LOCUS       NM_001548               4302 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens interferon induced protein with tetratricopeptide
            repeats 1 (IFIT1), transcript variant 1, mRNA.
ACCESSION   NM_001548 NM_001001887 XM_498423 XM_499551
VERSION     NM_001548.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4302)
  AUTHORS   Ishibashi,H.K., Nakamura,Y., Saruga,T., Imaizumi,T., Kurose,A.,
            Kawaguchi,S., Seya,K., Sasaki,E. and Ishibashi,Y.
  TITLE     TLR3 signaling-induced interferon-stimulated gene 56 plays a role
            in the pathogenesis of rheumatoid arthritis
  JOURNAL   Exp Biol Med (Maywood) 249, 10122 (2024)
   PUBMED   38881847
  REMARK    GeneRIF: TLR3 signaling-induced interferon-stimulated gene 56 plays
            a role in the pathogenesis of rheumatoid arthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4302)
  AUTHORS   Fensterl,V. and Sen,G.C.
  TITLE     The ISG56/IFIT1 gene family
  JOURNAL   J Interferon Cytokine Res 31 (1), 71-78 (2011)
   PUBMED   20950130
  REMARK    Review article
REFERENCE   3  (bases 1 to 4302)
  AUTHORS   Rebouillat,D., Marie,I. and Hovanessian,A.G.
  TITLE     Molecular cloning and characterization of two related and
            interferon-induced 56-kDa and 30-kDa proteins highly similar to
            2'-5' oligoadenylate synthetase
  JOURNAL   Eur J Biochem 257 (2), 319-330 (1998)
   PUBMED   9826176
REFERENCE   4  (bases 1 to 4302)
  AUTHORS   Lafage,M., Clauss,I., Couez,D., Simonetti,J., Wathelet,M.G. and
            Huez,G.
  TITLE     The interferon- and virus-inducible IFI-56K and IFI-54K genes are
            located on human chromosome 10 at bands q23-q24
  JOURNAL   Genomics 13 (2), 458-460 (1992)
   PUBMED   1377167
REFERENCE   5  (bases 1 to 4302)
  AUTHORS   Wathelet,M.G., Szpirer,J., Nols,C.B., Clauss,I.M., De Wit,L.,
            Islam,M.Q., Levan,G., Horisberger,M.A., Content,J., Szpirer,C. et
            al.
  TITLE     Cloning and chromosomal location of human genes inducible by type I
            interferon
  JOURNAL   Somat Cell Mol Genet 14 (5), 415-426 (1988)
   PUBMED   3175763
REFERENCE   6  (bases 1 to 4302)
  AUTHORS   Wathelet,M.G., Clauss,I.M., Content,J. and Huez,G.A.
  TITLE     The IFI-56K and IFI-54K interferon-inducible human genes belong to
            the same gene family
  JOURNAL   FEBS Lett 231 (1), 164-171 (1988)
   PUBMED   3360121
REFERENCE   7  (bases 1 to 4302)
  AUTHORS   Wathelet,M.G., Clauss,I.M., Nols,C.B., Content,J. and Huez,G.A.
  TITLE     New inducers revealed by the promoter sequence analysis of two
            interferon-activated human genes
  JOURNAL   Eur J Biochem 169 (2), 313-321 (1987)
   PUBMED   3121313
REFERENCE   8  (bases 1 to 4302)
  AUTHORS   Kusari,J., Szabo,P., Grzeschik,K.H. and Sen,G.C.
  TITLE     Chromosomal localization of the interferon-inducible human gene
            encoding mRNA 561
  JOURNAL   J Interferon Res 7 (1), 53-59 (1987)
   PUBMED   3585080
REFERENCE   9  (bases 1 to 4302)
  AUTHORS   Wathelet,M., Moutschen,S., Defilippi,P., Cravador,A., Collet,M.,
            Huez,G. and Content,J.
  TITLE     Molecular cloning, full-length sequence and preliminary
            characterization of a 56-kDa protein induced by human interferons
  JOURNAL   Eur J Biochem 155 (1), 11-17 (1986)
   PUBMED   3753936
REFERENCE   10 (bases 1 to 4302)
  AUTHORS   Chebath,J., Merlin,G., Metz,R., Benech,P. and Revel,M.
