LOCUS       NM_021034                611 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens interferon induced transmembrane protein 3 (IFITM3),
            transcript variant 1, mRNA.
ACCESSION   NM_021034
VERSION     NM_021034.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 611)
  AUTHORS   Elessawy,S.M., Shehab,A., Soliman,D.A., Eldeeb,M.A. and Taha,S.I.
  TITLE     Interferon-Induced Transmembrane Protein-3 Rs12252-G Variant
            Increases COVID-19 Mortality Potential in Egyptian Population
  JOURNAL   Viral Immunol 37 (4), 186-193 (2024)
   PUBMED   38717821
  REMARK    GeneRIF: Interferon-Induced Transmembrane Protein-3 Rs12252-G
            Variant Increases COVID-19 Mortality Potential in Egyptian
            Population.
REFERENCE   2  (bases 1 to 611)
  AUTHORS   Munir,M., Embry,A., Doench,J.G., Heaton,N.S., Wilen,C.B. and
            Orchard,R.C.
  TITLE     Genome-wide CRISPR activation screen identifies JADE3 as an
            antiviral activator of NF-kB-dependent IFITM3 expression
  JOURNAL   J Biol Chem 300 (4), 107153 (2024)
   PUBMED   38462163
  REMARK    GeneRIF: Genome-wide CRISPR activation screen identifies JADE3 as
            an antiviral activator of NF-kB-dependent IFITM3 expression.
REFERENCE   3  (bases 1 to 611)
  AUTHORS   Du,S., Wang,Y., Wang,J., Ma,Y., Xu,W., Shi,X., Li,L., Hao,P.,
            Liu,Q., Liao,M., Zhou,B., Jin,N., Wong,Y.K., Hu,L., Wang,J., Liu,W.
            and Li,C.
  TITLE     IFITM3 inhibits severe fever with thrombocytopenia syndrome virus
            entry and interacts with viral Gc protein
  JOURNAL   J Med Virol 96 (3), e29491 (2024)
   PUBMED   38402626
  REMARK    GeneRIF: IFITM3 inhibits severe fever with thrombocytopenia
            syndrome virus entry and interacts with viral Gc protein.
REFERENCE   4  (bases 1 to 611)
  AUTHORS   Fernandez-de-Las-Penas,C., Diaz-Gil,G., Gil-Crujera,A.,
            Gomez-Sanchez,S.M., Ambite-Quesada,S., Torres-Macho,J.,
            Ryan-Murua,P., Franco-Moreno,A.I., Pellicer-Valero,O.J.,
            Arendt-Nielsen,L. and Giordano,R.
  TITLE     Inflammatory Polymorphisms (IL-6 rs1800796, IL-10 rs1800896,
            TNF-alpha rs1800629, and IFITM3 rs12252) Are Not Associated with
            Post-COVID Symptoms in Previously Hospitalized COVID-19 Survivors
  JOURNAL   Viruses 16 (2), 275 (2024)
   PUBMED   38400050
  REMARK    GeneRIF: Inflammatory Polymorphisms (IL-6 rs1800796, IL-10
            rs1800896, TNF-alpha rs1800629, and IFITM3 rs12252) Are Not
            Associated with Post-COVID Symptoms in Previously Hospitalized
            COVID-19 Survivors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 611)
  AUTHORS   Benmansour,R., Tagajdid,M.R., El Hamzaoui,H., Fjouji,S., Doghmi,N.,
            Houba,A., Belbacha,I., Elkochri,S., Aabi,R., Elannaz,H.,
            Laraqui,A., El Mchichi,B., Chmitah,T., Touil,N., Ennibi,K.,
            Eljaoudi,R., Elmir,E., Amine Lahlou,I. and Oumzil,H.
  TITLE     TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among
            severe COVID-19 ICU patients in Morocco
  JOURNAL   Int J Immunopathol Pharmacol 38, 3946320241257241 (2024)
   PUBMED   38760017
  REMARK    GeneRIF: TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide
            polymorphisms among severe COVID-19 ICU patients in Morocco.
REFERENCE   6  (bases 1 to 611)
  AUTHORS   Cuddapah,S., Cui,K. and Zhao,K.
  TITLE     Transcriptional enhancer factor 1 (TEF-1/TEAD1) mediates activation
            of IFITM3 gene by BRGl
  JOURNAL   FEBS Lett 582 (2), 391-397 (2008)
   PUBMED   18177740
  REMARK    GeneRIF: regulation of IFITM3 by TEF-1 demonstrates that TEF-1
            dependent regulation is more widespread than its previously
            established role in the expression of muscle specific genes
REFERENCE   7  (bases 1 to 611)
  AUTHORS   Tanaka,S.S., Yamaguchi,Y.L., Tsoi,B., Lickert,H. and Tam,P.P.
