LOCUS       NM_012420               4029 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens interferon induced protein with tetratricopeptide
            repeats 5 (IFIT5), mRNA.
ACCESSION   NM_012420
VERSION     NM_012420.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4029)
  AUTHORS   Jiang,Y., Zhang,C., Zhang,J., Han,D. and Shi,X.
  TITLE     Comprehensive analysis of the prognosis and biological significance
            for IFIT family in skin cutaneous melanoma
  JOURNAL   Int Immunopharmacol 101 (Pt A), 108344 (2021)
   PUBMED   34763233
  REMARK    GeneRIF: Comprehensive analysis of the prognosis and biological
            significance for IFIT family in skin cutaneous melanoma.
REFERENCE   2  (bases 1 to 4029)
  AUTHORS   Zhang,N., Shi,H., Yan,M. and Liu,G.
  TITLE     IFIT5 Negatively Regulates the Type I IFN Pathway by Disrupting
            TBK1-IKKepsilon-IRF3 Signalosome and Degrading IRF3 and IKKepsilon
  JOURNAL   J Immunol 206 (9), 2184-2197 (2021)
   PUBMED   33858962
  REMARK    GeneRIF: IFIT5 Negatively Regulates the Type I IFN Pathway by
            Disrupting TBK1-IKKepsilon-IRF3 Signalosome and Degrading IRF3 and
            IKKepsilon.
REFERENCE   3  (bases 1 to 4029)
  AUTHORS   Dobiezynska,A., Miszkiewicz,J., Darzynkiewicz,Z.M., Tyras,M.,
            Stankiewicz-Drogon,A., Trylska,J., Darzynkiewicz,E. and Grzela,R.
  TITLE     Development of bis-ANS-based modified fluorescence titration assay
            for IFIT/RNA studies
  JOURNAL   Biochem Biophys Res Commun 533 (3), 391-396 (2020)
   PUBMED   32962861
  REMARK    GeneRIF: Development of bis-ANS-based modified fluorescence
            titration assay for IFIT/RNA studies.
REFERENCE   4  (bases 1 to 4029)
  AUTHORS   Huang,J., Lo,U.G., Wu,S., Wang,B., Pong,R.C., Lai,C.H., Lin,H.,
            He,D., Hsieh,J.T. and Wu,K.
  TITLE     The roles and mechanism of IFIT5 in bladder cancer
            epithelial-mesenchymal transition and progression
  JOURNAL   Cell Death Dis 10 (6), 437 (2019)
   PUBMED   31164632
  REMARK    GeneRIF: Expression of interferon induced protein with
            tetratricopeptide repeats 5 (IFIT5) is positively correlated with
            pathological characteristics, and predicts a poor prognosis of
            bladder cancer patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4029)
  AUTHORS   Zheng,C., Zheng,Z., Zhang,Z., Meng,J., Liu,Y., Ke,X., Hu,Q. and
            Wang,H.
  TITLE     IFIT5 positively regulates NF-kappaB signaling through synergizing
            the recruitment of IkappaB kinase (IKK) to TGF-beta-activated
            kinase 1 (TAK1)
  JOURNAL   Cell Signal 27 (12), 2343-2354 (2015)
   PUBMED   26334375
  REMARK    GeneRIF: IFIT5 promotes SeV-induced IKK phosphorylation and
            NF-kappaB activation by regulating the recruitment of IKK to TAK1.
REFERENCE   6  (bases 1 to 4029)
  AUTHORS   Diamond,M.S. and Farzan,M.
  TITLE     The broad-spectrum antiviral functions of IFIT and IFITM proteins
  JOURNAL   Nat Rev Immunol 13 (1), 46-57 (2013)
   PUBMED   23237964
  REMARK    Review article
REFERENCE   7  (bases 1 to 4029)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (bases 1 to 4029)
  AUTHORS   Pichlmair,A., Lassnig,C., Eberle,C.A., Gorna,M.W., Baumann,C.L.,
            Burkard,T.R., Burckstummer,T., Stefanovic,A., Krieger,S.,
            Bennett,K.L., Rulicke,T., Weber,F., Colinge,J., Muller,M. and
            Superti-Furga,G.
  TITLE     IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA
  JOURNAL   Nat Immunol 12 (7), 624-630 (2011)
   PUBMED   21642987
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4029)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 4029)
  AUTHORS   Niikura,T., Hirata,R. and Weil,S.C.
  TITLE     A novel interferon-inducible gene expressed during myeloid
            differentiation
  JOURNAL   Blood Cells Mol Dis 23 (3), 337-349 (1997)
   PUBMED   9398535
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC392439.1 and AL353146.9.
