LOCUS       NM_002173                939 bp    mRNA    linear   PRI 03-JUN-2024
DEFINITION  Homo sapiens interferon alpha 16 (IFNA16), mRNA.
ACCESSION   NM_002173
VERSION     NM_002173.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 939)
  AUTHORS   Gnatenko,D.V., Liu,Z., Hearing,P., Sohn,S.Y., Hu,Y., Falanga,A.,
            Wu,S., Malone,L.E., Zhu,W. and Bahou,W.F.
  TITLE     Cytokine pathway variants modulate platelet production: IFNA16 is a
            thrombocytosis susceptibility locus in humans
  JOURNAL   Blood Adv 6 (16), 4884-4900 (2022)
   PUBMED   35381074
  REMARK    GeneRIF: Cytokine pathway variants modulate platelet production:
            IFNA16 is a thrombocytosis susceptibility locus in humans.
REFERENCE   2  (bases 1 to 939)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 939)
  AUTHORS   Mesev,E.V., LeDesma,R.A. and Ploss,A.
  TITLE     Decoding type I and III interferon signalling during viral
            infection
  JOURNAL   Nat Microbiol 4 (6), 914-924 (2019)
   PUBMED   30936491
  REMARK    Review article
REFERENCE   4  (bases 1 to 939)
  AUTHORS   Yang,X.R., Liang,X., Pfeiffer,R.M., Wheeler,W., Maeder,D.,
            Burdette,L., Yeager,M., Chanock,S., Tucker,M.A. and Goldstein,A.M.
  TITLE     Associations of 9p21 variants with cutaneous malignant melanoma,
            nevi, and pigmentation phenotypes in melanoma-prone families with
            and without CDKN2A mutations
  JOURNAL   Fam Cancer 9 (4), 625-633 (2010)
   PUBMED   20574843
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 939)
  AUTHORS   Myers,M.P., Andersen,J.N., Cheng,A., Tremblay,M.L., Horvath,C.M.,
            Parisien,J.P., Salmeen,A., Barford,D. and Tonks,N.K.
  TITLE     TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B
  JOURNAL   J Biol Chem 276 (51), 47771-47774 (2001)
   PUBMED   11694501
REFERENCE   6  (bases 1 to 939)
  AUTHORS   Olopade,O.I., Bohlander,S.K., Pomykala,H., Maltepe,E., Van
            Melle,E., Le Beau,M.M. and Diaz,M.O.
  TITLE     Mapping of the shortest region of overlap of deletions of the short
            arm of chromosome 9 associated with human neoplasia
  JOURNAL   Genomics 14 (2), 437-443 (1992)
   PUBMED   1385305
REFERENCE   7  (bases 1 to 939)
  AUTHORS   Sen,G.C. and Lengyel,P.
  TITLE     The interferon system. A bird's eye view of its biochemistry
  JOURNAL   J Biol Chem 267 (8), 5017-5020 (1992)
   PUBMED   1371992
  REMARK    Review article
REFERENCE   8  (bases 1 to 939)
  AUTHORS   Henco,K., Brosius,J., Fujisawa,A., Fujisawa,J.I., Haynes,J.R.,
            Hochstadt,J., Kovacic,T., Pasek,M., Schambock,A., Schmid,J. et al.
  TITLE     Structural relationship of human interferon alpha genes and
            pseudogenes
  JOURNAL   J Mol Biol 185 (2), 227-260 (1985)
   PUBMED   4057246
REFERENCE   9  (bases 1 to 939)
  AUTHORS   Fuke,M., Hendrix,L.C. and Bollon,A.P.
  TITLE     Pseudogene IFN-alpha L: removal of the stop codon in the signal
            sequence permits expression of active human interferon
  JOURNAL   Gene 32 (1-2), 135-140 (1984)
   PUBMED   6397400
REFERENCE   10 (bases 1 to 939)
  AUTHORS   Torczynski,R.M., Fuke,M. and Bollon,A.P.
  TITLE     Human genomic library screened with 17-base oligonucleotide probes
            yields a novel interferon gene
  JOURNAL   Proc Natl Acad Sci U S A 81 (20), 6451-6455 (1984)
   PUBMED   6387705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M28585.1 and AL512606.6.
            
            On Nov 14, 2015 this sequence version replaced NM_002173.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: M28585.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380216.1/ ENSP00000369564.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-691               M28585.1           1-691
            692-693             AL512606.6         50154-50155         c
            694-939             M28585.1           694-939
FEATURES             Location/Qualifiers
     source          1..939
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..939
                     /gene="IFNA16"
                     /gene_synonym="IFN-alpha-16; IFN-alphaO"
                     /note="interferon alpha 16"
                     /db_xref="GeneID:3449"
                     /db_xref="HGNC:HGNC:5421"
                     /db_xref="MIM:147580"
     exon            1..939
                     /gene="IFNA16"
                     /gene_synonym="IFN-alpha-16; IFN-alphaO"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..576
                     /gene="IFNA16"
                     /gene_synonym="IFN-alpha-16; IFN-alphaO"
                     /note="IFN-alpha-N-protein; interferon alpha-WA"
                     /codon_start=1
                     /product="interferon alpha-16 precursor"
                     /protein_id="NP_002164.1"
                     /db_xref="CCDS:CCDS34996.1"
                     /db_xref="GeneID:3449"
                     /db_xref="HGNC:HGNC:5421"
                     /db_xref="MIM:147580"
                     /translation="MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQM
                     GRISHFSCLKDRYDFGFPQEVFDGNQFQKAQAISAFHEMIQQTFNLFSTKDSSAAWDE
                     TLLDKFYIELFQQLNDLEACVTQEVGVEEIALMNEDSILAVRKYFQRITLYLMGKKYS
                     PCAWEVVRAEIMRSFSFSTNLQKGLRRKD"
ORIGIN      
        1 atcccaatgg ccctgtcctt ttctttactg atggccgtgc tggtgctcag ctacaaatcc
       61 atctgttctc tgggctgtga tctgcctcag actcacagcc tgggtaatag gagggccttg
      121 atactcctgg cacaaatggg aagaatctct catttctcct gcctgaagga cagatatgat
      181 ttcggattcc cccaggaggt gtttgatggc aaccagttcc agaaggctca agccatctct
      241 gccttccatg agatgatcca gcagaccttc aatctcttca gcacaaagga ttcatctgct
      301 gcttgggatg agaccctcct agacaaattc tacattgaac ttttccagca actgaatgac
      361 ctagaagcct gtgtgacaca ggaggttggg gtggaagaga ttgccctgat gaatgaggac
      421 tccatcctgg ctgtgaggaa atactttcaa agaatcactc tttatctgat ggggaagaaa
      481 tacagccctt gtgcctggga ggttgtcaga gcagaaatca tgagatcctt ctctttttca
      541 acaaacttgc aaaaaggatt aagaaggaag gattgaaaac tcattcaaca tggaaatgat
      601 cctcattgat taatacatca tctcacactt tcatgagttc ttccatttca aagactcact
      661 tctataacca ccacaagttg aatcaaaatt ttcaaatgtt ttcaggagtg taaagaagca
      721 tcgtgtttac ctgtgcaggc actagtcctt tacagatgac catgctgatg tctctattca
      781 tctatttatt taaatattta tttatttaac tatttttaag gtttaaatca tgttttatgt
      841 aatatcatgt gtacctttac attttgctta atgtaacaat atatgttctt catatttagt
      901 taatatatta acttcctttt cattaaattt ttactatac
//
