LOCUS       NM_172139                709 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens interferon lambda 3 (IFNL3), transcript variant 2,
            mRNA.
ACCESSION   NM_172139
VERSION     NM_172139.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 709)
  AUTHORS   De,M., Sukla,S., Bharatiya,S., Keshri,S., Roy,D.G., Roy,S.,
            Dutta,D., Saha,S., Ejazi,S.A., Ravichandiran,V., Ali,N.,
            Chatterjee,M. and Chinnaswamy,S.
  TITLE     IFN-lambda3 is induced by Leishmania donovani and can inhibit
            parasite growth in cell line models but not in the mouse model,
            while it shows a significant association with leishmaniasis in
            humans
  JOURNAL   Infect Immun 92 (2), e0050423 (2024)
   PUBMED   38193711
  REMARK    GeneRIF: IFN-lambda3 is induced by Leishmania donovani and can
            inhibit parasite growth in cell line models but not in the mouse
            model, while it shows a significant association with leishmaniasis
            in humans.
REFERENCE   2  (bases 1 to 709)
  AUTHORS   Sardar,S., Muhammad,S., Haq,M., Haq,N.U. and Kashif Khan,A.M.
  TITLE     Predictive Potential Of Il28b Gene In Hcv Patients, Resistant To
            Daclatasvir And Sofosbuvir In KPK Population
  JOURNAL   J Ayub Med Coll Abbottabad 35 (4), 523-529 (2023)
   PUBMED   38406928
  REMARK    GeneRIF: Predictive Potential Of Il28b Gene In Hcv Patients,
            Resistant To Daclatasvir And Sofosbuvir In KPK Population.
REFERENCE   3  (bases 1 to 709)
  AUTHORS   Matic,S., Milovanovic,D., Mijailovic,Z., Djurdjevic,P.,
            Sazdanovic,P., Stefanovic,S., Todorovic,D., Popovic,S.,
            Vitosevic,K., Vukicevic,V., Vukic,M., Vukovic,N., Milivojevic,N.,
            Zivanovic,M., Jakovljevic,V., Filipovic,N., Djordjevic,N. and
            Baskic,D.
  TITLE     Its all about IFN-lambda4: Protective role of IFNL4 polymorphism
            against COVID-19-related pneumonia in females
  JOURNAL   J Med Virol 95 (10), e29152 (2023)
   PUBMED   37812032
  REMARK    GeneRIF: Its all about IFN-lambda4: Protective role of IFNL4
            polymorphism against COVID-19-related pneumonia in females.
REFERENCE   4  (bases 1 to 709)
  AUTHORS   Sekimoto,Y., Sekiya,M., Nojiri,S., Hayakawa,E., Masui,Y.,
            Tajima,M., Nishino,K., Nishizaki,Y. and Takahashi,K.
  TITLE     IFN-lambda3 and CCL17 as predictors of disease progression in
            patients with mild to moderate COVID-19: A cohort study in a
            real-world setting
  JOURNAL   Respir Investig 61 (2), 153-156 (2023)
   PUBMED   36682084
  REMARK    GeneRIF: IFN-lambda3 and CCL17 as predictors of disease progression
            in patients with mild to moderate COVID-19: A cohort study in a
            real-world setting.
REFERENCE   5  (bases 1 to 709)
  AUTHORS   Abd Elrahman,M., Ibrahim,M.K., Khairy,A., Yosry,A., Zayed,N.,
            Tawefeek,S., Barakat,A.Z., Elbatae,H. and Bader El Din,N.G.
  TITLE     The Impact of interferon lambda 3 Polymorphism on Hepato-Cellular
            Carcinoma Progression in Hepatitis C Virus Patients:
            Treatment-Naive and Experienced
  JOURNAL   Asian Pac J Cancer Prev 24 (1), 215-221 (2023)
   PUBMED   36708570
  REMARK    GeneRIF: The Impact of interferon lambda 3 Polymorphism on
            Hepato-Cellular Carcinoma Progression in Hepatitis C Virus
            Patients: Treatment-Naive and Experienced.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 709)
  AUTHORS   Mennechet,F.J. and Uze,G.
