LOCUS       NM_001289125            4074 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens interferon alpha and beta receptor subunit 2 (IFNAR2),
            transcript variant 4, mRNA.
ACCESSION   NM_001289125
VERSION     NM_001289125.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4074)
  AUTHORS   Benmansour,R., Tagajdid,M.R., El Hamzaoui,H., Fjouji,S., Doghmi,N.,
            Houba,A., Belbacha,I., Elkochri,S., Aabi,R., Elannaz,H.,
            Laraqui,A., El Mchichi,B., Chmitah,T., Touil,N., Ennibi,K.,
            Eljaoudi,R., Elmir,E., Amine Lahlou,I. and Oumzil,H.
  TITLE     TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among
            severe COVID-19 ICU patients in Morocco
  JOURNAL   Int J Immunopathol Pharmacol 38, 3946320241257241 (2024)
   PUBMED   38760017
  REMARK    GeneRIF: TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide
            polymorphisms among severe COVID-19 ICU patients in Morocco.
REFERENCE   2  (bases 1 to 4074)
  AUTHORS   Yaugel-Novoa,M., Bourlet,T., Longet,S., Botelho-Nevers,E. and
            Paul,S.
  TITLE     Association of IFNAR1 and IFNAR2 with COVID-19 severity
  JOURNAL   Lancet Microbe 4 (7), e487 (2023)
   PUBMED   37028439
  REMARK    GeneRIF: Association of IFNAR1 and IFNAR2 with COVID-19 severity.
            Erratum:[Lancet Microbe. 2023 Jun;4(6):e394. doi:
            10.1016/S2666-5247(23)00116-7. PMID: 37068499]
REFERENCE   3  (bases 1 to 4074)
  AUTHORS   Jalkanen,J., Khan,S., Elima,K., Huttunen,T., Wang,N., Hollmen,M.,
            Elo,L.L. and Jalkanen,S.
  TITLE     Polymorphism in interferon alpha/beta receptor contributes to
            glucocorticoid response and outcome of ARDS and COVID-19
  JOURNAL   Crit Care 27 (1), 112 (2023)
   PUBMED   36927455
  REMARK    GeneRIF: Polymorphism in interferon alpha/beta receptor contributes
            to glucocorticoid response and outcome of ARDS and COVID-19.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4074)
  AUTHORS   Dieter,C., de Almeida Brondani,L., Lemos,N.E., Schaeffer,A.F.,
            Zanotto,C., Ramos,D.T., Girardi,E., Pellenz,F.M., Camargo,J.L.,
            Moresco,K.S., da Silva,L.L., Aubin,M.R., de Oliveira,M.S.,
            Rech,T.H., Canani,L.H., Gerchman,F., Leitao,C.B. and Crispim,D.
  TITLE     Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are
            Associated with Worse Clinical Outcomes in COVID-19
  JOURNAL   Genes (Basel) 14 (1), 29 (2022)
   PUBMED   36672770
  REMARK    GeneRIF: Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2
            Genes Are Associated with Worse Clinical Outcomes in COVID-19.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4074)
  AUTHORS   Hanrath,A.T., Hatton,C.F., Gothe,F., Browne,C., Vowles,J.,
            Leary,P., Cockell,S.J., Cowley,S.A., James,W.S., Hambleton,S. and
            Duncan,C.J.A.
  TITLE     Type I interferon receptor (IFNAR2) deficiency reveals Zika virus
            cytopathicity in human macrophages and microglia
  JOURNAL   Front Immunol 13, 1035532 (2022)
   PUBMED   36439115
  REMARK    GeneRIF: Type I interferon receptor (IFNAR2) deficiency reveals
            Zika virus cytopathicity in human macrophages and microglia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4074)
  AUTHORS   Hurtado-Guerrero,I., Hernaez,B., Pinto-Medel,M.J., Calonge,E.,
            Rodriguez-Bada,J.L., Urbaneja,P., Alonso,A., Mena-Vazquez,N.,
            Aliaga,P., Issazadeh-Navikas,S., Pavia,J., Leyva,L., Alcami,J.,
            Alcami,A., Fernandez,O. and Oliver-Martos,B.
  TITLE     Antiviral, Immunomodulatory and Antiproliferative Activities of
            Recombinant Soluble IFNAR2 without IFN-ss Mediation
  JOURNAL   J Clin Med 9 (4), 959 (2020)
   PUBMED   32244308
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4074)
  AUTHORS   Lutfalla,G., Holland,S.J., Cinato,E., Monneron,D., Reboul,J.,
            Rogers,N.C., Smith,J.M., Stark,G.R., Gardiner,K., Mogensen,K.E. et
            al.
