LOCUS       NM_000629               6075 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens interferon alpha and beta receptor subunit 1 (IFNAR1),
            transcript variant 2, mRNA.
ACCESSION   NM_000629
VERSION     NM_000629.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6075)
  AUTHORS   Woon,S.T., Tjandra,F., Mackay,J., Lumley,T., Grainger,P., Wood,A.,
            Hsiao,K.C. and Ameratunga,R.
  TITLE     Detection of interferon alpha and beta receptor subunit 1 (IFNAR1)
            loss-of-function Glu386 * variant by tri-allelic genotyping
  JOURNAL   Pathology 56 (1), 92-97 (2024)
   PUBMED   37973454
  REMARK    GeneRIF: Detection of interferon alpha and beta receptor subunit 1
            (IFNAR1) loss-of-function Glu386 * variant by tri-allelic
            genotyping.
REFERENCE   2  (bases 1 to 6075)
  AUTHORS   Yaugel-Novoa,M., Bourlet,T., Longet,S., Botelho-Nevers,E. and
            Paul,S.
  TITLE     Association of IFNAR1 and IFNAR2 with COVID-19 severity
  JOURNAL   Lancet Microbe 4 (7), e487 (2023)
   PUBMED   37028439
  REMARK    GeneRIF: Association of IFNAR1 and IFNAR2 with COVID-19 severity.
            Erratum:[Lancet Microbe. 2023 Jun;4(6):e394. doi:
            10.1016/S2666-5247(23)00116-7.. PMID: 37068499]
REFERENCE   3  (bases 1 to 6075)
  AUTHORS   Xiong,J., Jiang,Y., Zhang,J., Chen,Y. and Hu,Y.
  TITLE     CK1alpha upregulates the IFNAR1 expression to prompt the anti-HBV
            effect of type I IFN in hepatoma carcinoma cells
  JOURNAL   Virol Sin 37 (6), 894-903 (2022)
   PUBMED   35985475
  REMARK    GeneRIF: CK1alpha upregulates the IFNAR1 expression to prompt the
            anti-HBV effect of type I IFN in hepatoma carcinoma cells.
REFERENCE   4  (bases 1 to 6075)
  AUTHORS   Yang,L., Zhang,X., Huang,X., Dong,X., Jing,S., Zhang,Y., Zhao,B.,
            Wang,Z. and Qu,H.
  TITLE     Correlation between IFNAR1 expression in peripheral blood T
            lymphocytes and inflammatory cytokines, tumor-infiltrating
            lymphocytes, and chemosensitivity in patients with colorectal
            cancer
  JOURNAL   Cytokine 159, 156008 (2022)
   PUBMED   36063748
  REMARK    GeneRIF: Correlation between IFNAR1 expression in peripheral blood
            T lymphocytes and inflammatory cytokines, tumor-infiltrating
            lymphocytes, and chemosensitivity in patients with colorectal
            cancer.
REFERENCE   5  (bases 1 to 6075)
  AUTHORS   C West,R., Ezashi,T., B Schoolcraft,W. and Yuan,Y.
  TITLE     Beyond fusion: A novel role for ERVW-1 in trophoblast proliferation
            and type I interferon receptor expression
  JOURNAL   Placenta 126, 150-159 (2022)
   PUBMED   35816776
  REMARK    GeneRIF: Beyond fusion: A novel role for ERVW-1 in trophoblast
            proliferation and type I interferon receptor expression.
REFERENCE   6  (bases 1 to 6075)
  AUTHORS   Colamonici,O., Yan,H., Domanski,P., Handa,R., Smalley,D.,
            Mullersman,J., Witte,M., Krishnan,K. and Krolewski,J.
  TITLE     Direct binding to and tyrosine phosphorylation of the alpha subunit
            of the type I interferon receptor by p135tyk2 tyrosine kinase
  JOURNAL   Mol Cell Biol 14 (12), 8133-8142 (1994)
   PUBMED   7526154
REFERENCE   7  (bases 1 to 6075)
  AUTHORS   Lutfalla,G., Gardiner,K., Proudhon,D., Vielh,E. and Uze,G.
  TITLE     The structure of the human interferon alpha/beta receptor gene
  JOURNAL   J Biol Chem 267 (4), 2802-2809 (1992)
   PUBMED   1370833
REFERENCE   8  (bases 1 to 6075)
  AUTHORS   Flores,I., Mariano,T.M. and Pestka,S.
