LOCUS       NM_172140                775 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens interferon lambda 1 (IFNL1), mRNA.
ACCESSION   NM_172140
VERSION     NM_172140.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 775)
  AUTHORS   Sankuntaw,N., Punyadee,N., Chantratita,W. and Lulitanond,V.
  TITLE     Coinfection with respiratory syncytial virus and rhinovirus
            increases IFN-lambda1 and CXCL10 expression in human primary
            bronchial epithelial cells
  JOURNAL   New Microbiol 47 (1), 60-67 (2024)
   PUBMED   38700885
  REMARK    GeneRIF: Coinfection with respiratory syncytial virus and
            rhinovirus increases IFN-lambda1 and CXCL10 expression in human
            primary bronchial epithelial cells.
REFERENCE   2  (bases 1 to 775)
  AUTHORS   Hammad,M.O., Alseoudy,M.M., Borg,A.M., El-Mesery,A., Elgamal,M.,
            Abdelghany,D.A. and Elzeiny,D.
  TITLE     IFNL1 rs30461 polymorphism as a risk factor for COVID-19 severity:
            A cross-sectional study
  JOURNAL   Cytokine 176, 156500 (2024)
   PUBMED   38271827
  REMARK    GeneRIF: IFNL1 rs30461 polymorphism as a risk factor for COVID-19
            severity: A cross-sectional study.
REFERENCE   3  (bases 1 to 775)
  AUTHORS   Ha,J.L., Kaser,E., Guan,T., Mayberry,T.G., Smith,L.A., D'mello,K.,
            Bai,Q., Wakefield,M.R., Dong,L. and Fang,Y.
  TITLE     Up and away with cervical cancer: IL-29 is a promising cytokine for
            immunotherapy of cervical cancer due to its powerful upregulation
            of p18, p27, and TRAILR1
  JOURNAL   Med Oncol 41 (3), 65 (2024)
   PUBMED   38281234
  REMARK    GeneRIF: Up and away with cervical cancer: IL-29 is a promising
            cytokine for immunotherapy of cervical cancer due to its powerful
            upregulation of p18, p27, and TRAILR1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 775)
  AUTHORS   Sardarmelli,Z., Sheikh,V., Solgi,G. and Behzad,M.
  TITLE     Enhanced production of interleukin-29 and related genes are
            associated with T helper 1 cell parameters in patients with type 2
            diabetes mellitus
  JOURNAL   Hum Immunol 84 (3), 235-240 (2023)
   PUBMED   36635158
  REMARK    GeneRIF: Enhanced production of interleukin-29 and related genes
            are associated with T helper 1 cell parameters in patients with
            type 2 diabetes mellitus.
REFERENCE   5  (bases 1 to 775)
  AUTHORS   Hao,N., Zhou,Z., Zhang,F., Li,Y., Hu,R., Zou,J., Zheng,R., Wang,L.,
            Xu,L., Tan,W., Li,C. and Wang,F.
  TITLE     Interleukin-29 Accelerates Vascular Calcification via
            JAK2/STAT3/BMP2 Signaling
  JOURNAL   J Am Heart Assoc 12 (1), e027222 (2023)
   PUBMED   36537334
  REMARK    GeneRIF: Interleukin-29 Accelerates Vascular Calcification via
            JAK2/STAT3/BMP2 Signaling.
REFERENCE   6  (bases 1 to 775)
  AUTHORS   Meager,A., Visvalingam,K., Dilger,P., Bryan,D. and Wadhwa,M.
  TITLE     Biological activity of interleukins-28 and -29: comparison with
            type I interferons
  JOURNAL   Cytokine 31 (2), 109-118 (2005)
   PUBMED   15899585
  REMARK    GeneRIF: we found IL-28A and IL-29 act similarly to IFNs, but are
            less effective generally and have activity in a more limited range
            of cell lines
REFERENCE   7  (bases 1 to 775)
  AUTHORS   Brand,S., Zitzmann,K., Dambacher,J., Beigel,F., Olszak,T.,
            Vlotides,G., Eichhorst,S.T., Goke,B., Diepolder,H. and
            Auernhammer,C.J.