  TITLE     Mutant U5A cells are complemented by an interferon-alpha beta
            receptor subunit generated by alternative processing of a new
            member of a cytokine receptor gene cluster
  JOURNAL   EMBO J 14 (20), 5100-5108 (1995)
   PUBMED   7588638
REFERENCE   8  (bases 1 to 4074)
  AUTHORS   Domanski,P., Witte,M., Kellum,M., Rubinstein,M., Hackett,R.,
            Pitha,P. and Colamonici,O.R.
  TITLE     Cloning and expression of a long form of the beta subunit of the
            interferon alpha beta receptor that is required for signaling
  JOURNAL   J Biol Chem 270 (37), 21606-21611 (1995)
   PUBMED   7665574
REFERENCE   9  (bases 1 to 4074)
  AUTHORS   Novick,D., Cohen,B., Tal,N. and Rubinstein,M.
  TITLE     Soluble and membrane-anchored forms of the human IFN-alpha/beta
            receptor
  JOURNAL   J Leukoc Biol 57 (5), 712-718 (1995)
   PUBMED   7759950
REFERENCE   10 (bases 1 to 4074)
  AUTHORS   Raz,R., Cheung,K., Ling,L. and Levy,D.E.
  TITLE     Three distinct loci on human chromosome 21 contribute to
            interferon-alpha/beta responsiveness
  JOURNAL   Somat Cell Mol Genet 21 (2), 139-145 (1995)
   PUBMED   7570186
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY104613.1, L41942.1 and
            AP000295.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 30, 2019 this sequence version replaced NM_001289125.2.
            
            Summary: The protein encoded by this gene is a type I membrane
            protein that forms one of the two chains of a receptor for
            interferons alpha and beta. Binding and activation of the receptor
            stimulates Janus protein kinases, which in turn phosphorylate
            several proteins, including STAT1 and STAT2. The protein belongs to
            the type II cytokine receptor family. Mutations in this gene are
            associated with Immunodeficiency 45. [provided by RefSeq, Jul
            2020].
            
            Transcript Variant: This variant (4) uses an alternate splice site
            in the 5' UTR, compared to variant 1. Variants 1 and 4 both encode
            isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L41942.1, SRR14038195.2552787.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000342136.9/ ENSP00000343957.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                HY104613.1         44-79
            37-2280             L41942.1           1-2244
            2281-4074           AP000295.1         7011-8804
FEATURES             Location/Qualifiers
     source          1..4074
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..4074
                     /gene="IFNAR2"
                     /gene_synonym="IFN-alpha-REC; IFN-R; IFN-R-2; IFNABR;
                     IFNARB; IMD45"
                     /note="interferon alpha and beta receptor subunit 2"
                     /db_xref="GeneID:3455"
                     /db_xref="HGNC:HGNC:5433"
                     /db_xref="MIM:602376"
     exon            1..279
                     /gene="IFNAR2"
                     /gene_synonym="IFN-alpha-REC; IFN-R; IFN-R-2; IFNABR;
                     IFNARB; IMD45"
                     /inference="alignment:Splign:2.1.0"
     exon            280..417
                     /gene="IFNAR2"
                     /gene_synonym="IFN-alpha-REC; IFN-R; IFN-R-2; IFNABR;
                     IFNARB; IMD45"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..1910
                     /gene="IFNAR2"
                     /gene_synonym="IFN-alpha-REC; IFN-R; IFN-R-2; IFNABR;
                     IFNARB; IMD45"
                     /note="isoform a precursor is encoded by transcript
                     variant 4; human interferon alpha/beta receptor;
                     interferon-alpha/beta receptor beta chain; interferon
                     (alpha, beta and omega) receptor 2; IFN-alpha/beta
                     receptor 2; type I interferon receptor 2; interferon alpha
                     binding protein; IFNalpha/beta receptor subunit 2"
