LOCUS       NM_006417               1682 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens interferon induced protein 44 (IFI44), transcript
            variant 1, mRNA.
ACCESSION   NM_006417
VERSION     NM_006417.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1682)
  AUTHORS   Elsayed Ramadan Genena,S., Hamouda,M.A.F., Salama,N.M.,
            Zahran,E.S., Abdel Latif,A.A. and Dawood,A.A.
  TITLE     Interferon-induced protein 44 (IFI44) and interferon regulatory
            factor 4 (IRF4) gene expression in rheumatoid arthritis
  JOURNAL   J Immunoassay Immunochem 45 (5), 432-451 (2024)
   PUBMED   39051937
  REMARK    GeneRIF: Interferon-induced protein 44 (IFI44) and interferon
            regulatory factor 4 (IRF4) gene expression in rheumatoid arthritis.
REFERENCE   2  (bases 1 to 1682)
  AUTHORS   Rupa,D., Chuang,H.W., Hu,C.E., Su,W.M., Wu,S.R., Lee,H.S. and
            Yuan,T.C.
  TITLE     ACSL4 upregulates IFI44 and IFI44L expression and promotes the
            proliferation and invasiveness of head and neck squamous cell
            carcinoma cells
  JOURNAL   Cancer Sci 115 (9), 3026-3040 (2024)
   PUBMED   38989827
  REMARK    GeneRIF: ACSL4 upregulates IFI44 and IFI44L expression and promotes
            the proliferation and invasiveness of head and neck squamous cell
            carcinoma cells.
REFERENCE   3  (bases 1 to 1682)
  AUTHORS   Zheng,Q., Wang,D., Lin,R., Lv,Q. and Wang,W.
  TITLE     IFI44 is an immune evasion biomarker for SARS-CoV-2 and
            Staphylococcus aureus infection in patients with RA
  JOURNAL   Front Immunol 13, 1013322 (2022)
   PUBMED   36189314
  REMARK    GeneRIF: IFI44 is an immune evasion biomarker for SARS-CoV-2 and
            Staphylococcus aureus infection in patients with RA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1682)
  AUTHORS   Busse,D.C., Habgood-Coote,D., Clare,S., Brandt,C., Bassano,I.,
            Kaforou,M., Herberg,J., Levin,M., Eleouet,J.F., Kellam,P. and
            Tregoning,J.S.
  TITLE     Interferon-Induced Protein 44 and Interferon-Induced Protein
            44-Like Restrict Replication of Respiratory Syncytial Virus
  JOURNAL   J Virol 94 (18), e00297-20 (2020)
   PUBMED   32611756
  REMARK    GeneRIF: Interferon-Induced Protein 44 and Interferon-Induced
            Protein 44-Like Restrict Replication of Respiratory Syncytial
            Virus.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1682)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1682)
  AUTHORS   Mailaparambil,B., Jochum,J., Forster,J., Heinze,J., Krueger,M. and
            Heinzmann,A.
  TITLE     Polymorphisms of interferons and their receptors in the genetics of
            severe RSV-associated diseases
  JOURNAL   Arch Virol 153 (11), 2133-2137 (2008)
   PUBMED   18953482
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1682)
  AUTHORS   Hallen,L.C., Burki,Y., Ebeling,M., Broger,C., Siegrist,F.,
            Oroszlan-Szovik,K., Bohrmann,B., Certa,U. and Foser,S.
  TITLE     Antiproliferative activity of the human IFN-alpha-inducible protein
            IFI44
  JOURNAL   J Interferon Cytokine Res 27 (8), 675-680 (2007)
   PUBMED   17784819
  REMARK    GeneRIF: Binds and depletes intracellular GTP, abolishing
            extracellular signal-regulated kinase (ERK) signaling and resulting
            finally in cell cycle arrest.
REFERENCE   8  (bases 1 to 1682)
  AUTHORS   Hwang,Y., Chen,E.Y., Gu,Z.J., Chuang,W.L., Yu,M.L., Lai,M.Y.,
            Chao,Y.C., Lee,C.M., Wang,J.H., Dai,C.Y., Shian-Jy Bey,M.,
            Liao,Y.T., Chen,P.J. and Chen,D.S.
  TITLE     Genetic predisposition of responsiveness to therapy for chronic
            hepatitis C
  JOURNAL   Pharmacogenomics 7 (5), 697-709 (2006)
   PUBMED   16886895
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   9  (bases 1 to 1682)
  AUTHORS   Izmailova,E., Bertley,F.M., Huang,Q., Makori,N., Miller,C.J.,
            Young,R.A. and Aldovini,A.
  TITLE     HIV-1 Tat reprograms immature dendritic cells to express
            chemoattractants for activated T cells and macrophages
  JOURNAL   Nat Med 9 (2), 191-197 (2003)
   PUBMED   12539042
REFERENCE   10 (bases 1 to 1682)
  AUTHORS   Kitamura,A., Takahashi,K., Okajima,A. and Kitamura,N.
