LOCUS       NM_170743               4566 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens interferon lambda receptor 1 (IFNLR1), transcript
            variant 1, mRNA.
ACCESSION   NM_170743
VERSION     NM_170743.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4566)
  AUTHORS   Novotny,L.A., Evans,J.G., Guo,H., Kappler,C.S. and Meissner,E.G.
  TITLE     Interferon lambda receptor-1 isoforms differentially influence gene
            expression and HBV replication in stem cell-derived hepatocytes
  JOURNAL   Antiviral Res 221, 105779 (2024)
   PUBMED   38070830
  REMARK    GeneRIF: Interferon lambda receptor-1 isoforms differentially
            influence gene expression and HBV replication in stem cell-derived
            hepatocytes.
REFERENCE   2  (bases 1 to 4566)
  AUTHORS   Evans,J.G., Novotny,L.A. and Meissner,E.G.
  TITLE     Influence of Canonical and Non-Canonical IFNLR1 Isoform Expression
            on Interferon Lambda Signaling
  JOURNAL   Viruses 15 (3), 632 (2023)
   PUBMED   36992341
  REMARK    GeneRIF: Influence of Canonical and Non-Canonical IFNLR1 Isoform
            Expression on Interferon Lambda Signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4566)
  AUTHORS   Hausmann,L.D., de Almeida,B.S., de Souza,I.R., Drehmer,M.N.,
            Fernandes,B.L., Wilkens,R.S., Vieira,D.S.C., Lofgren,S.E.,
            Lindenau,J.D., de Toledo E Silva,G. and Muniz,Y.C.N.
  TITLE     Association of TNFRSF1A and IFNLR1 Gene Polymorphisms with the Risk
            of Developing Breast Cancer and Clinical Pathologic Features
  JOURNAL   Biochem Genet 59 (5), 1233-1246 (2021)
   PUBMED   33751344
  REMARK    GeneRIF: Association of TNFRSF1A and IFNLR1 Gene Polymorphisms with
            the Risk of Developing Breast Cancer and Clinical Pathologic
            Features.
REFERENCE   4  (bases 1 to 4566)
  AUTHORS   Liu,L., Qi,Y., Huang,D., Xu,Y., Li,M., Hong,Z., Gu,Y., Jia,B.,
            Luo,X., Zhang,S. and Zhang,S.
  TITLE     Downregulated expression of IL-28RA is involved in the pathogenesis
            of pancreatic ductal adenocarcinoma
  JOURNAL   Int J Oncol 59 (2) (2021)
   PUBMED   34195850
  REMARK    GeneRIF: Downregulated expression of IL28RA is involved in the
            pathogenesis of pancreatic ductal adenocarcinoma.
REFERENCE   5  (bases 1 to 4566)
  AUTHORS   Drehmer,M.N., Castro,G.V., Pereira,I.A., de Souza,I.R. and
            Lofgren,S.E.
  TITLE     Interferon III-related IL28RA variant is associated with rheumatoid
            arthritis and systemic lupus erythematosus and specific disease
            sub-phenotypes
  JOURNAL   Int J Rheum Dis 24 (1), 49-55 (2021)
   PUBMED   33269531
  REMARK    GeneRIF: Interferon III-related IL28RA variant is associated with
            rheumatoid arthritis and systemic lupus erythematosus and specific
            disease sub-phenotypes.
REFERENCE   6  (bases 1 to 4566)
  AUTHORS   Dumoutier,L., Tounsi,A., Michiels,T., Sommereyns,C., Kotenko,S.V.
            and Renauld,J.C.
