LOCUS       NM_000605               1144 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens interferon alpha 2 (IFNA2), mRNA.
ACCESSION   NM_000605
VERSION     NM_000605.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1144)
  AUTHORS   Eremenko,E.E., Kwan,P.O., Ding,J., Ghosh,S. and Tredget,E.E.
  TITLE     The effects of TGF-beta1 and IFN-alpha2b on decorin, decorin
            isoforms and type I collagen in hypertrophic scar dermal
            fibroblasts
  JOURNAL   Wound Repair Regen 32 (2), 135-145 (2024)
   PUBMED   38243615
  REMARK    GeneRIF: The effects of TGF-beta1 and IFN-alpha2b on decorin,
            decorin isoforms and type I collagen in hypertrophic scar dermal
            fibroblasts.
REFERENCE   2  (bases 1 to 1144)
  AUTHORS   Joly,C., Desjardins,D., Porcher,R., Pere,H., Bruneau,T., Zhang,Q.,
            Bastard,P., Cobat,A., Resmini,L., Lenoir,O., Savale,L.,
            Lecuroux,C., Verstuyft,C., Roque-Afonso,A.M., Veyer,D., Baron,G.,
            Resche-Rigon,M., Ravaud,P., Casanova,J.L., Le Grand,R., Hermine,O.,
            Tharaux,P.L. and Mariette,X.
  TITLE     More rapid blood interferon alpha2 decline in fatal versus
            surviving COVID-19 patients
  JOURNAL   Front Immunol 14, 1250214 (2023)
   PUBMED   38077399
  REMARK    GeneRIF: More rapid blood interferon alpha2 decline in fatal versus
            surviving COVID-19 patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1144)
  AUTHORS   Hadjadj,J., Yatim,N., Barnabei,L., Corneau,A., Boussier,J.,
            Smith,N., Pere,H., Charbit,B., Bondet,V., Chenevier-Gobeaux,C.,
            Breillat,P., Carlier,N., Gauzit,R., Morbieu,C., Pene,F., Marin,N.,
            Roche,N., Szwebel,T.A., Merkling,S.H., Treluyer,J.M., Veyer,D.,
            Mouthon,L., Blanc,C., Tharaux,P.L., Rozenberg,F., Fischer,A.,
            Duffy,D., Rieux-Laucat,F., Kerneis,S. and Terrier,B.
  TITLE     Impaired type I interferon activity and inflammatory responses in
            severe COVID-19 patients
  JOURNAL   Science 369 (6504), 718-724 (2020)
   PUBMED   32661059
  REMARK    GeneRIF: Impaired type I interferon activity and inflammatory
            responses in severe COVID-19 patients.
REFERENCE   4  (bases 1 to 1144)
  AUTHORS   Nile,S.H., Nile,A., Qiu,J., Li,L., Jia,X. and Kai,G.
  TITLE     COVID-19: Pathogenesis, cytokine storm and therapeutic potential of
            interferons
  JOURNAL   Cytokine Growth Factor Rev 53, 66-70 (2020)
   PUBMED   32418715
  REMARK    Review article
REFERENCE   5  (bases 1 to 1144)
  AUTHORS   Li,G. and De Clercq,E.
  TITLE     Therapeutic options for the 2019 novel coronavirus (2019-nCoV)
  JOURNAL   Nat Rev Drug Discov 19 (3), 149-150 (2020)
   PUBMED   32127666
REFERENCE   6  (bases 1 to 1144)
  AUTHORS   Noel,N., Jacquelin,B., Huot,N., Goujard,C., Lambotte,O. and
            Muller-Trutwin,M.
  TITLE     Interferon-associated therapies toward HIV control: The back and
            forth
  JOURNAL   Cytokine Growth Factor Rev 40, 99-112 (2018)
   PUBMED   29555233
  REMARK    Review article
REFERENCE   7  (bases 1 to 1144)
  AUTHORS   Sutter,K., Dickow,J. and Dittmer,U.
  TITLE     Interferon alpha subtypes in HIV infection
  JOURNAL   Cytokine Growth Factor Rev 40, 13-18 (2018)
   PUBMED   29475588
  REMARK    Review article
REFERENCE   8  (bases 1 to 1144)
  AUTHORS   Paul,F., Pellegrini,S. and Uze,G.
  TITLE     IFNA2: The prototypic human alpha interferon
  JOURNAL   Gene 567 (2), 132-137 (2015)
   PUBMED   25982860
  REMARK    GeneRIF: The structure, mechanism of action and biological
            activities of IFNalpha2. [Review]
            Review article
REFERENCE   9  (bases 1 to 1144)
  AUTHORS   El-Baky,N.A. and Redwan,E.M.
  TITLE     Therapeutic alpha-interferons protein: structure, production, and
            biosimilar
  JOURNAL   Prep Biochem Biotechnol 45 (2), 109-127 (2015)
   PUBMED   24785737
  REMARK    Review article
REFERENCE   10 (bases 1 to 1144)
  AUTHORS   Olopade,O.I., Bohlander,S.K., Pomykala,H., Maltepe,E., Van
            Melle,E., Le Beau,M.M. and Diaz,M.O.
  TITLE     Mapping of the shortest region of overlap of deletions of the short
            arm of chromosome 9 associated with human neoplasia
  JOURNAL   Genomics 14 (2), 437-443 (1992)
   PUBMED   1385305
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353732.14 and BC104163.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000605.3.
