LOCUS       NM_172138                951 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens interferon lambda 2 (IFNL2), mRNA.
ACCESSION   NM_172138
VERSION     NM_172138.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 951)
  AUTHORS   Huang,Y., Ju,T., Zhang,H., Cao,D., Li,X., Yang,J. and Yan,D.
  TITLE     Lower level of IL-28A as a predictive index of the artificial liver
            support system in effective treatment of patients with HBV-ACLF
  JOURNAL   J Clin Lab Anal 36 (12), e24766 (2022)
   PUBMED   36336888
  REMARK    GeneRIF: Lower level of IL-28A as a predictive index of the
            artificial liver support system in effective treatment of patients
            with HBV-ACLF.
REFERENCE   2  (bases 1 to 951)
  AUTHORS   Yang,Y., Chen,J., Yi,C., Yang,F., Tang,M., Li,Z. and Bai,X.
  TITLE     Assessment of serum interleukin-28 as a biomarker to predict
            mortality in traumatic patients with sepsis
  JOURNAL   Cytokine 157, 155959 (2022)
   PUBMED   35816926
  REMARK    GeneRIF: Assessment of serum interleukin-28 as a biomarker to
            predict mortality in traumatic patients with sepsis.
REFERENCE   3  (bases 1 to 951)
  AUTHORS   Fukuda,Y., Homma,T., Inoue,H., Goto,Y., Sato,Y., Ikeda,H.,
            Onitsuka,C., Sato,H., Akimoto,K., Ebato,T., Suganuma,H.,
            Kawahara,T., Mikuni,H., Uchida,Y., Suzuki,S., Tanaka,A. and
            Sagara,H.
  TITLE     Serum IL-28A/IFN-lambda2 is linked to disease severity of COVID-19
  JOURNAL   Sci Rep 12 (1), 5458 (2022)
   PUBMED   35361913
  REMARK    GeneRIF: Serum IL-28A/IFN-lambda2 is linked to disease severity of
            COVID-19.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 951)
  AUTHORS   Azamor,T., Cunha,D.P., da Silva,A.M.V., Bezerra,O.C.L.,
            Ribeiro-Alves,M., Calvo,T.L., Kehdy,F.S.G., Manta,F.S.N.,
            Pinto,T.G.T., Ferreira,L.P., Portari,E.A., Guida,L.D.C., Gomes,L.,
            Moreira,M.E.L., de Carvalho,E.F., Cardoso,C.C., Muller,M., Ano
            Bom,A.P.D., Neves,P.C.D.C., Vasconcelos,Z. and Moraes,M.O.
  TITLE     Congenital Zika Syndrome Is Associated With Interferon Alfa
            Receptor 1
  JOURNAL   Front Immunol 12, 764746 (2021)
   PUBMED   34899713
  REMARK    GeneRIF: Congenital Zika Syndrome Is Associated With Interferon
            Alfa Receptor 1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 951)
  AUTHORS   Shahbazi,M., Amri Maleh,P., Bagherzadeh,M., Moulana,Z.,
            Sepidarkish,M., Rezanejad,M., Mirzakhani,M., Ebrahimpour,S.,
            Ghorbani,H., Ahmadnia,Z., Javanian,M., Bayani,M. and
            Mohammadnia-Afrouzi,M.
  TITLE     Linkage of Lambda Interferons in Protection Against Severe COVID-19
  JOURNAL   J Interferon Cytokine Res 41 (4), 149-152 (2021)
   PUBMED   33885337
  REMARK    GeneRIF: Linkage of Lambda Interferons in Protection Against Severe
            COVID-19.
REFERENCE   6  (bases 1 to 951)
  AUTHORS   Brand,S., Beigel,F., Olszak,T., Zitzmann,K., Eichhorst,S.T.,
            Otte,J.M., Diebold,J., Diepolder,H., Adler,B., Auernhammer,C.J.,
            Goke,B. and Dambacher,J.
  TITLE     IL-28A and IL-29 mediate antiproliferative and antiviral signals in
            intestinal epithelial cells and murine CMV infection increases
            colonic IL-28A expression
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 289 (5), G960-G968 (2005)
   PUBMED   16051921
  REMARK    GeneRIF: IECs express functional receptors for IFN-lambdas, which
            mediate antiviral and antiproliferative signals in IECs, suggesting
            a potential for therapeutic use in certain viral infections and as
            (antiproliferative) anticancer therapy
REFERENCE   7  (bases 1 to 951)
  AUTHORS   Meager,A., Visvalingam,K., Dilger,P., Bryan,D. and Wadhwa,M.
