LOCUS       NM_003641                668 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens interferon induced transmembrane protein 1 (IFITM1),
            mRNA.
ACCESSION   NM_003641
VERSION     NM_003641.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 668)
  AUTHORS   Verma,S., Chen,Y.C., Marin,M., Gillespie,S.E. and Melikyan,G.B.
  TITLE     IFITM1 and IFITM3 Proteins Inhibit the Infectivity of Progeny HIV-1
            without Disrupting Envelope Glycoprotein Clusters
  JOURNAL   Viruses 15 (12), 2390 (2023)
   PUBMED   38140631
  REMARK    GeneRIF: IFITM1 and IFITM3 Proteins Inhibit the Infectivity of
            Progeny HIV-1 without Disrupting Envelope Glycoprotein Clusters.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 668)
  AUTHORS   Allen,P.C., Roberts,K., Rubio,J.E., Tiwari,H.K., Absher,D.M.,
            Cooper,S.J., Myers,R.M. and Brown,E.E.
  TITLE     Genome-wide DNA methylation analysis implicates enrichment of
            interferon pathway in African American patients with Systemic Lupus
            Erythematosus and European Americans with lupus nephritis
  JOURNAL   J Autoimmun 139, 103089 (2023)
   PUBMED   37506491
  REMARK    GeneRIF: Genome-wide DNA methylation analysis implicates enrichment
            of interferon pathway in African American patients with Systemic
            Lupus Erythematosus and European Americans with lupus nephritis.
REFERENCE   3  (bases 1 to 668)
  AUTHORS   Dobashi,M., Shiratori,T., Imaizumi,T., Hashimoto,S., Kawaguchi,S.,
            Seya,K. and Tasaka,S.
  TITLE     Toll-like receptor 3 signaling induces interferon-induced
            transmembrane protein 1 in BEAS-2B cells
  JOURNAL   Exp Biol Med (Maywood) 247 (21), 1917-1922 (2022)
   PUBMED   36112878
  REMARK    GeneRIF: Toll-like receptor 3 signaling induces interferon-induced
            transmembrane protein 1 in BEAS-2B cells.
REFERENCE   4  (bases 1 to 668)
  AUTHORS   Gomez-Herranz,M., Faktor,J., Yebenes Mayordomo,M., Pilch,M.,
            Nekulova,M., Hernychova,L., Ball,K.L., Vojtesek,B., Hupp,T.R. and
            Kote,S.
  TITLE     Emergent Role of IFITM1/3 towards Splicing Factor (SRSF1) and
            Antigen-Presenting Molecule (HLA-B) in Cervical Cancer
  JOURNAL   Biomolecules 12 (8), 1090 (2022)
   PUBMED   36008984
  REMARK    GeneRIF: Emergent Role of IFITM1/3 towards Splicing Factor (SRSF1)
            and Antigen-Presenting Molecule (HLA-B) in Cervical Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 668)
  AUTHORS   Liu,Z., Zhang,W., Zhang,B., Chen,S. and Ling,C.
  TITLE     MiR-504-3p Has Tumor-Suppressing Activity and Decreases IFITM1
            Expression in Non-Small Cell Lung Cancer Cells
  JOURNAL   Genet Test Mol Biomarkers 26 (7-8), 351-359 (2022)
   PUBMED   36027039
  REMARK    GeneRIF: MiR-504-3p Has Tumor-Suppressing Activity and Decreases
            IFITM1 Expression in Non-Small Cell Lung Cancer Cells.
REFERENCE   6  (bases 1 to 668)
  AUTHORS   Bradbury,L.E., Kansas,G.S., Levy,S., Evans,R.L. and Tedder,T.F.
  TITLE     The CD19/CD21 signal transducing complex of human B lymphocytes
            includes the target of antiproliferative antibody-1 and Leu-13
            molecules
  JOURNAL   J Immunol 149 (9), 2841-2850 (1992)
   PUBMED   1383329
REFERENCE   7  (bases 1 to 668)
  AUTHORS   Takahashi,S., Doss,C., Levy,S. and Levy,R.
  TITLE     TAPA-1, the target of an antiproliferative antibody, is associated
            on the cell surface with the Leu-13 antigen
  JOURNAL   J Immunol 145 (7), 2207-2213 (1990)
   PUBMED   2398277
REFERENCE   8  (bases 1 to 668)
  AUTHORS   Reid,L.E., Brasnett,A.H., Gilbert,C.S., Porter,A.C., Gewert,D.R.,
            Stark,G.R. and Kerr,I.M.
