LOCUS       NM_001547               3393 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens interferon induced protein with tetratricopeptide
            repeats 2 (IFIT2), mRNA.
ACCESSION   NM_001547
VERSION     NM_001547.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3393)
  AUTHORS   Hu,J., Huang,X., Zheng,L., Zhang,Y., Zeng,H., Nie,L., Pang,X. and
            Zhang,H.
  TITLE     MiR-199a-5P promotes osteogenic differentiation of human stem cells
            from apical papilla via targeting IFIT2 in apical periodontitis
  JOURNAL   Front Immunol 14, 1149339 (2023)
   PUBMED   37063854
  REMARK    GeneRIF: MiR-199a-5P promotes osteogenic differentiation of human
            stem cells from apical papilla via targeting IFIT2 in apical
            periodontitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3393)
  AUTHORS   Chen,C., Tian,J., He,Z., Xiong,W., He,Y. and Liu,S.
  TITLE     Identified Three Interferon Induced Proteins as Novel Biomarkers of
            Human Ischemic Cardiomyopathy
  JOURNAL   Int J Mol Sci 22 (23), 13116 (2021)
   PUBMED   34884921
  REMARK    GeneRIF: Identified Three Interferon Induced Proteins as Novel
            Biomarkers of Human Ischemic Cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3393)
  AUTHORS   Jiang,Y., Zhang,C., Zhang,J., Han,D. and Shi,X.
  TITLE     Comprehensive analysis of the prognosis and biological significance
            for IFIT family in skin cutaneous melanoma
  JOURNAL   Int Immunopharmacol 101 (Pt A), 108344 (2021)
   PUBMED   34763233
  REMARK    GeneRIF: Comprehensive analysis of the prognosis and biological
            significance for IFIT family in skin cutaneous melanoma.
REFERENCE   4  (bases 1 to 3393)
  AUTHORS   Meng,X., Chen,Y., Macip,S. and Leppard,K.
  TITLE     PML-II regulates ERK and AKT signal activation and IFNalpha-induced
            cell death
  JOURNAL   Cell Commun Signal 19 (1), 70 (2021)
   PUBMED   34215258
  REMARK    GeneRIF: PML-II regulates ERK and AKT signal activation and
            IFNalpha-induced cell death.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3393)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3393)
  AUTHORS   Lafage,M., Clauss,I., Couez,D., Simonetti,J., Wathelet,M.G. and
            Huez,G.
  TITLE     The interferon- and virus-inducible IFI-56K and IFI-54K genes are
            located on human chromosome 10 at bands q23-q24
  JOURNAL   Genomics 13 (2), 458-460 (1992)
   PUBMED   1377167
REFERENCE   7  (bases 1 to 3393)
  AUTHORS   Wathelet,M.G., Szpirer,J., Nols,C.B., Clauss,I.M., De Wit,L.,
            Islam,M.Q., Levan,G., Horisberger,M.A., Content,J., Szpirer,C. et
            al.
  TITLE     Cloning and chromosomal location of human genes inducible by type I
            interferon
  JOURNAL   Somat Cell Mol Genet 14 (5), 415-426 (1988)
   PUBMED   3175763
REFERENCE   8  (bases 1 to 3393)
  AUTHORS   Wathelet,M.G., Clauss,I.M., Content,J. and Huez,G.A.
  TITLE     Regulation of two interferon-inducible human genes by interferon,
            poly(rI).poly(rC) and viruses
  JOURNAL   Eur J Biochem 174 (2), 323-329 (1988)
   PUBMED   2454816
REFERENCE   9  (bases 1 to 3393)
  AUTHORS   Wathelet,M.G., Clauss,I.M., Content,J. and Huez,G.A.
  TITLE     The IFI-56K and IFI-54K interferon-inducible human genes belong to
            the same gene family
  JOURNAL   FEBS Lett 231 (1), 164-171 (1988)
   PUBMED   3360121
REFERENCE   10 (bases 1 to 3393)
  AUTHORS   Ulker,N., Zhang,X. and Samuel,C.E.
