LOCUS       NM_024013                878 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens interferon alpha 1 (IFNA1), mRNA.
ACCESSION   NM_024013
VERSION     NM_024013.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 878)
  AUTHORS   Braga,M., Shiga,M.A.S., Silva,P.E.S., Yamanaka,A.H.U., Souza,V.H.,
            Grava,S., Simao,A.N.C., Neves,J.S.F., de Lima Neto,Q.A.,
            Zacarias,J.M.V. and Visentainer,J.E.L.
  TITLE     Association between polymorphisms in TLR3, TICAM1 and IFNA1 genes
            and covid-19 severity in Southern Brazil
  JOURNAL   Expert Rev Mol Diagn 24 (6), 525-531 (2024)
   PUBMED   38864429
  REMARK    GeneRIF: Association between polymorphisms in TLR3, TICAM1 and
            IFNA1 genes and covid-19 severity in Southern Brazil.
REFERENCE   2  (bases 1 to 878)
  AUTHORS   Ma,Y.T., Zheng,L., Zhao,C.W., Zhang,Y., Xu,X.W., Wang,X.Y.,
            Niu,G.P., Man,Z.S., Gu,F. and Chen,Y.Q.
  TITLE     Interferon-alpha induces differentiation of cancer stem cells and
            immunosuppression in hepatocellular carcinoma by upregulating CXCL8
            secretion
  JOURNAL   Cytokine 177, 156555 (2024)
   PUBMED   38387232
  REMARK    GeneRIF: Interferon-alpha induces differentiation of cancer stem
            cells and immunosuppression in hepatocellular carcinoma by
            upregulating CXCL8 secretion.
REFERENCE   3  (bases 1 to 878)
  AUTHORS   Kuga,T., Chiba,A., Murayama,G., Hosomi,K., Nakagawa,T., Yahagi,Y.,
            Noto,D., Kusaoi,M., Kawano,F., Yamaji,K., Tamura,N. and Miyake,S.
  TITLE     Enhanced GATA4 expression in senescent systemic lupus erythematosus
            monocytes promotes high levels of IFNalpha production
  JOURNAL   Front Immunol 15, 1320444 (2024)
   PUBMED   38605949
  REMARK    GeneRIF: Enhanced GATA4 expression in senescent systemic lupus
            erythematosus monocytes promotes high levels of IFNalpha
            production.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 878)
  AUTHORS   Queiroz,M.A.F., Oliveira,A.Q.T., Moura,T.C.F., Brito,W.R.D.S.,
            Santana,E.G.M., Lima,L.L.P., Lopes,F.T., Bichara,C.D.A.,
            Amoras,E.D.S.G., Ishak,R., Vallinoto,I.M.V.C. and Vallinoto,A.C.R.
  TITLE     The Expression Levels of TREX1 and IFN-alpha Are Associated with
            Immune Reconstitution in HIV-1-Infected Individuals
  JOURNAL   Viruses 16 (4), 499 (2024)
   PUBMED   38675842
  REMARK    GeneRIF: The Expression Levels of TREX1 and IFN-alpha Are
            Associated with Immune Reconstitution in HIV-1-Infected
            Individuals.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 878)
  AUTHORS   Queiroz,M.A.F., Brito,W.R.D.S., Pereira,K.A.S., Pereira,L.M.S.,
            Amoras,E.D.S.G., Lima,S.S., Santos,E.F.D., Costa,F.P.D.,
            Sarges,K.M.L., Cantanhede,M.H.D., Brito,M.T.F.M., Silva,A.L.S.D.,
            Leite,M.M., Viana,M.N.D.S.A., Rodrigues,F.B.B., Silva,R.D.,
            Viana,G.M.R., Chaves,T.D.S.S., Verissimo,A.O.L., Carvalho,M.D.S.,
            Henriques,D.F., Silva,C.P.D., Nunes,J.A.L., Costa,I.B.,
            Cayres-Vallinoto,I.M.V., Brasil-Costa,I., Quaresma,J.A.S.,
            Falcao,L.F.M., Santos,E.J.M.D. and Vallinoto,A.C.R.
  TITLE     Severe COVID-19 and long COVID are associated with high expression
            of STING, cGAS and IFN-alpha
  JOURNAL   Sci Rep 14 (1), 4974 (2024)
   PUBMED   38424312
  REMARK    GeneRIF: Severe COVID-19 and long COVID are associated with high
            expression of STING, cGAS and IFN-alpha.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 878)
  AUTHORS   Olopade,O.I., Bohlander,S.K., Pomykala,H., Maltepe,E., Van
            Melle,E., Le Beau,M.M. and Diaz,M.O.
  TITLE     Mapping of the shortest region of overlap of deletions of the short
            arm of chromosome 9 associated with human neoplasia
  JOURNAL   Genomics 14 (2), 437-443 (1992)
   PUBMED   1385305
REFERENCE   7  (bases 1 to 878)
  AUTHORS   Gottlinger,H.G., Dorfman,T., Sodroski,J.G. and Haseltine,W.A.