  TITLE     Role of the interleukin (IL)-28 receptor tyrosine residues for
            antiviral and antiproliferative activity of IL-29/interferon-lambda
            1: similarities with type I interferon signaling
  JOURNAL   J Biol Chem 279 (31), 32269-32274 (2004)
   PUBMED   15166220
  REMARK    GeneRIF: interleukin (IL)-28 receptor tyrosine residues have roles
            in antiviral and antiproliferative activity of
            IL-29/interferon-lambda 1
REFERENCE   7  (bases 1 to 4566)
  AUTHORS   Dumoutier,L., Lejeune,D., Hor,S., Fickenscher,H. and Renauld,J.C.
  TITLE     Cloning of a new type II cytokine receptor activating signal
            transducer and activator of transcription (STAT)1, STAT2 and STAT3
  JOURNAL   Biochem J 370 (Pt 2), 391-396 (2003)
   PUBMED   12521379
REFERENCE   8  (bases 1 to 4566)
  AUTHORS   Kotenko,S.V., Gallagher,G., Baurin,V.V., Lewis-Antes,A., Shen,M.,
            Shah,N.K., Langer,J.A., Sheikh,F., Dickensheets,H. and
            Donnelly,R.P.
  TITLE     IFN-lambdas mediate antiviral protection through a distinct class
            II cytokine receptor complex
  JOURNAL   Nat Immunol 4 (1), 69-77 (2003)
   PUBMED   12483210
  REMARK    GeneRIF: distinct receptor complex that is utilized by all three
            IFN-lambda proteins for signaling and is composed of two subunits,
            a receptor designated CRF2-12 (also designated as IFN-lambdaR1) and
            a second subunit, CRF2-4 (also known as IL-10R2)
REFERENCE   9  (bases 1 to 4566)
  AUTHORS   Sheppard,P., Kindsvogel,W., Xu,W., Henderson,K., Schlutsmeyer,S.,
            Whitmore,T.E., Kuestner,R., Garrigues,U., Birks,C., Roraback,J.,
            Ostrander,C., Dong,D., Shin,J., Presnell,S., Fox,B., Haldeman,B.,
            Cooper,E., Taft,D., Gilbert,T., Grant,F.J., Tackett,M., Krivan,W.,
            McKnight,G., Clegg,C., Foster,D. and Klucher,K.M.
  TITLE     IL-28, IL-29 and their class II cytokine receptor IL-28R
  JOURNAL   Nat Immunol 4 (1), 63-68 (2003)
   PUBMED   12469119
  REMARK    GeneRIF: IL-28 and IL-29 interact with a heterodimeric class II
            cytokine receptor that consisted of IL-10 receptor beta
            (IL-10Rbeta) and an orphan class II receptor chain, designated
            IL-28Ralpha.
REFERENCE   10 (bases 1 to 4566)
  AUTHORS   Rejmanowski,T.
  TITLE     [Herniation of the muscles in lower limbs in children]
  JOURNAL   Chir Narzadow Ruchu Ortop Pol 41 (1), 21-25 (1976)
   PUBMED   1248321
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590683.16, BC140872.1 and
            AF439325.1.
            
            On Nov 22, 2018 this sequence version replaced NM_170743.3.