  TITLE     Mechanism of interferon action. I. Characterization of a 54-kDa
            protein induced by gamma interferon with properties similar to a
            cytoskeletal component
  JOURNAL   J Biol Chem 262 (35), 16798-16803 (1987)
   PUBMED   3119591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC005987.1, EB387611.1, AA143609.1, AL353751.13 and AA765174.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001547.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.111580.1,
                                           SRR1803611.208246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371826.4/ ENSP00000360891.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-824               BC005987.1         1-824
            825-1133            EB387611.1         298-606
            1134-1300           AA143609.1         1-167               c
            1301-3177           AL353751.13        85722-87598
            3178-3393           AA765174.1         16-231              c
FEATURES             Location/Qualifiers
     source          1..3393
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     gene            1..3393
                     /gene="IFIT2"
                     /gene_synonym="cig42; G10P2; GARG-39; IFI-54; IFI-54K;
                     IFI54; IFIT-2; ISG-54; ISG-54 K; ISG-54K; ISG54; P54"
                     /note="interferon induced protein with tetratricopeptide
                     repeats 2"
                     /db_xref="GeneID:3433"
                     /db_xref="HGNC:HGNC:5409"
                     /db_xref="MIM:147040"
     exon            1..83
                     /gene="IFIT2"
                     /gene_synonym="cig42; G10P2; GARG-39; IFI-54; IFI-54K;
                     IFI54; IFIT-2; ISG-54; ISG-54 K; ISG-54K; ISG54; P54"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1497
                     /gene="IFIT2"
                     /gene_synonym="cig42; G10P2; GARG-39; IFI-54; IFI-54K;
                     IFI54; IFIT-2; ISG-54; ISG-54 K; ISG-54K; ISG54; P54"
                     /note="Interferon, alpha-inducible protein (MW 54kD);
                     interferon-induced protein 54; interferon-induced 54 kDa
                     protein"
                     /codon_start=1
                     /product="interferon-induced protein with
                     tetratricopeptide repeats 2"
                     /protein_id="NP_001538.4"
                     /db_xref="CCDS:CCDS41548.1"
                     /db_xref="GeneID:3433"
                     /db_xref="HGNC:HGNC:5409"
                     /db_xref="MIM:147040"
                     /translation="MSENNKNSLESSLRQLKCHFTWNLMEGENSLDDFEDKVFYRTEF
                     QNREFKATMCNLLAYLKHLKGQNEAALECLRKAEELIQQEHADQAEIRSLVTWGNYAW
                     VYYHMGRLSDVQIYVDKVKHVCEKFSSPYRIESPELDCEEGWTRLKCGGNQNERAKVC
                     FEKALEKKPKNPEFTSGLAIASYRLDNWPPSQNAIDPLRQAIRLNPDNQYLKVLLALK
                     LHKMREEGEEEGEGEKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEY
                     IPNNAYLHCQIGCCYRAKVFQVMNLRENGMYGKRKLLELIGHAVAHLKKADEANDNLF
                     RVCSILASLHALADQYEDAEYYFQKEFSKELTPVAKQLLHLRYGNFQLYQMKCEDKAI
                     HHFIEGVKINQKSREKEKMKDKLQKIAKMRLSKNGADSEALHVLAFLQELNEKMQQAD
                     EDSERGLESGSLIPSASSWNGE"
     exon            84..3393
                     /gene="IFIT2"
                     /gene_synonym="cig42; G10P2; GARG-39; IFI-54; IFI-54K;
                     IFI54; IFIT-2; ISG-54; ISG-54 K; ISG-54K; ISG54; P54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3016..3021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFIT2"
                     /gene_synonym="cig42; G10P2; GARG-39; IFI-54; IFI-54K;
                     IFI54; IFIT-2; ISG-54; ISG-54 K; ISG-54K; ISG54; P54"
                     /note="hexamer: AATAAA"
     polyA_site      3046
                     /gene="IFIT2"
                     /gene_synonym="cig42; G10P2; GARG-39; IFI-54; IFI-54K;
                     IFI54; IFIT-2; ISG-54; ISG-54 K; ISG-54K; ISG54; P54"
                     /note="major polyA site"
     regulatory      3374..3379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFIT2"
                     /gene_synonym="cig42; G10P2; GARG-39; IFI-54; IFI-54K;
                     IFI54; IFIT-2; ISG-54; ISG-54 K; ISG-54K; ISG54; P54"
                     /note="hexamer: AATAAA"
     polyA_site      3393
                     /gene="IFIT2"
