LOCUS       NM_001549               2390 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens interferon induced protein with tetratricopeptide
            repeats 3 (IFIT3), transcript variant 1, mRNA.
ACCESSION   NM_001549
VERSION     NM_001549.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2390)
  AUTHORS   Tanaka,Y., Imaizumi,T., Kobori,Y., Tachizaki,M., Shiratori,T.,
            Dobashi,M., Sato,M., Kawaguchi,S., Seya,K. and Tasaka,S.
  TITLE     Expression of ISG60 is induced by TLR3 signaling in BEAS-2B
            bronchial epithelial cells: Possible involvement in CXCL10
            expression
  JOURNAL   Mol Med Rep 30 (3) (2024)
   PUBMED   38963029
  REMARK    GeneRIF: Expression of ISG60 is induced by TLR3 signaling in
            BEAS-2B bronchial epithelial cells: Possible involvement in CXCL10
            expression.
REFERENCE   2  (bases 1 to 2390)
  AUTHORS   Hu,H., Li,B., Chen,H., Fan,G., Ye,Z., Ji,S., Yu,X., Xu,X. and
            Qin,Y.
  TITLE     NMI promotes tumor progression and gemcitabine resistance in
            pancreatic cancer via STAT3-IFIT3 axis
  JOURNAL   Mol Carcinog 63 (2), 195-208 (2024)
   PUBMED   37846815
  REMARK    GeneRIF: NMI promotes tumor progression and gemcitabine resistance
            in pancreatic cancer via STAT3-IFIT3 axis.
REFERENCE   3  (bases 1 to 2390)
  AUTHORS   Liu,P., Kong,X., Yi,S., Chen,Y. and Luo,W.
  TITLE     IFIT3 accelerates the progression of head and neck squamous cell
            carcinoma by targeting PD-L1 to activate PI3K/AKT signaling pathway
  JOURNAL   World J Surg Oncol 22 (1), 34 (2024)
   PUBMED   38273364
  REMARK    GeneRIF: IFIT3 accelerates the progression of head and neck
            squamous cell carcinoma by targeting PD-L1 to activate PI3K/AKT
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2390)
  AUTHORS   Chai,B., Li,Y., Guo,Y., Zhang,Z., Jia,K., Chai,X. and Suo,Y.
  TITLE     ETV7 promotes colorectal cancer progression through upregulation of
            IFIT3
  JOURNAL   Funct Integr Genomics 24 (1), 8 (2024)
   PUBMED   38200280
  REMARK    GeneRIF: ETV7 promotes colorectal cancer progression through
            upregulation of IFIT3.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2390)
  AUTHORS   Lu,Y.J., Deng,Y.T., Ko,H.H., Peng,H.H., Lee,H.C., Kuo,M.Y. and
            Cheng,S.J.
  TITLE     Lysyl oxidase-like 2 promotes stemness and enhances antitumor
            effects of gefitinib in head and neck cancer via IFIT1 and IFIT3
  JOURNAL   Cancer Sci 114 (10), 3957-3971 (2023)
   PUBMED   37496288
  REMARK    GeneRIF: Lysyl oxidase-like 2 promotes stemness and enhances
            antitumor effects of gefitinib in head and neck cancer via IFIT1
            and IFIT3.
REFERENCE   6  (bases 1 to 2390)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 2390)
  AUTHORS   Izmailova,E., Bertley,F.M., Huang,Q., Makori,N., Miller,C.J.,
            Young,R.A. and Aldovini,A.
  TITLE     HIV-1 Tat reprograms immature dendritic cells to express
            chemoattractants for activated T cells and macrophages
  JOURNAL   Nat Med 9 (2), 191-197 (2003)
   PUBMED   12539042
REFERENCE   8  (bases 1 to 2390)
  AUTHORS   de Veer,M.J., Sim,H., Whisstock,J.C., Devenish,R.J. and Ralph,S.J.
  TITLE     IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of
            interferon-stimulated genes
  JOURNAL   Genomics 54 (2), 267-277 (1998)
   PUBMED   9828129
REFERENCE   9  (bases 1 to 2390)
  AUTHORS   Zhu,H., Cong,J.P. and Shenk,T.