            
            Summary: The protein encoded by this gene belongs to the class II
            cytokine receptor family. This protein forms a receptor complex
            with interleukine 10 receptor, beta (IL10RB). The receptor complex
            has been shown to interact with three closely related cytokines,
            including interleukin 28A (IL28A), interleukin 28B (IL28B), and
            interleukin 29 (IL29). The expression of all three cytokines can be
            induced by viral infection. The cells overexpressing this protein
            have been found to have enhanced responses to IL28A and IL29, but
            decreased response to IL28B. Three alternatively spliced transcript
            variants encoding distinct isoforms have been reported. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF439325.1, AK160364.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327535.6/ ENSP00000327824.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL590683.16        51875-51888         c
            15-1732             BC140872.1         50-1767
            1733-4566           AF439325.1         1692-4525
FEATURES             Location/Qualifiers
     source          1..4566
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..4566
                     /gene="IFNLR1"
                     /gene_synonym="CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2"
                     /note="interferon lambda receptor 1"
                     /db_xref="GeneID:163702"
                     /db_xref="HGNC:HGNC:18584"
                     /db_xref="MIM:607404"
     exon            1..99
                     /gene="IFNLR1"
                     /gene_synonym="CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1604
                     /gene="IFNLR1"
                     /gene_synonym="CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interleukin 28 receptor A; interleukin or
                     cytokine receptor 2; interleukin-28 receptor subunit
                     alpha; class II cytokine receptor CRF2/12; CRF2-12;
                     IL-28RA; IL-28R-alpha; IFN-lambda-R1; IFN-lambda receptor
                     1; IL-28 receptor subunit alpha; cytokine receptor
                     class-II member 12; cytokine receptor family 2 member 12;
                     likely interleukin or cytokine receptor 2; interleukin 28
                     alpha receptor; interleukin 28 receptor, alpha
                     (interferon, lambda receptor)"
                     /codon_start=1
                     /product="interferon lambda receptor 1 isoform 1
                     precursor"
                     /protein_id="NP_734464.1"
                     /db_xref="CCDS:CCDS248.1"
                     /db_xref="GeneID:163702"
                     /db_xref="HGNC:HGNC:18584"
                     /db_xref="MIM:607404"
                     /translation="MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWL
                     PGLGNPQDVTYFVAYQSSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRT
                     VSPSSKSPWVESEYLDYLFEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEV
                     AFWKEGAGNKTLFPVTPHGQPVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCF
                     LLEVPEANWAFLVLPSLLILLLVIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPV
                     ATFQPSRPESVNDLFLCPQKELTRGVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDT
                     EDGVSFQPYIEPPSFLGQEHQAPGHSEAGGVDSGRPRAPLVPSEGSSAWDSSDRSWAS
                     TVDSSWDRAGSSGYLAEKGPGQGPGGDGHQESLPPPEFSKDSGFLEELPEDNLSSWAT
