LOCUS       NM_002170               1069 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens interferon alpha 8 (IFNA8), mRNA.
ACCESSION   NM_002170
VERSION     NM_002170.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1069)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1069)
  AUTHORS   Mesev,E.V., LeDesma,R.A. and Ploss,A.
  TITLE     Decoding type I and III interferon signalling during viral
            infection
  JOURNAL   Nat Microbiol 4 (6), 914-924 (2019)
   PUBMED   30936491
  REMARK    Review article
REFERENCE   3  (bases 1 to 1069)
  AUTHORS   Cha,L., de Jong,E., French,M.A. and Fernandez,S.
  TITLE     IFN-alpha exerts opposing effects on activation-induced and
            IL-7-induced proliferation of T cells that may impair homeostatic
            maintenance of CD4+ T cell numbers in treated HIV infection
  JOURNAL   J Immunol 193 (5), 2178-2186 (2014)
   PUBMED   25063872
  REMARK    GeneRIF: These data suggest that increased IFN-alpha8 activity may
            promote the loss of T cells by accelerating cell turnover and
            activation-induced cell death while decreasing the renewal of T
            cells by inhibiting the proliferative effect of IL-7.
REFERENCE   4  (bases 1 to 1069)
  AUTHORS   Hillyer,P., Raviv,N., Gold,D.M., Dougherty,D., Liu,J.,
            Johnson,T.R., Graham,B.S. and Rabin,R.L.
  TITLE     Subtypes of type I IFN differentially enhance cytokine expression
            by suboptimally stimulated CD4(+) T cells
  JOURNAL   Eur J Immunol 43 (12), 3197-3208 (2013)
   PUBMED   24030809
  REMARK    GeneRIF: IFN-alpha8 and -alpha10 most potently enhanced expression
            of IFN-gamma, IL-2, and IL-4.
REFERENCE   5  (bases 1 to 1069)
  AUTHORS   Kempaiah,P., Anyona,S.B., Raballah,E., Davenport,G.C., Were,T.,
            Hittner,J.B., Ong'echa,J.M. and Perkins,D.J.
  TITLE     Reduced interferon (IFN)-alpha conditioned by IFNA2 (-173) and
            IFNA8 (-884) haplotypes is associated with enhanced susceptibility
            to severe malarial anemia and longitudinal all-cause mortality
  JOURNAL   Hum Genet 131 (8), 1375-1391 (2012)
   PUBMED   22570109
  REMARK    GeneRIF: variation at IFNA2 -173 and IFNA8 -884 conditions reduced
            IFN-alpha production, and increased susceptibility to SMA and
            mortality
REFERENCE   6  (bases 1 to 1069)
  AUTHORS   Olopade,O.I., Bohlander,S.K., Pomykala,H., Maltepe,E., Van
            Melle,E., Le Beau,M.M. and Diaz,M.O.
  TITLE     Mapping of the shortest region of overlap of deletions of the short
            arm of chromosome 9 associated with human neoplasia
  JOURNAL   Genomics 14 (2), 437-443 (1992)
   PUBMED   1385305
REFERENCE   7  (bases 1 to 1069)
  AUTHORS   Henco,K., Brosius,J., Fujisawa,A., Fujisawa,J.I., Haynes,J.R.,
            Hochstadt,J., Kovacic,T., Pasek,M., Schambock,A., Schmid,J. et al.
  TITLE     Structural relationship of human interferon alpha genes and
            pseudogenes
  JOURNAL   J Mol Biol 185 (2), 227-260 (1985)
   PUBMED   4057246
REFERENCE   8  (bases 1 to 1069)
  AUTHORS   Bowden,D.W., Mao,J., Gill,T., Hsiao,K., Lillquist,J.S., Testa,D.
            and Vovis,G.F.
  TITLE     Cloning of eukaryotic genes in single-strand phage vectors: the
            human interferon genes
  JOURNAL   Gene 27 (1), 87-99 (1984)
   PUBMED   6325303
REFERENCE   9  (bases 1 to 1069)
  AUTHORS   Goeddel,D.V., Leung,D.W., Dull,T.J., Gross,M., Lawn,R.M.,
            McCandliss,R., Seeburg,P.H., Ullrich,A., Yelverton,E. and Gray,P.W.
