LOCUS       NM_176891               1475 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens interferon epsilon (IFNE), mRNA.
ACCESSION   NM_176891
VERSION     NM_176891.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1475)
  AUTHORS   Zhang,L., Zhou,Y., Xing,X., Li,H., Zhang,Z., Qian,R. and Hu,X.
  TITLE     Upregulation of IFNE in cervical biopsies of patients with
            high-risk human papillomavirus infections
  JOURNAL   Immun Inflamm Dis 11 (12), e1111 (2023)
   PUBMED   38156399
  REMARK    GeneRIF: Upregulation of IFNE in cervical biopsies of patients with
            high-risk human papillomavirus infections.
REFERENCE   2  (bases 1 to 1475)
  AUTHORS   Marks,Z.R.C., Campbell,N.K., Mangan,N.E., Vandenberg,C.J.,
            Gearing,L.J., Matthews,A.Y., Gould,J.A., Tate,M.D., Wray-McCann,G.,
            Ying,L., Rosli,S., Brockwell,N., Parker,B.S., Lim,S.S.,
            Bilandzic,M., Christie,E.L., Stephens,A.N., de Geus,E.,
            Wakefield,M.J., Ho,G.Y., McNally,O., McNeish,I.A., Bowtell,D.D.L.,
            de Weerd,N.A., Scott,C.L., Bourke,N.M. and Hertzog,P.J.
  CONSRTM   Australian Ovarian Cancer Study
  TITLE     Interferon-epsilon is a tumour suppressor and restricts ovarian
            cancer
  JOURNAL   Nature 620 (7976), 1063-1070 (2023)
   PUBMED   37587335
  REMARK    GeneRIF: Interferon-epsilon is a tumour suppressor and restricts
            ovarian cancer.
REFERENCE   3  (bases 1 to 1475)
  AUTHORS   Coldbeck-Shackley,R.C., Romeo,O., Rosli,S., Gearing,L.J.,
            Gould,J.A., Lim,S.S., Van der Hoek,K.H., Eyre,N.S., Shue,B.,
            Robertson,S.A., Best,S.M., Tate,M.D., Hertzog,P.J. and Beard,M.R.
  TITLE     Constitutive expression and distinct properties of IFN-epsilon
            protect the female reproductive tract from Zika virus infection
  JOURNAL   PLoS Pathog 19 (3), e1010843 (2023)
   PUBMED   36897927
  REMARK    GeneRIF: Constitutive expression and distinct properties of
            IFN-epsilon protect the female reproductive tract from Zika virus
            infection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1475)
  AUTHORS   Bourke,N.M., Achilles,S.L., Huang,S.U., Cumming,H.E., Lim,S.S.,
            Papageorgiou,I., Gearing,L.J., Chapman,R., Thakore,S., Mangan,N.E.,
            Mesiano,S. and Hertzog,P.J.
  TITLE     Spatiotemporal regulation of human IFN-epsilon and innate immunity
            in the female reproductive tract
  JOURNAL   JCI Insight 7 (18), e135407 (2022)
   PUBMED   35862222
  REMARK    GeneRIF: Spatiotemporal regulation of human IFN-epsilon and innate
            immunity in the female reproductive tract.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1475)
  AUTHORS   Mesev,E.V., LeDesma,R.A. and Ploss,A.
  TITLE     Decoding type I and III interferon signalling during viral
            infection
  JOURNAL   Nat Microbiol 4 (6), 914-924 (2019)
   PUBMED   30936491
  REMARK    Review article
REFERENCE   6  (bases 1 to 1475)
  AUTHORS   Schunkert,H., Gotz,A., Braund,P., McGinnis,R., Tregouet,D.A.,
            Mangino,M., Linsel-Nitschke,P., Cambien,F., Hengstenberg,C.,
            Stark,K., Blankenberg,S., Tiret,L., Ducimetiere,P., Keniry,A.,
            Ghori,M.J., Schreiber,S., El Mokhtari,N.E., Hall,A.S., Dixon,R.J.,
            Goodall,A.H., Liptau,H., Pollard,H., Schwarz,D.F., Hothorn,L.A.,
            Wichmann,H.E., Konig,I.R., Fischer,M., Meisinger,C., Ouwehand,W.,
            Deloukas,P., Thompson,J.R., Erdmann,J., Ziegler,A. and Samani,N.J.