  TITLE     Interferon-induced 56,000 Mr protein and its mRNA in human cells:
            molecular cloning and partial sequence of the cDNA
  JOURNAL   Nucleic Acids Res 11 (5), 1213-1226 (1983)
   PUBMED   6186990
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314588.1, AL353146.9 and
            BU625391.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001548.4.
            
            Summary: This gene encodes a protein containing tetratricopeptide
            repeats that was originally identified as induced upon treatment
            with interferon. The encoded protein may inhibit viral replication
            and translational initiation. This gene is located in a cluster on
            chromosome 10 with five other closely related genes. There is a
            pseudogene for this gene on chromosome 13. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed.
            [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.62557.1,
                                           SRR1803614.209879.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371804.4/ ENSP00000360869.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-554               AK314588.1         1-554
            555-3605            AL353146.9         13879-16929
            3606-4302           BU625391.1         18-714              c
FEATURES             Location/Qualifiers
     source          1..4302
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     gene            1..4302
                     /gene="IFIT1"
                     /gene_synonym="C56; G10P1; IFI-56; IFI-56K; IFI56; IFIT-1;
                     IFNAI1; ISG56; P56; RNM561"
                     /note="interferon induced protein with tetratricopeptide
                     repeats 1"
                     /db_xref="GeneID:3434"
                     /db_xref="HGNC:HGNC:5407"
                     /db_xref="MIM:147690"
     exon            1..95
                     /gene="IFIT1"
                     /gene_synonym="C56; G10P1; IFI-56; IFI-56K; IFI56; IFIT-1;
                     IFNAI1; ISG56; P56; RNM561"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1527
                     /gene="IFIT1"
                     /gene_synonym="C56; G10P1; IFI-56; IFI-56K; IFI56; IFIT-1;
                     IFNAI1; ISG56; P56; RNM561"
                     /note="isoform 1 is encoded by transcript variant 1;
                     interferon-induced 56 kDa protein; interferon,
                     alpha-inducible protein (MW 56kD); interferon-inducible
                     mRNA 561"
                     /codon_start=1
                     /product="interferon-induced protein with
                     tetratricopeptide repeats 1 isoform 1"
                     /protein_id="NP_001539.3"
                     /db_xref="CCDS:CCDS31243.1"
                     /db_xref="GeneID:3434"
                     /db_xref="HGNC:HGNC:5407"
                     /db_xref="MIM:147690"
                     /translation="MSTNGDDHQVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIE
                     FLDTKYSVGIHNLLAYVKHLKGQNEEALKSLKEAENLMQEEHDNQANVRSLVTWGNFA
                     WMYYHMGRLAEAQTYLDKVENICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERA
                     KACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNHKPFSLLPLRQAVRLNPDNGY
                     IKVLLALKLQDEGQEAEGEKYIEEALANMSSQTYVFRYAAKFYRRKGSVDKALELLKK
                     ALQETPTSVLLHHQIGLCYKAQMIQIKEATKGQPRGQNREKLDKMIRSAIFHFESAVE
                     KKPTFEVAHLDLARMYIEAGNHRKAEENFQKLLCMKPVVEETMQDIHFHYGRFQEFQK
