LOCUS       NM_006435               1006 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens interferon induced transmembrane protein 2 (IFITM2),
            mRNA.
ACCESSION   NM_006435
VERSION     NM_006435.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1006)
  AUTHORS   Liu,Y., Liang,J., Huang,J., Li,X., Huang,J. and Wang,J.
  TITLE     Unveiling the immunoregulatory role of interferon-induced
            transmembrane protein 2 through the JAK/STAT3/PDL1 pathway in
            gastric cancer
  JOURNAL   Int Immunopharmacol 142 (Pt B), 113221 (2024)
   PUBMED   39321709
  REMARK    GeneRIF: Unveiling the immunoregulatory role of interferon-induced
            transmembrane protein 2 through the JAK/STAT3/PDL1 pathway in
            gastric cancer.
REFERENCE   2  (bases 1 to 1006)
  AUTHORS   Chen,L., Li,X., Deng,Y., Bi,Y., Yan,Z., Yang,Y., Zhang,X., Li,H.,
            Xie,J. and Feng,R.
  TITLE     IFITM2 Presents Antiviral Response through Enhancing Type I IFN
            Signaling Pathway
  JOURNAL   Viruses 15 (4), 866 (2023)
   PUBMED   37112847
  REMARK    GeneRIF: IFITM2 Presents Antiviral Response through Enhancing Type
            I IFN Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1006)
  AUTHORS   Nchioua,R., Schundner,A., Kmiec,D., Prelli Bozzo,C., Zech,F.,
            Koepke,L., Graf,A., Krebs,S., Blum,H., Frick,M., Sparrer,K.M.J. and
            Kirchhoff,F.
  TITLE     SARS-CoV-2 Variants of Concern Hijack IFITM2 for Efficient
            Replication in Human Lung Cells
  JOURNAL   J Virol 96 (11), e0059422 (2022)
   PUBMED   35543509
  REMARK    GeneRIF: SARS-CoV-2 Variants of Concern Hijack IFITM2 for Efficient
            Replication in Human Lung Cells.
REFERENCE   4  (bases 1 to 1006)
  AUTHORS   Majdoul,S. and Compton,A.A.
  TITLE     Lessons in self-defence: inhibition of virus entry by intrinsic
            immunity
  JOURNAL   Nat Rev Immunol 22 (6), 339-352 (2022)
   PUBMED   34646033
  REMARK    Review article
REFERENCE   5  (bases 1 to 1006)
  AUTHORS   Hornich,B.F., Grosskopf,A.K., Dcosta,C.J., Schlagowski,S. and
            Hahn,A.S.
  TITLE     Interferon-Induced Transmembrane Proteins Inhibit Infection by the
            Kaposi's Sarcoma-Associated Herpesvirus and the Related Rhesus
            Monkey Rhadinovirus in a Cell-Specific Manner
  JOURNAL   mBio 12 (6), e0211321 (2021)
   PUBMED   34933450
  REMARK    GeneRIF: Interferon-Induced Transmembrane Proteins Inhibit
            Infection by the Kaposi's Sarcoma-Associated Herpesvirus and the
            Related Rhesus Monkey Rhadinovirus in a Cell-Specific Manner.
REFERENCE   6  (bases 1 to 1006)
  AUTHORS   Daniel-Carmi,V., Makovitzki-Avraham,E., Reuven,E.M., Goldstein,I.,
            Zilkha,N., Rotter,V., Tzehoval,E. and Eisenbach,L.
  TITLE     The human 1-8D gene (IFITM2) is a novel p53 independent
            pro-apoptotic gene
  JOURNAL   Int J Cancer 125 (12), 2810-2819 (2009)
   PUBMED   19544527
  REMARK    GeneRIF: Single Nucleotide Polymorphisms in 1-8D is associated with
            neoplasms.
REFERENCE   7  (bases 1 to 1006)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   8  (bases 1 to 1006)
  AUTHORS   Lewin,A.R., Reid,L.E., McMahon,M., Stark,G.R. and Kerr,I.M.
  TITLE     Molecular analysis of a human interferon-inducible gene family
  JOURNAL   Eur J Biochem 199 (2), 417-423 (1991)
   PUBMED   1906403
REFERENCE   9  (bases 1 to 1006)
  AUTHORS   Kelly,J.M., Gilbert,C.S., Stark,G.R. and Kerr,I.M.
  TITLE     Differential regulation of interferon-induced mRNAs and c-myc mRNA
            by alpha- and gamma-interferons
  JOURNAL   Eur J Biochem 153 (2), 367-371 (1985)
   PUBMED   3935435
REFERENCE   10 (bases 1 to 1006)
  AUTHORS   Friedman,R.L., Manly,S.P., McMahon,M., Kerr,I.M. and Stark,G.R.
