LOCUS       NM_002172               1004 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens interferon alpha 14 (IFNA14), mRNA.
ACCESSION   NM_002172
VERSION     NM_002172.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1004)
  AUTHORS   Al Shboul,S., Boyle,S., Singh,A., Saleh,T., Alrjoub,M., Abu Al
            Karsaneh,O., Mryyian,A., Dawoud,R., Gul,S., Abu Baker,S., Ball,K.,
            Hupp,T. and Brennan,P.M.
  TITLE     FISH analysis reveals CDKN2A and IFNA14 co-deletion is
            heterogeneous and is a prominent feature of glioblastoma
  JOURNAL   Brain Tumor Pathol 41 (1), 4-17 (2024)
   PUBMED   38097874
  REMARK    GeneRIF: FISH analysis reveals CDKN2A and IFNA14 co-deletion is
            heterogeneous and is a prominent feature of glioblastoma.
REFERENCE   2  (bases 1 to 1004)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1004)
  AUTHORS   Mesev,E.V., LeDesma,R.A. and Ploss,A.
  TITLE     Decoding type I and III interferon signalling during viral
            infection
  JOURNAL   Nat Microbiol 4 (6), 914-924 (2019)
   PUBMED   30936491
  REMARK    Review article
REFERENCE   4  (bases 1 to 1004)
  AUTHORS   Abraham,S., Choi,J.G., Ortega,N.M., Zhang,J., Shankar,P. and
            Swamy,N.M.
  TITLE     Gene therapy with plasmids encoding IFN-beta or IFN-alpha14 confers
            long-term resistance to HIV-1 in humanized mice
  JOURNAL   Oncotarget 7 (48), 78412-78420 (2016)
   PUBMED   27729616
  REMARK    GeneRIF: Gene therapy with plasmids encoding IFN-beta and -alpha14,
            but not the commonly used -alpha2, confers long-term suppression of
            HIV-1 replication.
REFERENCE   5  (bases 1 to 1004)
  AUTHORS   Silva,L.K., Blanton,R.E., Parrado,A.R., Melo,P.S., Morato,V.G.,
            Reis,E.A., Dias,J.P., Castro,J.M., Vasconcelos,P.F., Goddard,K.A.,
            Barreto,M.L., Reis,M.G. and Teixeira,M.G.
  TITLE     Dengue hemorrhagic fever is associated with polymorphisms in JAK1
  JOURNAL   Eur J Hum Genet 18 (11), 1221-1227 (2010)
   PUBMED   20588308
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1004)
  AUTHORS   Olopade,O.I., Bohlander,S.K., Pomykala,H., Maltepe,E., Van
            Melle,E., Le Beau,M.M. and Diaz,M.O.
  TITLE     Mapping of the shortest region of overlap of deletions of the short
            arm of chromosome 9 associated with human neoplasia
  JOURNAL   Genomics 14 (2), 437-443 (1992)
   PUBMED   1385305
REFERENCE   7  (bases 1 to 1004)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   8  (bases 1 to 1004)
  AUTHORS   Sen,G.C. and Lengyel,P.
  TITLE     The interferon system. A bird's eye view of its biochemistry
  JOURNAL   J Biol Chem 267 (8), 5017-5020 (1992)
   PUBMED   1371992
  REMARK    Review article
REFERENCE   9  (bases 1 to 1004)
  AUTHORS   Henco,K., Brosius,J., Fujisawa,A., Fujisawa,J.I., Haynes,J.R.,
            Hochstadt,J., Kovacic,T., Pasek,M., Schambock,A., Schmid,J. et al.
  TITLE     Structural relationship of human interferon alpha genes and
            pseudogenes
  JOURNAL   J Mol Biol 185 (2), 227-260 (1985)
   PUBMED   4057246
REFERENCE   10 (bases 1 to 1004)
  AUTHORS   Goeddel,D.V., Leung,D.W., Dull,T.J., Gross,M., Lawn,R.M.,
            McCandliss,R., Seeburg,P.H., Ullrich,A., Yelverton,E. and Gray,P.W.