                     /codon_start=1
                     /product="interferon alpha/beta receptor 2 isoform a
                     precursor"
                     /protein_id="NP_001276054.1"
                     /db_xref="CCDS:CCDS13621.1"
                     /db_xref="GeneID:3455"
                     /db_xref="HGNC:HGNC:5433"
                     /db_xref="MIM:602376"
                     /translation="MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKIS
                     LRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRST
                     HEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEE
                     ELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQ
                     AVIKSPLKCTLLPPGQESESAESAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSL
                     PKVLNFHNFLAWPFPNLPPLEAMDMVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSG
                     GGYTMHGLTVRPLGQASATSTESQLIDPESEEEPDLPEVDVELPTMPKDSPQQLELLS
                     GPCERRKSPLQDPFPEEDYSSTEGSGGRITFNVDLNSVFLRVLDDEDSDDLEAPLMLS
                     SHLEEMVDPEDPDNVQSNHLLASGEGTQPTFPSPSSEGLWSEDAPSDQSDTSESDVDL
                     GDGYIMR"
     exon            418..459
                     /gene="IFNAR2"
                     /gene_synonym="IFN-alpha-REC; IFN-R; IFN-R-2; IFNABR;
                     IFNARB; IMD45"
                     /inference="alignment:Splign:2.1.0"
     exon            460..583
                     /gene="IFNAR2"
                     /gene_synonym="IFN-alpha-REC; IFN-R; IFN-R-2; IFNABR;
                     IFNARB; IMD45"
                     /inference="alignment:Splign:2.1.0"
     exon            584..756
                     /gene="IFNAR2"
                     /gene_synonym="IFN-alpha-REC; IFN-R; IFN-R-2; IFNABR;
                     IFNARB; IMD45"
                     /inference="alignment:Splign:2.1.0"
     exon            757..902
                     /gene="IFNAR2"
                     /gene_synonym="IFN-alpha-REC; IFN-R; IFN-R-2; IFNABR;
                     IFNARB; IMD45"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1071
                     /gene="IFNAR2"
                     /gene_synonym="IFN-alpha-REC; IFN-R; IFN-R-2; IFNABR;
                     IFNARB; IMD45"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1202
                     /gene="IFNAR2"
                     /gene_synonym="IFN-alpha-REC; IFN-R; IFN-R-2; IFNABR;
                     IFNARB; IMD45"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..4074
                     /gene="IFNAR2"
                     /gene_synonym="IFN-alpha-REC; IFN-R; IFN-R-2; IFNABR;
                     IFNARB; IMD45"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4074
                     /gene="IFNAR2"
                     /gene_synonym="IFN-alpha-REC; IFN-R; IFN-R-2; IFNABR;
                     IFNARB; IMD45"
                     /note="major polyA site"
ORIGIN      
        1 gtatcgctcc tcgtaggccg gggctcggcg cgcgcacccg cactaaagac gcttcttccc
       61 ggcgggtagg aatcccgccg gcgagccgaa cagttccccg agcgcagccc gcggaccacc
      121 acccggccgc acgggccgct tttgtccccc gcccgccgct tctgtccgag aggccgcccg
      181 cgaggcgcat cctgaccgcg agcgtcgggt cccagagccg ggcgcggctg gggcccgagg
      241 ctagcatctc tcgggagccg caaggcgaga gctgcaaagt ttaattagac acttcagaat
      301 tttgatcacc taatgttgat ttcagatgta aaagtcaaga gaagactcta aaaatagcaa
      361 agatgctttt gagccagaat gccttcatct tcagatcact taatttggtt ctcatggtgt
      421 atatcagcct cgtgtttggt atttcatatg attcgcctga ttacacagat gaatcttgca
      481 ctttcaagat atcattgcga aatttccggt ccatcttatc atgggaatta aaaaaccact
      541 ccattgtacc aactcactat acattgctgt atacaatcat gagtaaacca gaagatttga
      601 aggtggttaa gaactgtgca aataccacaa gatcattttg tgacctcaca gatgagtgga
      661 gaagcacaca cgaggcctat gtcaccgtcc tagaaggatt cagcgggaac acaacgttgt
      721 tcagttgctc acacaatttc tggctggcca tagacatgtc ttttgaacca ccagagtttg
      781 agattgttgg ttttaccaac cacattaatg tgatggtgaa atttccatct attgttgagg
      841 aagaattaca gtttgattta tctctcgtca ttgaagaaca gtcagaggga attgttaaga
