LOCUS       NM_021268                980 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens interferon alpha 17 (IFNA17), mRNA.
ACCESSION   NM_021268
VERSION     NM_021268.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 980)
  AUTHORS   Matuozzo,D., Talouarn,E., Marchal,A., Zhang,P., Manry,J.,
            Seeleuthner,Y., Zhang,Y., Bolze,A., Chaldebas,M., Milisavljevic,B.,
            Gervais,A., Bastard,P., Asano,T., Bizien,L., Barzaghi,F.,
            Abolhassani,H., Abou Tayoun,A., Aiuti,A., Alavi Darazam,I.,
            Allende,L.M., Alonso-Arias,R., Arias,A.A., Aytekin,G., Bergman,P.,
            Bondesan,S., Bryceson,Y.T., Bustos,I.G., Cabrera-Marante,O.,
            Carcel,S., Carrera,P., Casari,G., Chaibi,K., Colobran,R.,
            Condino-Neto,A., Covill,L.E., Delmonte,O.M., El Zein,L., Flores,C.,
            Gregersen,P.K., Gut,M., Haerynck,F., Halwani,R., Hancerli,S.,
            Hammarstrom,L., Hatipoglu,N., Karbuz,A., Keles,S., Kyheng,C.,
            Leon-Lopez,R., Franco,J.L., Mansouri,D., Martinez-Picado,J., Metin
            Akcan,O., Migeotte,I., Morange,P.E., Morelle,G., Martin-Nalda,A.,
            Novelli,G., Novelli,A., Ozcelik,T., Palabiyik,F.,
            Pan-Hammarstrom,Q., de Diego,R.P., Planas-Serra,L.,
            Pleguezuelo,D.E., Prando,C., Pujol,A., Reyes,L.F., Riviere,J.G.,
            Rodriguez-Gallego,C., Rojas,J., Rovere-Querini,P., Schluter,A.,
            Shahrooei,M., Sobh,A., Soler-Palacin,P., Tandjaoui-Lambiotte,Y.,
            Tipu,I., Tresoldi,C., Troya,J., van de Beek,D., Zatz,M.,
            Zawadzki,P., Al-Muhsen,S.Z., Alosaimi,M.F., Alsohime,F.M.,
            Baris-Feldman,H., Butte,M.J., Constantinescu,S.N., Cooper,M.A.,
            Dalgard,C.L., Fellay,J., Heath,J.R., Lau,Y.L., Lifton,R.P.,
            Maniatis,T., Mogensen,T.H., von Bernuth,H., Lermine,A., Vidaud,M.,
            Boland,A., Deleuze,J.F., Nussbaum,R., Kahn-Kirby,A., Mentre,F.,
            Tubiana,S., Gorochov,G., Tubach,F., Hausfater,P., Meyts,I.,
            Zhang,S.Y., Puel,A., Notarangelo,L.D., Boisson-Dupuis,S., Su,H.C.,
            Boisson,B., Jouanguy,E., Casanova,J.L., Zhang,Q., Abel,L. and
            Cobat,A.
  CONSRTM   COVID Human Genetic Effort; COVIDeF Study Group; French COVID
            Cohort Study Group; CoV-Contact Cohort; COVID-STORM Clinicians;
            COVID Clinicians; Orchestra Working Group; Amsterdam UMC Covid-19
            Biobank; NIAID-USUHS COVID Study Group
  TITLE     Rare predicted loss-of-function variants of type I IFN immunity
            genes are associated with life-threatening COVID-19
  JOURNAL   Genome Med 15 (1), 22 (2023)
   PUBMED   37020259
  REMARK    GeneRIF: Rare predicted loss-of-function variants of type I IFN
            immunity genes are associated with life-threatening COVID-19.
            Erratum:[Genome Med. 2024 Jan 6;16(1):6. doi:
            10.1186/s13073-023-01278-0.. PMID: 38184654]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 980)
  AUTHORS   Mesev,E.V., LeDesma,R.A. and Ploss,A.
