LOCUS       NM_006820               5829 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens interferon induced protein 44 like (IFI44L),
            transcript variant 1, mRNA.
ACCESSION   NM_006820 XM_001725615 XM_001726761 XM_001726800
VERSION     NM_006820.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5829)
  AUTHORS   Rupa,D., Chuang,H.W., Hu,C.E., Su,W.M., Wu,S.R., Lee,H.S. and
            Yuan,T.C.
  TITLE     ACSL4 upregulates IFI44 and IFI44L expression and promotes the
            proliferation and invasiveness of head and neck squamous cell
            carcinoma cells
  JOURNAL   Cancer Sci 115 (9), 3026-3040 (2024)
   PUBMED   38989827
  REMARK    GeneRIF: ACSL4 upregulates IFI44 and IFI44L expression and promotes
            the proliferation and invasiveness of head and neck squamous cell
            carcinoma cells.
REFERENCE   2  (bases 1 to 5829)
  AUTHORS   Zhang,Q., Wu,R., Tan,Y., Huang,J. and Luo,S.
  TITLE     Novel polymorphism of IFI44L associated with the susceptibility and
            clinical characteristics of systemic lupus erythematosus in a
            Chinese population
  JOURNAL   Int Immunopharmacol 117, 109979 (2023)
   PUBMED   36893516
  REMARK    GeneRIF: Novel polymorphism of IFI44L associated with the
            susceptibility and clinical characteristics of systemic lupus
            erythematosus in a Chinese population.
REFERENCE   3  (bases 1 to 5829)
  AUTHORS   Takashima,Y., Hamano,M., Yoshii,K., Hayano,A., Fukai,J.,
            Iwadate,Y., Kajiwara,K., Hondoh,H. and Yamanaka,R.
  TITLE     Reciprocal expression of the immune response genes CXCR3 and IFI44L
            as module hubs are associated with patient survivals in primary
            central nervous system lymphoma
  JOURNAL   Int J Clin Oncol 28 (3), 468-481 (2023)
   PUBMED   36607476
  REMARK    GeneRIF: Reciprocal expression of the immune response genes CXCR3
            and IFI44L as module hubs are associated with patient survivals in
            primary central nervous system lymphoma.
REFERENCE   4  (bases 1 to 5829)
  AUTHORS   Zeng,Y., Chen,H.Q., Zhang,Z., Fan,J., Li,J.Z., Zhou,S.M., Wang,N.,
            Yan,S.P., Cao,J., Liu,J.Y., Zhou,Z.Y. and Liu,W.B.
  TITLE     IFI44L as a novel epigenetic silencing tumor suppressor promotes
            apoptosis through JAK/STAT1 pathway during lung carcinogenesis
  JOURNAL   Environ Pollut 319, 120943 (2023)
   PUBMED   36584854
  REMARK    GeneRIF: IFI44L as a novel epigenetic silencing tumor suppressor
            promotes apoptosis through JAK/STAT1 pathway during lung
            carcinogenesis.
REFERENCE   5  (bases 1 to 5829)
  AUTHORS   Luo,S., Wu,R., Li,Q. and Zhang,G.
  TITLE     Epigenetic Regulation of IFI44L Expression in Monocytes Affects the
            Functions of Monocyte-Derived Dendritic Cells in Systemic Lupus
            Erythematosus
  JOURNAL   J Immunol Res 2022, 4053038 (2022)
   PUBMED   35592687
  REMARK    GeneRIF: Epigenetic Regulation of IFI44L Expression in Monocytes
            Affects the Functions of Monocyte-Derived Dendritic Cells in
            Systemic Lupus Erythematosus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5829)
  AUTHORS   Ruderfer,D.M., Fanous,A.H., Ripke,S., McQuillin,A., Amdur,R.L.,
            Gejman,P.V., O'Donovan,M.C., Andreassen,O.A., Djurovic,S.,
            Hultman,C.M., Kelsoe,J.R., Jamain,S., Landen,M., Leboyer,M.,
            Nimgaonkar,V., Nurnberger,J., Smoller,J.W., Craddock,N., Corvin,A.,
            Sullivan,P.F., Holmans,P., Sklar,P. and Kendler,K.S.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Bipolar Disorder Working Group of the Psychiatric Genomics
            Consortium; Cross-Disorder Working Group of the Psychiatric
            Genomics Consortium
  TITLE     Polygenic dissection of diagnosis and clinical dimensions of
            bipolar disorder and schizophrenia
  JOURNAL   Mol Psychiatry 19 (9), 1017-1024 (2014)
   PUBMED   24280982
REFERENCE   7  (bases 1 to 5829)
  AUTHORS   Bloch,D.B., Li,P., Bloch,E.G., Berenson,D.F., Galdos,R.L.,
            Arora,P., Malhotra,R., Wu,C. and Yang,W.