  TITLE     The structure of eight distinct cloned human leukocyte interferon
            cDNAs
  JOURNAL   Nature 290 (5801), 20-26 (1981)
   PUBMED   6163083
REFERENCE   10 (bases 1 to 1069)
  AUTHORS   Yelverton,E., Leung,D., Weck,P., Gray,P.W. and Goeddel,D.V.
  TITLE     Bacterial synthesis of a novel human leukocyte interferon
  JOURNAL   Nucleic Acids Res 9 (3), 731-741 (1981)
   PUBMED   6164048
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353732.14.
            
            On May 17, 2019 this sequence version replaced NM_002170.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: V00550.1, V00545.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380205.2/ ENSP00000369553.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AL353732.14        65854-65883
            31-1069             AL353732.14        65884-66922
FEATURES             Location/Qualifiers
     source          1..1069
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..1069
                     /gene="IFNA8"
                     /gene_synonym="IFN-alphaB"
                     /note="interferon alpha 8"
                     /db_xref="GeneID:3445"
                     /db_xref="HGNC:HGNC:5429"
                     /db_xref="MIM:147568"
     exon            1..1069
                     /gene="IFNA8"
                     /gene_synonym="IFN-alphaB"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..630
                     /gene="IFNA8"
                     /gene_synonym="IFN-alphaB"
                     /note="interferon alpha-B'; interferon alpha type 201;
                     leIF B; IFN-alpha-8; interferon alpha-B2"
                     /codon_start=1
                     /product="interferon alpha-8 precursor"
                     /protein_id="NP_002161.2"
                     /db_xref="CCDS:CCDS6507.1"
                     /db_xref="GeneID:3445"
                     /db_xref="HGNC:HGNC:5429"
                     /db_xref="MIM:147568"
                     /translation="MALTFYLLVALVVLSYKSFSSLGCDLPQTHSLGNRRALILLAQM
                     RRISPFSCLKDRHDFEFPQEEFDDKQFQKAQAISVLHEMIQQTFNLFSTKDSSAALDE
                     TLLDEFYIELDQQLNDLESCVMQEVGVIESPLMYEDSILAVRKYFQRITLYLTEKKYS
                     SCAWEVVRAEIMRSFSLSINLQKRLKSKE"
ORIGIN      
        1 agagacccag gttaagggtc atccatctga accagctcag cagcatccac aacatctaca
       61 atggccttga ctttttattt actggtggcc ctagtggtgc tcagctacaa gtcattcagc
      121 tctctgggct gtgatctgcc tcagactcac agcctgggta acaggagggc cttgatactc
      181 ctggcacaaa tgcgaagaat ctctcctttc tcctgcctga aggacagaca tgactttgaa
      241 ttcccccagg aggagtttga tgataaacag ttccagaagg ctcaagccat ctctgtcctc
      301 catgagatga tccagcagac cttcaacctc ttcagcacaa aggactcatc tgctgctttg
      361 gatgagaccc ttctagatga attctacatc gaacttgacc agcagctgaa tgacctggag
      421 tcctgtgtga tgcaggaagt gggggtgata gagtctcccc tgatgtacga ggactccatc
      481 ctggctgtga ggaaatactt ccaaagaatc actctatatc tgacagagaa gaaatacagc
      541 tcttgtgcct gggaggttgt cagagcagaa atcatgagat ccttctcttt atcaatcaac
      601 ttgcaaaaaa gattgaagag taaggaatga gacctggtac aacacggaaa tgattcttat
      661 agactaatac agcagctcac acttcgacaa gttgtgctct ttcaaagacc cttgtttctg
      721 ccaaaaccat gctatgaatt gaatcaaatg tgtcaagtgt tttcaggagt gttaagcaac
      781 atcctgttca gctgtatggg cactagtccc ttacagatga ccatgctgat ggatctattc
      841 atctatttat ttaaatcttt atttagttaa ctatctatag ggcttaaatt agttttgttc
      901 atattatatt atgtgaactt ttacattgtg aattgtgtaa caaaaacatg ttctttatat
      961 ttattatttt gccttgttta ttaaattttt actatagaaa aattctttat ttattcttta
     1021 aaattgaact ccaaccctga ttgtgcaaac tgattaaaga atggatggt
//
