LOCUS       NM_020124               1164 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens interferon kappa (IFNK), mRNA.
ACCESSION   NM_020124
VERSION     NM_020124.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1164)
  AUTHORS   Sarkar,M.K., Uppala,R., Zeng,C., Billi,A.C., Tsoi,L.C., Kidder,A.,
            Xing,X., Perez White,B.E., Shao,S., Plazyo,O., Sirobhushanam,S.,
            Xing,E., Jiang,Y., Gallagher,K.A., Voorhees,J.J., Kahlenberg,J.M.
            and Gudjonsson,J.E.
  TITLE     Keratinocytes sense and eliminate CRISPR DNA through
            STING/IFN-kappa activation and APOBEC3G induction
  JOURNAL   J Clin Invest 133 (9), e159393 (2023)
   PUBMED   36928117
  REMARK    GeneRIF: Keratinocytes sense and eliminate CRISPR DNA through
            STING/IFN-kappa activation and APOBEC3G induction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1164)
  AUTHORS   Xiao,Y., Huang,Y., Jiang,J., Chen,Y. and Wei,C.
  TITLE     Identification of the prognostic value of Th1/Th2 ratio and a novel
            prognostic signature in basal-like breast cancer
  JOURNAL   Hereditas 160 (1), 2 (2023)
   PUBMED   36694223
  REMARK    GeneRIF: Identification of the prognostic value of Th1/Th2 ratio
            and a novel prognostic signature in basal-like breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1164)
  AUTHORS   Wolf,S.J., Audu,C.O., Joshi,A., denDekker,A., Melvin,W.J.,
            Davis,F.M., Xing,X., Wasikowski,R., Tsoi,L.C., Kunkel,S.L.,
            Gudjonsson,J.E., O'Riordan,M.X., Kahlenberg,J.M. and Gallagher,K.A.
  TITLE     IFN-kappa is critical for normal wound repair and is decreased in
            diabetic wounds
  JOURNAL   JCI Insight 7 (9), e152765 (2022)
   PUBMED   35358091
  REMARK    GeneRIF: IFN-kappa is critical for normal wound repair and is
            decreased in diabetic wounds.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1164)
  AUTHORS   Gharaee-Kermani,M., Estadt,S.N., Tsoi,L.C., Wolf-Fortune,S.J.,
            Liu,J., Xing,X., Theros,J., Reed,T.J., Lowe,L., Gruszka,D.,
            Ward,N.L., Gudjonsson,J.E. and Kahlenberg,J.M.
  TITLE     IFN-kappa Is a Rheostat for Development of Psoriasiform
            Inflammation
  JOURNAL   J Invest Dermatol 142 (1), 155-165 (2022)
   PUBMED   34364883
  REMARK    GeneRIF: IFN-kappa Is a Rheostat for Development of Psoriasiform
            Inflammation.
REFERENCE   5  (bases 1 to 1164)
  AUTHORS   Li,Y., Song,Y., Zhu,L., Wang,X., Richers,B., Leung,D.Y.M. and
            Bin,L.
  TITLE     Interferon Kappa Is Important for Keratinocyte Host Defense against
            Herpes Simplex Virus-1
  JOURNAL   J Immunol Res 2020, 5084682 (2020)
   PUBMED   32352019
  REMARK    GeneRIF: Interferon Kappa Is Important for Keratinocyte Host
            Defense against Herpes Simplex Virus-1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1164)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   7  (bases 1 to 1164)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   8  (bases 1 to 1164)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 1164)
  AUTHORS   Nardelli,B., Zaritskaya,L., Semenuk,M., Cho,Y.H., LaFleur,D.W.,
            Shah,D., Ullrich,S., Girolomoni,G., Albanesi,C. and Moore,P.A.
  TITLE     Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine
            production by cells of the innate immune system
  JOURNAL   J Immunol 169 (9), 4822-4830 (2002)
   PUBMED   12391192
  REMARK    GeneRIF: IFN-kappa is able to directly modulate cytokine release
            from monocytes and dendritic cells, inhibit inducible IL-12 release
            from monocytes, and bind strongly to heparin.
REFERENCE   10 (bases 1 to 1164)
  AUTHORS   LaFleur,D.W., Nardelli,B., Tsareva,T., Mather,D., Feng,P.,
            Semenuk,M., Taylor,K., Buergin,M., Chinchilla,D., Roshke,V.,
            Chen,G., Ruben,S.M., Pitha,P.M., Coleman,T.A. and Moore,P.A.