                     KSDVNAIIHYLKAIKIEQASLTRDKSINSLKKLVLRKLRRKALDLESLSLLGFVYKLE
                     GNMNEALEYYERALRLAADFENSVRQGP"
     exon            96..4302
                     /gene="IFIT1"
                     /gene_synonym="C56; G10P1; IFI-56; IFI-56K; IFI56; IFIT-1;
                     IFNAI1; ISG56; P56; RNM561"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1779..1784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFIT1"
                     /gene_synonym="C56; G10P1; IFI-56; IFI-56K; IFI56; IFIT-1;
                     IFNAI1; ISG56; P56; RNM561"
                     /note="hexamer: AATAAA"
     polyA_site      1798
                     /gene="IFIT1"
                     /gene_synonym="C56; G10P1; IFI-56; IFI-56K; IFI56; IFIT-1;
                     IFNAI1; ISG56; P56; RNM561"
                     /note="major polyA site"
     regulatory      1836..1841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFIT1"
                     /gene_synonym="C56; G10P1; IFI-56; IFI-56K; IFI56; IFIT-1;
                     IFNAI1; ISG56; P56; RNM561"
                     /note="hexamer: AATAAA"
     polyA_site      1857
                     /gene="IFIT1"
                     /gene_synonym="C56; G10P1; IFI-56; IFI-56K; IFI56; IFIT-1;
                     IFNAI1; ISG56; P56; RNM561"
     regulatory      4282..4287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFIT1"
                     /gene_synonym="C56; G10P1; IFI-56; IFI-56K; IFI56; IFIT-1;
                     IFNAI1; ISG56; P56; RNM561"
                     /note="hexamer: AATAAA"
     polyA_site      4302
                     /gene="IFIT1"
                     /gene_synonym="C56; G10P1; IFI-56; IFI-56K; IFI56; IFIT-1;
                     IFNAI1; ISG56; P56; RNM561"
ORIGIN      
        1 aactgaaaat ccacaagaca gaatagccag atctcagagg agcctggcta agcaaaaccc
       61 tgcagaacgg ctgcctaatt tacagcaacc atgagtacaa atggtgatga tcatcaggtc
      121 aaggatagtc tggagcaatt gagatgtcac tttacatggg agttatccat tgatgacgat
      181 gaaatgcctg atttagaaaa cagagtcttg gatcagattg aattcctaga caccaaatac
      241 agtgtgggaa tacacaacct actagcctat gtgaaacacc tgaaaggcca gaatgaggaa
      301 gccctgaaga gcttaaaaga agctgaaaac ttaatgcagg aagaacatga caaccaagca
      361 aatgtgagga gtctggtgac ctggggcaac tttgcctgga tgtattacca catgggcaga
      421 ctggcagaag cccagactta cctggacaag gtggagaaca tttgcaagaa gctttcaaat
      481 cccttccgct atagaatgga gtgtccagaa atagactgtg aggaaggatg ggccttgctg
      541 aagtgtggag gaaaaaatta tgaacgggcc aaggcctgct ttgaaaaggt gcttgaagtg
      601 gaccctgaaa accctgaatc cagcgctggg tatgcgatct ctgcctatcg cctggatggc
      661 tttaaattag ccacaaaaaa tcacaagcca ttttctttgc ttcccctaag gcaggctgtc
      721 cgcttaaatc cagacaatgg atatattaag gttctccttg ccctgaagct tcaggatgaa
      781 ggacaggaag ctgaaggaga aaagtacatt gaagaagctc tagccaacat gtcctcacag
      841 acctatgtct ttcgatatgc agccaagttt taccgaagaa aaggctctgt ggataaagct
      901 cttgagttat taaaaaaggc cttgcaggaa acacccactt ctgtcttact gcatcaccag
      961 atagggcttt gctacaaggc acaaatgatc caaatcaagg aggctacaaa agggcagcct
     1021 agagggcaga acagagaaaa gctagacaaa atgataagat cagccatatt tcattttgaa
     1081 tctgcagtgg aaaaaaagcc cacatttgag gtggctcatc tagacctggc aagaatgtat
     1141 atagaagcag gcaatcacag aaaagctgaa gagaattttc aaaaattgtt atgcatgaaa
     1201 ccagtggtag aagaaacaat gcaagacata catttccact atggtcggtt tcaggaattt
     1261 caaaagaaat ctgacgtcaa tgcaattatc cattatttaa aagctataaa aatagaacag
     1321 gcatcattaa caagggataa aagtatcaat tctttgaaga aattggtttt aaggaaactt
     1381 cggagaaagg cattagatct ggaaagcttg agcctccttg ggttcgtcta caaattggaa
