LOCUS       NM_000619               1211 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens interferon gamma (IFNG), mRNA.
ACCESSION   NM_000619
VERSION     NM_000619.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1211)
  AUTHORS   Lin,C.I., Wang,Y.W., Su,K.Y. and Chuang,Y.H.
  TITLE     Interleukin-37 exacerbates liver inflammation and promotes
            IFN-gamma production in NK cells
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113086 (2024)
   PUBMED   39260304
  REMARK    GeneRIF: Interleukin-37 exacerbates liver inflammation and promotes
            IFN-gamma production in NK cells.
REFERENCE   2  (bases 1 to 1211)
  AUTHORS   Wang,S., Cheng,T., Chen,X., Zeng,C., Qin,W. and Xu,Y.
  TITLE     IFN-gamma induces acute graft-versus-host disease by promoting
            HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic
            degradation of p53
  JOURNAL   Clin Sci (Lond) 138 (20), 1287-1304 (2024)
   PUBMED   39312196
  REMARK    GeneRIF: IFN-gamma induces acute graft-versus-host disease by
            promoting HMGB1-mediated nuclear-to-cytoplasm translocation and
            autophagic degradation of p53.
REFERENCE   3  (bases 1 to 1211)
  AUTHORS   Hanin,A., Comi,M., Sumida,T.S. and Hafler,D.A.
  TITLE     Cholesterol promotes IFNG mRNA expression in CD4+ effector/memory
            cells by SGK1 activation
  JOURNAL   Life Sci Alliance 7 (12), e202402890 (2024)
   PUBMED   39366761
  REMARK    GeneRIF: Cholesterol promotes IFNG mRNA expression in CD4[+]
            effector/memory cells by SGK1 activation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1211)
  AUTHORS   Hautala,N.M., Joensuu,M., Paakkola,T., Glumoff,V., Kettunen,K.,
            Saarela,J., Siiskonen,M., Chen,Z., Pylkas,K. and Hautala,T.
  TITLE     Recurrent ocular toxoplasmosis is associated with interferon-gamma
            deficiency possibly due to genetic origin
  JOURNAL   BMJ Open Ophthalmol 9 (1), e001769 (2024)
   PUBMED   39277179
  REMARK    GeneRIF: Recurrent ocular toxoplasmosis is associated with
            interferon-gamma deficiency possibly due to genetic origin.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1211)
  AUTHORS   Walter,M.R., Windsor,W.T., Nagabhushan,T.L., Lundell,D.J.,
            Lunn,C.A., Zauodny,P.J. and Narula,S.K.
  TITLE     Crystal structure of a complex between interferon-gamma and its
            soluble high-affinity receptor
  JOURNAL   Nature 376 (6537), 230-235 (1995)
   PUBMED   7617032
REFERENCE   6  (bases 1 to 1211)
  AUTHORS   Emilie,D., Maillot,M.C., Nicolas,J.F., Fior,R. and Galanaud,P.
  TITLE     Antagonistic effect of interferon-gamma on tat-induced
            transactivation of HIV long terminal repeat
  JOURNAL   J Biol Chem 267 (29), 20565-20570 (1992)
   PUBMED   1400376
REFERENCE   7  (bases 1 to 1211)
  AUTHORS   Grzesiek,S., Dobeli,H., Gentz,R., Garotta,G., Labhardt,A.M. and
            Bax,A.
  TITLE     1H, 13C, and 15N NMR backbone assignments and secondary structure
            of human interferon-gamma
  JOURNAL   Biochemistry 31 (35), 8180-8190 (1992)
   PUBMED   1525157
REFERENCE   8  (bases 1 to 1211)
  AUTHORS   Slodowski,O., Bohm,J., Schone,B. and Otto,B.
  TITLE     Carboxy-terminal truncated rhuIFN-gamma with a substitution of
            Gln133 or Ser132 to leucine leads to higher biological activity
            than in the wild type
  JOURNAL   Eur J Biochem 202 (3), 1133-1140 (1991)
   PUBMED   1662603
REFERENCE   9  (bases 1 to 1211)
  AUTHORS   Gray,P.W. and Goeddel,D.V.
  TITLE     Structure of the human immune interferon gene
  JOURNAL   Nature 298 (5877), 859-863 (1982)
   PUBMED   6180322
REFERENCE   10 (bases 1 to 1211)
  AUTHORS   Devos,R., Cheroutre,H., Taya,Y., Degrave,W., Van Heuverswyn,H. and
            Fiers,W.
  TITLE     Molecular cloning of human immune interferon cDNA and its
            expression in eukaryotic cells
  JOURNAL   Nucleic Acids Res 10 (8), 2487-2501 (1982)
   PUBMED   6176945
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC070256.1, V00543.1 and
            AC007458.14.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000619.2.