  TITLE     Human interferon omega (omega) binds to the alpha/beta receptor
  JOURNAL   J Biol Chem 266 (30), 19875-19877 (1991)
   PUBMED   1834641
REFERENCE   9  (bases 1 to 6075)
  AUTHORS   Lutfalla,G., Roeckel,N., Mogensen,K.E., Mattei,M.G. and Uze,G.
  TITLE     Assignment of the human interferon-alpha receptor gene to
            chromosome 21q22.1 by in situ hybridization
  JOURNAL   J Interferon Res 10 (5), 515-517 (1990)
   PUBMED   2148760
REFERENCE   10 (bases 1 to 6075)
  AUTHORS   Uze,G., Lutfalla,G. and Gresser,I.
  TITLE     Genetic transfer of a functional human interferon alpha receptor
            into mouse cells: cloning and expression of its cDNA
  JOURNAL   Cell 60 (2), 225-234 (1990)
   PUBMED   2153461
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG548299.1, BC021825.1,
            J03171.1, BG116121.1, CA309858.1, BX537636.1, AK123813.1,
            BC035603.1, R15745.1 and AP000298.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000629.2.
            
            Summary: The protein encoded by this gene is a type I membrane
            protein that forms one of the two chains of a receptor for
            interferons alpha and beta. Binding and activation of the receptor
            stimulates Janus protein kinases, which in turn phosphorylate
            several proteins, including STAT1 and STAT2. The protein belongs to
            the type II cytokine receptor family and functions as an antiviral
            factor. [provided by RefSeq, Jul 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.34674.1,
                                           SRR1803614.24038.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000270139.8/ ENSP00000270139.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-469               BG548299.1         67-535
            470-2069            BC021825.1         463-2062
            2070-2087           J03171.1           2061-2078
            2088-2100           BG116121.1         688-700
            2101-2761           J03171.1           2095-2755
            2762-3276           CA309858.1         16-530              c
            3277-3754           BX537636.1         364-841
            3755-3830           AK123813.1         465-540
            3831-4598           BX537636.1         917-1684
            4599-6020           BC035603.1         682-2103
            6021-6034           R15745.1           5-18                c
            6035-6075           AP000298.1         7615-7655
FEATURES             Location/Qualifiers
     source          1..6075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..6075
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /note="interferon alpha and beta receptor subunit 1"
                     /db_xref="GeneID:3454"
                     /db_xref="HGNC:HGNC:5432"
                     /db_xref="MIM:107450"
     exon            1..162
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1760
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; alpha-type antiviral protein; beta-type
                     antiviral protein; interferon-beta receptor 1;
                     interferon-alpha/beta receptor alpha chain; interferon
                     alpha/beta receptor 1; CRF2-1; IFN-R-1; IFN-alpha/beta
                     receptor 1; type I interferon receptor 1; cytokine
                     receptor class-II member 1; cytokine receptor family 2
                     member 1; interferon (alpha, beta and omega) receptor 1;
                     IFNalpha/beta receptor 1"