  TITLE     Biological activity of interleukins-28 and -29: comparison with
            type I interferons
  JOURNAL   Cytokine 31 (2), 109-118 (2005)
   PUBMED   15899585
  REMARK    GeneRIF: we found IL-28A and IL-29 act similarly to IFNs, but are
            less effective generally and have activity in a more limited range
            of cell lines
REFERENCE   8  (bases 1 to 951)
  AUTHORS   Brand,S., Zitzmann,K., Dambacher,J., Beigel,F., Olszak,T.,
            Vlotides,G., Eichhorst,S.T., Goke,B., Diepolder,H. and
            Auernhammer,C.J.
  TITLE     SOCS-1 inhibits expression of the antiviral proteins 2',5'-OAS and
            MxA induced by the novel interferon-lambdas IL-28A and IL-29
  JOURNAL   Biochem Biophys Res Commun 331 (2), 543-548 (2005)
   PUBMED   15850793
  REMARK    GeneRIF: IL-28A and IL-29 induced mRNA expression of the antiviral
            proteins 2',5'-OAS and MxA was abolished by overexpression of
            SOCS-1
REFERENCE   9  (bases 1 to 951)
  AUTHORS   Kotenko,S.V., Gallagher,G., Baurin,V.V., Lewis-Antes,A., Shen,M.,
            Shah,N.K., Langer,J.A., Sheikh,F., Dickensheets,H. and
            Donnelly,R.P.
  TITLE     IFN-lambdas mediate antiviral protection through a distinct class
            II cytokine receptor complex
  JOURNAL   Nat Immunol 4 (1), 69-77 (2003)
   PUBMED   12483210
  REMARK    GeneRIF: closely positioned genes on human chromosome 19 encode
            distinct but paralogous proteins, which we designate
            interferon-lambda1 (IFN-lambda1), IFN-lambda2 and IFN-lambda3
REFERENCE   10 (bases 1 to 951)
  AUTHORS   Sheppard,P., Kindsvogel,W., Xu,W., Henderson,K., Schlutsmeyer,S.,
            Whitmore,T.E., Kuestner,R., Garrigues,U., Birks,C., Roraback,J.,
            Ostrander,C., Dong,D., Shin,J., Presnell,S., Fox,B., Haldeman,B.,
            Cooper,E., Taft,D., Gilbert,T., Grant,F.J., Tackett,M., Krivan,W.,
            McKnight,G., Clegg,C., Foster,D. and Klucher,K.M.
  TITLE     IL-28, IL-29 and their class II cytokine receptor IL-28R
  JOURNAL   Nat Immunol 4 (1), 63-68 (2003)
   PUBMED   12469119
  REMARK    GeneRIF: identified from the human genomic sequence a family of
            three cytokines, designated interleukin 28A (IL-28A), IL-28B and
            IL-29, that are distantly related to type I interferons (IFNs) and
            the IL-10 family
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011445.6, AY129148.1 and AA774195.1.
            
            On Aug 7, 2019 this sequence version replaced NM_172138.1.