      901 agcataaacc cgaaataaaa ggaaacatga gtggaaattt cacctatatc attgacaagt
      961 taattccaaa cacgaactac tgtgtatctg tttatttaga gcacagtgat gagcaagcag
     1021 taataaagtc tcccttaaaa tgcaccctcc ttccacctgg ccaggaatca gaatcagcag
     1081 aatctgccaa aataggagga ataattactg tgtttttgat agcattggtc ttgacaagca
     1141 ccatagtgac actgaaatgg attggttata tatgcttaag aaatagcctc cccaaagtct
     1201 tgaattttca taacttttta gcctggccat ttcctaacct gccaccgttg gaagccatgg
     1261 atatggtgga ggtcatttac atcaacagaa agaagaaagt gtgggattat aattatgatg
     1321 atgaaagtga tagcgatact gaggcagcgc ccaggacaag tggcggtggc tataccatgc
     1381 atggactgac tgtcaggcct ctgggtcagg cctctgccac ctctacagaa tcccagttga
     1441 tagacccgga gtccgaggag gagcctgacc tgcctgaggt tgatgtggag ctccccacga
     1501 tgccaaagga cagccctcag cagttggaac tcttgagtgg gccctgtgag aggagaaaga
     1561 gtccactcca ggaccctttt cccgaagagg actacagctc cacggagggg tctgggggca
     1621 gaattacctt caatgtggac ttaaactctg tgtttttgag agttcttgat gacgaggaca
     1681 gtgacgactt agaagcccct ctgatgctat cgtctcatct ggaagagatg gttgacccag
     1741 aggatcctga taatgtgcaa tcaaaccatt tgctggccag cggggaaggg acacagccaa
     1801 cctttcccag cccctcttca gagggcctgt ggtccgaaga tgctccatct gatcaaagtg
     1861 acacttctga gtcagatgtt gaccttgggg atggttatat aatgagatga ctccaaaact
     1921 attgaatgaa cttggacaga caagcaccta cagggttctt tgtctctgca tcctaacttg
     1981 ctgccttatc gtctgcaagt gttctccaag ggaaggagga ggaaactgtg gtgttccttt
     2041 cttccaggtg acatcaccta tgcacattcc cagtatgggg accatagtat cattcagtgc
     2101 attgtttaca tattcaaagt ggtgcacttt gaaggaagca catgtgcacc tttcctttac
     2161 actaatgcac ttaggatgtt tctgcatcat gtctaccagg gagcagggtt ccccacagtt
     2221 tcagaggtgg tccaggaccc tatgatattt ctcttctttc gttctttttt tttttttttt
     2281 ttgagacaga gtctcgttct gtcgcccaag ctggagcgca atggtgtgat cttggctcac
     2341 tgcaacatcc gcctcccagg ttcaagtgat tctcctgcct cagcctccct cgcaagtagc
     2401 tgggattaca ggcgcctgcc accatgccta gcaaattttt gtatttttag tagagacagg
     2461 attttaccat gttggccagg ctggtctcaa actcctgacc tcaagtgatc tgccctcctc
     2521 agcctcgtaa agtgctggga ttacaggggt gagccgctgt gcctggctgg ccctgtgata
     2581 tttctgtgaa ataaattggg ccagggtggg agcagggaaa gaaaaggaaa atagtagcaa
     2641 gagctgcaaa gcaggcagga agggaggagg agagccaggt gagcagtgga gagaaggggg
     2701 gccctgcaca aggaaacagg gaagagccat cgaagtttca gtcggtgagc cttgggcacc
     2761 tcacccatgt cacatcctgt ctcctgcaat tggaattcca ccttgtccag ccctccccag
     2821 ttaaagtggg gaagacagac tttaggatca cgtgtgtgac taatacagaa aggaaacatg
     2881 gcgtcgggga gagggataaa acctgaatgc catattttaa gttaaaaaaa aaaaaagcaa
     2941 acacaaagat gcttcaagat cttcaggaga agtatggtat acaagtttca gggaccctat
     3001 ttgacaattt tcagagtgct ctctatgctg attccgagtc gagtgtgtca gctgtgatta
     3061 cagtgcctgt ggatctaggc cgggttgggg gggtgtgggc gggggaaggg aagtctggcc
     3121 cggagcaatt gctcctgccg gtaaccccag cactttggga tgcctaaaca ggcgtatcgc
     3181 ttgaggccag taattcgaga ccagcctggg caacatggca aatctgtctc tacaaaacaa
     3241 aattagaaaa attaactggg cgtagtggca tgtgcctgtt gtcccagcta cttgggaggc
     3301 tgaggtggga gaatggcttg agcccaggaa gcggaggttg cagtgagcca agatcatgtc
     3361 actgcacttc agcctgggtg acagaaccag accctgtctt taaaaaggga gttggtgggg
     3421 agaggttcta gaatgtcatg tagcaaccag tttaaggact gggactcagg gatccaactc
     3481 ccacagtttc cctgtgtgac cctaggcatt tgacttagcc tttctgagcc tcaggttttt
     3541 tgtttctgaa gtaaaaggat tggactaggt aatctccaag atcctaggaa cccaggagaa
     3601 agatgagaaa atgtacaaga atgaacactc aggtggaaat gctgcaatcc tgagaagctc
     3661 ccaggatgaa tgaaaggcac aggacctctt acccctcacc cctgcccccc tcaagagctg
     3721 gtttctcaaa cctttctctt aggccccttc aaagggggaa aactaaaaat tatacaagtt
     3781 atagttcaag gactttaaat agattattta tatgattgct cataaggatg aggctgtgag
     3841 gagggaacac cttatttaat ctaatgaaat tccataggaa agaggccttt tgtatattga
     3901 atcaatttat ctgccttctc agtgcatctg tcatattctg aaagattctg ggttgatctt
     3961 ttgcgataac ctctatggct gtgagtgtgt gtgtgtgttt gtgtattttt taacattttg
     4021 tataatgatt ggaggttggt aaaaagtaac acaacagtac ttttttaata caaa
//