  TITLE     LMKB/MARF1 localizes to mRNA processing bodies, interacts with
            Ge-1, and regulates IFI44L gene expression
  JOURNAL   PLoS One 9 (4), e94784 (2014)
   PUBMED   24755989
  REMARK    GeneRIF: LMKB is the first protein identified to date that
            interacts with this portion of Ge-1. LMKB was expressed in human B
            and T lymphocyte cell lines; depletion of LMKB increased expression
            of IFI44L.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5829)
  CONSRTM   Cross-Disorder Group of the Psychiatric Genomics Consortium
  TITLE     Identification of risk loci with shared effects on five major
            psychiatric disorders: a genome-wide analysis
  JOURNAL   Lancet 381 (9875), 1371-1379 (2013)
   PUBMED   23453885
  REMARK    Erratum:[Lancet. 2013 Apr 20;381(9875):1360]
REFERENCE   9  (bases 1 to 5829)
  AUTHORS   Schoggins,J.W., Wilson,S.J., Panis,M., Murphy,M.Y., Jones,C.T.,
            Bieniasz,P. and Rice,C.M.
  TITLE     A diverse range of gene products are effectors of the type I
            interferon antiviral response
  JOURNAL   Nature 472 (7344), 481-485 (2011)
   PUBMED   21478870
  REMARK    Erratum:[Nature. 2015 Sep 3;525(7567):144. doi:
            10.1038/nature14554.. PMID: 26153858]
REFERENCE   10 (bases 1 to 5829)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC390321.1, AK225442.1, AC104837.2 and AW015958.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006820.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223087.1, SRR1803613.79097.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370751.10/ ENSP00000359787.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DC390321.1         67-99
            34-1598             AK225442.1         1-1565
            1599-5690           AC104837.2         38248-42339
            5691-5829           AW015958.1         16-154              c
FEATURES             Location/Qualifiers
     source          1..5829
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..5829
                     /gene="IFI44L"
                     /gene_synonym="C1orf29; GS3686; TLDC5B"
                     /note="interferon induced protein 44 like"
                     /db_xref="GeneID:10964"
                     /db_xref="HGNC:HGNC:17817"
                     /db_xref="MIM:613975"
     exon            1..124
                     /gene="IFI44L"
                     /gene_synonym="C1orf29; GS3686; TLDC5B"
                     /inference="alignment:Splign:2.1.0"
     exon            125..612
                     /gene="IFI44L"
                     /gene_synonym="C1orf29; GS3686; TLDC5B"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1493
                     /gene="IFI44L"
                     /gene_synonym="C1orf29; GS3686; TLDC5B"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="interferon-induced protein 44-like isoform 1"
                     /protein_id="NP_006811.2"
                     /db_xref="CCDS:CCDS687.2"
                     /db_xref="GeneID:10964"
                     /db_xref="HGNC:HGNC:17817"
                     /db_xref="MIM:613975"
                     /translation="MEVTTRLTWNDENHLRKLLGNVSLSLLYKSSVHGGSIEDMVERC
                     SRQGCTITMAYIDYNMIVAFMLGNYINLHESSTEPNDSLWFSLQKKNDTTEIETLLLN