  TITLE     Decoding type I and III interferon signalling during viral
            infection
  JOURNAL   Nat Microbiol 4 (6), 914-924 (2019)
   PUBMED   30936491
  REMARK    Review article
REFERENCE   3  (bases 1 to 980)
  AUTHORS   Elaldi,N., Yilmaz,M., Bagci,B., Yelkovan,I., Bagci,G., Gozel,M.G.,
            Engin,A., Bakir,M. and Dokmetas,I.
  TITLE     Relationship between IFNA1, IFNA5, IFNA10, and IFNA17 gene
            polymorphisms and Crimean-Congo hemorrhagic fever prognosis in a
            Turkish population range
  JOURNAL   J Med Virol 88 (7), 1159-1167 (2016)
   PUBMED   26694082
  REMARK    GeneRIF: results show that IFNA1 rs1332190 and IFNA17 rs9298814
            SNPs may play an important role in Crimean-Congo hemorrhagic fever
            susceptibility
REFERENCE   4  (bases 1 to 980)
  AUTHORS   Silva,L.K., Blanton,R.E., Parrado,A.R., Melo,P.S., Morato,V.G.,
            Reis,E.A., Dias,J.P., Castro,J.M., Vasconcelos,P.F., Goddard,K.A.,
            Barreto,M.L., Reis,M.G. and Teixeira,M.G.
  TITLE     Dengue hemorrhagic fever is associated with polymorphisms in JAK1
  JOURNAL   Eur J Hum Genet 18 (11), 1221-1227 (2010)
   PUBMED   20588308
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 980)
  AUTHORS   Makrythanasis,P., Tzetis,M., Rapti,A., Papatheodorou,A., Tsipi,M.,
            Kitsiou,S., Tsiamouri,A., Poulou,M., Roussos,C. and Kanavakis,E.
  TITLE     Cystic fibrosis conductance regulator, tumor necrosis factor,
            interferon alpha-10, interferon alpha-17, and interferon gamma
            genotyping as potential risk markers in pulmonary sarcoidosis
            pathogenesis in Greek patients
  JOURNAL   Genet Test Mol Biomarkers 14 (4), 577-584 (2010)
   PUBMED   20722470
  REMARK    GeneRIF: We did not reproduce the associations previously noted
            with the TNF, IFNA10, IFNA17, and IFNG genes with pulmonary
            sarcoidosis.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 980)
  AUTHORS   Olopade,O.I., Bohlander,S.K., Pomykala,H., Maltepe,E., Van
            Melle,E., Le Beau,M.M. and Diaz,M.O.
  TITLE     Mapping of the shortest region of overlap of deletions of the short
            arm of chromosome 9 associated with human neoplasia
  JOURNAL   Genomics 14 (2), 437-443 (1992)
   PUBMED   1385305
REFERENCE   7  (bases 1 to 980)
  AUTHORS   Zoon,K.C., Miller,D., Bekisz,J., zur Nedden,D., Enterline,J.C.,
            Nguyen,N.Y. and Hu,R.Q.
  TITLE     Purification and characterization of multiple components of human
            lymphoblastoid interferon-alpha
  JOURNAL   J Biol Chem 267 (21), 15210-15216 (1992)
   PUBMED   1634550
REFERENCE   8  (bases 1 to 980)
  AUTHORS   Sen,G.C. and Lengyel,P.
  TITLE     The interferon system. A bird's eye view of its biochemistry
  JOURNAL   J Biol Chem 267 (8), 5017-5020 (1992)
   PUBMED   1371992
  REMARK    Review article
REFERENCE   9  (bases 1 to 980)
  AUTHORS   Savel'ev,V.I., Zlochevskii,M.L., Sorokin,A.V., Naroditskaia,V.A.
            and Bolotin,A.P.
