LOCUS       NM_021068                970 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens interferon alpha 4 (IFNA4), mRNA.
ACCESSION   NM_021068
VERSION     NM_021068.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 970)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 970)
  AUTHORS   Miyazaki,R., Saiga,H., Kato,T., Bakoshi,T., Senba,R., Shintani,A.,
            Suzuki,M., Takao,K., Sasaki,I., Iizuka,A., Sugiyama,M., Iwami,N.,
            Fukuda-Ohta,Y., Hemmi,H., Tanaka,T., Miyake,M., Kaisho,T. and
            Hoshino,K.
  TITLE     The mechanism of action of Spi-B in the transcriptional activation
            of the interferon-alpha4 gene
  JOURNAL   Biochem Biophys Res Commun 525 (2), 477-482 (2020)
   PUBMED   32111355
  REMARK    GeneRIF: The mechanism of action of Spi-B in the transcriptional
            activation of the interferon-alpha4 gene.
REFERENCE   3  (bases 1 to 970)
  AUTHORS   Mesev,E.V., LeDesma,R.A. and Ploss,A.
  TITLE     Decoding type I and III interferon signalling during viral
            infection
  JOURNAL   Nat Microbiol 4 (6), 914-924 (2019)
   PUBMED   30936491
  REMARK    Review article
REFERENCE   4  (bases 1 to 970)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 970)
  AUTHORS   Xiao,C.X., Xiao,J.J., Xu,H.Z., Wang,H.H., Chen,X., Liu,Y.S., Li,P.,
            Shi,Y., Nie,Y.Z., Li,S., Wu,K.C., Liu,Z.J., Ren,J.L. and Guleng,B.
  TITLE     Exome sequencing identifies novel compound heterozygous IFNA4 and
            IFNA10 mutations as a cause of impaired function in Crohn's disease
            patients
  JOURNAL   Sci Rep 5, 10514 (2015)
   PUBMED   26000985
  REMARK    GeneRIF: Heterozygous IFNA4 variants is a cause of impaired
            function and CD-susceptibility genes in Chinese individuals from
            multiple center based study.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 970)
  AUTHORS   Shuai,K., Horvath,C.M., Huang,L.H., Qureshi,S.A., Cowburn,D. and
            Darnell,J.E. Jr.
  TITLE     Interferon activation of the transcription factor Stat91 involves
            dimerization through SH2-phosphotyrosyl peptide interactions
  JOURNAL   Cell 76 (5), 821-828 (1994)
   PUBMED   7510216
REFERENCE   7  (bases 1 to 970)
  AUTHORS   Olopade,O.I., Bohlander,S.K., Pomykala,H., Maltepe,E., Van
            Melle,E., Le Beau,M.M. and Diaz,M.O.
  TITLE     Mapping of the shortest region of overlap of deletions of the short
            arm of chromosome 9 associated with human neoplasia
  JOURNAL   Genomics 14 (2), 437-443 (1992)
   PUBMED   1385305
REFERENCE   8  (bases 1 to 970)
  AUTHORS   Henco,K., Brosius,J., Fujisawa,A., Fujisawa,J.I., Haynes,J.R.,
            Hochstadt,J., Kovacic,T., Pasek,M., Schambock,A., Schmid,J. et al.
  TITLE     Structural relationship of human interferon alpha genes and
            pseudogenes
  JOURNAL   J Mol Biol 185 (2), 227-260 (1985)
   PUBMED   4057246
REFERENCE   9  (bases 1 to 970)
  AUTHORS   Mizoguchi,J., Pitha,P.M. and Raj,N.B.
  TITLE     Efficient expression in Escherichia coli of two species of human
            interferon-alpha and their hybrid molecules
  JOURNAL   DNA 4 (3), 221-232 (1985)
   PUBMED   3891272
REFERENCE   10 (bases 1 to 970)
  AUTHORS   Linnane,A.W., Beilharz,M.W., McMullen,G.L., Macreadie,I.G.,
            Murphy,M., Nisbet,I.T., Novitski,C.E. and Woodrow,G.C.
  TITLE     Nucleotide sequence and expression in E. coli of a human
            interferon-alpha gene selected from a genomic library using
            synthetic oligonucleotides
  JOURNAL   Biochem Int 8 (5), 725-732 (1984)
   PUBMED   6089830
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL512606.6.
            
            On Aug 11, 2021 this sequence version replaced NM_021068.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC113642.1, M27318.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000421715.3/ ENSP00000412897.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-970               AL512606.6         20153-21122         c
FEATURES             Location/Qualifiers
     source          1..970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..970
                     /gene="IFNA4"
                     /gene_synonym="IFN-alpha4a; INFA4"
                     /note="interferon alpha 4"
                     /db_xref="GeneID:3441"
                     /db_xref="HGNC:HGNC:5425"
                     /db_xref="MIM:147564"
     exon            1..970
                     /gene="IFNA4"
                     /gene_synonym="IFN-alpha4a; INFA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..626
                     /gene="IFNA4"
                     /gene_synonym="IFN-alpha4a; INFA4"
                     /note="IFN-alpha-4; interferon alpha-4B; interferon
                     alpha-76; interferon alpha-M1"
                     /codon_start=1
                     /product="interferon alpha-4 precursor"
                     /protein_id="NP_066546.1"
                     /db_xref="CCDS:CCDS6498.1"
                     /db_xref="GeneID:3441"
                     /db_xref="HGNC:HGNC:5425"
                     /db_xref="MIM:147564"
                     /translation="MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQM
                     GRISHFSCLKDRHDFGFPEEEFDGHQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQ
                     SLLEKFSTELYQQLNDLEACVIQEVGVEETPLMNEDSILAVRKYFQRITLYLTEKKYS
                     PCAWEVVRAEIMRSLSFSTNLQKRLRRKD"
ORIGIN      
        1 ggccgaagtt caaggttatc catctcaagt agcctagcaa tatttgcaac atcccaatgg
       61 ccctgtcctt ttctttactg atggccgtgc tggtgctcag ctacaaatcc atctgttctc
      121 tgggctgtga tctgcctcag acccacagcc tgggtaatag gagggccttg atactcctgg
      181 cacaaatggg aagaatctct catttctcct gcctgaagga cagacatgat ttcggattcc
      241 ccgaggagga gtttgatggc caccagttcc agaaggctca agccatctct gtcctccatg
      301 agatgatcca gcagaccttc aatctcttca gcacagagga ctcatctgct gcttgggaac
      361 agagcctcct agaaaaattt tccactgaac tttaccagca actgaatgac ctggaagcat
      421 gtgtgataca ggaggttggg gtggaagaga ctcccctgat gaatgaggac tccatcctgg
      481 ctgtgaggaa atacttccaa agaatcactc tttatctaac agagaagaaa tacagccctt
      541 gtgcctggga ggttgtcaga gcagaaatca tgagatccct ctcgttttca acaaacttgc
      601 aaaaaagatt aaggaggaag gattgaaacc tggttcaaca tggaaatgat cctgattgac
      661 taatacatta tctcacactt tcatgagttc ttccatttca aagactcact tctataacca
      721 ccacgagttg aatcaaaatt ttcaaatgtt ttcagcagtg tgaagaagct tggtgtatac
      781 ctgtgcaggc actagtcctt tacagatgac aatgctgatg tctctgttca tctatttatt
      841 taaatattta tttattttta aaatttaaat tattttttat gtgatatcat gagtaccttt
      901 acattgtggt gaatgtaaca atatatgttc ttcatattta gccaatatat taatttcctt
      961 tttcattaaa
//