                     /codon_start=1
                     /product="interferon alpha/beta receptor 1 isoform 2
                     precursor"
                     /protein_id="NP_000620.2"
                     /db_xref="CCDS:CCDS13624.1"
                     /db_xref="GeneID:3454"
                     /db_xref="HGNC:HGNC:5432"
                     /db_xref="MIM:107450"
                     /translation="MMVVLLGATTLVLVAVAPWVLSAAAGGKNLKSPQKVEVDIIDDN
                     FILRWNRSDESVGNVTFSFDYQKTGMDNWIKLSGCQNITSTKCNFSSLKLNVYEEIKL
                     RIRAEKENTSSWYEVDSFTPFRKAQIGPPEVHLEAEDKAIVIHISPGTKDSVMWALDG
                     LSFTYSLVIWKNSSGVEERIENIYSRHKIYKLSPETTYCLKVKAALLTSWKIGVYSPV
                     HCIKTTVENELPPPENIEVSVQNQNYVLKWDYTYANMTFQVQWLHAFLKRNPGNHLYK
                     WKQIPDCENVKTTQCVFPQNVFQKGIYLLRVQASDGNNTSFWSEEIKFDTEIQAFLLP
                     PVFNIRSLSDSFHIYIGAPKQSGNTPVIQDYPLIYEIIFWENTSNAERKIIEKKTDVT
                     VPNLKPLTVYCVKARAHTMDEKLNKSSVFSDAVCEKTKPGNTSKIWLIVGICIALFAL
                     PFVIYAAKVFLRCINYVFFPSLKPSSSIDEYFSEQPLKNLLLSTSEEQIEKCFIIENI
                     STIATVEETNQTDEDHKKYSSQTSQDSGNYSNEDESESKTSEELQQDFV"
     exon            163..286
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /inference="alignment:Splign:2.1.0"
     exon            287..462
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /inference="alignment:Splign:2.1.0"
     exon            463..617
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /inference="alignment:Splign:2.1.0"
     exon            618..759
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /inference="alignment:Splign:2.1.0"
     exon            760..874
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1074
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1229
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1380
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1526
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..6075
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2233..2238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /note="hexamer: ATTAAA"
     polyA_site      2252
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /note="major polyA site"
     regulatory      5496..5501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /note="hexamer: AATAAG"
     polyA_site      5515
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
     regulatory      6008..6013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /note="hexamer: AATAAA"
     polyA_site      6034
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
     regulatory      6054..6059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
                     /note="hexamer: AACAAA"
     polyA_site      6075
                     /gene="IFNAR1"
                     /gene_synonym="AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;
                     IMD106"
ORIGIN      
        1 ggtgtgactt aggacggggc gatggcggct gagaggagct gcgcgtgcgc gaacatgtaa
       61 ctggtgggat ctgcggcggc tcccagatga tggtcgtcct cctgggcgcg acgaccctag
      121 tgctcgtcgc cgtggcgcca tgggtgttgt ccgcagccgc aggtggaaaa aatctaaaat
      181 ctcctcaaaa agtagaggtc gacatcatag atgacaactt tatcctgagg tggaacagga
      241 gcgatgagtc tgtcgggaat gtgacttttt cattcgatta tcaaaaaact gggatggata
      301 attggataaa attgtctggg tgtcagaata ttactagtac caaatgcaac ttttcttcac
      361 tcaagctgaa tgtttatgaa gaaattaaat tgcgtataag agcagaaaaa gaaaacactt
      421 cttcatggta tgaggttgac tcatttacac catttcgcaa agctcagatt ggtcctccag