  TITLE     A single DNA response element can confer inducibility by both
            alpha- and gamma-interferons
  JOURNAL   Proc Natl Acad Sci U S A 86 (3), 840-844 (1989)
   PUBMED   2492664
REFERENCE   9  (bases 1 to 668)
  AUTHORS   Kelly,J.M., Gilbert,C.S., Stark,G.R. and Kerr,I.M.
  TITLE     Differential regulation of interferon-induced mRNAs and c-myc mRNA
            by alpha- and gamma-interferons
  JOURNAL   Eur J Biochem 153 (2), 367-371 (1985)
   PUBMED   3935435
REFERENCE   10 (bases 1 to 668)
  AUTHORS   Friedman,R.L., Manly,S.P., McMahon,M., Kerr,I.M. and Stark,G.R.
  TITLE     Transcriptional and posttranscriptional regulation of
            interferon-induced gene expression in human cells
  JOURNAL   Cell 38 (3), 745-755 (1984)
   PUBMED   6548414
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC136475.7.
            
            On May 21, 2020 this sequence version replaced NM_003641.4.
            
            Summary: Interferon-induced transmembrane (IFITM) proteins are a
            family of interferon induced antiviral proteins. The family
            contains five members, including IFITM1, IFITM2 and IFITM3 that
            belong to the CD225 superfamily. The protein encoded by this gene
            restricts cellular entry by diverse viral pathogens, such as
            influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq,
            Nov 2021].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU558290.1, BG534713.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000408968.4/ ENSP00000386187.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               AC136475.7         98584-98900
            318-668             AC136475.7         99466-99816
FEATURES             Location/Qualifiers
     source          1..668
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..668
                     /gene="IFITM1"
                     /gene_synonym="9-27; CD225; DSPA2a; IFI17; LEU13"
                     /note="interferon induced transmembrane protein 1"
                     /db_xref="GeneID:8519"
                     /db_xref="HGNC:HGNC:5412"
                     /db_xref="MIM:604456"
     exon            1..317
                     /gene="IFITM1"
                     /gene_synonym="9-27; CD225; DSPA2a; IFI17; LEU13"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..509
                     /gene="IFITM1"
                     /gene_synonym="9-27; CD225; DSPA2a; IFI17; LEU13"
                     /note="interferon-induced protein 17; leu-13 antigen;
                     interferon-inducible protein 9-27; dispanin subfamily A
                     member 2a"
                     /codon_start=1
                     /product="interferon-induced transmembrane protein 1"
                     /protein_id="NP_003632.4"
                     /db_xref="CCDS:CCDS41584.1"
                     /db_xref="GeneID:8519"
                     /db_xref="HGNC:HGNC:5412"
                     /db_xref="MIM:604456"
                     /translation="MHKEEHEVAVLGPPPSTILPRSTVINIHSETSVPDHVVWSLFNT
                     LFLNWCCLGFIAFAYSVKSRDRKMVGDVTGAQAYASTAKCLNIWALILGILMTIGFIL
                     LLVFGSVTVYHIMLQIIQEKRGY"
     exon            318..668
                     /gene="IFITM1"
                     /gene_synonym="9-27; CD225; DSPA2a; IFI17; LEU13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      647..652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFITM1"
                     /gene_synonym="9-27; CD225; DSPA2a; IFI17; LEU13"
                     /note="hexamer: AATAAA"
     polyA_site      668
                     /gene="IFITM1"
                     /gene_synonym="9-27; CD225; DSPA2a; IFI17; LEU13"
                     /note="major polyA site"
ORIGIN      
        1 gaaacgacag gggaaaggag gtctcactga gcaccgtccc agcatccgga caccacagcg
       61 gcccttcgct ccacgcagaa aaccacactt ctcaaacctt cactcaacac ttccttcccc
      121 aaagccagaa gatgcacaag gaggaacatg aggtggctgt gctggggcca ccccccagca
      181 ccatccttcc aaggtccacc gtgatcaaca tccacagcga gacctccgtg cccgaccatg
      241 tcgtctggtc cctgttcaac accctcttct tgaactggtg ctgtctgggc ttcatagcat
      301 tcgcctactc cgtgaagtct agggacagga agatggttgg cgacgtgacc ggggcccagg
      361 cctatgcctc caccgccaag tgcctgaaca tctgggccct gattctgggc atcctcatga
      421 ccattggatt catcctgtta ctggtattcg gctctgtgac agtctaccat attatgttac
      481 agataataca ggaaaaacgg ggttactagt agccgcccat agcctgcaac ctttgcactc
      541 cactgtgcaa tgctggccct gcacgctggg gctgttgccc ctgccccctt ggtcctgccc
      601 ctagatacag cagtttatac ccacacacct gtctacagtg tcattcaata aagtgcacgt
      661 gcttgtga
//