  TITLE     [Cloning and the determination of the nucleotide sequences in 2
            genes of human leukocyte interferons]
  JOURNAL   Antibiot Med Biotekhnol 31 (8), 592-596 (1986)
   PUBMED   3767336
REFERENCE   10 (bases 1 to 980)
  AUTHORS   Mizoguchi,J., Pitha,P.M. and Raj,N.B.
  TITLE     Efficient expression in Escherichia coli of two species of human
            interferon-alpha and their hybrid molecules
  JOURNAL   DNA 4 (3), 221-232 (1985)
   PUBMED   3891272
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL162420.13.
            
            On Mar 24, 2010 this sequence version replaced NM_021268.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: M11026.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000413767.2/ ENSP00000411940.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-980               AL162420.13        6471-7450           c
FEATURES             Location/Qualifiers
     source          1..980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..980
                     /gene="IFNA17"
                     /gene_synonym="IFN-alphaI; IFNA; INFA; LEIF2C1"
                     /note="interferon alpha 17"
                     /db_xref="GeneID:3451"
                     /db_xref="HGNC:HGNC:5422"
                     /db_xref="MIM:147583"
     exon            1..980
                     /gene="IFNA17"
                     /gene_synonym="IFN-alphaI; IFNA; INFA; LEIF2C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..619
                     /gene="IFNA17"
                     /gene_synonym="IFN-alphaI; IFNA; INFA; LEIF2C1"
                     /note="interferon alpha-WA; leIF I; IFN-alpha-17;
                     interferon alpha-T; interferon alpha-88; interferon
                     alpha-I'"
                     /codon_start=1
                     /product="interferon alpha-17 precursor"
                     /protein_id="NP_067091.1"
                     /db_xref="CCDS:CCDS6500.1"
                     /db_xref="GeneID:3451"
                     /db_xref="HGNC:HGNC:5422"
                     /db_xref="MIM:147583"
                     /translation="MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQM
                     GRISPFSCLKDRHDFGLPQEEFDGNQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQ
                     SLLEKFSTELYQQLNNLEACVIQEVGMEETPLMNEDSILAVRKYFQRITLYLTEKKYS
                     PCAWEVVRAEIMRSLSFSTNLQKILRRKD"
ORIGIN      
        1 gttcaaggtt acccatctca agtagcctag caacatttgc aacatcccaa tggccctgtc
       61 cttttcttta ctgatggccg tgctggtgct cagctacaaa tccatctgtt ctctaggctg
      121 tgatctgcct cagacccaca gcctgggtaa taggagggcc ttgatactcc tggcacaaat
      181 gggaagaatc tctcctttct cctgcctgaa ggacagacat gactttggac ttccccagga
      241 ggagtttgat ggcaaccagt tccagaagac tcaagccatc tctgtcctcc atgagatgat
      301 ccagcagacc ttcaatctct tcagcacaga ggactcatct gctgcttggg aacagagcct
      361 cctagaaaaa ttttccactg aactttacca gcaactgaat aacctggaag catgtgtgat
      421 acaggaggtt gggatggaag agactcccct gatgaatgag gactccatcc tggctgtgag
      481 gaaatacttc caaagaatca ctctttatct aacagagaag aaatacagcc cttgtgcctg
      541 ggaggttgtc agagcagaaa tcatgagatc tctctctttt tcaacaaact tgcaaaaaat
      601 attaaggagg aaggattgaa aactggttca acatggcaat gatcctgatt gactaataca
      661 ttatctcaca ctttcatgag ttcctccatt tcaaagactc acttctataa ccaccacgag
      721 ttgaatcaaa attttcaaat gttttcagca gtgtaaagaa gcgtcgtgta tacctgtgca
      781 ggcactagta ctttacagat gaccatgctg atgtctctgt tcatctattt atttaaatat
      841 ttatttaatt atttttaaga tttaaattat ttttttatgt aatatcatgt gtacctttac
      901 attgtggtga atgtaacaat atatgttctt catatttagc caatatatta atttcctttt
      961 tcattaaatt tttactatac
//