      481 aagtacattt agaagctgaa gataaggcaa tagtgataca catctctcct ggaacaaaag
      541 atagtgttat gtgggctttg gatggtttaa gctttacata tagcttagtt atctggaaaa
      601 actcttcagg tgtagaagaa aggattgaaa atatttattc cagacataaa atttataaac
      661 tctcaccaga gactacttat tgtctaaaag ttaaagcagc actacttacg tcatggaaaa
      721 ttggtgtcta tagtccagta cattgtataa agaccacagt tgaaaatgaa ctacctccac
      781 cagaaaatat agaagtcagt gtccaaaatc agaactatgt tcttaaatgg gattatacat
      841 atgcaaacat gacctttcaa gttcagtggc tccacgcctt tttaaaaagg aatcctggaa
      901 accatttgta taaatggaaa caaatacctg actgtgaaaa tgtcaaaact acccagtgtg
      961 tctttcctca aaacgttttc caaaaaggaa tttaccttct ccgcgtacaa gcatctgatg
     1021 gaaataacac atctttttgg tctgaagaga taaagtttga tactgaaata caagctttcc
     1081 tacttcctcc agtctttaac attagatccc ttagtgattc attccatatc tatatcggtg
     1141 ctccaaaaca gtctggaaac acgcctgtga tccaggatta tccactgatt tatgaaatta
     1201 ttttttggga aaacacttca aatgctgaga gaaaaattat cgagaaaaaa actgatgtta
     1261 cagttcctaa tttgaaacca ctgactgtat attgtgtgaa agccagagca cacaccatgg
     1321 atgaaaagct gaataaaagc agtgttttta gtgacgctgt atgtgagaaa acaaaaccag
     1381 gaaatacctc taaaatttgg cttatagttg gaatttgtat tgcattattt gctctcccgt
     1441 ttgtcattta tgctgcgaaa gtcttcttga gatgcatcaa ttatgtcttc tttccatcac
     1501 ttaaaccttc ttccagtata gatgagtatt tctctgaaca gccattgaag aatcttctgc
     1561 tttcaacttc tgaggaacaa atcgaaaaat gtttcataat tgaaaatata agcacaattg
     1621 ctacagtaga agaaactaat caaactgatg aagatcataa aaaatacagt tcccaaacta
     1681 gccaagattc aggaaattat tctaatgaag atgaaagcga aagtaaaaca agtgaagaac
     1741 tacagcagga ctttgtatga ccagaaatga actgtgtcaa gtataaggtt tttcagcagg
     1801 agttacactg ggagcctgag gtcctcacct tcctctcagt aactacagag aggacgtttc
     1861 cctgtttagg gaaagaaaaa acatcttcag atcataggtc ctaaaaatac gggcaagctc
     1921 ttaactattt aaaaatgaaa ttacaggccc gggcacggtg gctcacacct gtaatcccag
     1981 cactttggga ggctgaggca ggcagatcat gaggtcaaga gatcgagacc agcctggcca
     2041 acgtggtgaa accccatctc tactaaaaat acaaaaatta gccgggtgtg gtggcgcgcg
     2101 cctgttgtct tagctactca ggaggctgag gcaggagaat cgcttgaaaa caggaggtgg
     2161 aggttgcagt gagccgagat cacgccactg cactccagcc tggtgacagc gtgagactct
     2221 ttaaaaaaag aaattaaaag agttgagaca aacgtttcct acattctttt ccatgtgtaa
     2281 aatcatgaaa aagcctgtca ccggacttgc attggatgag atgagtcaga ccaaaacagt
     2341 ggccacccgt cttcctcctg tgagcctaag tgcagccgtg ctagctgcgc accgtggcta
     2401 aggatgacgt ctgtgttcct gtccatcact gatgctgctg gctactgcat gtgccacacc
     2461 tgtctgttcg ccattcctaa cattctgttt cattcttcct cgggagatat ttcaaacatt
     2521 tggtcttttc ttttaacact gagggtaggc ccttaggaaa tttatttagg aaagtctgaa
     2581 cacgttatca cttggttttc tggaaagtag cttaccctag aaaacagctg caaatgccag
     2641 aaagatgatc cctaaaaatg ttgagggact tctgttcatt catcccgaga acattggctt
     2701 ccacatcaca gtatctaccc ttacatggtt taggattaaa gccaggcaat cttttactat
     2761 gcattaagac ctctgattca aaacttatta gaacagtagc ttctgctgga atttgcaatc
     2821 actgaagtca tagaaaatag gtaactatct aattagagaa ataattgttg tattttaaga
     2881 tctgagagtg tgtacaagtt ttagtataca tgccatgcca gaagatagtg tatgcaagaa
     2941 gtcttgggac cagaaaatgg caatgatagg agactgacat agaagaagaa tgcttcccta
     3001 ggaaaaaggt cgctggcttt ggtgcaagag gaagaagaat gttccactgg aagcctgagc
     3061 acctaatcag ctctcagtga tcaacccact cttgttatgg gtggtctctg tcactttgaa
     3121 tgccaggctg gcttctcgtc tagcagtatt cagatacccc ttctgctcag cctgcttggc
     3181 gttaaaatac aaatcattga actgaggggg aaaaatgtaa ctaggaagaa aaacccaatt
     3241 taagaaatta cataatgctt tccaaaggca cctacaactt agttttaaat tacttgctac