     1441 ggaaatatga atgaagccct ggagtactat gagcgggccc tgagactggc tgctgacttt
     1501 gagaactctg tgagacaagg tccttaggca cccagatatc agccactttc acatttcatt
     1561 tcattttatg ctaacattta ctaatcatct tttctgctta ctgttttcag aaacattata
     1621 attcactgta atgatgtaat tcttgaataa taaatctgac aaaatattag ttgtgttcaa
     1681 caattagtga aacagaatgt gtgtatgcat gtaagaaaga gaaatcattt gtatgagtgc
     1741 tatgtagtag agaaaaaatg ttagttaact ttgtaggaaa taaaacattg gacttacact
     1801 aaatgtttaa ttcattcatt ttattgtgaa ataaaaataa aatccttagc tcctccacca
     1861 actgaacaga ccctcttggc caaggagacc ccagaaacct taaaaactaa gtttcccaac
     1921 catgacaaga tgagagatca ttcacacctc attatattcc ctcccttgct aactgccatt
     1981 ggactttttc cactgagtta aacagaaacc catggaaaac aaagaacaga agactcactc
     2041 cttggctgac ttcacctagc tcactccacg tagcgccaca gccagactcc cctcccctct
     2101 tgcggtttcc acatgacaac tgatcagcct tccctcctga taagtgacca ctgcccacag
     2161 actggttctg gccagtccat ggaggctgca cacagggtgc ctctatgtcc tttgtttcac
     2221 cttttgatat agaaaggcta attttgctgt attttaatgt taagtctcca ccacagagtg
     2281 aacacagaat gcatgtgaca tacatgttta cataccacta ttgtgtgact gcccctcatg
     2341 aatattcata gccccccata acctgttaac tatgtgtgtc tagccaatcc accaaccata
     2401 aaacttctgt aataccctcc cttcctccaa gagcctgctt ttggttgctg tggtaggctc
     2461 tgcttcccag gctgcaggtt gcaggagagg aggctgcagt ggctcacgcc tgtaatctca
     2521 gcacttcgat gggacgaggc aggcagatca cctgaaccca ggagttcgag agcagccttg
     2581 gcaatggcaa aaccaaccgt ctctacaaaa aatgcaaaaa cttagctggg tgtggtggca
     2641 tgcacctgta gcttcagttc cagctactca ggaggctgag gtgagtggac tgctggagcc
     2701 agggagttcg aggctgcagt gtcgagatct tgccactgca ctccattctg gatgatagaa
     2761 cgagacccca tctcaaaaaa aaaaaaagtt ctctccaatt gtatatagct tgtgatttta
     2821 tgtcaacact atcaataaat agctttcagt gcaagaaacc aaaaatactg taataaacag
     2881 gcacatattc ttcccaaacc tcatgcagtt tacaatctag tgagagacac agatagcagt
     2941 acagagtcaa ttaaaggtta gttttcttca tgaagatgtt ttaattttaa ttcaatgtga
     3001 aagggttcca aggagtttat cttgttttat gccattttat ttgaagcact acttactaag
     3061 tcatttgctg atattaatct agttaaatca agaaatatta catgaaaatg ttgctaaatc
     3121 agagatcatg ggtaacaatc acctttgatt atgaataatc atattttatt gaaaggcaag
     3181 gcacaacaaa taataagaag gaaaaaataa ataagcaatg ttattgatct ttcattctgt
     3241 atatgttttg gggggaatat actagtttct tttagtggct gtaacaaatt accacaaact
     3301 tggtgactta aaatttcaca gatttactct ttcttacagt tctggaggtc agaagtctga
     3361 aatgggtttc aatgagccaa agtcaaggta ttgatgacgc tacactcctc cggaggctct
     3421 aggcagatag ccttttccag cttccagagg ctgcctgaat tctttcatcc atcttaaaaa
     3481 ccaacagtgt agtagcctca aatctctctc tctgcttcct tcttcacatc tccttctctc
     3541 ctctgactct tttgcctctt tcttctaagg acgcaccagg tccacctgca taatccagaa
     3601 taattgcccc atccgcaaat ccttaattta ataacatctg caaagtccct tttgctatgt
     3661 aaagtagcat gttcacaggt tctggagact tggccatgga tacgattgcg gggggggcat
     3721 tattcttacc acagagcacc ccaagaaaat ctccaaattt tgggcttcca atccattttg
     3781 cttcaattat ttaatatttt tactccttcc agtagatact gatttcatcc attgccctta
     3841 agaaggtagg acagagatta tggcacatct cacattaaat gctatatttt cgttggaaat
     3901 acattttttg cttcaacttt tattttaaat tcaagggtac atgtgcagga tgttcaggtt
     3961 tgttacacag gtaaacgtgt gccatggcgg tttgctgaac agatcatccc atcaccaaca
     4021 gatcatccca ttgagaggtg aagccggctg ggcttctggg ttgggtgggg acttggagaa
     4081 cttttctgtc tagctaaagt attgtaaaat ggaccagtca acactctgta aaatggacca
     4141 atcagctctc tgtaaaatgg accaatcagc aggatgtggg tggggccaag taagggaata
     4201 aaagcaggcc acccgagctg gcagcggcaa cccgctcggg tccccttcca tgctgtggaa
     4261 gttttgttct ttcgctcttt caataaatct tgctgctgct ca
//
