LOCUS       NM_021057                737 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens interferon alpha 7 (IFNA7), mRNA.
ACCESSION   NM_021057
VERSION     NM_021057.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 737)
  AUTHORS   Ding,M., Malhotra,R., Ottosson,T., Lundqvist,M., Mebrahtu,A.,
            Brengdahl,J., Gehrmann,U., Back,E., Ross-Thriepland,D.,
            Isaksson,I., Magnusson,B., Sachsenmeier,K.F., Tegel,H., Hober,S.,
            Uhlen,M., Mayr,L.M., Davies,R., Rockberg,J. and Schiavone,L.H.
  TITLE     Secretome screening reveals immunomodulating functions of
            IFNalpha-7, PAP and GDF-7 on regulatory T-cells
  JOURNAL   Sci Rep 11 (1), 16767 (2021)
   PUBMED   34408239
  REMARK    GeneRIF: Secretome screening reveals immunomodulating functions of
            IFNalpha-7, PAP and GDF-7 on regulatory T-cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 737)
  AUTHORS   Mesev,E.V., LeDesma,R.A. and Ploss,A.
  TITLE     Decoding type I and III interferon signalling during viral
            infection
  JOURNAL   Nat Microbiol 4 (6), 914-924 (2019)
   PUBMED   30936491
  REMARK    Review article
REFERENCE   3  (bases 1 to 737)
  AUTHORS   Mosbruger,T.L., Duggal,P., Goedert,J.J., Kirk,G.D., Hoots,W.K.,
            Tobler,L.H., Busch,M., Peters,M.G., Rosen,H.R., Thomas,D.L. and
            Thio,C.L.
  TITLE     Large-scale candidate gene analysis of spontaneous clearance of
            hepatitis C virus
  JOURNAL   J Infect Dis 201 (9), 1371-1380 (2010)
   PUBMED   20331378
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 737)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 737)
  AUTHORS   Myers,M.P., Andersen,J.N., Cheng,A., Tremblay,M.L., Horvath,C.M.,
            Parisien,J.P., Salmeen,A., Barford,D. and Tonks,N.K.
  TITLE     TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B
  JOURNAL   J Biol Chem 276 (51), 47771-47774 (2001)
   PUBMED   11694501
REFERENCE   6  (bases 1 to 737)
  AUTHORS   Shuai,K., Horvath,C.M., Huang,L.H., Qureshi,S.A., Cowburn,D. and
            Darnell,J.E. Jr.
  TITLE     Interferon activation of the transcription factor Stat91 involves
            dimerization through SH2-phosphotyrosyl peptide interactions
  JOURNAL   Cell 76 (5), 821-828 (1994)
   PUBMED   7510216
REFERENCE   7  (bases 1 to 737)
  AUTHORS   Olopade,O.I., Bohlander,S.K., Pomykala,H., Maltepe,E., Van
            Melle,E., Le Beau,M.M. and Diaz,M.O.
  TITLE     Mapping of the shortest region of overlap of deletions of the short
            arm of chromosome 9 associated with human neoplasia
  JOURNAL   Genomics 14 (2), 437-443 (1992)
   PUBMED   1385305
REFERENCE   8  (bases 1 to 737)
  AUTHORS   Henco,K., Brosius,J., Fujisawa,A., Fujisawa,J.I., Haynes,J.R.,
            Hochstadt,J., Kovacic,T., Pasek,M., Schambock,A., Schmid,J. et al.
  TITLE     Structural relationship of human interferon alpha genes and
            pseudogenes
  JOURNAL   J Mol Biol 185 (2), 227-260 (1985)
   PUBMED   4057246
REFERENCE   9  (bases 1 to 737)
  AUTHORS   Cohen,S., Velan,B., Grosfeld,H., Shalita,Z., Leitner,M. and
            Shafferman,A.
  TITLE     Cloning, expression and biological activity of a new variant of
            human interferon alpha identified in virus induced lymphoblastoid
            cells
  JOURNAL   Dev Biol Stand 60, 111-122 (1985)
   PUBMED   2995168
REFERENCE   10 (bases 1 to 737)
  AUTHORS   Ullrich,A., Gray,A., Goeddel,D.V. and Dull,T.J.
  TITLE     Nucleotide sequence of a portion of human chromosome 9 containing a
            leukocyte interferon gene cluster
  JOURNAL   J Mol Biol 156 (3), 467-486 (1982)
   PUBMED   6181262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M34913.1 and BC074991.2.
            
            On Jul 26, 2005 this sequence version replaced NM_021057.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: M34913.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239347.3/ ENSP00000239347.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                M34913.1           1-68
            69-636              BC074991.2         67-634
            637-737             M34913.1           637-737
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..737
                     /gene="IFNA7"
                     /gene_synonym="IFN-alphaJ; IFNA-J"
                     /note="interferon alpha 7"
                     /db_xref="GeneID:3444"
                     /db_xref="HGNC:HGNC:5428"
                     /db_xref="MIM:147567"
     exon            1..737
                     /gene="IFNA7"
                     /gene_synonym="IFN-alphaJ; IFNA-J"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..610
                     /gene="IFNA7"
                     /gene_synonym="IFN-alphaJ; IFNA-J"
                     /note="IFN-alpha 7; leIF J; IFN-alpha-J1; interferon
                     alpha-J; interferon alpha-J1"
                     /codon_start=1
                     /product="interferon alpha-7 precursor"
                     /protein_id="NP_066401.2"
                     /db_xref="CCDS:CCDS34995.1"
                     /db_xref="GeneID:3444"
                     /db_xref="HGNC:HGNC:5428"
                     /db_xref="MIM:147567"
                     /translation="MARSFSLLMVVLVLSYKSICSLGCDLPQTHSLRNRRALILLAQM
                     GRISPFSCLKDRHEFRFPEEEFDGHQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQ
                     SLLEKFSTELYQQLNDLEACVIQEVGVEETPLMNEDFILAVRKYFQRITLYLMEKKYS
                     PCAWEVVRAEIMRSFSFSTNLKKGLRRKD"
ORIGIN      
        1 tacccacctc aggtagccta gtgatatttg caaaatccca atggcccggt ccttttcttt
       61 actgatggtc gtgctggtac tcagctacaa atccatctgc tctctgggct gtgatctgcc
      121 tcagacccac agcctgcgta ataggagggc cttgatactc ctggcacaaa tgggaagaat
      181 ctctcctttc tcctgcttga aggacagaca tgaattcaga ttcccagagg aggagtttga
      241 tggccaccag ttccagaaga ctcaagccat ctctgtcctc catgagatga tccagcagac
      301 cttcaatctc ttcagcacag aggactcatc tgctgcttgg gaacagagcc tcctagaaaa
      361 attttccact gaactttacc agcaactgaa tgacctggaa gcatgtgtga tacaggaggt
      421 tggggtggaa gagactcccc tgatgaatga ggacttcatc ctggctgtga ggaaatactt
      481 ccaaagaatc actctttatc taatggagaa gaaatacagc ccttgtgcct gggaggttgt
      541 cagagcagaa atcatgagat ccttctcttt ttcaacaaac ttgaaaaaag gattaaggag
      601 gaaggattga aaactggttc atcatggaaa tgattctcat tgactaatgc atcatctcac
      661 actttcatga gttcttccat ttcaaagact cacttctata accaccacaa gttgaatcaa
      721 aatttccaaa tgttttc
//