                     /gene_synonym="cig42; G10P2; GARG-39; IFI-54; IFI-54K;
                     IFI54; IFIT-2; ISG-54; ISG-54 K; ISG-54K; ISG54; P54"
ORIGIN      
        1 ggcagaagag gaagatttct gaagagtgca gctgcctgaa ccgagccctg ccgaacagct
       61 gagaattgca ctgcaaccat gagtgagaac aataagaatt ccttggagag cagcctacgg
      121 caactaaaat gccatttcac ctggaacttg atggagggag aaaactcctt ggatgatttt
      181 gaagacaaag tattttaccg gactgagttt cagaatcgtg aattcaaagc cacaatgtgc
      241 aacctactgg cctatctaaa gcacctcaaa gggcaaaacg aggcagccct ggaatgctta
      301 cgtaaagctg aagagttaat ccagcaagag catgctgacc aggcagaaat cagaagtctg
      361 gtcacctggg gaaactatgc ctgggtctac tatcacatgg gccgactctc agacgttcag
      421 atttatgtag acaaggtgaa acatgtctgt gagaagtttt ccagtcccta tagaattgag
      481 agtccagagc ttgactgtga ggaagggtgg acacggttaa agtgtggagg aaaccaaaat
      541 gaaagagcga aggtgtgctt tgagaaggct ctggaaaaga agccaaagaa cccagaattc
      601 acctctggac tggcaatagc aagctaccgt ctggacaact ggccaccatc tcagaacgcc
      661 attgaccctc tgaggcaagc cattcggctg aatcctgaca accagtacct taaagtcctc
      721 ctggctctga agcttcataa gatgcgtgaa gaaggtgaag aggaaggtga aggagagaag
      781 ttagttgaag aagccttgga gaaagcccca ggtgtaacag atgttcttcg cagtgcagcc
      841 aagttttatc gaagaaaaga tgagccagac aaagcgattg aactgcttaa aaaggcttta
      901 gaatacatac caaacaatgc ctacctgcat tgccaaattg ggtgctgcta tagggcaaaa
      961 gtcttccaag taatgaatct aagagagaat ggaatgtatg ggaaaagaaa gttactggaa
     1021 ctaataggac acgctgtggc tcatctgaag aaagctgatg aggccaatga taatctcttc
     1081 cgtgtctgtt ccattcttgc cagcctccat gctctagcag atcagtatga agacgcagag
     1141 tattacttcc aaaaggaatt cagtaaagag cttactcctg tagcgaaaca actgctccat
     1201 ctgcggtatg gcaactttca gctgtaccaa atgaagtgtg aagacaaggc catccaccac
     1261 tttatagagg gtgtaaaaat aaaccagaaa tcaagggaga aagaaaagat gaaagacaaa
     1321 ctgcaaaaaa ttgccaaaat gcgactttct aaaaatggag cagattctga ggctttgcat
     1381 gtcttggcat tccttcagga gctgaatgaa aaaatgcaac aagcagatga agactctgag
     1441 aggggtttgg agtctggaag cctcatccct tcagcatcaa gctggaatgg ggaatgaaga
     1501 atagagatgt ggtgcccact aggctactgc tgaaagggag ctgaaattcc tccaccaagt
     1561 tggtattcaa aatatgtaat gactggtatg gcaaaagatt ggactaagac actggccata
     1621 ccactggaca gggttatgtt aacacctgaa ttgctgggtc ttgagagagc ccaaggagtt
     1681 ctgggagagg gaccagattg gggggtaggt ccacgggctt ggtgatagaa ttatttctcg
     1741 attgacttct tgagtgcaat ttgaactgta acatttgctt agtcaccttt agtggagtaa
     1801 tctactgggc ttgtttctat atttatataa agcagccaaa tccttcatgt aatattgaag
     1861 tccatttttg caatgttgtt ccatacttgg agtcattttg catcccatag aggttagtcc
     1921 tgcatagcca gtaatgtgct aagttcatcc aaaagctggc ggaccaaagt ctaaataggg
     1981 ctcagtatcc cccatcgctt atctctgcct ccttcctcct ccttcccagt ctatcatcaa
     2041 ccttgagtat tctacacaat gtgaattcaa gtgcctgatt aattgaggtg gcaacatagt
     2101 ttgagacgag ggcagagaac aggaagatac atagctagaa gcgacgggta caaaaagcaa
     2161 tgtgtacaag aagactttca gcaagtatac agagagttca cctctactct gccctcctca
     2221 tagtcataat gtagcaagta aagaatgaga atggattctg tacaatacac tagaaaccaa
     2281 cataatgtat ttctttaaaa cctgtgtgaa aaaataaatg ttccaccagt agggataggg
     2341 gaaaagtaac caaaagagag aaagagaaag gaatgctggt ttatctttgt agattgtaat
     2401 cgaatggaga aatttgcagt attttagcca ctattaggaa tttttttttt ttgtaaaatg
     2461 aagactgaac tctgttcaaa tgctttcatg aacctggttt gagacggtag gaaagcaaca
     2521 aaacgtggga acctggtgac taagggcctg gtgcaaggac ttgggaaatg tcattgataa
     2581 tagatggtgg ggttttcccc cctttagaaa tgttggatat taagtgatat aaacacttct
     2641 tttaactccg aaaatcttct gagaaatcac aaaattcacg gtatgcttgg aacgattgag
     2701 attttctagg tagatgctga atagcctaga catcaaagtt ggtgtgaacc aaaatagagt
     2761 cagctgaccc agcatcagcc acactctggg ttggaaaatg tttgcctgtt ggaattaatt
     2821 taagcttaag tatatatcaa cattatttta ttgtgcaatt aaaacaatac aaattcatgg
     2881 ttttttaaag ttaaaaattc taaccactgt aacaacagtt tttgtgttat tttctgtatt
     2941 aaacatcttg ttgcacgcat ttgaggtcat cagggtgcaa aatttgtatt cctgaaaatg
     3001 tcatatattt tcattaataa ataacctaaa tatgataaaa cataaagcag tgttctggtt
     3061 catctggaat tttgctgtac tttaaatctt tcagactcag ctactgataa atgaaacgtt
     3121 acacaggtgt gaaccaaatc caaataacct cgactggtct actatcataa tcacctgaac
     3181 agaacaaaac tttttcctca gctttaagag tccagggctt cggataacag ctgccatctg
     3241 ccacctgcta ccattgacct acgtgaacac agacattctg tctccacctt gatggtgggt
     3301 gggctgctcc ccttttcttt gttaaatttt gtgctttcat cacattttct ctattctgac
     3361 ctctgttatg agaaataaaa gtcactgatt cca
//