  TITLE     The structure of eight distinct cloned human leukocyte interferon
            cDNAs
  JOURNAL   Nature 290 (5801), 20-26 (1981)
   PUBMED   6163083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL162420.13 and BC074956.2.
            
            On May 17, 2019 this sequence version replaced NM_002172.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: V00542.1, BC104159.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380222.4/ ENSP00000369571.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AL162420.13        19208-19233         c
            27-666              BC074956.2         1-640
            667-804             AL162420.13        18430-18567         c
            805-1004            AL162420.13        18230-18429         c
FEATURES             Location/Qualifiers
     source          1..1004
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..1004
                     /gene="IFNA14"
                     /gene_synonym="IFN-alphaH; LEIF2H"
                     /note="interferon alpha 14"
                     /db_xref="GeneID:3448"
                     /db_xref="HGNC:HGNC:5420"
                     /db_xref="MIM:147579"
     exon            1..1004
                     /gene="IFNA14"
                     /gene_synonym="IFN-alphaH; LEIF2H"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..640
                     /gene="IFNA14"
                     /gene_synonym="IFN-alphaH; LEIF2H"
                     /note="leIF H; IFN-alpha-14; interferon alpha-H;
                     interferon lambda-2-H"
                     /codon_start=1
                     /product="interferon alpha-14 precursor"
                     /protein_id="NP_002163.2"
                     /db_xref="CCDS:CCDS6501.1"
                     /db_xref="GeneID:3448"
                     /db_xref="HGNC:HGNC:5420"
                     /db_xref="MIM:147579"
                     /translation="MALPFALMMALVVLSCKSSCSLGCNLSQTHSLNNRRTLMLMAQM
                     RRISPFSCLKDRHDFEFPQEEFDGNQFQKAQAISVLHEMMQQTFNLFSTKNSSAAWDE
                     TLLEKFYIELFQQMNDLEACVIQEVGVEETPLMNEDSILAVKKYFQRITLYLMEKKYS
                     PCAWEVVRAEIMRSLSFSTNLQKRLRRKD"
ORIGIN      
        1 agaaaaccta caacccaagg ttcagtgtta cccctcatca accagcccag cagcatcttc
       61 gggattccca atggcattgc cctttgcttt aatgatggcc ctggtggtgc tcagctgcaa
      121 gtcaagctgc tctctgggct gtaatctgtc tcaaacccac agcctgaata acaggaggac
      181 tttgatgctc atggcacaaa tgaggagaat ctctcctttc tcctgcctga aggacagaca
      241 tgactttgaa tttccccagg aggaatttga tggcaaccag ttccagaaag ctcaagccat
      301 ctctgtcctc catgagatga tgcagcagac cttcaatctc ttcagcacaa agaactcatc
      361 tgctgcttgg gatgagaccc tcctagaaaa attctacatt gaacttttcc agcaaatgaa
      421 tgacctggaa gcctgtgtga tacaggaggt tggggtggaa gagactcccc tgatgaatga
      481 ggactccatc ctggctgtga agaaatactt ccaaagaatc actctttatc tgatggagaa
      541 gaaatacagc ccttgtgcct gggaggttgt cagagcagaa atcatgagat ccctctcttt
      601 ttcaacaaac ttgcaaaaaa gattaaggag gaaggattga aaactggttc atcatggaaa
      661 tgattctcat tgactaatac atcatctcac actttcatga gttcttccat ttcaaagact
      721 cacttctcct ataaccacca caagttgaat caaaattttc aaatgttttc aggagtgtaa
      781 agaagcatca tgtatacctg tgcaggcact agtcctttac agatgaccat gctgatgtct
      841 cctttcatct atttatttaa atatttattt atttaactat ttttattatt taaattattt
      901 tttatgtaat atcatgtgta cctttacatt gtggttaata taacaaatat gttcttcata
      961 tttagccaat atattaattt cctttttcat taaattttta ctat
//