            
            On Nov 22, 2018 this sequence version replaced NM_012420.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this transcript
            is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP264380.1, SRR1803611.8290.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371795.5/ ENSP00000360860.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-473               DC392439.1         1-473
            474-4029            AL353146.9         28581-32136
FEATURES             Location/Qualifiers
     source          1..4029
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     gene            1..4029
                     /gene="IFIT5"
                     /gene_synonym="ISG58; P58; RI58"
                     /note="interferon induced protein with tetratricopeptide
                     repeats 5"
                     /db_xref="GeneID:24138"
                     /db_xref="HGNC:HGNC:13328"
                     /db_xref="MIM:616135"
     exon            1..236
                     /gene="IFIT5"
                     /gene_synonym="ISG58; P58; RI58"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1680
                     /gene="IFIT5"
                     /gene_synonym="ISG58; P58; RI58"
                     /note="retinoic acid- and interferon-inducible protein
                     (58kD); IFIT-5; retinoic acid- and interferon-inducible 58
                     kDa protein; interferon-induced 58 kDa protein"
                     /codon_start=1
                     /product="interferon-induced protein with
                     tetratricopeptide repeats 5"
                     /protein_id="NP_036552.1"
                     /db_xref="CCDS:CCDS7403.1"
                     /db_xref="GeneID:24138"
                     /db_xref="HGNC:HGNC:13328"
                     /db_xref="MIM:616135"
                     /translation="MSEIRKDTLKAILLELECHFTWNLLKEDIDLFEVEDTIGQQLEF
                     LTTKSRLALYNLLAYVKHLKGQNKDALECLEQAEEIIQQEHSDKEEVRSLVTWGNYAW
                     VYYHMDQLEEAQKYTGKIGNVCKKLSSPSNYKLECPETDCEKGWALLKFGGKYYQKAK
                     AAFEKALEVEPDNPEFNIGYAITVYRLDDSDREGSVKSFSLGPLRKAVTLNPDNSYIK
                     VFLALKLQDVHAEAEGEKYIEEILDQISSQPYVLRYAAKFYRRKNSWNKALELLKKAL
                     EVTPTSSFLHHQMGLCYRAQMIQIKKATHNRPKGKDKLKVDELISSAIFHFKAAMERD
                     SMFAFAYTDLANMYAEGGQYSNAEDIFRKALRLENITDDHKHQIHYHYGRFQEFHRKS
                     ENTAIHHYLEALKVKDRSPLRTKLTSALKKLSTKRLCHNALDVQSLSALGFVYKLEGE
                     KRQAAEYYEKAQKIDPENAEFLTALCELRLSI"
     exon            237..4029
                     /gene="IFIT5"
                     /gene_synonym="ISG58; P58; RI58"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2956
                     /gene="IFIT5"
                     /gene_synonym="ISG58; P58; RI58"
                     /note="major polyA site"
     regulatory      4008..4013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFIT5"
                     /gene_synonym="ISG58; P58; RI58"
                     /note="hexamer: AATAAA"
     polyA_site      4029
                     /gene="IFIT5"
                     /gene_synonym="ISG58; P58; RI58"
                     /note="major polyA site"
ORIGIN      
        1 agtttctgag cgctcggcat ctgattcaat ctccagtttc ctgttcttgc tggggctggg
       61 gtctctcctt taacaaagac acgccgcgcg gccgagtcca ggggctgcag aggcctggcg
      121 cgcgcacgcg cacgcgcacg cccaccgcgc ggcttcccgc ggtccccggt gctgaggaga
      181 gagcgatccg agggactgcg ccgcccggac ggcctgcaga gcgctgccat catgagtgaa
      241 attcgtaagg acaccttgaa ggccattctg ttggagttag aatgtcattt tacatggaat
      301 ttacttaagg aagacattga tctgtttgag gtagaagata caattgggca acagcttgaa
      361 tttcttacca caaaatctag acttgctctt tataacctat tggcctatgt gaaacaccta
      421 aaaggccaaa ataaagacgc ccttgagtgc ttggaacaag cagaagaaat aatccagcaa
      481 gaacactcag acaaagaaga agtacgaagc ctggtcactt ggggaaacta tgcctgggtg
      541 tattatcaca tggaccagct tgaagaagct cagaagtata caggtaagat agggaatgtc
      601 tgtaagaaat tgtccagtcc ttctaactac aagttggagt gtcctgagac tgactgtgag
      661 aaaggctggg cactcttgaa atttggagga aagtattatc aaaaggctaa agcggctttt
      721 gagaaggctc tggaagtgga gcctgacaat ccagaattta acatcggcta tgctatcaca
