LOCUS       NM_002175               1024 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens interferon alpha 21 (IFNA21), mRNA.
ACCESSION   NM_002175
VERSION     NM_002175.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1024)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1024)
  AUTHORS   Kalpana,B., Murthy,D.K. and Balakrishna,N.
  TITLE     9p21.3 coronary artery disease risk locus and interferon alpha 21:
            Association study in an Asian Indian population
  JOURNAL   Indian Heart J 71 (6), 476-480 (2019)
   PUBMED   32248921
  REMARK    GeneRIF: IFNA21 may be involved in inflammatory processes in an
            age-dependent manner and in progression of coronary artery disease.
            Several 9p21 SNPs may modulate inflammatory processes mediated by
            IFNA21 and may, therefore, contribute to pathophysiology of
            coronary artery disease.
REFERENCE   3  (bases 1 to 1024)
  AUTHORS   Mesev,E.V., LeDesma,R.A. and Ploss,A.
  TITLE     Decoding type I and III interferon signalling during viral
            infection
  JOURNAL   Nat Microbiol 4 (6), 914-924 (2019)
   PUBMED   30936491
  REMARK    Review article
REFERENCE   4  (bases 1 to 1024)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1024)
  AUTHORS   Vazquez,N., Schmeisser,H., Dolan,M.A., Bekisz,J., Zoon,K.C. and
            Wahl,S.M.
  TITLE     Structural variants of IFNalpha preferentially promote antiviral
            functions
  JOURNAL   Blood 118 (9), 2567-2577 (2011)
   PUBMED   21757613
  REMARK    GeneRIF: Structural AA changes in the C-helix interacting with
            IFNAlphaR1 may change the signaling dynamics leading to elevated
            APOBEC3 & lower IDO by an engineered mutant derived from the
            amino-terminal region of IFNalpha21b and the COOH-terminus from
            IFNalpha2c.
REFERENCE   6  (bases 1 to 1024)
  AUTHORS   Mo,X.Y., Ma,W., Zhang,Y., Zhao,H., Deng,Y., Yuan,W., Wang,Y.,
            Li,Y., Zhu,C., Liu,M. and Wu,X.
  TITLE     Microarray analyses of differentially expressed human genes and
            biological processes in ECV304 cells infected with rubella virus
  JOURNAL   J Med Virol 79 (11), 1783-1791 (2007)
   PUBMED   17854033
REFERENCE   7  (bases 1 to 1024)
  AUTHORS   Shuai,K., Horvath,C.M., Huang,L.H., Qureshi,S.A., Cowburn,D. and
            Darnell,J.E. Jr.
  TITLE     Interferon activation of the transcription factor Stat91 involves
            dimerization through SH2-phosphotyrosyl peptide interactions
  JOURNAL   Cell 76 (5), 821-828 (1994)
   PUBMED   7510216
REFERENCE   8  (bases 1 to 1024)
  AUTHORS   Olopade,O.I., Bohlander,S.K., Pomykala,H., Maltepe,E., Van
            Melle,E., Le Beau,M.M. and Diaz,M.O.
  TITLE     Mapping of the shortest region of overlap of deletions of the short
            arm of chromosome 9 associated with human neoplasia
  JOURNAL   Genomics 14 (2), 437-443 (1992)
   PUBMED   1385305
REFERENCE   9  (bases 1 to 1024)
  AUTHORS   Gren,E., Berzin,V., Jansone,I., Tsimanis,A., Vishnevsky,Y. and
            Apsalons,U.
  TITLE     Novel human leukocyte interferon subtype and structural comparison
            of alpha interferon genes
  JOURNAL   J Interferon Res 4 (4), 609-617 (1984)
   PUBMED   6548765
REFERENCE   10 (bases 1 to 1024)
  AUTHORS   Goeddel,D.V., Leung,D.W., Dull,T.J., Gross,M., Lawn,R.M.,
            McCandliss,R., Seeburg,P.H., Ullrich,A., Yelverton,E. and Gray,P.W.