  TITLE     Use of differential display analysis to assess the effect of human
            cytomegalovirus infection on the accumulation of cellular RNAs:
            induction of interferon-responsive RNAs
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13985-13990 (1997)
   PUBMED   9391139
REFERENCE   10 (bases 1 to 2390)
  AUTHORS   Yu,M., Tong,J.H., Mao,M., Kan,L.X., Liu,M.M., Sun,Y.W., Fu,G.,
            Jing,Y.K., Yu,L., Lepaslier,D., Lanotte,M., Wang,Z.Y., Chen,Z.,
            Waxman,S., Wang,Y.X., Tan,J.Z. and Chen,S.J.
  TITLE     Cloning of a gene (RIG-G) associated with retinoic acid-induced
            differentiation of acute promyelocytic leukemia cells and
            representing a new member of a family of interferon-stimulated
            genes
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7406-7411 (1997)
   PUBMED   9207104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290427.1, AL353751.13 and BM790031.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001549.5.
            
            Transcript Variant: This variant (1) encodes isoform a. Variants 1
            and 2 both encode isoform a, using different start codons but
            encoding identical proteins.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.227443.1,
                                           SRR1660809.103323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371818.9/ ENSP00000360883.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1607              AK290427.1         89-1695
            1608-1983           AL353751.13        118729-119104
            1984-2390           BM790031.1         1-407
FEATURES             Location/Qualifiers
     source          1..2390
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     gene            1..2390
                     /gene="IFIT3"
                     /gene_synonym="CIG-49; cig41; GARG-49; IFI60; IFIT4; IRG2;
                     ISG60; P60; RIG-G"
                     /note="interferon induced protein with tetratricopeptide
                     repeats 3"
                     /db_xref="GeneID:3437"
                     /db_xref="HGNC:HGNC:5411"
                     /db_xref="MIM:604650"
     exon            1..82
                     /gene="IFIT3"
                     /gene_synonym="CIG-49; cig41; GARG-49; IFI60; IFIT4; IRG2;
                     ISG60; P60; RIG-G"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1550
                     /gene="IFIT3"
                     /gene_synonym="CIG-49; cig41; GARG-49; IFI60; IFIT4; IRG2;
                     ISG60; P60; RIG-G"
                     /note="isoform a is encoded by transcript variant 1;
                     interferon-induced protein with tetratricopeptide repeats
                     4; interferon-induced 60 kDa protein; CIG49; IFIT-3;
                     IFIT-4; ISG-60; IFI-60K; retinoic acid-induced gene G
                     protein"
                     /codon_start=1
                     /product="interferon-induced protein with
                     tetratricopeptide repeats 3 isoform a"
                     /protein_id="NP_001540.2"
                     /db_xref="CCDS:CCDS7402.1"
                     /db_xref="GeneID:3437"
                     /db_xref="HGNC:HGNC:5411"
                     /db_xref="MIM:604650"
                     /translation="MSEVTKNSLEKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEF
                     LNTEFKATMYNLLAYIKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAW
                     VYYHLGRLSDAQIYVDKVKQTCKKFSNPYSIEYSELDCEEGWTQLKCGRNERAKVCFE
                     KALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQ
                     KMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGY
                     LYHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLNPLNAYSD
                     LAEFLETECYQTPFNKEVPDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKS
                     TDKEEIKDQPQNVSENLLPQNAPNYWYLQGLIHKQNGDLLQAAKCYEKELGRLLRDAP
                     SGIGSIFLSASELEDGSEEMGQGAVSSSPRELLSNSEQLN"
     exon            83..2390
                     /gene="IFIT3"
                     /gene_synonym="CIG-49; cig41; GARG-49; IFI60; IFIT4; IRG2;
                     ISG60; P60; RIG-G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2363..2368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFIT3"
                     /gene_synonym="CIG-49; cig41; GARG-49; IFI60; IFIT4; IRG2;
                     ISG60; P60; RIG-G"
                     /note="hexamer: AATAAA"
     polyA_site      2390
                     /gene="IFIT3"
                     /gene_synonym="CIG-49; cig41; GARG-49; IFI60; IFIT4; IRG2;
                     ISG60; P60; RIG-G"
                     /note="major polyA site"
ORIGIN      
        1 gcagacagga agacttctga agaacaaatc agcctggtca ccagcttttc ggaacagcag
       61 agacacagag ggcagtcatg agtgaggtca ccaagaattc cctggagaaa atccttccac
      121 agctgaaatg ccatttcacc tggaacttat tcaaggaaga cagtgtctca agggatctag
      181 aagatagagt gtgtaaccag attgaatttt taaacactga gttcaaagct acaatgtaca
      241 acttgttggc ctacataaaa cacctagatg gtaacaacga ggcagccctg gaatgcttac
      301 ggcaagctga agagttaatc cagcaagaac atgctgacca agcagaaatc agaagtctag
      361 tcacttgggg aaactacgcc tgggtctact atcacttggg cagactctca gatgctcaga
      421 tttatgtaga taaggtgaaa caaacctgca agaaattttc aaatccatac agtattgagt
      481 attctgaact tgactgtgag gaagggtgga cacaactgaa gtgtggaaga aatgaaaggg
      541 cgaaggtgtg ttttgagaag gctctggaag aaaagcccaa caacccagaa ttctcctctg
      601 gactggcaat tgcgatgtac catctggata atcacccaga gaaacagttc tctactgatg
      661 ttttgaagca ggccattgag ctgagtcctg ataaccaata cgtcaaggtt ctcttgggcc
      721 tgaaactgca gaagatgaat aaagaagctg aaggagagca gtttgttgaa gaagccttgg
      781 aaaagtctcc ttgccaaaca gatgtcctcc gcagtgcagc caaattttac agaagaaaag
      841 gtgacctaga caaagctatt gaactgtttc aacgggtgtt ggaatccaca ccaaacaatg
      901 gctacctcta tcaccagatt gggtgctgct acaaggcaaa agtaagacaa atgcagaata
      961 caggagaatc tgaagctagt ggaaataaag agatgattga agcactaaag caatatgcta
     1021 tggactattc gaataaagct cttgagaagg gactgaatcc tctgaatgca tactccgatc
     1081 tcgctgagtt cctggagacg gaatgttatc agacaccatt caataaggaa gtccctgatg
     1141 ctgaaaagca acaatcccat cagcgctact gcaaccttca gaaatataat gggaagtctg
     1201 aagacactgc tgtgcaacat ggtttagagg gtttgtccat aagcaaaaaa tcaactgaca
     1261 aggaagagat caaagaccaa ccacagaatg tatctgaaaa tctgcttcca caaaatgcac
     1321 caaattattg gtatcttcaa ggattaattc ataagcagaa tggagatctg ctgcaagcag
     1381 ccaaatgtta tgagaaggaa ctgggccgcc tgctaaggga tgccccttca ggcataggca
     1441 gtattttcct gtcagcatct gagcttgagg atggtagtga ggaaatgggc cagggcgcag
     1501 tcagctccag tcccagagag ctcctctcta actcagagca actgaactga gacagaggag
     1561 gaaaacagag catcagaagc ctgcagtggt ggttgtgacg ggtaggacga taggaagaca
     1621 gggggcccca acctgggatt gctgagcagg gaagctttgc atgttgctct aaggtacatt
     1681 tttaaagagt tgttttttgg ccgggcgcag tggctcatgc ctgtaatccc agcactttgg
     1741 gaggccgagg tgggcggatc acgaggtctg gagtttgaga ccatcctggc taacacagtg
     1801 aaatcccgtc tctactaaaa atacaaaaaa ttagccaggc gtggtggctg gcacctgtag
     1861 tcccagctac ttgggaggct gaggcaggag aatggcgtga acctggaagg aagaggttgc
     1921 agtgagccaa gattgcgccc ctgcactcca gcctgggcaa cagagcaaga ctccatctca
     1981 aaaaaaaaaa aaaaaaaaaa aaagagttgt tttctcatgt tcattatagt tcattacagt
     2041 tacatagtcc gaaggtctta caactaatca ctggtagcaa taaatgcttc aggcccacat
     2101 gatgctgatt agttctcagt tttcattcag ttcacaatat aaccaccatt cctgccctcc
     2161 ctgccaaggg tcataaatgg tgactgccta acaacaaaat ttgcagtctc atctcatttt
     2221 catccagact tctggaactc aaagattaac ttttgactaa ccctggaata tctcttatct
     2281 cacttatagc ttcaggcatg tatttatatg tattcttgat agcaatacca taatcaatgt
     2341 gtattcctga tagtaatgct acaataaatc caaacatttc aactctgtta
//