      781 gtgtatcggc tggatgattc tgatagagaa gggtctgtaa agagcttttc tctggggcct
      841 ttgagaaagg ctgttaccct gaacccagat aacagctata ttaaggtttt tctggcactg
      901 aagcttcaag atgtacatgc agaagctgaa ggggaaaagt atattgaaga aatcctggac
      961 caaatatcat cccagcctta cgtccttcgt tatgcagcca agttctatag gagaaaaaat
     1021 tcctggaaca aagctctcga acttttaaaa aaggccttgg aggtgacacc aacttcttct
     1081 ttcctgcatc accagatggg actttgctac agggcacaaa tgatccaaat caagaaggcc
     1141 acacacaaca gacctaaagg aaaggataaa ctaaaggttg atgagctgat ttcatctgct
     1201 atatttcatt tcaaagcagc catggaacga gactctatgt ttgcatttgc ctacacagac
     1261 ctggccaaca tgtacgctga aggaggccag tatagcaatg ctgaggacat tttccggaaa
     1321 gctcttcgtc tggagaacat aaccgatgat cacaaacatc agatccatta ccactatggc
     1381 cgctttcagg aatttcaccg taaatcagaa aatactgcca tccatcatta tttagaagcc
     1441 ttaaaggtca aagacagatc accccttcgc accaaactga caagtgctct gaagaaattg
     1501 tctaccaaga gactttgtca caatgcttta gatgtgcaga gtttaagtgc cctagggttt
     1561 gtttacaagc tggaaggaga aaagaggcaa gctgctgagt actatgagaa ggcacaaaag
     1621 atagatccag aaaatgcaga attcctgact gctctctgtg agctccgact ttccatttaa
     1681 atacatactc taggaaatta gctctaagtt tttcccttca ttttgggttc tcctgtttgt
     1741 ttttttttta ttattttaat cccttgttta ttatagagct aatatttatt gaatagttat
     1801 tgtgtaccaa gcattgtgct aaatacttta tatgcattat gatgaatctt gtgcggtttt
     1861 ctttcttttt ttctttttaa ttaaaatact ataatccatt gagaaatagc aatattctag
     1921 ctattgtaac ttctaaaaat ggtatggcca ttagatctgt gctttttatc tctgctcttt
     1981 gaatttctca tattatatag taaatatatt cctacgtaaa cctttgatac ctagatcagg
     2041 aatactcttc caggagtaca aaattacatt attgatagtt aagctcttaa ttgtgtagct
     2101 tgcaaaagac agcacttttt agttacagat gttttgactt tgatgaggat atttagctat
     2161 caatctaata gtcacctaaa atatcttttt tgttggaaaa aagtttataa taaaaaagtt
     2221 tgtcatctct agtgacttca ataaagaaaa aactagaaga ggagaaaaag gatttcctca
     2281 aattttaaat atgtaacttc agggattcaa tccccaaatg tttattaagt agctagaaat
     2341 aattatgtgg aaaaaaatga ataatggaaa atagtgagtc tcaaattgtt ctcttttttt
     2401 ttttaactaa aacaaatctg caatgaatct agatgcaatt aattttattc cttccaacta
     2461 aaattacaat atttttaggt taaaattatt gagatataaa gcagccattg ggaaattggg
     2521 agaaatgata aacaaatgga aaaagaagat gtccctaacc tacacccata gattaccaag
     2581 gtttcagtgt actagttttg aatctgttct gaatggagtt tttataccct caatttctgg
     2641 cctttggcta ttttagcatt tcaaagtgac ttctatgaag cttttttttt aatgtgaaat
     2701 tttcagaatg ttgttttttt catgtagata ctccaggaag agttaagcac tgctttcagt
     2761 tttaatatcc accttgaggg gtcgctgctt gagggctctt atcccagggg actttttaat
     2821 tcggatgtta cttaatgtgg cttctctaat gtagtttctt tgattaccga ctacacaatt
     2881 atgtaccatc acagtattag tggaaaagta ccatgtgatt taattctcca ttcctccaat
     2941 gtaactctta aaattattat gtatgtgtgt gtgttttact ttttgttttt tatcatcttt
     3001 aaaatttcta ttatggtttg attattataa aaataatgaa ttctcactgt aaatttcaaa
     3061 aaaaaattac aaaagtatgt gaatttaaaa atgagagcag tcctctcacc ctaccacagt
     3121 tccacaccct caaggtaaac ttataactta taatttgata tgtaaacttc cagatctttt
     3181 ttctatgcgt aatcagacat acatatatac tgcagtgtat ctcacgtatt aatttttaaa
     3241 aatcttttgt tttacttaat tctgttttta ttattattat tattttgttt gatctattaa
     3301 ggaagaacaa ggaagggaat gatctttact caagaatttc agaaagtcag cactgaagtc
     3361 ctgacctatc agtagacaca tttgtccctt tcagatattt taggatattc tagcaaagca
     3421 ggccatttct cccacctgaa agtacataac ttctatcact tgccacataa ttaaaagaac
     3481 tcacattaag cggttactca gacagttaat catagaaaag attatttgct tcatcagttc
     3541 atagaaaaga ttatttgctt catcagttaa cttgttttta taaatcaggg ctgtgttcat
     3601 acacagaagg ggcctgagat ttctgcactt taaacaagct cctcctaggt gaggatgctg
     3661 tggctgttct aattacattt tgagtagtaa ggtctacagc attgttcctc aaacttggct
     3721 acgtattgga atcacctaaa aagttaaaac aaaacatgga tgtctgggtc ccgccccata
     3781 gagaatgact taattggcat ggggtgcagt ccaggcatca tgatttttag atttcccagt
     3841 tggaacttgt gcagcaaagt ttgggagcta ctgatggaca tgtgaaaagt aagtataaat
     3901 ggaataaaat taattaggct aataggctta acccaggaaa tcctaagttc cttgaatatc
     3961 cagtttgcat ttggactcct catcatatac ttggtatata atactctaat aaaagctgcc
     4021 tgagttgaa
//
