LOCUS       NM_002171                963 bp    mRNA    linear   PRI 03-JUN-2024
DEFINITION  Homo sapiens interferon alpha 10 (IFNA10), mRNA.
ACCESSION   NM_002171
VERSION     NM_002171.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 963)
  AUTHORS   Kousathanas,A., Pairo-Castineira,E., Rawlik,K., Stuckey,A.,
            Odhams,C.A., Walker,S., Russell,C.D., Malinauskas,T., Wu,Y.,
            Millar,J., Shen,X., Elliott,K.S., Griffiths,F., Oosthuyzen,W.,
            Morrice,K., Keating,S., Wang,B., Rhodes,D., Klaric,L., Zechner,M.,
            Parkinson,N., Siddiq,A., Goddard,P., Donovan,S., Maslove,D.,
            Nichol,A., Semple,M.G., Zainy,T., Maleady-Crowe,F., Todd,L.,
            Salehi,S., Knight,J., Elgar,G., Chan,G., Arumugam,P., Patch,C.,
            Rendon,A., Bentley,D., Kingsley,C., Kosmicki,J.A., Horowitz,J.E.,
            Baras,A., Abecasis,G.R., Ferreira,M.A.R., Justice,A., Mirshahi,T.,
            Oetjens,M., Rader,D.J., Ritchie,M.D., Verma,A., Fowler,T.A.,
            Shankar-Hari,M., Summers,C., Hinds,C., Horby,P., Ling,L.,
            McAuley,D., Montgomery,H., Openshaw,P.J.M., Elliott,P., Walsh,T.,
            Tenesa,A., Fawkes,A., Murphy,L., Rowan,K., Ponting,C.P., Vitart,V.,
            Wilson,J.F., Yang,J., Bretherick,A.D., Scott,R.H., Hendry,S.C.,
            Moutsianas,L., Law,A., Caulfield,M.J. and Baillie,J.K.
  CONSRTM   GenOMICC investigators; 23andMe investigators; COVID-19 Human
            Genetics Initiative
  TITLE     Whole-genome sequencing reveals host factors underlying critical
            COVID-19
  JOURNAL   Nature 607 (7917), 97-103 (2022)
   PUBMED   35255492
REFERENCE   2  (bases 1 to 963)
  AUTHORS   Mesev,E.V., LeDesma,R.A. and Ploss,A.
  TITLE     Decoding type I and III interferon signalling during viral
            infection
  JOURNAL   Nat Microbiol 4 (6), 914-924 (2019)
   PUBMED   30936491
  REMARK    Review article
REFERENCE   3  (bases 1 to 963)
  AUTHORS   Xiao,C.X., Xiao,J.J., Xu,H.Z., Wang,H.H., Chen,X., Liu,Y.S., Li,P.,
            Shi,Y., Nie,Y.Z., Li,S., Wu,K.C., Liu,Z.J., Ren,J.L. and Guleng,B.
  TITLE     Exome sequencing identifies novel compound heterozygous IFNA4 and
            IFNA10 mutations as a cause of impaired function in Crohn's disease
            patients
  JOURNAL   Sci Rep 5, 10514 (2015)
   PUBMED   26000985
  REMARK    GeneRIF: Heterozygous IFNA10 variants is a cause of impaired
            function and CD-susceptibility genes in Chinese individuals from
            multiple center based study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 963)
  AUTHORS   Hillyer,P., Raviv,N., Gold,D.M., Dougherty,D., Liu,J.,
            Johnson,T.R., Graham,B.S. and Rabin,R.L.
  TITLE     Subtypes of type I IFN differentially enhance cytokine expression
            by suboptimally stimulated CD4(+) T cells
  JOURNAL   Eur J Immunol 43 (12), 3197-3208 (2013)
   PUBMED   24030809
  REMARK    GeneRIF: IFN-alpha8 and -alpha10 most potently enhanced expression
            of IFN-gamma, IL-2, and IL-4.
REFERENCE   5  (bases 1 to 963)
  AUTHORS   Makrythanasis,P., Tzetis,M., Rapti,A., Papatheodorou,A., Tsipi,M.,
            Kitsiou,S., Tsiamouri,A., Poulou,M., Roussos,C. and Kanavakis,E.
  TITLE     Cystic fibrosis conductance regulator, tumor necrosis factor,
            interferon alpha-10, interferon alpha-17, and interferon gamma
            genotyping as potential risk markers in pulmonary sarcoidosis
            pathogenesis in Greek patients
  JOURNAL   Genet Test Mol Biomarkers 14 (4), 577-584 (2010)
   PUBMED   20722470
  REMARK    GeneRIF: We did not reproduce the associations previously noted
            with the TNF, IFNA10, IFNA17, and IFNG genes with pulmonary
            sarcoidosis.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 963)
  AUTHORS   Miterski,B., Jaeckel,S., Epplen,J.T., Pohlau,D. and Hardt,C.
  TITLE     The interferon gene cluster: a candidate region for MS
            predisposition? Multiple Sclerosis Study Group
  JOURNAL   Genes Immun 1 (1), 37-44 (1999)
   PUBMED   11197304
REFERENCE   7  (bases 1 to 963)
  AUTHORS   Olopade,O.I., Bohlander,S.K., Pomykala,H., Maltepe,E., Van
            Melle,E., Le Beau,M.M. and Diaz,M.O.