  TITLE     The structure of eight distinct cloned human leukocyte interferon
            cDNAs
  JOURNAL   Nature 290 (5801), 20-26 (1981)
   PUBMED   6163083
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390882.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 12, 2008 this sequence version replaced NM_002175.1.
            
            Summary: This gene is a member of the alpha interferon gene cluster
            on the short arm of chromosome 9. Interferons are cytokines
            produced in response to viral infection that mediate the immune
            response and interfere with viral replication. The encoded protein
            is a type I interferon and may play a specific role in the
            antiviral response to rubella virus. [provided by RefSeq, Sep
            2011].
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no single transcript was available for the full length
            of the gene. The extent of this transcript is supported by
            transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380225.1/ ENSP00000369574.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1024              AL390882.12        1806-2829
FEATURES             Location/Qualifiers
     source          1..1024
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..1024
                     /gene="IFNA21"
                     /gene_synonym="IFN-alphaI; LeIF F; leIF-F"
                     /note="interferon alpha 21"
                     /db_xref="GeneID:3452"
                     /db_xref="HGNC:HGNC:5424"
                     /db_xref="MIM:147584"
     exon            1..1024
                     /gene="IFNA21"
                     /gene_synonym="IFN-alphaI; LeIF F; leIF-F"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..618
                     /gene="IFNA21"
                     /gene_synonym="IFN-alphaI; LeIF F; leIF-F"
                     /note="leukocyte interferon protein; IFN-alpha-21;
                     interferon alpha-F"
                     /codon_start=1
                     /product="interferon alpha-21 precursor"
                     /protein_id="NP_002166.2"
                     /db_xref="CCDS:CCDS6497.1"
                     /db_xref="GeneID:3452"
                     /db_xref="HGNC:HGNC:5424"
                     /db_xref="MIM:147584"
                     /translation="MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQM
                     GRISPFSCLKDRHDFGFPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTKDSSATWEQ
                     SLLEKFSTELNQQLNDLEACVIQEVGVEETPLMNVDSILAVKKYFQRITLYLTEKKYS
                     PCAWEVVRAEIMRSFSLSKIFQERLRRKE"
ORIGIN      
        1 ttcaaggtta cccatctcaa gtagcctagc aatattggca acatcccaat ggccctgtcc
       61 ttttctttac tgatggccgt gctggtgctc agctacaaat ccatctgttc tctgggctgt
      121 gatctgcctc agacccacag cctgggtaat aggagggcct tgatactcct ggcacaaatg
      181 ggaagaatct ctcctttctc ctgcctgaag gacagacatg actttggatt cccccaggag
      241 gagtttgatg gcaaccagtt ccagaaggct caagccatct ctgtcctcca tgagatgatc
      301 cagcagacct tcaatctctt cagcacaaag gactcatctg ctacttggga acagagcctc
      361 ctagaaaaat tttccactga acttaaccag cagctgaatg acctggaagc ctgcgtgata
      421 caggaggttg gggtggaaga gactcccctg atgaatgtgg actccatcct ggctgtgaag
      481 aaatacttcc aaagaatcac tctttatctg acagagaaga aatacagccc ttgtgcctgg
      541 gaggttgtca gagcagaaat catgagatcc ttctctttat caaaaatttt tcaagaaaga
      601 ttaaggagga aggaatgaaa cctgtttcaa catggaaatg atctgtattg actaatacac
      661 cagtccacac ttctatgact tctgccattt caaagactca tttctcctat aaccaccgca
      721 tgagttgaat caaaattttc agatcttttc aggagtgtaa ggaaacatca tgtttacctg
      781 tgcaggcact agtcctttac agatgaccat gctgatagat ctaattatct atctattgaa
      841 atatttattt atttattaga tttaaattat ttttgtccat gtaatattat gtgtactttt
      901 acattgtgtt atatcaaaat atgttattta tatttagtca atatattatt ttctttttat
      961 taatttttac tattaaaact tcttatatta tttgtttatt ctttaataaa gaaataccaa
     1021 gccc
//
