LOCUS       NM_002038                812 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens interferon alpha inducible protein 6 (IFI6),
            transcript variant 1, mRNA.
ACCESSION   NM_002038
VERSION     NM_002038.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 812)
  AUTHORS   Hassan,M. M, ElTahlawi,S., Shaker,O.G. and Magdy,M.
  TITLE     The role of glucose-dependent insulinotropic polypeptide 3 (G1P-3)
            and nucleolar phosphoprotein-1 (NPM1) in pathogenesis of psoriasis
  JOURNAL   Indian J Dermatol Venereol Leprol 89 (6), 828-833 (2023)
   PUBMED   37067145
  REMARK    GeneRIF: The role of glucose-dependent insulinotropic polypeptide 3
            (G1P-3) and nucleolar phosphoprotein-1 (NPM1) in pathogenesis of
            psoriasis.
REFERENCE   2  (bases 1 to 812)
  AUTHORS   Pan,C., Hu,T., Liu,P., Ma,D., Cao,S., Shang,Q., Zhang,L., Chen,Q.,
            Fang,Q. and Wang,J.
  TITLE     BM-MSCs display altered gene expression profiles in B-cell acute
            lymphoblastic leukemia niches and exert pro-proliferative effects
            via overexpression of IFI6
  JOURNAL   J Transl Med 21 (1), 593 (2023)
   PUBMED   37670388
  REMARK    GeneRIF: BM-MSCs display altered gene expression profiles in B-cell
            acute lymphoblastic leukemia niches and exert pro-proliferative
            effects via overexpression of IFI6.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 812)
  AUTHORS   Gao,Y., Dai,J., Xu,X.P., Liu,P.F. and Shi,R.H.
  TITLE     Role of interferon alpha-inducible protein 6 in modulating the
            proliferation, apoptosis and senescence of oesophageal squamous
            cell carcinoma cells
  JOURNAL   J Physiol Pharmacol 74 (3) (2023)
   PUBMED   37661181
  REMARK    GeneRIF: Role of interferon alpha-inducible protein 6 in modulating
            the proliferation, apoptosis and senescence of oesophageal squamous
            cell carcinoma cells.
REFERENCE   4  (bases 1 to 812)
  AUTHORS   Villamayor,L., Rivero,V., Lopez-Garcia,D., Topham,D.J.,
            Martinez-Sobrido,L., Nogales,A. and DeDiego,M.L.
  TITLE     Interferon alpha inducible protein 6 is a negative regulator of
            innate immune responses by modulating RIG-I activation
  JOURNAL   Front Immunol 14, 1105309 (2023)
   PUBMED   36793726
  REMARK    GeneRIF: Interferon alpha inducible protein 6 is a negative
            regulator of innate immune responses by modulating RIG-I
            activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 812)
  AUTHORS   Kubo,Y., Yasui,K., Izumida,M., Hayashi,H. and Matsuyama,T.
  TITLE     IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral
            Activity of gamma-Interferon and IDO1 Restricts Retrovirus
            Infection by Autophagy Enhancement
  JOURNAL   Cells 11 (14), 2240 (2022)
   PUBMED   35883685
  REMARK    GeneRIF: IDO1, FAT10, IFI6, and GILT Are Involved in the
            Antiretroviral Activity of gamma-Interferon and IDO1 Restricts
            Retrovirus Infection by Autophagy Enhancement.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 812)
  AUTHORS   Itzhaki,J.E., Barnett,M.A., MacCarthy,A.B., Buckle,V.J., Brown,W.R.
            and Porter,A.C.
  TITLE     Targeted breakage of a human chromosome mediated by cloned human
            telomeric DNA
  JOURNAL   Nat Genet 2 (4), 283-287 (1992)
   PUBMED   1303280
REFERENCE   7  (bases 1 to 812)
  AUTHORS   Itzhaki,J.E. and Porter,A.C.
  TITLE     Targeted disruption of a human interferon-inducible gene detected
            by secretion of human growth hormone
  JOURNAL   Nucleic Acids Res 19 (14), 3835-3842 (1991)
   PUBMED   1713665
REFERENCE   8  (bases 1 to 812)
  AUTHORS   Clauss,I.M., Wathelet,M.G., Szpirer,J., Content,J., Islam,M.Q.,
            Levan,G., Szpirer,C. and Huez,G.A.
  TITLE     Chromosomal localization of two human genes inducible by
            interferons, double-stranded RNA, and viruses
  JOURNAL   Cytogenet Cell Genet 53 (2-3), 166-168 (1990)
   PUBMED   1695131
REFERENCE   9  (bases 1 to 812)
  AUTHORS   Porter,A.C., Chernajovsky,Y., Dale,T.C., Gilbert,C.S., Stark,G.R.
            and Kerr,I.M.
  TITLE     Interferon response element of the human gene 6-16
  JOURNAL   EMBO J 7 (1), 85-92 (1988)
   PUBMED   3359997
REFERENCE   10 (bases 1 to 812)
  AUTHORS   Kelly,J.M., Porter,A.C., Chernajovsky,Y., Gilbert,C.S., Stark,G.R.
            and Kerr,I.M.