  TITLE     Interferon-lambda-treated dendritic cells specifically induce
            proliferation of FOXP3-expressing suppressor T cells
  JOURNAL   Blood 107 (11), 4417-4423 (2006)
   PUBMED   16478884
  REMARK    GeneRIF: IFN-lambdas are thus able to generate tolerogenic DCs, an
            activity that could thwart IFN-beta functions
REFERENCE   7  (bases 1 to 709)
  AUTHORS   Li,M. and He,S.
  TITLE     Purification and characterization of recombinant human
            interleukin-29 expressed in Escherichia coli
  JOURNAL   J Biotechnol 122 (3), 334-340 (2006)
   PUBMED   16413080
REFERENCE   8  (bases 1 to 709)
  AUTHORS   Li,M.C., Wang,H.Y., Wang,H.Y., Li,T. and He,S.H.
  TITLE     Liposome-mediated IL-28 and IL-29 expression in A549 cells and
            anti-viral effect of IL-28 and IL-29 on WISH cells
  JOURNAL   Acta Pharmacol Sin 27 (4), 453-459 (2006)
   PUBMED   16539846
REFERENCE   9  (bases 1 to 709)
  AUTHORS   Kotenko,S.V., Gallagher,G., Baurin,V.V., Lewis-Antes,A., Shen,M.,
            Shah,N.K., Langer,J.A., Sheikh,F., Dickensheets,H. and
            Donnelly,R.P.
  TITLE     IFN-lambdas mediate antiviral protection through a distinct class
            II cytokine receptor complex
  JOURNAL   Nat Immunol 4 (1), 69-77 (2003)
   PUBMED   12483210
  REMARK    GeneRIF: closely positioned genes on human chromosome 19 encode
            distinct but paralogous proteins, which we designate
            interferon-lambda1 (IFN-lambda1), IFN-lambda2 and IFN-lambda3
REFERENCE   10 (bases 1 to 709)
  AUTHORS   Sheppard,P., Kindsvogel,W., Xu,W., Henderson,K., Schlutsmeyer,S.,
            Whitmore,T.E., Kuestner,R., Garrigues,U., Birks,C., Roraback,J.,
            Ostrander,C., Dong,D., Shin,J., Presnell,S., Fox,B., Haldeman,B.,
            Cooper,E., Taft,D., Gilbert,T., Grant,F.J., Tackett,M., Krivan,W.,
            McKnight,G., Clegg,C., Foster,D. and Klucher,K.M.
  TITLE     IL-28, IL-29 and their class II cytokine receptor IL-28R
  JOURNAL   Nat Immunol 4 (1), 63-68 (2003)
   PUBMED   12469119
  REMARK    GeneRIF: identified from the human genomic sequence a family of
            three cytokines, designated interleukin 28A (IL-28A), IL-28B and
            IL-29, that are distantly related to type I interferons (IFNs) and
            the IL-10 family
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC130316.1 and AC011445.6.
            
            On May 17, 2019 this sequence version replaced NM_172139.3.