  TITLE     IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct
            roles in mouse primordial germ cell homing and repulsion
  JOURNAL   Dev Cell 9 (6), 745-756 (2005)
   PUBMED   16326387
REFERENCE   8  (bases 1 to 611)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 611)
  AUTHORS   Vaarala,M.H., Porvari,K., Kyllonen,A. and Vihko,P.
  TITLE     Differentially expressed genes in two LNCaP prostate cancer cell
            lines reflecting changes during prostate cancer progression
  JOURNAL   Lab Invest 80 (8), 1259-1268 (2000)
   PUBMED   10950117
REFERENCE   10 (bases 1 to 611)
  AUTHORS   Lewin,A.R., Reid,L.E., McMahon,M., Stark,G.R. and Kerr,I.M.
  TITLE     Molecular analysis of a human interferon-inducible gene family
  JOURNAL   Eur J Biochem 199 (2), 417-423 (1991)
   PUBMED   1906403
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB261103.1 and AI355192.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021034.2.
            
            Summary: Interferon-induced transmembrane (IFITM) proteins are a
            family of interferon induced antiviral proteins. The family
            contains five members, including IFITM1, IFITM2 and IFITM3 and
            belong to the CD225 superfamily. The protein encoded by this gene
            restricts cellular entry by diverse viral pathogens, such as
            influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq,
            Nov 2021].
            
            Transcript Variant: This variant (1) represents the longer,
            protein-coding transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB150526.1, BC022439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000399808.5/ ENSP00000382707.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-511               DB261103.1         55-565
            512-611             AI355192.1         14-113              c
FEATURES             Location/Qualifiers
     source          1..611
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..611
                     /gene="IFITM3"
                     /gene_synonym="1-8U; DSPA2b; IP15"
                     /note="interferon induced transmembrane protein 3"
                     /db_xref="GeneID:10410"
                     /db_xref="HGNC:HGNC:5414"
                     /db_xref="MIM:605579"
     exon            1..296
                     /gene="IFITM3"
                     /gene_synonym="1-8U; DSPA2b; IP15"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..449
                     /gene="IFITM3"
                     /gene_synonym="1-8U; DSPA2b; IP15"
                     /note="interferon-inducible protein 1-8U; dispanin
                     subfamily A member 2b"
                     /codon_start=1
                     /product="interferon-induced transmembrane protein 3"
                     /protein_id="NP_066362.2"
                     /db_xref="CCDS:CCDS41585.1"
                     /db_xref="GeneID:10410"
                     /db_xref="HGNC:HGNC:5414"
                     /db_xref="MIM:605579"
                     /translation="MNHTVQTFFSPVNSGQPPNYEMLKEEHEVAVLGAPHNPAPPTST
                     VIHIRSETSVPDHVVWSLFNTLFMNPCCLGFIAFAYSVKSRDRKMVGDVTGAQAYAST
                     AKCLNIWALILGILMTILLIVIPVLIFQAYG"
     exon            297..611
                     /gene="IFITM3"
                     /gene_synonym="1-8U; DSPA2b; IP15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      589..594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFITM3"
                     /gene_synonym="1-8U; DSPA2b; IP15"
                     /note="hexamer: AATAAA"
     polyA_site      611
                     /gene="IFITM3"
                     /gene_synonym="1-8U; DSPA2b; IP15"
                     /note="major polyA site"
ORIGIN      
        1 gagaaccatc ccagtaaccc gaccgccgct ggtcttcgct ggacaccatg aatcacactg
       61 tccaaacctt cttctctcct gtcaacagtg gccagccccc caactatgag atgctcaagg
      121 aggagcacga ggtggctgtg ctgggggcgc cccacaaccc tgctcccccg acgtccaccg
      181 tgatccacat ccgcagcgag acctccgtgc ccgaccatgt cgtctggtcc ctgttcaaca
      241 ccctcttcat gaacccctgc tgcctgggct tcatagcatt cgcctactcc gtgaagtcta
      301 gggacaggaa gatggttggc gacgtgaccg gggcccaggc ctatgcctcc accgccaagt
      361 gcctgaacat ctgggccctg attctgggca tcctcatgac cattctgctc atcgtcatcc
      421 cagtgctgat cttccaggcc tatggataga tcaggaggca tcactgaggc caggagctct
      481 gcccatgacc tgtatcccac gtactccaac ttccattcct cgccctgccc ccggagccga
      541 gtcctgtatc agccctttat cctcacacgc ttttctacaa tggcattcaa taaagtgcac
      601 gtgtttctgg t
//