  TITLE     SOCS-1 inhibits expression of the antiviral proteins 2',5'-OAS and
            MxA induced by the novel interferon-lambdas IL-28A and IL-29
  JOURNAL   Biochem Biophys Res Commun 331 (2), 543-548 (2005)
   PUBMED   15850793
  REMARK    GeneRIF: IL-28A and IL-29 induced mRNA expression of the antiviral
            proteins 2',5'-OAS and MxA was abolished by overexpression of
            SOCS-1
REFERENCE   8  (bases 1 to 775)
  AUTHORS   Dumoutier,L., Tounsi,A., Michiels,T., Sommereyns,C., Kotenko,S.V.
            and Renauld,J.C.
  TITLE     Role of the interleukin (IL)-28 receptor tyrosine residues for
            antiviral and antiproliferative activity of IL-29/interferon-lambda
            1: similarities with type I interferon signaling
  JOURNAL   J Biol Chem 279 (31), 32269-32274 (2004)
   PUBMED   15166220
  REMARK    GeneRIF: IL-29 antiviral and antiproliferative activity requires
            interleukin (IL)-28 receptor tyrosine residues
REFERENCE   9  (bases 1 to 775)
  AUTHORS   Kotenko,S.V., Gallagher,G., Baurin,V.V., Lewis-Antes,A., Shen,M.,
            Shah,N.K., Langer,J.A., Sheikh,F., Dickensheets,H. and
            Donnelly,R.P.
  TITLE     IFN-lambdas mediate antiviral protection through a distinct class
            II cytokine receptor complex
  JOURNAL   Nat Immunol 4 (1), 69-77 (2003)
   PUBMED   12483210
  REMARK    GeneRIF: closely positioned genes on human chromosome 19 encode
            distinct but paralogous proteins, which we designate
            interferon-lambda1 (IFN-lambda1), IFN-lambda2 and IFN-lambda3
REFERENCE   10 (bases 1 to 775)
  AUTHORS   Sheppard,P., Kindsvogel,W., Xu,W., Henderson,K., Schlutsmeyer,S.,
            Whitmore,T.E., Kuestner,R., Garrigues,U., Birks,C., Roraback,J.,
            Ostrander,C., Dong,D., Shin,J., Presnell,S., Fox,B., Haldeman,B.,
            Cooper,E., Taft,D., Gilbert,T., Grant,F.J., Tackett,M., Krivan,W.,
            McKnight,G., Clegg,C., Foster,D. and Klucher,K.M.
  TITLE     IL-28, IL-29 and their class II cytokine receptor IL-28R
  JOURNAL   Nat Immunol 4 (1), 63-68 (2003)
   PUBMED   12469119
  REMARK    GeneRIF: identified from the human genomic sequence a family of
            three cytokines, designated interleukin 28A (IL-28A), IL-28B and
            IL-29, that are distantly related to type I interferons (IFNs) and
            the IL-10 family
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY129150.1 and AC011445.6.
            
            On Nov 22, 2018 this sequence version replaced NM_172140.1.