                     WGTLPPEPNLVPGGPPVSLQTLTFCWESSPEEEEEARESEIEDSDAGSWGAESTQRTE
                     DRGRTLGHYMAR"
     exon            100..223
                     /gene="IFNLR1"
                     /gene_synonym="CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2"
                     /inference="alignment:Splign:2.1.0"
     exon            224..408
                     /gene="IFNLR1"
                     /gene_synonym="CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2"
                     /inference="alignment:Splign:2.1.0"
     exon            409..551
                     /gene="IFNLR1"
                     /gene_synonym="CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..711
                     /gene="IFNLR1"
                     /gene_synonym="CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..842
                     /gene="IFNLR1"
                     /gene_synonym="CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..4566
                     /gene="IFNLR1"
                     /gene_synonym="CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4538..4543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFNLR1"
                     /gene_synonym="CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2"
                     /note="hexamer: AATAAA"
     polyA_site      4566
                     /gene="IFNLR1"
                     /gene_synonym="CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2"
                     /note="major polyA site"
ORIGIN      
        1 ggggacctgg gcccgggcgg ggacgccgcg gcaggaaggc catggcgggg cccgagcgct
       61 ggggccccct gctcctgtgc ctgctgcagg ccgctccagg gaggccccgt ctggcccctc
      121 cccagaatgt gacgctgctc tcccagaact tcagcgtgta cctgacatgg ctcccagggc
      181 ttggcaaccc ccaggatgtg acctattttg tggcctatca gagctctccc acccgtagac
      241 ggtggcgcga agtggaagag tgtgcgggaa ccaaggagct gctatgttct atgatgtgcc
      301 tgaagaaaca ggacctgtac aacaagttca agggacgcgt gcggacggtt tctcccagct
      361 ccaagtcccc ctgggtggag tccgaatacc tggattacct ttttgaagtg gagccggccc
      421 cacctgtcct ggtgctcacc cagacggagg agatcctgag tgccaatgcc acgtaccagc
      481 tgcccccctg catgccccca ctggatctga agtatgaggt ggcattctgg aaggaggggg
      541 ccggaaacaa gaccctattt ccagtcactc cccatggcca gccagtccag atcactctcc
      601 agccagctgc cagcgaacac cactgcctca gtgccagaac catctacacg ttcagtgtcc
      661 cgaaatacag caagttctct aagcccacct gcttcttgct ggaggtccca gaagccaact
      721 gggctttcct ggtgctgcca tcgcttctga tactgctgtt agtaattgcc gcagggggtg
      781 tgatctggaa gaccctcatg gggaacccct ggtttcagcg ggcaaagatg ccacgggccc
      841 tggacttttc tggacacaca caccctgtgg caacctttca gcccagcaga ccagagtccg
      901 tgaatgactt gttcctctgt ccccaaaagg aactgaccag aggggtcagg ccgacgcctc
      961 gagtcagggc cccagccacc caacagacaa gatggaagaa ggaccttgca gaggacgaag
     1021 aggaggagga tgaggaggac acagaagatg gcgtcagctt ccagccctac attgaaccac
     1081 cttctttcct ggggcaagag caccaggctc cagggcactc ggaggctggt ggggtggact
     1141 cagggaggcc cagggctcct ctggtcccaa gcgaaggctc ctctgcttgg gattcttcag
     1201 acagaagctg ggccagcact gtggactcct cctgggacag ggctgggtcc tctggctatt
     1261 tggctgagaa ggggccaggc caagggccgg gtggggatgg gcaccaagaa tctctcccac
     1321 cacctgaatt ctccaaggac tcgggtttcc tggaagagct cccagaagat aacctctcct
     1381 cctgggccac ctggggcacc ttaccaccgg agccgaatct ggtccctggg ggacccccag
     1441 tttctcttca gacactgacc ttctgctggg aaagcagccc tgaggaggaa gaggaggcga
     1501 gggaatcaga aattgaggac agcgatgcgg gcagctgggg ggctgagagc acccagagga
     1561 ccgaggacag gggccggaca ttggggcatt acatggccag gtgagctgtc ccccgacatc
     1621 ccaccgaatc tgatgctgct gctgcctttg caaggactac tgggcttccc aagaaactca
