LOCUS       NM_001010987            1972 bp    mRNA    linear   PRI 03-JUN-2024
DEFINITION  Homo sapiens interferon induced protein with tetratricopeptide
            repeats 1B (IFIT1B), mRNA.
ACCESSION   NM_001010987 XM_495843
VERSION     NM_001010987.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1972)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1972)
  AUTHORS   Diamond,M.S. and Farzan,M.
  TITLE     The broad-spectrum antiviral functions of IFIT and IFITM proteins
  JOURNAL   Nat Rev Immunol 13 (1), 46-57 (2013)
   PUBMED   23237964
  REMARK    Review article
REFERENCE   3  (bases 1 to 1972)
  AUTHORS   Pichlmair,A., Lassnig,C., Eberle,C.A., Gorna,M.W., Baumann,C.L.,
            Burkard,T.R., Burckstummer,T., Stefanovic,A., Krieger,S.,
            Bennett,K.L., Rulicke,T., Weber,F., Colinge,J., Muller,M. and
            Superti-Furga,G.
  TITLE     IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA
  JOURNAL   Nat Immunol 12 (7), 624-630 (2011)
   PUBMED   21642987
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1972)
  AUTHORS   Wathelet,M.G., Szpirer,J., Nols,C.B., Clauss,I.M., De Wit,L.,
            Islam,M.Q., Levan,G., Horisberger,M.A., Content,J., Szpirer,C. et
            al.
  TITLE     Cloning and chromosomal location of human genes inducible by type I
            interferon
  JOURNAL   Somat Cell Mol Genet 14 (5), 415-426 (1988)
   PUBMED   3175763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353751.13.
            
            On May 7, 2010 this sequence version replaced NM_001010987.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647300.1, BC137368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004, SAMEA2149398
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371809.3/ ENSP00000360874.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AL353751.13        156599-156683
            86-1972             AL353751.13        161862-163748
FEATURES             Location/Qualifiers
     source          1..1972
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     gene            1..1972
                     /gene="IFIT1B"
                     /gene_synonym="bA149I23.6; IFIT1L"
                     /note="interferon induced protein with tetratricopeptide
                     repeats 1B"
                     /db_xref="GeneID:439996"
                     /db_xref="HGNC:HGNC:23442"
     exon            1..85
                     /gene="IFIT1B"
                     /gene_synonym="bA149I23.6; IFIT1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1505
                     /gene="IFIT1B"
                     /gene_synonym="bA149I23.6; IFIT1L"
                     /note="interferon-induced protein with tetratricopeptide
                     repeats 1-like protein"
                     /codon_start=1
                     /product="interferon-induced protein with
                     tetratricopeptide repeats 1B"
                     /protein_id="NP_001010987.1"
                     /db_xref="CCDS:CCDS31242.1"
                     /db_xref="GeneID:439996"
                     /db_xref="HGNC:HGNC:23442"
                     /translation="MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQ
                     FLDTKYNVGIHNLLAYVKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFA
                     WVYYHMGRLAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERA
                     KTCFEKALEGNPENPEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVY
                     IRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKM
                     ALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDRLVQLAICKFEKTIM
                     LKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHG
                     KSQDKAITHYLKGLKIEKMSHSREKLLNALEKLAKRCIHQNVRVVESVSLLGLIHKLK
                     GEVSDALLCYERALRLAADLNPIF"
     exon            86..1972
                     /gene="IFIT1B"
                     /gene_synonym="bA149I23.6; IFIT1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1950..1955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFIT1B"
                     /gene_synonym="bA149I23.6; IFIT1L"
                     /note="hexamer: AATAAA"
     polyA_site      1972
                     /gene="IFIT1B"
                     /gene_synonym="bA149I23.6; IFIT1L"
                     /note="major polyA site"
ORIGIN      
        1 agaactctgt ggatgaacct tgaaggagcc tccaagcctg aaccaaagca ctacagatca
       61 cctgctatct tcatagcacc atgagtgaag aatctgatgg aaagcttatt gaagacagcc
      121 tgattcagct gagatgtcac tttacatgga agttgttaat tgaagcccct gaaattcctg
      181 atttagaaaa caggatctgg gaagagattc agttcctgga caccaaatac aatgtgggaa
      241 tacacaacct actagcctat gtgaaacacc tgaaaggcca gaatgaggaa gccctggtca
      301 gcttgaaaaa ggctgaagac ttaattcaga aagaacatgc caaccaagca gatattagaa
      361 gtctggtgac ctggggcaac tttgcctggg tgtattacca catgggcaga ttggcagaag
      421 cccagactta cctggacaag gtggagaaca cttgcaagaa gtttgcaaat ccttcccgct
      481 atagaatgga gtgtccagag gtggactgtg aggaaggatg ggccttggcg aagtgtggtg
      541 gaaagaatta tgaacgggcc aagacctgct ttgaaaaggc tctggaaggg aaccctgaaa
      601 accctgaatt caatactggg tacgcaatca ccgtctatcg cctggataaa tttaacacag
      661 catcagggag gaataaggca ttttctctgc acgtcctaaa acgagctgtc aggctaaatc
      721 cagatgatgt atatattagg gttctccttg ccctgaagct tcaggatgaa ggacaggaag
      781 ctgaaggaga aaagtacatt gaagaagctc tgaccagtat atcttcacag gcctatgtct
      841 ttcaatatgc agccaagttt tatcgaagaa aagggtctgt ggataaagct cttgagctct
      901 taaaaatggc cttggagaca acacccactt ctgccttcct gcatcaccaa atggggcttt
      961 gctacagggc acaaatgatc caaatcaagg aagctacaaa ctggcagcct agagggcaag
     1021 atagggaaac tgtggacaga ttggttcaat tggctatatg caaatttgaa aagactataa
     1081 tgttaaagcg aacatttgag atggcctatg ttgacctggc tgaaacgtat gcagaaatag
     1141 gccaccacag aaaggctgag gaacattttc agaaagggtt acgcatgaag atctttgaag
     1201 atcagctaaa gcaagagatt cattaccact acggccgttt ccaagaacat catgggaaat
     1261 ctcaagataa agcaattacc cattatttaa aaggtttgaa aatagaaaaa atgtcccatt
     1321 ccagggaaaa acttctcaat gctttagaga aattggctaa aagatgtatt caccagaatg
     1381 tacgggttgt ggaaagtgtc agcctccttg ggcttatcca caaattgaaa ggagaagtaa
     1441 gtgatgcttt gctgtgctat gagagggctc tgaggctggc tgctgacctg aaccctatat
     1501 tttaacatag aggtcaccat tatccattta atggtcttat aactaaatag aatgactatg
     1561 aaattaaata atgcaaactt aaagctgttg gaaatttacc ttattttgag ccttgagagg
     1621 aatgtggctg tgtggcctga gttatgtagc atgcaactgc aacttctgct ttttcctgta
     1681 aatgatcagg aaaggccttg tggcaccaga cataagaccc cctgaaagta tcatccctcc
     1741 tgatggaatg gtaaagcaat ctttcttgga acatagcaag tagtaaccga tcaaattgct
     1801 ataacgtgtg tactgacctt atgtggaaaa tgctgcaacc ctgtttactg cctatgtaag
     1861 tgaaatctta acttccccat tttggaatgc tgactccagt cattaggtgt ctgtatttcc
     1921 tgagtggtta ccctcaagct ttgtgctcaa ataaactcta tacttaatca ta
//