            
            Summary: This gene encodes a cytokine distantly related to type I
            interferons and the IL-10 family. This gene, interleukin 28A
            (IL28A), and interleukin 29 (IL29) are three closely related
            cytokine genes that form a cytokine gene cluster on a chromosomal
            region mapped to 19q13. Expression of the cytokines encoded by the
            three genes can be induced by viral infection. All three cytokines
            have been shown to interact with a heterodimeric class II cytokine
            receptor that consists of interleukin 10 receptor, beta (IL10RB)
            and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate 5' terminal
            exon resulting in a novel 5' UTR, and the use of a downstream start
            codon compared to variant 1. The encoded isoform (2) has a shorter
            N-terminus, and contains a signal peptide, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC130314.1, AY336714.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2148093 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000413851.3/ ENSP00000409000.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-656               BC130316.1         1-656
            657-709             AC011445.6         24655-24707         c
FEATURES             Location/Qualifiers
     source          1..709
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..709
                     /gene="IFNL3"
                     /gene_synonym="IFN-lambda-3; IFN-lambda-4; IL-28B; IL-28C;
                     IL28B; IL28C"
                     /note="interferon lambda 3"
                     /db_xref="GeneID:282617"
                     /db_xref="HGNC:HGNC:18365"
                     /db_xref="MIM:607402"
     exon            1..219
                     /gene="IFNL3"
                     /gene_synonym="IFN-lambda-3; IFN-lambda-4; IL-28B; IL-28C;
                     IL28B; IL28C"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..630
                     /gene="IFNL3"
                     /gene_synonym="IFN-lambda-3; IFN-lambda-4; IL-28B; IL-28C;
                     IL28B; IL28C"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; interleukin-28B; interferon, lambda 4;
                     interleukin-28C; cytokine Zcyto22"
                     /codon_start=1
                     /product="interferon lambda-3 isoform 2 precursor"
                     /protein_id="NP_742151.2"
                     /db_xref="CCDS:CCDS12530.1"
                     /db_xref="GeneID:282617"
                     /db_xref="HGNC:HGNC:18365"
                     /db_xref="MIM:607402"
                     /translation="MTGDCMPVLVLMAAVLTVTGAVPVARLRGALPDARGCHIAQFKS
                     LSPQELQAFKRAKDALEESLLLKDCKCRSRLFPRTWDLRQLQVRERPVALEAELALTL
                     KVLEATADTDPALGDVLDQPLHTLHHILSQLRACIQPQPTAGPRTRGRLHHWLHRLQE
                     APKKESPGCLEASVTFNLFRLLTRDLNCVASGDLCV"
     exon            220..297
                     /gene="IFNL3"
                     /gene_synonym="IFN-lambda-3; IFN-lambda-4; IL-28B; IL-28C;
                     IL28B; IL28C"
                     /inference="alignment:Splign:2.1.0"
     exon            298..447
                     /gene="IFNL3"
                     /gene_synonym="IFN-lambda-3; IFN-lambda-4; IL-28B; IL-28C;
                     IL28B; IL28C"
                     /inference="alignment:Splign:2.1.0"
     exon            448..531
                     /gene="IFNL3"
                     /gene_synonym="IFN-lambda-3; IFN-lambda-4; IL-28B; IL-28C;
                     IL28B; IL28C"
                     /inference="alignment:Splign:2.1.0"
     exon            532..709
                     /gene="IFNL3"
                     /gene_synonym="IFN-lambda-3; IFN-lambda-4; IL-28B; IL-28C;
                     IL28B; IL28C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcattccc tcagctccct ttctctctgt gacacagaca tgaccgggga ctgcatgcca
       61 gtgctggtgc tgatggccgc agtgctgacc gtgactggag cagttcctgt cgccaggctc
      121 cgcggggctc tcccggatgc aaggggctgc cacatagccc agttcaagtc cctgtctcca
      181 caggagctgc aggcctttaa gagggccaaa gatgccttag aagagtcgct tctgctgaag
      241 gactgcaagt gccgctcccg cctcttcccc aggacctggg acctgaggca gctgcaggtg
      301 agggagcgcc ccgtggcttt ggaggctgag ctggccctga cgctgaaggt tctggaggcc
      361 accgctgaca ctgacccagc cctgggggat gtcttggacc agccccttca caccctgcac
      421 catatcctct cccagctccg ggcctgtatc cagcctcagc ccacggcagg gcccaggacc
      481 cggggccgcc tccaccattg gctgcaccgg ctccaggagg ccccaaaaaa ggagtcccct
      541 ggctgcctcg aggcctctgt caccttcaac ctcttccgcc tcctcacgcg agacctgaat
      601 tgtgttgcca gcggggacct gtgtgtctga cccttccgcc agtcatgcaa cctgagattt
      661 tatttataaa ttagccactt ggcttaattt attgtcaccc agtcgctat
//