                     TAPKIIDEQLVCRLSKTDIFIICRDNKIYLDKMITRNLKLRFYGHRQYLECEVFRVEG
                     IKDNLDDIKRIIKAREHRNRLLADIRDYRPYADLVSEIRILLVGPVGSGKSSFFNSVK
                     SIFHGHVTGQAVVGSDITSITERYRIYSVKDGKNGKSLPFMLCDTMGLDGAEGAGLCM
                     DDIPHILKGCMPDRYQFNSRKPITPEHSTFITSPSLKDRIHCVAYVLDINSIDNLYSK
                     MLAKVKQVHKEVLNCGIAYVALLTKVDDCSEVLQDNFLNMSRSMTSQSRVMNVHKMLG
                     IPISNILMVGNYASDLELDPMKDILILSALRQMLRAADDFLEDLPLEETGAIERALQP
                     CI"
     exon            613..661
                     /gene="IFI44L"
                     /gene_synonym="C1orf29; GS3686; TLDC5B"
                     /inference="alignment:Splign:2.1.0"
     exon            662..857
                     /gene="IFI44L"
                     /gene_synonym="C1orf29; GS3686; TLDC5B"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1010
                     /gene="IFI44L"
                     /gene_synonym="C1orf29; GS3686; TLDC5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1182
                     /gene="IFI44L"
                     /gene_synonym="C1orf29; GS3686; TLDC5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1283
                     /gene="IFI44L"
                     /gene_synonym="C1orf29; GS3686; TLDC5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1458
                     /gene="IFI44L"
                     /gene_synonym="C1orf29; GS3686; TLDC5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..5829
                     /gene="IFI44L"
                     /gene_synonym="C1orf29; GS3686; TLDC5B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2460..2465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFI44L"
                     /gene_synonym="C1orf29; GS3686; TLDC5B"
                     /note="hexamer: AATAAA"
     polyA_site      2483
                     /gene="IFI44L"
                     /gene_synonym="C1orf29; GS3686; TLDC5B"
                     /note="major polyA site"
     regulatory      5803..5808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFI44L"
                     /gene_synonym="C1orf29; GS3686; TLDC5B"
                     /note="hexamer: AATAAA"
     polyA_site      5829
                     /gene="IFI44L"
                     /gene_synonym="C1orf29; GS3686; TLDC5B"
ORIGIN      
        1 ctttcctaga gtctctgaag ccacagatct cttaagaact ttctgtctcc aaaccgtggc
       61 tgctcgataa atcagacaga acagttaatc ctcaatttaa gcctgatcta acccctagaa
      121 acagatatag aacaatggaa gtgacaacaa gattgacatg gaatgatgaa aatcatctgc
      181 gcaagctgct tggaaatgtt tctttgagtc ttctctataa gtctagtgtt catggaggta
      241 gcattgaaga tatggttgaa agatgcagcc gtcagggatg tactataaca atggcttaca
      301 ttgattacaa tatgattgta gcctttatgc ttggaaatta tattaattta catgaaagtt
      361 ctacagagcc aaatgattcc ctatggtttt cacttcaaaa gaaaaatgac accactgaaa
      421 tagaaacttt actcttaaat acagcaccaa aaattattga tgagcaactg gtgtgtcgtt
      481 tatcgaaaac ggatattttc attatatgtc gagataataa aatttatcta gataaaatga
      541 taacaagaaa cttgaaacta aggttttatg gccaccgtca gtatttggaa tgtgaagttt
      601 ttcgagttga aggaattaag gataacctag acgacataaa gaggataatt aaagccagag
      661 agcacagaaa taggcttcta gcagacatca gagactatag gccctatgca gacttggttt