  CONSRTM   Cardiogenics Consortium
  TITLE     Repeated replication and a prospective meta-analysis of the
            association between chromosome 9p21.3 and coronary artery disease
  JOURNAL   Circulation 117 (13), 1675-1684 (2008)
   PUBMED   18362232
  REMARK    GeneRIF: A meta-analysis and a single-nucleotide polymorphism (SNP)
            rs1333049 representing the 9p21.3 locus provide unprecedented
            evidence for association between genetic variants at chromosome
            9p21.3 and risk of coronary artery disease.
REFERENCE   7  (bases 1 to 1475)
  AUTHORS   Matsumiya,T., Prescott,S.M. and Stafforini,D.M.
  TITLE     IFN-epsilon mediates TNF-alpha-induced STAT1 phosphorylation and
            induction of retinoic acid-inducible gene-I in human cervical
            cancer cells
  JOURNAL   J Immunol 179 (7), 4542-4549 (2007)
   PUBMED   17878351
  REMARK    GeneRIF: TNF-alpha leads to stabilization of IFN-epsilon mRNA,
            increased IFN-epsilon synthesis, engagement of type I IFNRs,
            increased STAT1 expression and phosphorylation, and up-regulation
            of retinoic acid-inducible gene-I expression
REFERENCE   8  (bases 1 to 1475)
  AUTHORS   Peng,F.W., Duan,Z.J., Zheng,L.S., Xie,Z.P., Gao,H.C., Zhang,H.,
            Li,W.P. and Hou,Y.D.
  TITLE     Purification of recombinant human interferon-epsilon and
            oligonucleotide microarray analysis of interferon-epsilon-regulated
            genes
  JOURNAL   Protein Expr Purif 53 (2), 356-362 (2007)
   PUBMED   17287131
REFERENCE   9  (bases 1 to 1475)
  AUTHORS   Pestka,S., Krause,C.D. and Walter,M.R.
  TITLE     Interferons, interferon-like cytokines, and their receptors
  JOURNAL   Immunol Rev 202, 8-32 (2004)
   PUBMED   15546383
  REMARK    Review article
REFERENCE   10 (bases 1 to 1475)
  AUTHORS   Hardy,M.P., Owczarek,C.M., Jermiin,L.S., Ejdeback,M. and
            Hertzog,P.J.
  TITLE     Characterization of the type I interferon locus and identification
            of novel genes
  JOURNAL   Genomics 84 (2), 331-345 (2004)
   PUBMED   15233997
  REMARK    GeneRIF: The structue and mRNA expression pattern of IFN-epsilon1
            suggest that it may have a function distinct from those other
            members of type I INF.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353732.14.