  TITLE     Transcriptional and posttranscriptional regulation of
            interferon-induced gene expression in human cells
  JOURNAL   Cell 38 (3), 745-755 (1984)
   PUBMED   6548414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC136475.7.
            
            On Feb 9, 2021 this sequence version replaced NM_006435.2.
            
            Summary: Interferon-induced transmembrane (IFITM) proteins are a
            family of interferon induced antiviral proteins. The family
            contains five members, including IFITM1, IFITM2 and IFITM3 and
            belong to the CD225 superfamily. The protein encoded by this gene
            restricts cellular entry by diverse viral pathogens, such as
            influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq,
            Nov 2021].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR998617.1, BC009696.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000616316.3/ ENSP00000484689.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-623               AC136475.7         92360-92982
            624-1006            AC136475.7         93557-93939
FEATURES             Location/Qualifiers
     source          1..1006
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..1006
                     /gene="IFITM2"
                     /gene_synonym="1-8D; DSPA2c"
                     /note="interferon induced transmembrane protein 2"
                     /db_xref="GeneID:10581"
                     /db_xref="HGNC:HGNC:5413"
                     /db_xref="MIM:605578"
     exon            1..623
                     /gene="IFITM2"
                     /gene_synonym="1-8D; DSPA2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..776
                     /gene="IFITM2"
                     /gene_synonym="1-8D; DSPA2c"
                     /note="interferon-inducible protein 1-8D; dispanin
                     subfamily A member 2c"
                     /codon_start=1
                     /product="interferon-induced transmembrane protein 2"
                     /protein_id="NP_006426.2"
                     /db_xref="CCDS:CCDS41583.1"
                     /db_xref="GeneID:10581"
                     /db_xref="HGNC:HGNC:5413"
                     /db_xref="MIM:605578"
                     /translation="MNHIVQTFSPVNSGQPPNYEMLKEEQEVAMLGVPHNPAPPMSTV
                     IHIRSETSVPDHVVWSLFNTLFMNTCCLGFIAFAYSVKSRDRKMVGDVTGAQAYASTA
                     KCLNIWALILGIFMTILLIIIPVLVVQAQR"
     exon            624..1006
                     /gene="IFITM2"
                     /gene_synonym="1-8D; DSPA2c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      984..989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFITM2"
                     /gene_synonym="1-8D; DSPA2c"
                     /note="hexamer: AATAAA"
     polyA_site      1006
                     /gene="IFITM2"
                     /gene_synonym="1-8D; DSPA2c"
                     /note="major polyA site"
ORIGIN      
        1 gtggggcctg gagtgtggag gcgtcagcgc aggcctggca ggagccctga accgggacag
       61 tgaggtcctg cagctgctgg cctggggtgt ggagactccc aacacagggg aagtctccag
      121 gaccccacac cactaacaag atgagacttg tgctcctttg ggctctagag aggaagcccc
      181 tcttagccct cagcccctct ttcctccctc tcctaaagta atttgatcct caggaatttg
      241 ttctgccctt atctggccct ggccagctct gcatttgaca aatgccagga agaggaaact
      301 gttgagaaaa cggaactact ggggaaaggg agggctcact gagaaccatc ccggtaaccc
      361 gatcaccgct ggtcaccatg aaccacattg tgcaaacctt ctctcctgtc aacagcggcc
      421 agcctcccaa ctacgagatg ctcaaggagg agcaggaagt ggctatgctg ggggtgcccc
      481 acaaccctgc tcccccgatg tccaccgtga tccacatccg cagcgagacc tccgtgcctg
      541 accatgtggt ctggtccctg ttcaacaccc tcttcatgaa cacctgctgc ctgggcttca
      601 tagcattcgc gtactccgtg aagtctaggg acaggaagat ggttggcgac gtgaccgggg
      661 cccaggccta tgcctccacc gccaagtgcc tgaacatctg ggccctgatt ttgggcatct
      721 tcatgaccat tctgctcatc atcatcccag tgttggtcgt ccaggcccag cgatagatca
      781 ggaggcatca ttgaggccag gagctctgcc cgtgacctgt atcccacgta ctctatcttc
      841 cattcctcgc cctgccccca gaggccagga gctctgccct tgacctgtat tccacttact
      901 ccaccttcca ttcctcgccc tgtccccaca gccgagtcct gcatcagccc tttatcctca
      961 cacgcttttc tacaatggca ttcaataaag tgtatatgtt tctggt
//
