LOCUS       NM_001414505            2818 bp    mRNA    linear   PRI 30-NOV-2022
DEFINITION  Homo sapiens IFNAR2-IL10RB readthrough (IFNAR2-IL10RB), mRNA.
ACCESSION   NM_001414505
VERSION     NM_001414505.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2818)
  AUTHORS   Ma Y, Huang Y, Zhao S, Yao Y, Zhang Y, Qu J, Wu N and Su J.
  TITLE     Integrative genomics analysis reveals a 21q22.11 locus contributing
            risk to COVID-19
  JOURNAL   Hum Mol Genet 30 (13), 1247-1258 (2021)
   PUBMED   33949668
REFERENCE   2  (bases 1 to 2818)
  AUTHORS   Pintarelli G, Dassano A, Cotroneo CE, Galvan A, Noci S, Piazza R,
            Pirola A, Spinelli R, Incarbone M, Palleschi A, Rosso L,
            Santambrogio L, Dragani TA and Colombo F.
  TITLE     Read-through transcripts in normal human lung parenchyma are
            down-regulated in lung adenocarcinoma
  JOURNAL   Oncotarget 7 (19), 27889-27898 (2016)
   PUBMED   27058892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000292.1, AP000294.1 and AP000295.1.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring IFNAR2 (interferon alpha and
            beta receptor subunit 2) and IL10RB (interleukin 10 receptor
            subunit beta) genes on chromosome 21. The readthrough transcript
            encodes a protein that shares sequence identity with the upstream
            and downstream gene products. [provided by RefSeq, Nov 2022].
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 3455, 3588
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AP000292.1         33153-33431
            280-371             AP000294.1         786-877
            372-413             AP000294.1         2573-2614
            414-537             AP000294.1         3851-3974
            538-710             AP000294.1         5618-5790
            711-856             AP000294.1         7609-7754
            857-1025            AP000294.1         11562-11730
            1026-1149           AP000295.1         11534-11657
            1150-1307           AP000295.1         19736-19893
            1308-1474           AP000295.1         22892-23058
            1475-1622           AP000295.1         26234-26381
            1623-1780           AP000295.1         31244-31401
            1781-2818           AP000295.1         39324-40361
FEATURES             Location/Qualifiers
     source          1..2818
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..2818
                     /gene="IFNAR2-IL10RB"
                     /note="IFNAR2-IL10RB readthrough"
                     /db_xref="GeneID:127882475"
     CDS             317..1954
                     /gene="IFNAR2-IL10RB"
                     /note="IFNAR2-IL10RB protein"
                     /codon_start=1
                     /product="IFNAR2-IL10RB readthrough"
                     /protein_id="NP_001401434.1"
                     /db_xref="GeneID:127882475"
                     /translation="MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKIS
                     LRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRST
                     HEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEE
                     ELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQ
                     AVIKSPLKCTLLPPGQESALGMVPPPENVRMNSVNFKNILQWESPAFAKGNLTFTAQY
                     LSYRIFQDKCMNTTLTECDFSSLSKYGDHTLRVRAEFADEHSDWVNITFCPVDDTIIG
                     PPGMQVEVLADSLHMRFLAPKIENEYETWTMKNVYNSWTYNVQYWKNGTDEKFQITPQ
                     YDFEVLRNLEPWTTYCVQVRGFLPDRNKAGEWSEPVCEQTTHDETVPSWMVAVILMAS
                     VFMVCLALLGCFALLWCVYKKTKYAFSPRNSLPQHLKEFLGHPHHNTLLFFSFPLSDE