     3301 tggggattac ccatggatat ccttaatagg caggaagtct gggaattctg gtggcctcta
     3361 gggcagtgtt ctcacagcac cgttccgaca gggaccagtg aaagaaaaga gacaaagtta
     3421 gaacgtgctg gggagcggcc atttctaagg ccagtctggt ttaagtagtc atttctgctg
     3481 aaaaaacaga tgatcctggt ggaagaaaag gttgaaggca gctgccctcg ggagggctgt
     3541 gatgctcggc acatcctgcc tggcacatac acgtgtctgc aggccacacc gtgcatgtcc
     3601 ccagacctgc cgcctggctt ctggagtgct tcaagcagag catggtgggt cattgaggag
     3661 acccaggaat ctcatctgag aacccactct ctgccggaga accccatggt gacacatttt
     3721 catctttctg accagaggct gttttttttt ttttttgaga cagtctcatt ctgttgccca
     3781 ggctggagtg cagtggcttg atctcggctc actgcaacct cgcctcccgg gttcaagcaa
     3841 ttctctgccg cagcctccag agtagctggg ataacaggtg cccaccacca caccccacta
     3901 atttttgtat ttgtattttt agtagagatg gggtttcacc atgttggtca ggctggtctt
     3961 ggactcctga cctcatgctc cacccgcttc ggcctcccaa agttctggga ttacaggtgt
     4021 gagccaccgt gcacggccgg cctgaccttt ggaaaagcct tgtcactttg gacgtttgcg
     4081 tctttgaaga ggcgatggga gcatatcatg actgcctgcc accattgctt ttcagactac
     4141 cacaactcaa tcatgctgtc caggacttct ggccctgtgt tcaccactgg gaaaacgtac
     4201 ttcagactgg atagcctaaa aaggagcaat gcccttgtag gatgtggaga agggaaaata
     4261 cggacattaa cattaaaaga caccagtgaa attgttaggt ctctaggaag ttggagcaca
     4321 aggcttcacg ctttaagacc atctgtggtt ttcagtgaac aagcgctgag caccagcagc
     4381 agaaaacaac aacaaaaaaa cacctcgttt ttaccttgtc ttctagacat gaaaaggcag
     4441 ttgcattcca ctctgcatta tgttctacat gttgctttat cagtatatgc ttagctgtaa
     4501 gtgacaagta ttttttctga acagaagttt acttagaaat accatgcact tgggggtacc
     4561 aattaaccgc ctgaaaatta gcatattgat agttcttaga gagaccagat ataatctaag
     4621 aatttatatg aaagatttgt atcattagag ccagaaataa ttttatatta atatataata
     4681 cagattaaca ttatatataa tatgtacctg tgtcacttct gacatgagcc tgtaaacata
     4741 tattcatata tgtacctgca catgtaccca cctgatgtag gtcttattcc tttagtatgg
     4801 acttaaagta cttattcata taccttgtaa ctaaaaatta gaacagctcc ctagaattgt
     4861 gaacttttaa gagtctgact agaaatttgc aacttataaa aaagttactt ttaaaaatat
     4921 aagttagggc taggcacagt ggctcatgcc tataatctca gcacttttgg gaggccaaga
     4981 caggaggatc acttcaggcc aggagttcaa gatcaaccaa cctgggtaac atggccagac
     5041 cccatctcta tttatatata tatatataaa acttagagtt tttatcttcc cctaaaagag
     5101 gccgtgatat ttgcagcagc ctcaaattgc tcttaagggg tttaggtgtg cagaagcttt
     5161 cctttcccta cccagtaacc atgtgactac taacgtggta tattgattta ttttgtttgc
     5221 tgtctgtctc ccctgcccca ctgctggaac agaggctcca agaaaacagg gaccttatta
     5281 ttcattactg catccccagt aatgaaagta cttagaaaat aattattgaa tgaatgaaat
     5341 ctaaactgtg aacctgaggg tgtttgtggc agtgtttgtt ttactgaatt gtagaaggac
     5401 ataaccgtgt tttcagtgtt tctatggaac aaacttgtac attttatttc acttgtgttt
     5461 tgtcttaaac cctactgctg gaaacaattt tatgtaataa gcaatgggcc caaaagtcta
     5521 ggagtttttt tgtacttagt gaatttgtat gcaacagaga tgctgcagct gatgccttta
     5581 aaaggtattc atcatggaag agctgaggcc tgtgcttggt gttccagagc ccagggttga
     5641 gcatcctgaa ggagccactg cagccgtcac tgtccccaga gcctgtggag atagagcctg
     5701 tttgctgctt tttcttcccg ctcttaagac atggctggag ctcagtcttc attgaatgaa
     5761 gtttgctgtg gtattgcata gccttgcttt cttgaactaa actgtttgcc cttcacaagt
     5821 agttcttctt tcaggattag ttcgttccaa ggaggctctt cagtctcaca gataagtaga
     5881 tctctcctgc tgtctggaca catttcactc ggaaattgaa tacaatttgt attcaggctg
     5941 ggaacctgaa cacacacttg tgtttttaag cttccctttt ttacagtgga caaggacaca
     6001 aataataaat aaatcatccc taatgcccaa gaaatgccct ggtacttagt aataacaaaa
     6061 taccagtaac ttcca
//