  TITLE     Interferon-kappa, a novel type I interferon expressed in human
            keratinocytes
  JOURNAL   J Biol Chem 276 (43), 39765-39771 (2001)
   PUBMED   11514542
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL451123.12.
            
            On Jul 21, 2020 this sequence version replaced NM_020124.2.
            
            Summary: This gene encodes a member of the type I interferon
            family. Type I interferons are a group of related glycoproteins
            that play an important role in host defenses against viral
            infections. This protein is expressed in keratinocytes and the gene
            is found on chromosome 9, adjacent to the type I interferon
            cluster. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF146759.2, AF315688.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276943.3/ ENSP00000276943.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-672               AL451123.12        64848-65519
            673-1164            AL451123.12        66565-67056
FEATURES             Location/Qualifiers
     source          1..1164
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.2"
     gene            1..1164
                     /gene="IFNK"
                     /gene_synonym="IFNT1; INFE1"
                     /note="interferon kappa"
                     /db_xref="GeneID:56832"
                     /db_xref="HGNC:HGNC:21714"
                     /db_xref="MIM:615326"
     exon            1..672
                     /gene="IFNK"
                     /gene_synonym="IFNT1; INFE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..671
                     /gene="IFNK"
                     /gene_synonym="IFNT1; INFE1"
                     /note="interferon-like protein; IFN-kappa"
                     /codon_start=1
                     /product="interferon kappa precursor"
                     /protein_id="NP_064509.2"
                     /db_xref="CCDS:CCDS6521.1"
                     /db_xref="GeneID:56832"
                     /db_xref="HGNC:HGNC:21714"
                     /db_xref="MIM:615326"
                     /translation="MSTKPDMIQKCLWLEILMGIFIAGTLSLDCNLLNVHLRRVTWQN
                     LRHLSSMSNSFPVECLRENIAFELPQEFLQYTQPMKRDIKKAFYEMSLQAFNIFSQHT
                     FKYWKERHLKQIQIGLDQQAEYLNQCLEEDKNENEDMKEMKENEMKPSEARVPQLSSL
                     ELRRYFHRIDNFLKEKKYSDCAWEIVRVEIRRCLYYFYKFTALFRRK"
     exon            673..1164
                     /gene="IFNK"
                     /gene_synonym="IFNT1; INFE1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcattgtca tatacacatc ttctggattt tttagcttgc aaaaaaaatg agcaccaaac
       61 ctgatatgat tcaaaagtgt ttgtggcttg agatccttat gggtatattc attgctggca
      121 ccctatccct ggactgtaac ttactgaacg ttcacctgag aagagtcacc tggcaaaatc
      181 tgagacatct gagtagtatg agcaattcat ttcctgtaga atgtctacga gaaaacatag
      241 cttttgagtt gccccaagag tttctgcaat acacccaacc tatgaagagg gacatcaaga
      301 aggccttcta tgaaatgtcc ctacaggcct tcaacatctt cagccaacac accttcaaat
      361 attggaaaga gagacacctc aaacaaatcc aaataggact tgatcagcaa gcagagtacc
      421 tgaaccaatg cttggaggaa gacaagaatg aaaatgaaga catgaaagaa atgaaagaga
      481 atgagatgaa accctcagaa gccagggtcc cccagctgag cagcctggaa ctgaggagat
      541 atttccacag gatagacaat ttcctgaaag aaaagaaata cagtgactgt gcctgggaga
      601 ttgtccgagt ggaaatcaga agatgtttgt attactttta caaatttaca gctctattca
      661 ggaggaaata agaatcatct accttcaagc aagaattaac agagattgtg gctacgcaaa
      721 tgcaccaaaa aagggtgaaa tatatctgaa atgtacctgg ttctgccctt ggaagccatt
      781 tcctgctcat gccactaaca gcatgctgcc aaactgttca gattcaagat tattccaagc
      841 gcagggccca aatgttatag ccaaagaaag tcttatgata aaagtgaggc aaatttcagc
      901 caagaagtta gaagagatgt ttaaaagaac aagaacaaat tgtggatcat ggtatatgca
      961 ggctatcagc agaaggatca gacaataaaa tgagttagtg caaaccattt agtaaaaata
     1021 actatcagca gagttgttcc agattaaaaa tagtactaca agcttgtaaa ggagttagga
     1081 catgcaagct actgagcata aaatatatac ttgctatttt tcatgacttt ctctaataaa
     1141 gtctttgcct gttctctcta ataa
//