      721 cagaaattcg tattcttttg gtgggtccag ttgggtctgg aaagtccagt tttttcaatt
      781 cagtcaagtc tatttttcat ggccatgtga ctggccaagc cgtagtgggg tctgatatca
      841 ccagcataac cgagcggtat aggatatatt ctgttaaaga tggaaaaaat ggaaaatctc
      901 tgccatttat gttgtgtgac actatggggc tagatggggc agaaggagca ggactgtgca
      961 tggatgacat tccccacatc ttaaaaggtt gtatgccaga cagatatcag tttaattccc
     1021 gtaaaccaat tacacctgag cattctactt ttatcacctc tccatctctg aaggacagga
     1081 ttcactgtgt ggcttatgtc ttagacatca actctattga caatctctac tctaaaatgt
     1141 tggcaaaagt gaagcaagtt cacaaagaag tattaaactg tggtatagca tatgtggcct
     1201 tgcttactaa agtggatgat tgcagtgagg ttcttcaaga caacttttta aacatgagta
     1261 gatctatgac ttctcaaagc cgggtcatga atgtccataa aatgctaggc attcctattt
     1321 ccaatatttt gatggttgga aattatgctt cagatttgga actggacccc atgaaggata
     1381 ttctcatcct ctctgcactg aggcagatgc tgcgggctgc agatgatttt ttagaagatt
     1441 tgcctcttga ggaaactggt gcaattgaga gagcgttaca gccctgcatt tgagataagt
     1501 tgccttgatt ctgacatttg gcccagcctg tactggtgtg ccgcaatgag agtcaatctc
     1561 tattgacagc ctgcttcaga ttttgctttt gttcgttttg ccttctgtcc ttggaacagt
     1621 catatctcaa gttcaaaggc caaaacctga gaagcggtgg gctaagatag gtcctactgc
     1681 aaaccacccc tccatatttc cgtaccattt acaattcagt ttctgtgaca tctttttaaa
     1741 ccactggagg aaaaatgaga tattctctaa tttattcttc tataacactc tatatagagc
     1801 tatgtgagta ctaatcacat tgaataatag ttataaaatt attgtataga catctgcttc
     1861 ttaaacagat tgtgagttct ttgagaaaca gcgtggattt tacttatctg tgtattcaca
     1921 gagcttagca cagtgcctgg taatgagcaa gcatacttgc cattactttt ccttcccact
     1981 ctctccaaca tcacattcac tttaaatttt tctgtatata gaaaggaaaa ctagcctggg
     2041 caacatgatg aaaccccatc tccactgcaa aaaaaaaaaa aaaaaataag aaagaacaaa
     2101 acaaacccca caaaaattag ctgggtatga tggcacgtgc ctgtagtccc agttactcag
     2161 gatgattgat tgagccttgg aggtggaggc tacagtgagc tgagattgtg ccactgtact
     2221 ctagccaggg agaaagagtg agatcctggc tcaaaaaaac caaataaaac aaaacaaaca
     2281 aacgaaaaac agaaaggaag actgaaagag aatgaaaagc tggggagagg aaataaaaat
     2341 aaagaaggaa gagtgtttca tttatatctg aatgaaaata tgaatgactc taagtaattg
     2401 aattaattaa aatgagccaa ctttttttta acaatttaca ttttatttct atgggaaaaa
     2461 ataaatattc ctcttctaac aaacccatgc ttgattttca ttaattgaat tccaaatcat
     2521 cctagccatg tgtccttcca tttaggttac tggggcaaat cagtaagaaa gttcttatat
     2581 ttatgctcca aataattctg aagtcctctt actagctgtg aaagctagta ctattaagaa
     2641 agaaaacaaa attcccaaaa gatagctttc actttttttt ttccttaaag acttcctaat
     2701 tctcttctcc aaattcttag tcttcttcaa aataatatgc tttggttcaa tagttatcca
     2761 cattctgaca gtctaattta gttttaatca gaattatact catcttttgg gtagtcatag
     2821 atattaagaa agcaagagtt tcttatgtcc agttatggaa tatttcctaa agcaaggctg
     2881 caggtgaagt tgtgctcaag tgaatgttca ggagacacaa ttcagtggaa gaaattaagt
     2941 ctttaaaaaa gacctaggaa taggagaacc atggaaattg aggaggtagg cctacaagta
     3001 gatattggga acaaaattag agaggcaacc agaaaaagtt attttaggct caccagagtt
     3061 gttcttattg cacagtaaca caccaatata ccaaaacagc aggtattgca gtagagaaag
     3121 agtttaataa ttgaatggca gaaaaatgag gaaggttgag gaaacctcaa atctacctcc
     3181 ctgctgagtc taagtttagg atttttaaga gaaaggcagg taaggtgctg aaggtctgga
     3241 gctgctgatt tgttggggta tagggaatga aatgaaacat acagagatga aaactggaag