                     NDVFDKLSVIAEDSESGKQNPGDSCSLGTPPGQGPQS"
ORIGIN      
        1 gtatcgctcc tcgtaggccg gggctcggcg cgcgcacccg cactaaagac gcttcttccc
       61 ggcgggtagg aatcccgccg gcgagccgaa cagttccccg agcgcagccc gcggaccacc
      121 acccggccgc acgggccgct tttgtccccc gcccgccgct tctgtccgag aggccgcccg
      181 cgaggcgcat cctgaccgcg agcgtcgggt cccagagccg ggcgcggctg gggcccgagg
      241 ctagcatctc tcgggagccg caaggcgaga gctgcaaaga tgtaaaagtc aagagaagac
      301 tctaaaaata gcaaagatgc ttttgagcca gaatgccttc atcttcagat cacttaattt
      361 ggttctcatg gtgtatatca gcctcgtgtt tggtatttca tatgattcgc ctgattacac
      421 agatgaatct tgcactttca agatatcatt gcgaaatttc cggtccatct tatcatggga
      481 attaaaaaac cactccattg taccaactca ctatacattg ctgtatacaa tcatgagtaa
      541 accagaagat ttgaaggtgg ttaagaactg tgcaaatacc acaagatcat tttgtgacct
      601 cacagatgag tggagaagca cacacgaggc ctatgtcacc gtcctagaag gattcagcgg
      661 gaacacaacg ttgttcagtt gctcacacaa tttctggctg gccatagaca tgtcttttga
      721 accaccagag tttgagattg ttggttttac caaccacatt aatgtgatgg tgaaatttcc
      781 atctattgtt gaggaagaat tacagtttga tttatctctc gtcattgaag aacagtcaga
      841 gggaattgtt aagaagcata aacccgaaat aaaaggaaac atgagtggaa atttcaccta
      901 tatcattgac aagttaattc caaacacgaa ctactgtgta tctgtttatt tagagcacag
      961 tgatgagcaa gcagtaataa agtctccctt aaaatgcacc ctccttccac ctggccagga
     1021 atcagcattg ggaatggtac cacctcccga aaatgtcaga atgaattctg ttaatttcaa
     1081 gaacattcta cagtgggagt cacctgcttt tgccaaaggg aacctgactt tcacagctca
     1141 gtacctaagt tataggatat tccaagataa atgcatgaat actaccttga cggaatgtga
     1201 tttctcaagt ctttccaagt atggtgacca caccttgaga gtcagggctg aatttgcaga
     1261 tgagcattca gactgggtaa acatcacctt ctgtcctgtg gatgacacca ttattggacc
     1321 ccctggaatg caagtagaag tacttgctga ttctttacat atgcgtttct tagcccctaa
     1381 aattgagaat gaatacgaaa cttggactat gaagaatgtg tataactcat ggacttataa
     1441 tgtgcaatac tggaaaaacg gtactgatga aaagtttcaa attactcccc agtatgactt
     1501 tgaggtcctc agaaacctgg agccatggac aacttattgt gttcaagttc gagggtttct
     1561 tcctgatcgg aacaaagctg gggaatggag tgagcctgtc tgtgagcaaa caacccatga
     1621 cgaaacggtc ccctcctgga tggtggccgt catcctcatg gcctcggtct tcatggtctg
     1681 cctggcactc ctcggctgct tcgccttgct gtggtgcgtt tacaagaaga caaagtacgc
     1741 cttctcccct aggaattctc ttccacagca cctgaaagag tttttgggcc atcctcatca
     1801 taacacactt ctgtttttct cctttccatt gtcggatgag aatgatgttt ttgacaagct
     1861 aagtgtcatt gcagaagact ctgagagcgg caagcagaat cctggtgaca gctgcagcct
     1921 cgggaccccg cctgggcagg ggccccaaag ctaggctctg agaaggaaac acactcggct
     1981 gggcacagtg acgtactcca tctcacatct gcctcagtga gggatcaggg cagcaaacaa
     2041 gggccaagac catctgagcc agccccacat ctagaactcc cagaccctgg acttagccac
     2101 cagagagcta cattttaaag gctgtcttgg caaaaatact ccatttggga actcactgcc
     2161 ttataaaggc tttcatgatg ttttcagaag ttggccactg agagtgtaat tttcagcctt
     2221 ttatatcact aaaataagat catgttttaa ttgtgagaaa cagggccgag cacagtggct
     2281 cacgcctgta ataccagcac cttagaggtc gaggcaggcg gatcacttga ggtcaggagt
     2341 tcaagaccag cctggccaat atggtgaaac ccagtctcta ctaaaaatac aaaaattagc
     2401 taggcatgat ggcgcatgcc tataatccca gctactcgag tgcctgaggc aggagaattg
     2461 catgaacccg ggaggaggag gaggaggttg cagtgagccg agatagcggc actgcactcc
     2521 agcctgggtg acaaagtgag actccatctc aaaaaaaaaa aaaaaaaaaa ttgtgagaaa
     2581 cagaaatact taaaatgagg aataagaatg gagatgttac atctggtaga tgtaacattc
     2641 taccagatta tggatggact gatctgaaaa tcgacctcaa ctcaagggtg gtcagctcaa
     2701 tgctacacag agcacggact tttggattct ttgcagtact ttgaatttat ttttctacct
     2761 atatatgttt tatatgctgc tggtgctcca ttaaagtttt actctgtgtt gcactata
//