            
            Summary: This gene encodes a soluble cytokine that is a member of
            the type II interferon class. The encoded protein is secreted by
            cells of both the innate and adaptive immune systems. The active
            protein is a homodimer that binds to the interferon gamma receptor
            which triggers a cellular response to viral and microbial
            infections. Mutations in this gene are associated with an increased
            susceptibility to viral, bacterial and parasitic infections and to
            several autoimmune diseases. [provided by RefSeq, Dec 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070256.1, SRR1163655.241293.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154529 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in cytokine storm inflammatory
                                      response
            MANE Ensembl match     :: ENST00000229135.4/ ENSP00000229135.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1010              BC070256.1         4-1013
            1011-1204           V00543.1           977-1170
            1205-1209           BC070256.1         1208-1212
            1210-1211           AC007458.14        93984-93985         c
FEATURES             Location/Qualifiers
     source          1..1211
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..1211
                     /gene="IFNG"
                     /gene_synonym="IFG; IFI; IMD69"
                     /note="interferon gamma"
                     /db_xref="GeneID:3458"
                     /db_xref="HGNC:HGNC:5438"
                     /db_xref="MIM:147570"
     exon            1..239
                     /gene="IFNG"
                     /gene_synonym="IFG; IFI; IMD69"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..626
                     /gene="IFNG"
                     /gene_synonym="IFG; IFI; IMD69"
                     /note="IFN-gamma; immune interferon"
                     /codon_start=1
                     /product="interferon gamma precursor"
                     /protein_id="NP_000610.2"
                     /db_xref="CCDS:CCDS8980.1"
                     /db_xref="GeneID:3458"
                     /db_xref="HGNC:HGNC:5438"
                     /db_xref="MIM:147570"
                     /translation="MKYTSYILAFQLCIVLGSLGCYCQDPYVKEAENLKKYFNAGHSD
                     VADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNV
                     KFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFR
                     GRRASQ"
     exon            240..308
                     /gene="IFNG"
                     /gene_synonym="IFG; IFI; IMD69"
                     /inference="alignment:Splign:2.1.0"
     exon            309..491
                     /gene="IFNG"
                     /gene_synonym="IFG; IFI; IMD69"
                     /inference="alignment:Splign:2.1.0"
     exon            492..1211
                     /gene="IFNG"
                     /gene_synonym="IFG; IFI; IMD69"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1189..1194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFNG"
                     /gene_synonym="IFG; IFI; IMD69"
                     /note="hexamer: AATAAA"
     polyA_site      1211
                     /gene="IFNG"
                     /gene_synonym="IFG; IFI; IMD69"
                     /note="major polyA site"
ORIGIN      
        1 acattgttct gatcatctga agatcagcta ttagaagaga aagatcagtt aagtcctttg
       61 gacctgatca gcttgataca agaactactg atttcaactt ctttggctta attctctcgg
      121 aaacgatgaa atatacaagt tatatcttgg cttttcagct ctgcatcgtt ttgggttctc
      181 ttggctgtta ctgccaggac ccatatgtaa aagaagcaga aaaccttaag aaatatttta
      241 atgcaggtca ttcagatgta gcggataatg gaactctttt cttaggcatt ttgaagaatt
      301 ggaaagagga gagtgacaga aaaataatgc agagccaaat tgtctccttt tacttcaaac
      361 tttttaaaaa ctttaaagat gaccagagca tccaaaagag tgtggagacc atcaaggaag
      421 acatgaatgt caagtttttc aatagcaaca aaaagaaacg agatgacttc gaaaagctga
      481 ctaattattc ggtaactgac ttgaatgtcc aacgcaaagc aatacatgaa ctcatccaag
      541 tgatggctga actgtcgcca gcagctaaaa cagggaagcg aaaaaggagt cagatgctgt
      601 ttcgaggtcg aagagcatcc cagtaatggt tgtcctgcct gcaatatttg aattttaaat
      661 ctaaatctat ttattaatat ttaacattat ttatatgggg aatatatttt tagactcatc
      721 aatcaaataa gtatttataa tagcaacttt tgtgtaatga aaatgaatat ctattaatat
      781 atgtattatt tataattcct atatcctgtg actgtctcac ttaatccttt gttttctgac
      841 taattaggca aggctatgtg attacaaggc tttatctcag gggccaacta ggcagccaac
      901 ctaagcaaga tcccatgggt tgtgtgttta tttcacttga tgatacaatg aacacttata
      961 agtgaagtga tactatccag ttactgccgg tttgaaaata tgcctgcaat ctgagccagt
     1021 gctttaatgg catgtcagac agaacttgaa tgtgtcaggt gaccctgatg aaaacatagc
     1081 atctcaggag atttcatgcc tggtgcttcc aaatattgtt gacaactgtg actgtaccca
     1141 aatggaaagt aactcatttg ttaaaattat caatatctaa tatatatgaa taaagtgtaa
     1201 gttcacaact a
//