            
            On Jul 29, 2020 this sequence version replaced NM_176891.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY358570.1, BC100872.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448696.4/ ENSP00000418018.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1475              AL353732.14        137576-139050       c
FEATURES             Location/Qualifiers
     source          1..1475
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..1475
                     /gene="IFNE"
                     /gene_synonym="IFN-E; IFNE1; IFNT1; INFE1; PRO655"
                     /note="interferon epsilon"
                     /db_xref="GeneID:338376"
                     /db_xref="HGNC:HGNC:18163"
                     /db_xref="MIM:615223"
     exon            1..1475
                     /gene="IFNE"
                     /gene_synonym="IFN-E; IFNE1; IFNT1; INFE1; PRO655"
                     /inference="alignment:Splign:2.1.0"
     CDS             620..1246
                     /gene="IFNE"
                     /gene_synonym="IFN-E; IFNE1; IFNT1; INFE1; PRO655"
                     /note="interferon tau-1; interferon epsilon 1;
                     IFN-epsilon"
                     /codon_start=1
                     /product="interferon epsilon precursor"
                     /protein_id="NP_795372.1"
                     /db_xref="CCDS:CCDS34997.1"
                     /db_xref="GeneID:338376"
                     /db_xref="HGNC:HGNC:18163"
                     /db_xref="MIM:615223"
                     /translation="MIIKHFFGTVLVLLASTTIFSLDLKLIIFQQRQVNQESLKLLNK
                     LQTLSIQQCLPHRKNFLLPQKSLSPQQYQKGHTLAILHEMLQQIFSLFRANISLDGWE
                     ENHTEKFLIQLHQQLEYLEALMGLEAEKLSGTLGSDNLRLQVKMYFRRIHDYLENQDY
                     STCAWAIVQVEISRCLFFVFSLTEKLSKQGRPLNDMKQELTTEFRSPR"
     regulatory      1444..1449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFNE"
                     /gene_synonym="IFN-E; IFNE1; IFNT1; INFE1; PRO655"
                     /note="hexamer: AATAAA"
     polyA_site      1475
                     /gene="IFNE"
                     /gene_synonym="IFN-E; IFNE1; IFNT1; INFE1; PRO655"
                     /note="major polyA site"
ORIGIN      
        1 cttagatatt aaactgatag gataagatat aaaataattt aagattgctg atatatgttt
       61 taaaattaat tatttgctca agcatttgtg acaatttaca gttctaattg aggttttaaa
      121 tttagtagtt tgtaggtatt ttaagttttg cccctgaatt ctttataggt gctgataagc
      181 ctttggtaag ttttactcca tgaaagacta ttactgaaaa aaacgtaatc tcaataaaag
      241 aactttaata agcttgacta aatatttaga aagcacattg tgttcagtga aactttgtat
      301 ataatgaata gaataataaa agattatgtt ggatgactag tctgtaattg cctcaaggaa
      361 agcatacaat gaataagtta ttttggtact tcctcaaaat agccaacaca atagggaaat
      421 ggagaaaatg tactctgaac accatgaaaa gggaacctga aaatctaatg tgtaaacttg
      481 gagaaatgac attagaaaac gaaagcaaca aaagagaaca ctctccaaaa taatctgaga
      541 tgcatgaaag gcaaacattc actagagctg gaatttccct aagtctatgc agggataagt
      601 agcatatttg accttcacca tgattatcaa gcacttcttt ggaactgtgt tggtgctgct
      661 ggcctctacc actatcttct ctctagattt gaaactgatt atcttccagc aaagacaagt
      721 gaatcaagaa agtttaaaac tcttgaataa gttgcaaacc ttgtcaattc agcagtgtct
      781 accacacagg aaaaactttc tgcttcctca gaagtctttg agtcctcagc agtaccaaaa
      841 aggacacact ctggccattc tccatgagat gcttcagcag atcttcagcc tcttcagggc
      901 aaatatttct ctggatggtt gggaggaaaa ccacacggag aaattcctca ttcaacttca
      961 tcaacagcta gaatacctag aagcactcat gggactggaa gcagagaagc taagtggtac
     1021 tttgggtagt gataacctta gattacaagt taaaatgtac ttccgaagga tccatgatta
     1081 cctggaaaac caggactaca gcacctgtgc ctgggccatt gtccaagtag aaatcagccg
     1141 atgtctgttc tttgtgttca gtctcacaga aaaactgagc aaacaaggaa gacccttgaa
     1201 cgacatgaag caagagctta ctacagagtt tagaagcccg aggtaggtgg agggactaga
     1261 ggacttctcc agacatgatt cttcatagag tggtaataca atttatagta caatcacatt
     1321 gctttgattt tgtgtatata tatatttatc tgtgttttaa gattgtgcat attgaccaca
     1381 attgttttta ttttgtaatg tggctttata tattctatcc attttaaatt gtttgtatgt
     1441 caaaataaat tcattaatat ggttgattct tcaaa
//