  TITLE     Effect of mutations affecting the p6 gag protein on human
            immunodeficiency virus particle release
  JOURNAL   Proc Natl Acad Sci U S A 88 (8), 3195-3199 (1991)
   PUBMED   2014240
REFERENCE   8  (bases 1 to 878)
  AUTHORS   Delcayre,A.X., Salas,F., Mathur,S., Kovats,K., Lotz,M. and
            Lernhardt,W.
  TITLE     Epstein Barr virus/complement C3d receptor is an interferon alpha
            receptor
  JOURNAL   EMBO J 10 (4), 919-926 (1991)
   PUBMED   1849076
REFERENCE   9  (bases 1 to 878)
  AUTHORS   Silverman,R.H. and Sengupta,D.N.
  TITLE     Translational regulation by HIV leader RNA, TAT, and
            interferon-inducible enzymes
  JOURNAL   J Exp Pathol 5 (2), 69-77 (1990)
   PUBMED   1708818
REFERENCE   10 (bases 1 to 878)
  AUTHORS   Capon,D.J., Shepard,H.M. and Goeddel,D.V.
  TITLE     Two distinct families of human and bovine interferon-alpha genes
            are coordinately expressed and encode functional polypeptides
  JOURNAL   Mol Cell Biol 5 (4), 768-779 (1985)
   PUBMED   2985969
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353732.14, V00538.1 and
            V00537.1.
            
            On May 17, 2019 this sequence version replaced NM_024013.2.
            
            Summary: This gene is a member of the alpha interferon gene cluster
            on chromosome 9. The encoded cytokine is a member of the type I
            interferon family that is produced in response to viral infection
            as a key part of the innate immune response with potent antiviral,
            antiproliferative and immunomodulatory properties. This cytokine,
            like other type I interferons, binds a plasma membrane receptor
            made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus
            is able to act on virtually all body cells. This cytokine is
            upregulated in preeclamptic placentas and is thought to be a
            mediator of preeclampsia. [provided by RefSeq, Aug 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB578886.1, V00538.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in cytokine storm inflammatory
                                      response
            MANE Ensembl match     :: ENST00000276927.3/ ENSP00000276927.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL353732.14        97176-97190
            16-478              V00538.1           1-463
            479-878             V00537.1           466-865
FEATURES             Location/Qualifiers
     source          1..878
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..878
                     /gene="IFNA1"
                     /gene_synonym="IFL; IFN; IFN-ALPHA; IFN-alphaD; IFNA13;
                     IFNA@; leIF D"
                     /note="interferon alpha 1"
                     /db_xref="GeneID:3439"
                     /db_xref="HGNC:HGNC:5417"
                     /db_xref="MIM:147660"
     exon            1..878
                     /gene="IFNA1"
                     /gene_synonym="IFL; IFN; IFN-ALPHA; IFN-alphaD; IFNA13;
                     IFNA@; leIF D"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..639
                     /gene="IFNA1"
                     /gene_synonym="IFL; IFN; IFN-ALPHA; IFN-alphaD; IFNA13;
                     IFNA@; leIF D"
                     /note="interferon alpha-1/13; interferon-alpha1;
                     interferon alpha 1b; IFN-alpha-1/13; interferon alpha-D"
                     /codon_start=1
                     /product="interferon alpha-1/13 precursor"
                     /protein_id="NP_076918.1"
                     /db_xref="CCDS:CCDS6508.1"
                     /db_xref="GeneID:3439"
                     /db_xref="HGNC:HGNC:5417"
                     /db_xref="MIM:147660"
                     /translation="MASPFALLMVLVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQM
                     SRISPSSCLMDRHDFGFPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDE
                     DLLDKFCTELYQQLNDLEACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYS
                     PCAWEVVRAEIMRSLSLSTNLQERLRRKE"
ORIGIN      
        1 agagaaccta gagcccaagg ttcagagtca cccatctcag caagcccaga agtatctgca
       61 atatctacga tggcctcgcc ctttgcttta ctgatggtcc tggtggtgct cagctgcaag
      121 tcaagctgct ctctgggctg tgatctccct gagacccaca gcctggataa caggaggacc
      181 ttgatgctcc tggcacaaat gagcagaatc tctccttcct cctgtctgat ggacagacat
      241 gactttggat ttccccagga ggagtttgat ggcaaccagt tccagaaggc tccagccatc
      301 tctgtcctcc atgagctgat ccagcagatc ttcaacctct ttaccacaaa agattcatct
      361 gctgcttggg atgaggacct cctagacaaa ttctgcaccg aactctacca gcagctgaat
      421 gacttggaag cctgtgtgat gcaggaggag agggtgggag aaactcccct gatgaatgcg
      481 gactccatct tggctgtgaa gaaatacttc cgaagaatca ctctctatct gacagagaag
      541 aaatacagcc cttgtgcctg ggaggttgtc agagcagaaa tcatgagatc cctctcttta
      601 tcaacaaact tgcaagaaag attaaggagg aaggaataac atctggtcca acatgaaaac
      661 aattcttatt gactcataca ccaggtcacg ctttcatgaa ttctgtcatt tcaaagactc
      721 tcacccctgc tataactatg accatgctga taaactgatt tatctattta aatatttatt
      781 taactattca taagatttaa attatttttg ttcatataac gtcatgtgca cctttacact
      841 gtggttagtg taataaaaca tgttccttat atttactc
//
