LOCUS       NM_002169                988 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens interferon alpha 5 (IFNA5), mRNA.
ACCESSION   NM_002169
VERSION     NM_002169.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 988)
  AUTHORS   Mesev,E.V., LeDesma,R.A. and Ploss,A.
  TITLE     Decoding type I and III interferon signalling during viral
            infection
  JOURNAL   Nat Microbiol 4 (6), 914-924 (2019)
   PUBMED   30936491
  REMARK    Review article
REFERENCE   2  (bases 1 to 988)
  AUTHORS   Hirankarn,N., Tangwattanachuleeporn,M., Wongpiyabovorn,J.,
            Wongchinsri,J. and Avihingsanon,Y.
  TITLE     Genetic association of interferon-alpha subtypes 1, 2 and 5 in
            systemic lupus erythematosus
  JOURNAL   Tissue Antigens 72 (6), 588-592 (2008)
   PUBMED   19000144
  REMARK    GeneRIF: This is the first report of positive association of IFNA
            gene in SLE, especially the role of specific subtypes IFNA1 and
            IFNA5.
            GeneRIF: Observational study of gene-gene interaction. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 988)
  AUTHORS   Mailaparambil,B., Jochum,J., Forster,J., Heinze,J., Krueger,M. and
            Heinzmann,A.
  TITLE     Polymorphisms of interferons and their receptors in the genetics of
            severe RSV-associated diseases
  JOURNAL   Arch Virol 153 (11), 2133-2137 (2008)
   PUBMED   18953482
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 988)
  AUTHORS   Janssen,R., Bont,L., Siezen,C.L., Hodemaekers,H.M., Ermers,M.J.,
            Doornbos,G., van 't Slot,R., Wijmenga,C., Goeman,J.J., Kimpen,J.L.,
            van Houwelingen,H.C., Kimman,T.G. and Hoebee,B.
  TITLE     Genetic susceptibility to respiratory syncytial virus bronchiolitis
            is predominantly associated with innate immune genes
  JOURNAL   J Infect Dis 196 (6), 826-834 (2007)
   PUBMED   17703412
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 988)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   6  (bases 1 to 988)
  AUTHORS   Olopade,O.I., Bohlander,S.K., Pomykala,H., Maltepe,E., Van
            Melle,E., Le Beau,M.M. and Diaz,M.O.
  TITLE     Mapping of the shortest region of overlap of deletions of the short
            arm of chromosome 9 associated with human neoplasia
  JOURNAL   Genomics 14 (2), 437-443 (1992)
   PUBMED   1385305
REFERENCE   7  (bases 1 to 988)
  AUTHORS   Henco,K., Brosius,J., Fujisawa,A., Fujisawa,J.I., Haynes,J.R.,
            Hochstadt,J., Kovacic,T., Pasek,M., Schambock,A., Schmid,J. et al.
  TITLE     Structural relationship of human interferon alpha genes and
            pseudogenes
  JOURNAL   J Mol Biol 185 (2), 227-260 (1985)
   PUBMED   4057246
REFERENCE   8  (bases 1 to 988)
  AUTHORS   Goeddel,D.V., Leung,D.W., Dull,T.J., Gross,M., Lawn,R.M.,
            McCandliss,R., Seeburg,P.H., Ullrich,A., Yelverton,E. and Gray,P.W.
  TITLE     The structure of eight distinct cloned human leukocyte interferon
            cDNAs
  JOURNAL   Nature 290 (5801), 20-26 (1981)
   PUBMED   6163083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL162420.13.
            
            On Feb 27, 2020 this sequence version replaced NM_002169.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC093755.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000610521.2/ ENSP00000484479.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-988               AL162420.13        83554-84541         c
FEATURES             Location/Qualifiers
     source          1..988
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..988
                     /gene="IFNA5"
                     /gene_synonym="IFN-alpha-5; IFN-alphaG; INA5; INFA5; leIF
                     G"
                     /note="interferon alpha 5"
                     /db_xref="GeneID:3442"
                     /db_xref="HGNC:HGNC:5426"
                     /db_xref="MIM:147565"
     exon            1..988
                     /gene="IFNA5"
                     /gene_synonym="IFN-alpha-5; IFN-alphaG; INA5; INFA5; leIF
                     G"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..627
                     /gene="IFNA5"
                     /gene_synonym="IFN-alpha-5; IFN-alphaG; INA5; INFA5; leIF
                     G"
                     /note="interferon alpha-G; interferon alpha-61"
                     /codon_start=1
                     /product="interferon alpha-5 precursor"
                     /protein_id="NP_002160.1"
                     /db_xref="CCDS:CCDS6502.1"
                     /db_xref="GeneID:3442"
                     /db_xref="HGNC:HGNC:5426"
                     /db_xref="MIM:147565"
                     /translation="MALPFVLLMALVVLNCKSICSLGCDLPQTHSLSNRRTLMIMAQM
                     GRISPFSCLKDRHDFGFPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTKDSSATWDE
                     TLLDKFYTELYQQLNDLEACMMQEVGVEDTPLMNVDSILTVRKYFQRITLYLTEKKYS
                     PCAWEVVRAEIMRSFSLSANLQERLRRKE"
ORIGIN      
        1 gcccaaggtt cagggtcact caatctcaac agcccagaag catctgcaac ctccccaatg
       61 gccttgccct ttgttttact gatggccctg gtggtgctca actgcaagtc aatctgttct
      121 ctgggctgtg atctgcctca gacccacagc ctgagtaaca ggaggacttt gatgataatg
      181 gcacaaatgg gaagaatctc tcctttctcc tgcctgaagg acagacatga ctttggattt
      241 cctcaggagg agtttgatgg caaccagttc cagaaggctc aagccatctc tgtcctccat
      301 gagatgatcc agcagacctt caatctcttc agcacaaagg actcatctgc tacttgggat
      361 gagacacttc tagacaaatt ctacactgaa ctttaccagc agctgaatga cctggaagcc
      421 tgtatgatgc aggaggttgg agtggaagac actcctctga tgaatgtgga ctctatcctg
      481 actgtgagaa aatactttca aagaatcacc ctctatctga cagagaagaa atacagccct
      541 tgtgcatggg aggttgtcag agcagaaatc atgagatcct tctctttatc agcaaacttg
      601 caagaaagat taaggaggaa ggaatgaaaa ctggttcaac atcgaaatga ttctcattga
      661 ctagtacacc atttcacact tcttgagttc tgccgtttca aatattaatt tctgctatat
      721 ccatgacttg agttgaatca aaattttcaa acgtttcaca cgtgttaagc aacacttctt
      781 tagctccaca gggacaaaat ctttacagat gatcatgcca atctatctat tctatctatt
      841 tatctatctg tctgtcttct atctaatcta tttaaatatt tatttattta taagatttaa
      901 attattttaa attatgtttg ttcaggtaat attacatcca cctttacttt gtggctaata
      961 taataaaata tgttctttat gttttgtc
//