            
            Summary: This gene is a member of the alpha interferon gene cluster
            on chromosome 9. The encoded cytokine is a member of the type I
            interferon family that is produced in response to viral infection
            as a key part of the innate immune response with potent antiviral,
            antiproliferative and immunomodulatory properties. This cytokine,
            like other type I interferons, binds a plasma membrane receptor
            made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus
            is able to act on virtually all body cells. The encoded protein is
            effective in reducing the symptoms and duration of the common cold
            and in treating many types of cancer, including some hematological
            malignancies and solid tumors. A deficiency of type I interferon in
            the blood is thought to be a hallmark of severe COVID-19 and may
            provide a rationale for a combined therapeutic approach. [provided
            by RefSeq, Aug 2020].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and experimental data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1163658.305173.1, V00549.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in cytokine storm inflammatory
                                      response
            MANE Ensembl match     :: ENST00000380206.4/ ENSP00000369554.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL353732.14        42135-42135         c
            2-24                AL353732.14        42112-42134         c
            25-829              BC104163.1         1-805
            830-1144            AL353732.14        40992-41306         c
FEATURES             Location/Qualifiers
     source          1..1144
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..1144
                     /gene="IFNA2"
                     /gene_synonym="IFN-alpha-2; IFN-alphaA; IFNA; IFNA2B; leIF
                     A"
                     /note="interferon alpha 2"
                     /db_xref="GeneID:3440"
                     /db_xref="HGNC:HGNC:5423"
                     /db_xref="MIM:147562"
     exon            1..1144
                     /gene="IFNA2"
                     /gene_synonym="IFN-alpha-2; IFN-alphaA; IFNA; IFNA2B; leIF
                     A"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..636
                     /gene="IFNA2"
                     /gene_synonym="IFN-alpha-2; IFN-alphaA; IFNA; IFNA2B; leIF
                     A"
                     /note="alpha-2a interferon; interferon alpha 2b;
                     interferon alpha A; interferon alpha 2a"
                     /codon_start=1
                     /product="interferon alpha-2 precursor"
                     /protein_id="NP_000596.2"
                     /db_xref="CCDS:CCDS6506.1"
                     /db_xref="GeneID:3440"
                     /db_xref="HGNC:HGNC:5423"
                     /db_xref="MIM:147562"
                     /translation="MALTFALLVALLVLSCKSSCSVGCDLPQTHSLGSRRTLMLLAQM
                     RRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDET
                     LLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSP
                     CAWEVVRAEIMRSFSLSTNLQESLRSKE"
     regulatory      942..947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFNA2"
                     /gene_synonym="IFN-alpha-2; IFN-alphaA; IFNA; IFNA2B; leIF
                     A"
                     /note="hexamer: AATAAA"
     polyA_site      970
                     /gene="IFNA2"
                     /gene_synonym="IFN-alpha-2; IFN-alphaA; IFNA; IFNA2B; leIF
                     A"
                     /note="major polyA site"
     regulatory      1125..1130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFNA2"
                     /gene_synonym="IFN-alpha-2; IFN-alphaA; IFNA; IFNA2B; leIF
                     A"
                     /note="hexamer: AATAAA"
     polyA_site      1144
                     /gene="IFNA2"
                     /gene_synonym="IFN-alpha-2; IFN-alphaA; IFNA; IFNA2B; leIF
                     A"
                     /note="major polyA site"
ORIGIN      
        1 agagaacctg gagcctaagg tttaggctca cccatttcaa ccagtctagc agcatctgca
       61 acatctacaa tggccttgac ctttgcttta ctggtggccc tcctggtgct cagctgcaag
      121 tcaagctgct ctgtgggctg tgatctgcct caaacccaca gcctgggtag caggaggacc
      181 ttgatgctcc tggcacagat gaggagaatc tctcttttct cctgcttgaa ggacagacat
      241 gactttggat ttccccagga ggagtttggc aaccagttcc aaaaggctga aaccatccct
      301 gtcctccatg agatgatcca gcagatcttc aatctcttca gcacaaagga ctcatctgct
      361 gcttgggatg agaccctcct agacaaattc tacactgaac tctaccagca gctgaatgac
      421 ctggaagcct gtgtgataca gggggtgggg gtgacagaga ctcccctgat gaaggaggac
      481 tccattctgg ctgtgaggaa atacttccaa agaatcactc tctatctgaa agagaagaaa
      541 tacagccctt gtgcctggga ggttgtcaga gcagaaatca tgagatcttt ttctttgtca
      601 acaaacttgc aagaaagttt aagaagtaag gaatgaaaac tggttcaaca tggaaatgat
      661 tttcattgat tcgtatgcca gctcaccttt ttatgatctg ccatttcaaa gactcatgtt
      721 tctgctatga ccatgacacg atttaaatct tttcaaatgt ttttaggagt attaatcaac
      781 attgtattca gctcttaagg cactagtccc ttacagagga ccatgctgac tgatccatta
      841 tctatttaaa tatttttaaa atattattta tttaactatt tataaaacaa cttatttttg
      901 ttcatattat gtcatgtgca cctttgcaca gtggttaatg taataaaata tgttctttgt
      961 atttggtaaa tttattttgt gttgttcatt gaacttttgc tatggaaact tttgtacttg
     1021 tttattcttt aaaatgaaat tccaagccta attgtgcaac ctgattacag aataactggt
     1081 acacttcatt tatccatcaa tattatattc aagatataag taaaaataaa ctttctgtaa
     1141 acca
//
