /gene="IFNW1"
                     /note="IFN-omega 1, interferon omega-1; interferon
                     alpha-II-1"
                     /codon_start=1
                     /product="interferon omega-1 precursor"
                     /protein_id="NP_002168.1"
                     /db_xref="CCDS:CCDS6496.1"
                     /db_xref="GeneID:3467"
                     /db_xref="HGNC:HGNC:5448"
                     /db_xref="MIM:147553"
                     /translation="MALLFPLLAALVMTSYSPVGSLGCDLPQNHGLLSRNTLVLLHQM
                     RRISPFLCLKDRRDFRFPQEMVKGSQLQKAHVMSVLHEMLQQIFSLFHTERSSAAWNM
                     TLLDQLHTGLHQQLQHLETCLLQVVGEGESAGAISSPALTLRRYFQGIRVYLKEKKYS
                     DCAWEVVRMEIMKSLFLSTNMQERLRSKDRDLGSS"
ORIGIN      
        1 tattgacaca gctgaagttt actggagttt agctgaagtc taatgcaaaa ttaatagatt
       61 gttgtcatcc tcttaaggtc atagggagaa cacacaaatg aaaacagtaa aagaaactga
      121 aagtacagag aaatgttcag aaaatgaaaa ccatgtgttt cctattaaaa gccatgcata
      181 caagcaatgt cttcagaaaa cctagggtcc aaggttaagc catatcccag ctcagtaaag
      241 ccaggagcat cctcatttcc caatggccct cctgttccct ctactggcag ccctagtgat
      301 gaccagctat agccctgttg gatctctggg ctgtgatctg cctcagaacc atggcctact
      361 tagcaggaac accttggtgc ttctgcacca aatgaggaga atctcccctt tcttgtgtct
      421 caaggacaga agagacttca ggttccccca ggagatggta aaagggagcc agttgcagaa
      481 ggcccatgtc atgtctgtcc tccatgagat gctgcagcag atcttcagcc tcttccacac
      541 agagcgctcc tctgctgcct ggaacatgac cctcctagac caactccaca ctggacttca
      601 tcagcaactg caacacctgg agacctgctt gctgcaggta gtgggagaag gagaatctgc
      661 tggggcaatt agcagccctg cactgacctt gaggaggtac ttccagggaa tccgtgtcta
      721 cctgaaagag aagaaataca gcgactgtgc ctgggaagtt gtcagaatgg aaatcatgaa
      781 atccttgttc ttatcaacaa acatgcaaga aagactgaga agtaaagata gagacctggg
      841 ctcatcttga aatgattctc attgattaat ttgccatata acacttgcac atgtgactct
      901 ggtcaattca aaagactctt atttcggctt taatcacaga attgactgaa ttagttctgc
      961 aaatactttg tcggtatatt aagccagtat atgttaaaaa gacttaggtt caggggcatc
     1021 agtccctaag atgttattta tttttactca tttatttatt cttacatttt atcatattta
     1081 tactatttat attcttatat aacaaatgtt tgcctttaca ttgtattaag ataacaaaac
     1141 atgttcagct ttccatttgg ttaaatattg tattttgtta tttattaaat tattttcaaa
     1201 c
//