  TITLE     Characterization of a human gene inducible by alpha- and
            beta-interferons and its expression in mouse cells
  JOURNAL   EMBO J 5 (7), 1601-1606 (1986)
   PUBMED   3017706
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445490.6 and AK024814.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002038.3.
            
            Summary: This gene was first identified as one of the many genes
            induced by interferon. The encoded protein may play a critical role
            in the regulation of apoptosis. A minisatellite that consists of 26
            repeats of a 12 nucleotide repeating element resembling the
            mammalian splice donor consensus sequence begins near the end of
            the second exon. Alternatively spliced transcript variants that
            encode different isoforms by using the two downstream repeat units
            as splice donor sites have been described. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) encodes the shortest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.391390.1, CD050928.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361157.11/ ENSP00000354736.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL445490.6         37674-37674
            2-585               AK024814.1         3-586
            586-812             AL445490.6         43576-43802
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..812
                     /gene="IFI6"
                     /gene_synonym="6-16; FAM14C; G1P3; IFI-6-16; IFI616"
                     /note="interferon alpha inducible protein 6"
                     /db_xref="GeneID:2537"
                     /db_xref="HGNC:HGNC:4054"
                     /db_xref="MIM:147572"
     exon            1..70
                     /gene="IFI6"
                     /gene_synonym="6-16; FAM14C; G1P3; IFI-6-16; IFI616"
                     /inference="alignment:Splign:2.1.0"
     exon            71..172
                     /gene="IFI6"
                     /gene_synonym="6-16; FAM14C; G1P3; IFI-6-16; IFI616"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..495
                     /gene="IFI6"
                     /gene_synonym="6-16; FAM14C; G1P3; IFI-6-16; IFI616"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; interferon, alpha-inducible protein clone
                     IFI-6-16; interferon-induced protein 6-16"
                     /codon_start=1
                     /product="interferon alpha-inducible protein 6 isoform a
                     precursor"
                     /protein_id="NP_002029.3"
                     /db_xref="CCDS:CCDS306.1"
                     /db_xref="GeneID:2537"
                     /db_xref="HGNC:HGNC:4054"
                     /db_xref="MIM:147572"
                     /translation="MRQKAVSLFLCYLLLFTCSGVEAGKKKCSESSDSGSGFWKALTF
                     MAVGGGLAVAGLPALGFTGAGIAANSVAASLMSWSAILNGGGVPAGGLVATLQSLGAG
                     GSSVVIGNIGALMGYATHKYLDSEEDEE"
     exon            173..250
                     /gene="IFI6"
                     /gene_synonym="6-16; FAM14C; G1P3; IFI-6-16; IFI616"
                     /inference="alignment:Splign:2.1.0"
     exon            251..400
                     /gene="IFI6"
                     /gene_synonym="6-16; FAM14C; G1P3; IFI-6-16; IFI616"
                     /inference="alignment:Splign:2.1.0"
     exon            401..812
                     /gene="IFI6"
                     /gene_synonym="6-16; FAM14C; G1P3; IFI-6-16; IFI616"
                     /inference="alignment:Splign:2.1.0"
     regulatory      791..796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFI6"
                     /gene_synonym="6-16; FAM14C; G1P3; IFI-6-16; IFI616"
                     /note="hexamer: AATAAA"
     polyA_site      812
                     /gene="IFI6"
                     /gene_synonym="6-16; FAM14C; G1P3; IFI-6-16; IFI616"
                     /note="major polyA site"
ORIGIN      
        1 gtttactcgc tgctgtgccc atctatcagc aggctccggg ctgaagattg cttctcttct
       61 ctcctccaag gtctagtgac ggagcccgcg cgcggcgcca ccatgcggca gaaggcggta
      121 tcgcttttct tgtgctacct gctgctcttc acttgcagtg gggtggaggc aggtaagaaa
      181 aagtgctcgg agagctcgga cagcggctcc gggttctgga aggccctgac cttcatggcc
      241 gtcggaggag gactcgcagt cgccgggctg cccgcgctgg gcttcaccgg cgccggcatc
      301 gcggccaact cggtggctgc ctcgctgatg agctggtctg cgatcctgaa tgggggcggc
      361 gtgcccgccg gggggctagt ggccacgctg cagagcctcg gggctggtgg cagcagcgtc
      421 gtcataggta atattggtgc cctgatgggc tacgccaccc acaagtatct cgatagtgag
      481 gaggatgagg agtagccagc agctcccaga acctcttctt ccttcttggc ctaactcttc
      541 cagttaggat ctagaacttt gccttttttt tttttttttt ttttttgaga tgggttctca
      601 ctatattgtc caggctagag tgcagtggct attcacagat gcgaacatag tacactgcag
      661 cctccaactc ctagcctcaa gtgatcctcc tgtctcaacc tcccaagtag gattacaagc
      721 atgcgccgac gatgcccaga atccagaact ttgtctatca ctctccccaa caacctagat
      781 gtgaaaacag aataaacttc acccagaaaa ca
//