  TITLE     Mapping of the shortest region of overlap of deletions of the short
            arm of chromosome 9 associated with human neoplasia
  JOURNAL   Genomics 14 (2), 437-443 (1992)
   PUBMED   1385305
REFERENCE   8  (bases 1 to 963)
  AUTHORS   Bartholomew,C. and Windass,J.D.
  TITLE     Identification of a functional allele of a human interferon-alpha
            gene previously characterized as a pseudogene
  JOURNAL   J Interferon Res 9 (4), 407-417 (1989)
   PUBMED   2526839
REFERENCE   9  (bases 1 to 963)
  AUTHORS   Henco,K., Brosius,J., Fujisawa,A., Fujisawa,J.I., Haynes,J.R.,
            Hochstadt,J., Kovacic,T., Pasek,M., Schambock,A., Schmid,J. et al.
  TITLE     Structural relationship of human interferon alpha genes and
            pseudogenes
  JOURNAL   J Mol Biol 185 (2), 227-260 (1985)
   PUBMED   4057246
REFERENCE   10 (bases 1 to 963)
  AUTHORS   Goeddel,D.V., Leung,D.W., Dull,T.J., Gross,M., Lawn,R.M.,
            McCandliss,R., Seeburg,P.H., Ullrich,A., Yelverton,E. and Gray,P.W.
  TITLE     The structure of eight distinct cloned human leukocyte interferon
            cDNAs
  JOURNAL   Nature 290 (5801), 20-26 (1981)
   PUBMED   6163083
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC069409.1 and V00551.1.
            
            On Aug 31, 2013 this sequence version replaced NM_002171.1.
            
            Summary: This gene encodes a protein that belongs to the type I
            interferon family of proteins, and is located in a cluster of alpha
            interferon genes on chromosome 9. Interferons are small regulatory
            molecules that function in cell signaling in response to viruses
            and other pathogens or tumor cells. This gene is intronless and the
            encoded protein is secreted. [provided by RefSeq, Aug 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: V00551.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000357374.2/ ENSP00000369566.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-720               BC069409.1         1-720
            721-963             V00551.1           721-963
FEATURES             Location/Qualifiers
     source          1..963
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..963
                     /gene="IFNA10"
                     /gene_synonym="IFN-alphaC"
                     /note="interferon alpha 10"
                     /db_xref="GeneID:3446"
                     /db_xref="HGNC:HGNC:5418"
                     /db_xref="MIM:147577"
     exon            1..963
                     /gene="IFNA10"
                     /gene_synonym="IFN-alphaC"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..616
                     /gene="IFNA10"
                     /gene_synonym="IFN-alphaC"
                     /note="leIF C; IFN-alpha-10; interferon alpha-C;
                     interferon alpha-6L"
                     /codon_start=1
                     /product="interferon alpha-10 precursor"
                     /protein_id="NP_002162.1"
                     /db_xref="CCDS:CCDS6499.1"
                     /db_xref="GeneID:3446"
                     /db_xref="HGNC:HGNC:5418"
                     /db_xref="MIM:147577"
                     /translation="MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLGQM
                     GRISPFSCLKDRHDFRIPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQ
                     SLLEKFSTELYQQLNDLEACVIQEVGVEETPLMNEDSILAVRKYFQRITLYLIERKYS
                     PCAWEVVRAEIMRSLSFSTNLQKRLRRKD"
ORIGIN      
        1 caaggttatc catctcaagt agcctagcaa tatttgcaac atcccaatgg ccctgtcctt
       61 ttctttactt atggccgtgc tggtgctcag ctacaaatcc atctgttctc taggctgtga
      121 tctgcctcag acccacagcc tgggtaatag gagggccttg atactcctgg gacaaatggg
      181 aagaatctct cctttctcct gcctgaagga cagacatgat ttccgaatcc cccaggagga
      241 gtttgatggc aaccagttcc agaaggctca agccatctct gtcctccatg agatgatcca
      301 gcagaccttc aatctcttca gcacagagga ctcatctgct gcttgggaac agagcctcct
      361 agaaaaattt tccactgaac tttaccagca actgaatgac ctggaagcat gtgtgataca
      421 ggaggttggg gtggaagaga ctcccctgat gaatgaggac tccatcctgg ctgtgaggaa
      481 atacttccaa agaatcactc tttatctaat agagaggaaa tacagccctt gtgcctggga
      541 ggttgtcaga gcagaaatca tgagatccct ctcgttttca acaaacttgc aaaaaagatt
      601 aaggaggaag gattgaaaac tggttcaaca tggcaatgat cctgattgac taatacatta
      661 tctcacactt tcatgagttc ttccatttca aagactcact tctataacca cgacgcgttg
      721 aatcaaaatt ttcaaatgtt ttcagcagtg taaagaagtg tcgtgtatac ctgtgcaggc
      781 actagtcctt tacagatgac cattctgatg tctctgttca tcttttgttt aaatatttat
      841 ttaattattt ttaaaattta tgtaatatca tgagtcgctt tacattgtgg ttaatgtaac
      901 aatatatgtt cttcatattt agccaatata ttaatttcct ttttcattaa atttttacta
      961 tac
//
