LOCUS       NM_021002                570 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens interferon alpha 6 (IFNA6), mRNA.
ACCESSION   NM_021002
VERSION     NM_021002.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 570)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 570)
  AUTHORS   Mesev,E.V., LeDesma,R.A. and Ploss,A.
  TITLE     Decoding type I and III interferon signalling during viral
            infection
  JOURNAL   Nat Microbiol 4 (6), 914-924 (2019)
   PUBMED   30936491
  REMARK    Review article
REFERENCE   3  (bases 1 to 570)
  AUTHORS   Yang,X.R., Liang,X., Pfeiffer,R.M., Wheeler,W., Maeder,D.,
            Burdette,L., Yeager,M., Chanock,S., Tucker,M.A. and Goldstein,A.M.
  TITLE     Associations of 9p21 variants with cutaneous malignant melanoma,
            nevi, and pigmentation phenotypes in melanoma-prone families with
            and without CDKN2A mutations
  JOURNAL   Fam Cancer 9 (4), 625-633 (2010)
   PUBMED   20574843
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 570)
  AUTHORS   Silva,L.K., Blanton,R.E., Parrado,A.R., Melo,P.S., Morato,V.G.,
            Reis,E.A., Dias,J.P., Castro,J.M., Vasconcelos,P.F., Goddard,K.A.,
            Barreto,M.L., Reis,M.G. and Teixeira,M.G.
  TITLE     Dengue hemorrhagic fever is associated with polymorphisms in JAK1
  JOURNAL   Eur J Hum Genet 18 (11), 1221-1227 (2010)
   PUBMED   20588308
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 570)
  AUTHORS   Schuurhof,A., Bont,L., Siezen,C.L., Hodemaekers,H., van
            Houwelingen,H.C., Kimman,T.G., Hoebee,B., Kimpen,J.L. and
            Janssen,R.
  TITLE     Interleukin-9 polymorphism in infants with respiratory syncytial
            virus infection: an opposite effect in boys and girls
  JOURNAL   Pediatr Pulmonol 45 (6), 608-613 (2010)
   PUBMED   20503287
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 570)
  AUTHORS   Nyman,T.A., Tolo,H., Parkkinen,J. and Kalkkinen,N.
  TITLE     Identification of nine interferon-alpha subtypes produced by Sendai
            virus-induced human peripheral blood leucocytes
  JOURNAL   Biochem J 329 (Pt 2) (Pt 2), 295-302 (1998)
   PUBMED   9425112
REFERENCE   7  (bases 1 to 570)
  AUTHORS   Tiefenbrun,N., Melamed,D., Levy,N., Resnitzky,D., Hoffman,I.,
            Reed,S.I. and Kimchi,A.
  TITLE     Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading
            to a reversible G0-like arrest
  JOURNAL   Mol Cell Biol 16 (7), 3934-3944 (1996)
   PUBMED   8668211
  REMARK    GeneRIF: Alpha interferon suppresses the cyclin D3 and cdc25A
            genes, leading to a reversible G0-like arrest.
REFERENCE   8  (bases 1 to 570)
  AUTHORS   Shuai,K., Horvath,C.M., Huang,L.H., Qureshi,S.A., Cowburn,D. and
            Darnell,J.E. Jr.
  TITLE     Interferon activation of the transcription factor Stat91 involves
            dimerization through SH2-phosphotyrosyl peptide interactions
  JOURNAL   Cell 76 (5), 821-828 (1994)
   PUBMED   7510216
REFERENCE   9  (bases 1 to 570)
  AUTHORS   Olopade,O.I., Bohlander,S.K., Pomykala,H., Maltepe,E., Van
            Melle,E., Le Beau,M.M. and Diaz,M.O.
  TITLE     Mapping of the shortest region of overlap of deletions of the short
            arm of chromosome 9 associated with human neoplasia
  JOURNAL   Genomics 14 (2), 437-443 (1992)
   PUBMED   1385305
REFERENCE   10 (bases 1 to 570)
  AUTHORS   Henco,K., Brosius,J., Fujisawa,A., Fujisawa,J.I., Haynes,J.R.,
            Hochstadt,J., Kovacic,T., Pasek,M., Schambock,A., Schmid,J. et al.
  TITLE     Structural relationship of human interferon alpha genes and
            pseudogenes
  JOURNAL   J Mol Biol 185 (2), 227-260 (1985)
   PUBMED   4057246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353732.14.
            
            On Mar 24, 2010 this sequence version replaced NM_021002.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC069471.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380210.2/ ENSP00000369558.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-570               AL353732.14        7055-7624           c
FEATURES             Location/Qualifiers
     source          1..570
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..570
                     /gene="IFNA6"
                     /gene_synonym="IFN-alphaK"
                     /note="interferon alpha 6"
                     /db_xref="GeneID:3443"
                     /db_xref="HGNC:HGNC:5427"
                     /db_xref="MIM:147566"
     CDS             1..570
                     /gene="IFNA6"
                     /gene_synonym="IFN-alphaK"
                     /note="leIF K; IFN-alpha-6; interferon alpha-K; interferon
                     alpha-54"
                     /codon_start=1
                     /product="interferon alpha-6 precursor"
                     /protein_id="NP_066282.1"
                     /db_xref="CCDS:CCDS6504.1"
                     /db_xref="GeneID:3443"
                     /db_xref="HGNC:HGNC:5427"
                     /db_xref="MIM:147566"
                     /translation="MALPFALLMALVVLSCKSSCSLDCDLPQTHSLGHRRTMMLLAQM
                     RRISLFSCLKDRHDFRFPQEEFDGNQFQKAEAISVLHEVIQQTFNLFSTKDSSVAWDE
                     RLLDKLYTELYQQLNDLEACVMQEVWVGGTPLMNEDSILAVRKYFQRITLYLTEKKYS
                     PCAWEVVRAEIMRSFSSSRNLQERLRRKE"
     exon            1..570
                     /gene="IFNA6"
                     /gene_synonym="IFN-alphaK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctttgc cttttgcttt actgatggcc ctggtggtgc tcagctgcaa gtcaagctgc
       61 tctctggact gtgatctgcc tcagacccac agcctgggtc acaggaggac catgatgctc
      121 ctggcacaaa tgaggagaat ctctcttttc tcctgtctga aggacagaca tgacttcaga
      181 tttccccagg aggagtttga tggcaaccag ttccagaagg ctgaagccat ctctgtcctc
      241 catgaggtga ttcagcagac cttcaacctc ttcagcacaa aggactcatc tgttgcttgg
      301 gatgagaggc ttctagacaa actctatact gaactttacc agcagctgaa tgacctggaa
      361 gcctgtgtga tgcaggaggt gtgggtggga gggactcccc tgatgaatga ggactccatc
      421 ctggctgtga gaaaatactt ccaaagaatc actctctacc tgacagagaa aaagtacagc
      481 ccttgtgcct gggaggttgt cagagcagaa atcatgagat ccttctcttc atcaagaaac
      541 ttgcaagaaa ggttaaggag gaaggaataa
//