     3301 tttttttttg tttgttttgt tttttttttg ttgttgtttt tttttttttt tgtttttttg
     3361 ctgagtcaat tccttggagg gggtcttcag actgactggt gtcagcagac ccatgggatt
     3421 ccaagatctg gaaaactttt tagatagaaa cttgatgttt cttaacgtta catatattat
     3481 cttatagaaa taactaaggg aagttagtgc cttgtgacca catctatgtg acttttaggc
     3541 agtaagaaac tataaggaaa ggagctaaca gtcatgctgt aagtagctac agggaattgg
     3601 cttaaagggc aagttggtta gtacttagct gtgtttttat tcaaagtcta cattttatgt
     3661 agtggttaat gtttgctgtt cattaggatg gtttcacagt taccatacaa atgtagaagc
     3721 aacaggtcca aaaagtaggg catgattttc tccatgtaat ccagggagaa aacaagccat
     3781 gaccattgtt ggttgggaga ctgaaggtga ttgaaggttc accatcatcc tcaccaactt
     3841 ttgggccata attcacccaa ccctttggtg gagcctgaaa aaaatctggg cagaatgtag
     3901 gacttcttta ttttgtttaa aggggtaaca cagagtgccc ttatgaagga gttggagatc
     3961 ctgcaaggaa gagaaggagt gaaggagaga tcaagagaga gaaacaatga ggaacatttc
     4021 atttgaccca acatccttta ggagcataaa tgttgacact aagttatccc ttttgtgcta
     4081 aaatggacag tattggcaaa atgataccac aacttcttat tctctggctc tatattgctt
     4141 tggaaacact taaacatcaa atggagttaa atacatattt gaaatttagg ttaggaaata
     4201 ttggtgagga ggcctcaaaa agggggaaac atcttttgtc tgggaggata ttttccattt
     4261 tgtggatttc cctgatcttt ttctaccacc ctgaggggtg gtgggaatta tcattttgct
     4321 acattttaga ggtcatccag gatttttgaa actttacatt ctttacggtt aagcaagatg
     4381 tacagctcag tcaaagacac taaattcttc ttagaaaaat agtgctaagg agtatagcag
     4441 atgacctata tgtgtgttgg ctgggagaat atcatcttaa agtgagagtg atgttgtgga
     4501 gacagttgaa atgtcaatgc tagagcctct gtggtgtgaa tgggcacgtt aggttgttgc
     4561 attagaaagt gactgtttct gacagaaatt tgtagctttg tgcaaactca cccaccatct
     4621 acctcaataa aatatagaga aaagaaaaat agagcagttt gagttctatg aggtatgcag
     4681 gcccagagag acataagtat gttcctttag tcttgcttcc tgtgtgccac actgcccctc
     4741 cacaaccata gctgggggca attgtttaaa gtcattttgt tcccgactag ctgccttgca
     4801 cattatcttc attttcctgg aatttgatac agagagcaat ttatagccaa ttgatagctt
     4861 atgctgtttc aatgtaaatt cgtggtaaat aacttaggaa ctgcctcttc tttttctttg
     4921 aaaacctact tataactgtt gctaataaga atgtgtattg ttcaggacaa cttgtctcca
     4981 tacagttggg ttgtaaccct catgcttggc ccaaataaac tctctactta tatcagtttt
     5041 tcctacactt cttcctttta ggtcaacaat accaagaggg gttactgtgc tgggtaatgt
     5101 gtaaacttgt gtcttgttta gaaagataaa tttaaagact atcacattgc tttttcataa
     5161 aacaagacag gtctacaatt aatttatttt gacgcaaatt gatagggggg ccaagtaagc
     5221 cccatatgct taatgatcag ctgatgaata atcatctcct agcaacataa ctcaatctaa
     5281 tgctaaggta cccacaagat ggcaaggctg atcaaagtcg tcatggaatc ctgcaaccaa
     5341 aagccatggg aatttggaag ccctcaaatc ccattcctaa tctgatgagt ctatggacca
     5401 atttgtggag gacagtagat taaatagatc tgatttttgc catcaatgta aggaggataa
     5461 aaacttgcat accaattgta cacccttgca aaatctttct ctgatgttgg agaaaatggg
     5521 ccagtgagat catggatata gaagtacagt caatgttcag ctgtaccctc ccacaatccc
     5581 acttccttcc tcaacacaat tcaaacaaat agactcagac tgtttcaggc tccaggacag
     5641 gaagtgcagt gtaggcaaaa ttgcaaaaat tgagggcaca ggggtggagg tgggggggtt
     5701 gaataacaag ctgtgctaaa taattacgtg taaatatatt ttttcatttt taaaaattga
     5761 tttcttttgc acattccatg acaatatatg tcacattttt aaaataaatg caaagaagca
     5821 tacatccaa
//