            
            Summary: This gene encodes a cytokine distantly related to type I
            interferons and the IL-10 family. This gene, interleukin 28A
            (IL28A), and interleukin 28B (IL28B) are three closely related
            cytokine genes that form a cytokine gene cluster on a chromosomal
            region mapped to 19q13. Expression of the cytokines encoded by the
            three genes can be induced by viral infection. All three cytokines
            have been shown to interact with a heterodimeric class II cytokine
            receptor that consists of interleukin 10 receptor, beta (IL10RB)
            and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY129150.1, BC117482.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333625.3/ ENSP00000329991.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-774               AY129150.1         83-856
            775-775             AC011445.6         79775-79775
FEATURES             Location/Qualifiers
     source          1..775
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..775
                     /gene="IFNL1"
                     /gene_synonym="IL-29; IL29"
                     /note="interferon lambda 1"
                     /db_xref="GeneID:282618"
                     /db_xref="HGNC:HGNC:18363"
                     /db_xref="MIM:607403"
     exon            1..186
                     /gene="IFNL1"
                     /gene_synonym="IL-29; IL29"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..618
                     /gene="IFNL1"
                     /gene_synonym="IL-29; IL29"
                     /note="interleukin-29; IFN-lambda-1; cytokine Zcyto21;
                     interleukin 29 (interferon, lambda 1)"
                     /codon_start=1
                     /product="interferon lambda-1 precursor"
                     /protein_id="NP_742152.1"
                     /db_xref="CCDS:CCDS12531.1"
                     /db_xref="GeneID:282618"
                     /db_xref="HGNC:HGNC:18363"
                     /db_xref="MIM:607403"
                     /translation="MAAAWTVVLVTLVLGLAVAGPVPTSKPTTTGKGCHIGRFKSLSP
                     QELASFKKARDALEESLKLKNWSCSSPVFPGNWDLRLLQVRERPVALEAELALTLKVL
                     EAAAGPALEDVLDQPLHTLHHILSQLQACIQPQPTAGPRPRGRLHHWLHRLQEAPKKE
                     SAGCLEASVTFNLFRLLTRDLKYVADGNLCLRTSTHPEST"
     exon            187..264
                     /gene="IFNL1"
                     /gene_synonym="IL-29; IL29"
                     /inference="alignment:Splign:2.1.0"
     exon            265..408
                     /gene="IFNL1"
                     /gene_synonym="IL-29; IL29"
                     /inference="alignment:Splign:2.1.0"
     exon            409..492
                     /gene="IFNL1"
                     /gene_synonym="IL-29; IL29"
                     /inference="alignment:Splign:2.1.0"
     exon            493..775
                     /gene="IFNL1"
                     /gene_synonym="IL-29; IL29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      754..759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFNL1"
                     /gene_synonym="IL-29; IL29"
                     /note="hexamer: AATAAA"
     polyA_site      775
                     /gene="IFNL1"
                     /gene_synonym="IL-29; IL29"
                     /note="major polyA site"
ORIGIN      
        1 agttgcgatt tagccatggc tgcagcttgg accgtggtgc tggtgacttt ggtgctaggc
       61 ttggccgtgg caggccctgt ccccacttcc aagcccacca caactgggaa gggctgccac
      121 attggcaggt tcaaatctct gtcaccacag gagctagcga gcttcaagaa ggccagggac
      181 gccttggaag agtcactcaa gctgaaaaac tggagttgca gctctcctgt cttccccggg
      241 aattgggacc tgaggcttct ccaggtgagg gagcgccctg tggccttgga ggctgagctg
      301 gccctgacgc tgaaggtcct ggaggccgct gctggcccag ccctggagga cgtcctagac
      361 cagccccttc acaccctgca ccacatcctc tcccagctcc aggcctgtat ccagcctcag
      421 cccacagcag ggcccaggcc ccggggccgc ctccaccact ggctgcaccg gctccaggag
      481 gcccccaaaa aggagtccgc tggctgcctg gaggcatctg tcaccttcaa cctcttccgc
      541 ctcctcacgc gagacctcaa atatgtggcc gatgggaacc tgtgtctgag aacgtcaacc
      601 caccctgagt ccacctgaca ccccacacct tatttatgcg ctgagcccta ctccttcctt
      661 aatttatttc ctctcaccct ttatttatga agctgcagcc ctgactgaga catagggctg
      721 agtttattgt tttactttta tacattatgc acaaataaac aacaaggaat tggaa
//