            
            Summary: This gene encodes a cytokine distantly related to type I
            interferons and the IL-10 family. This gene, interleukin 28B
            (IL28B), and interleukin 29 (IL29) are three closely related
            cytokine genes that form a cytokine gene cluster on a chromosomal
            region mapped to 19q13. Expression of the cytokines encoded by the
            three genes can be induced by viral infection. All three cytokines
            have been shown to interact with a heterodimeric class II cytokine
            receptor that consists of interleukin 10 receptor, beta (IL10RB)
            and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ126337.1, AY129148.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2148093 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331982.6/ ENSP00000333639.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC011445.6         49498-49618
            122-855             AY129148.1         1-734
            856-951             AA774195.1         169-264
FEATURES             Location/Qualifiers
     source          1..951
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..951
                     /gene="IFNL2"
                     /gene_synonym="IFNL2a; IFNL3a; IL-28A; IL28A"
                     /note="interferon lambda 2"
                     /db_xref="GeneID:282616"
                     /db_xref="HGNC:HGNC:18364"
                     /db_xref="MIM:607401"
     exon            1..183
                     /gene="IFNL2"
                     /gene_synonym="IFNL2a; IFNL3a; IL-28A; IL28A"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..776
                     /gene="IFNL2"
                     /gene_synonym="IFNL2a; IFNL3a; IL-28A; IL28A"
                     /note="interleukin-28A; IFN-lambda-2; cytokine Zcyto20;
                     interleukin 28A (interferon, lambda 2)"
                     /codon_start=1
                     /product="interferon lambda-2 precursor"
                     /protein_id="NP_742150.1"
                     /db_xref="CCDS:CCDS42567.1"
                     /db_xref="GeneID:282616"
                     /db_xref="HGNC:HGNC:18364"
                     /db_xref="MIM:607401"
                     /translation="MKLDMTGDCTPVLVLMAAVLTVTGAVPVARLHGALPDARGCHIA
                     QFKSLSPQELQAFKRAKDALEESLLLKDCRCHSRLFPRTWDLRQLQVRERPMALEAEL
                     ALTLKVLEATADTDPALVDVLDQPLHTLHHILSQFRACIQPQPTAGPRTRGRLHHWLY
                     RLQEAPKKESPGCLEASVTFNLFRLLTRDLNCVASGDLCV"
     exon            184..365
                     /gene="IFNL2"
                     /gene_synonym="IFNL2a; IFNL3a; IL-28A; IL28A"
                     /inference="alignment:Splign:2.1.0"
     exon            366..443
                     /gene="IFNL2"
                     /gene_synonym="IFNL2a; IFNL3a; IL-28A; IL28A"
                     /inference="alignment:Splign:2.1.0"
     exon            444..593
                     /gene="IFNL2"
                     /gene_synonym="IFNL2a; IFNL3a; IL-28A; IL28A"
                     /inference="alignment:Splign:2.1.0"
     exon            594..677
                     /gene="IFNL2"
                     /gene_synonym="IFNL2a; IFNL3a; IL-28A; IL28A"
                     /inference="alignment:Splign:2.1.0"
     exon            678..951
                     /gene="IFNL2"
                     /gene_synonym="IFNL2a; IFNL3a; IL-28A; IL28A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      932..937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFNL2"
                     /gene_synonym="IFNL2a; IFNL3a; IL-28A; IL28A"
                     /note="hexamer: AATAAA"
     polyA_site      951
                     /gene="IFNL2"
                     /gene_synonym="IFNL2a; IFNL3a; IL-28A; IL28A"
                     /note="major polyA site"
ORIGIN      
        1 aggaattaca tcccagacag agctcaaaac tgacagaaag agtcaaagcc aggacacagt
       61 ctgagatcca gaagagggga ctgaaaagaa cagagactcc agacaagacc caaacagacc
      121 ctgggtgaca gcctcagagt gtttcttctg ctgacaaaga ccagagatca ggaatgaaac
      181 tagacatgac tggggactgc acgccagtgc tggtgctgat ggccgcagtg ctgaccgtga
      241 ctggagcagt tcctgtcgcc aggctccacg gggctctccc ggatgcaagg ggctgccaca
      301 tagcccagtt caagtccctg tctccacagg agctgcaggc ctttaagagg gccaaagatg
      361 ccttagaaga gtcgcttctg ctgaaggact gcaggtgcca ctcccgcctc ttccccagga
      421 cctgggacct gaggcagctg caggtgaggg agcgccccat ggctttggag gctgagctgg
      481 ccctgacgct gaaggttctg gaggccaccg ctgacactga cccagccctg gtggacgtct
      541 tggaccagcc ccttcacacc ctgcaccata tcctctccca gttccgggcc tgtatccagc
      601 ctcagcccac ggcagggccc aggacccggg gccgcctcca ccattggctg taccggctcc
      661 aggaggcccc aaaaaaggag tcccctggct gcctcgaggc ctctgtcacc ttcaacctct
      721 tccgcctcct cacgcgagac ctgaattgtg ttgccagtgg ggacctgtgt gtctgaccct
      781 cccaccagtc atgcaacctg agattttatt tataaattag ccacttgtct taatttattg
      841 ccacccagtc gctatttatg tatttgtgtg tgtaaatcca actcacctcc aggaaaatgt
      901 ttatttttct actttttata acccttgttg aaataaacaa aggaaaagac a
//