     1681 agagcctccg tacctcccct gggcggcgga ggggcattgc acttccggga agtccaccta
     1741 gcggctgttt gcctgtcggg ctgagcaaca agatgcccct ccctcctgtg acccgccctc
     1801 tttaggctga gctataagag gggtggacac agggtgggct gaggtcagag gttggtgggg
     1861 tgtcatcacc cccattgtcc ctagggtgac aggccagggg gaaaaattat ccccggacaa
     1921 catgaaacag gtgaggtcag gtcactgcgg acatcaaggg cggacaccac caaggggccc
     1981 tctggaactt gagaccactg gaggcacacc tgctatacct catgcctttc ccagcagcca
     2041 ctgaactccc ccatcccagg gctcagcctc ctgattcatg ggtcccctag ttaggcccag
     2101 ataaaaatcc agttggctga gggttttgga tgggaaggga agggtggctg tcctcaaatc
     2161 ctggtctttg gagtcatggc actgtacggt tttagtgtca gacagaccgg ggttcaaatc
     2221 ccagctctgc tgttcactgg ttgtatgatc ttggggaaga catcttcctt ctctgcctcg
     2281 gcttcctcat ctgcagctac gcctgggtgt ggtgagggtt ctaggggatc tcagatgtgt
     2341 gtagcacgga gcctgctgtg tcctgggtgc tctctacgtg gtggccggta gaattctcca
     2401 tctatccagg ctccaggaga cccctgggca tctcccacct gtggccccta aacccagagt
     2461 gactgagagc acttaacatt cagcttgtct catccccagt ctacctcctt ccttctaccc
     2521 tcactgcctc ccagtcagga gagtgagctc tcagaagcca gagccccacc caaggggacc
     2581 ctggtctctc cgccttcacc tagcaatggg aaccctgctt cccaggggag gaaccaactg
     2641 ctccaccttc tagggaccca gtttgttgga gtaggacagt aacatggcag gaatcggact
     2701 tctgggcctg taatcccagt ttggatggca cgttagactc ttggttgacc gttgtggtcc
     2761 ttagaagtcc cattctccct tccagttatg agaaaccaat gccttctaga ttcaggtgac
     2821 tatccttacc tgggggtgct gatgcatcct cagttaacct acacccacct gaatatagat
     2881 gagcgtagct gagttttcac ccgtaggacc gaagtgtttt gtggtggagt atctgaacaa
     2941 ccttggctct gtggccattc aacctgccag gactaacatt tctggatttg tgaagaaggg
     3001 atcttcaaag ccattgaacc cacagagctg tgttgcttta aagccaccac aagggtacag
     3061 cattaaatgg cagaactgga aaagcttctt agggcatctc atccagggat tctcaaacca
     3121 tgtcccccag aggccttggg ctgcagttgc agggggcgcc atggggctat aggagcctcc
     3181 cactttcacc agagcagcct cactgtgccc tgattcacac actgtggctt tccacgtgag
     3241 gttttgttta gagggatcca ctactcaaga aaaagttagc aaaccactcc ttttgttgca
     3301 aaggagctga ggtcaagggt ggcaaaggca cttgtccaag gtcgcccagc agtgctgctc
     3361 tgatgacttg tgcacatccc caagggtaag agcttcgatc tctgcacagc cgggccaacc
     3421 tctgacccct tgtccatgtc agtaaaatat gaaggtcaca gccaggattt ctaagggtca
     3481 ggaggccttc accgctgctg gggcacacac acacacatgc atacacacat acgacacaca
     3541 cctgtgtctc cccaggggtt ttccctgcag tgaggcttgt ccagatgatt gagcccagga
     3601 gaggaagaac aaacaaacta cggagctggg gagggctgtg gcttggggcc agctcccagg
     3661 gaaattccca gacctgtacc gatgttctct ctggcaccag ccgagctgct tcgtggaggt
     3721 aacttcaaaa aagtaaaagc tatcatcagc atcatcttag acttgtatga aataaccact
     3781 ccgtttctat tcttaaacct taccattttt gttttgtttt gtttttttga gtcggagttt
     3841 tgttcttttt gcctaggctg gagtgcagtg gtacaatctc ggctcactgc aacctccacc
     3901 tcccgggttc aagtgattct cctgcctcag cctcccaagt agctgggatt acaggcaccc
     3961 gccaccacac ctggctaatt tttttgtatt tttagtagag acggggtttc accatgttgg
     4021 ccaggctggt ctcgaactcc tgacctcagg tgatccgccc gcctcggcct cccaaagtgc
     4081 tgggattaca ggcgtgagcc accgcgccca gccaaacctt actatttttt taaagaattt
     4141 tttccagagt ttaatttctg acatagctta agttttccag taactctaaa ctccatctcc
     4201 tttatcgtca ttaagtcatt cacaaaaagc caggagaagc atttggaaag ggcatgataa
     4261 tcagtataat aatttgcctt gtgtggtcag cacttaactg tttacaaagc cctttcacgt
     4321 gcacagcagg tgggaactgc gcggtgtggg ctgggcctgc gctggaagca tatcccgtga
     4381 aaagtgttag tgccttaggt gaaagcaaca tgtatccctt tagactacta acggtatatg
     4441 ttgttcttat gtatttgtat ttatttctat tttttctatg tttatgtcat atttaaacga
     4501 tatcctactg cttgttggta ttaccctaaa ctgtttaaat aaagagctct atttttaaag
     4561 aaaaaa
//