  TITLE     Induction of the human gene for p44, a hepatitis-C-associated
            microtubular aggregate protein, by interferon-alpha/beta
  JOURNAL   Eur J Biochem 224 (3), 877-883 (1994)
   PUBMED   7925411
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC300799.1, DN994910.1, BC022870.1 and CA426666.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006417.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.312280.1,
                                           SRR3476690.188286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370747.9/ ENSP00000359783.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               DC300799.1         402-566
            166-542             DN994910.1         182-558
            543-1617            BC022870.1         547-1621
            1618-1682           CA426666.1         22-86               c
FEATURES             Location/Qualifiers
     source          1..1682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..1682
                     /gene="IFI44"
                     /gene_synonym="MTAP44; p44; TLDC5"
                     /note="interferon induced protein 44"
                     /db_xref="GeneID:10561"
                     /db_xref="HGNC:HGNC:16938"
                     /db_xref="MIM:610468"
     exon            1..75
                     /gene="IFI44"
                     /gene_synonym="MTAP44; p44; TLDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            76..542
                     /gene="IFI44"
                     /gene_synonym="MTAP44; p44; TLDC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1420
                     /gene="IFI44"
                     /gene_synonym="MTAP44; p44; TLDC5"
                     /note="interferon-induced, hepatitis C-associated
                     microtubular aggregate protein (44kD);
                     microtubule-associated protein 44; TBC/LysM-associated
                     domain containing 5"
                     /codon_start=1
                     /product="interferon-induced protein 44"
                     /protein_id="NP_006408.3"
                     /db_xref="CCDS:CCDS688.1"
                     /db_xref="GeneID:10561"
                     /db_xref="HGNC:HGNC:16938"
                     /db_xref="MIM:610468"
                     /translation="MAVTTRLTWLHEKILQNHFGGKRLSLLYKGSVHGFRNGVLLDRC
                     CNQGPTLTVIYSEDHIIGAYAEESYQEGKYASIILFALQDTKISEWKLGLCTPETLFC
                     CDVTKYNSPTNFQIDGRNRKVIMDLKTMENLGLAQNCTISIQDYEVFRCEDSLDERKI
                     KGVIELRKSLLSALRTYEPYGSLVQQIRILLLGPIGAGKSSFFNSVRSVFQGHVTHQA
                     LVGTNTTGISEKYRTYSIRDGKDGKYLPFILCDSLGLSEKEGGLCRDDIFYILNGNIR
                     DRYQFNPMESIKLNHHDYIDSPSLKDRIHCVAFVFDASSIQYFSSQMIVKIKRIRREL
                     VNAGVVHVALLTHVDSMDLITKGDLIEIERCEPVRSKLEEVQRKLGFALSDISVVSNY
                     SSEWELDPVKDVLILSALRRMLWAADDFLEDLPFEQIGNLREEIINCAQGKK"
     exon            543..579
                     /gene="IFI44"
                     /gene_synonym="MTAP44; p44; TLDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            580..775
                     /gene="IFI44"
                     /gene_synonym="MTAP44; p44; TLDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            776..925
                     /gene="IFI44"
                     /gene_synonym="MTAP44; p44; TLDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1097
                     /gene="IFI44"
                     /gene_synonym="MTAP44; p44; TLDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1198
                     /gene="IFI44"
                     /gene_synonym="MTAP44; p44; TLDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1373
                     /gene="IFI44"
                     /gene_synonym="MTAP44; p44; TLDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1682
                     /gene="IFI44"
                     /gene_synonym="MTAP44; p44; TLDC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1659..1664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFI44"
                     /gene_synonym="MTAP44; p44; TLDC5"
                     /note="hexamer: AATAAA"
     polyA_site      1682
                     /gene="IFI44"
                     /gene_synonym="MTAP44; p44; TLDC5"
ORIGIN      
        1 cattttgtgc ctgcctagct atccagacag agcagctacc ctcagctcta gctgatacta
       61 cagacagtac aacagatcaa gaagtatggc agtgacaact cgtttgacat ggttgcacga
      121 aaagatcctg caaaatcatt ttggagggaa gcggcttagc cttctctata agggtagtgt
      181 ccatggattc cgtaatggag ttttgcttga cagatgttgt aatcaagggc ctactctaac
      241 agtgatttat agtgaagatc atattattgg agcatatgca gaagagagtt accaggaagg
      301 aaagtatgct tccatcatcc tttttgcact tcaagatact aaaatttcag aatggaaact
      361 aggactatgt acaccagaaa cactgttttg ttgtgatgtt acaaaatata actccccaac
      421 taatttccag atagatggaa gaaatagaaa agtgattatg gacttaaaga caatggaaaa
      481 tcttggactt gctcaaaatt gtactatctc tattcaggat tatgaagttt ttcgatgcga
      541 agattcactg gatgaaagaa agataaaagg ggtcattgag ctcaggaaga gcttactgtc
      601 tgccttgaga acttatgaac catatggatc cctggttcaa caaatacgaa ttctgctgct
      661 gggtccaatt ggagctggga agtccagctt tttcaactca gtgaggtctg ttttccaagg
      721 gcatgtaacg catcaggctt tggtgggcac taatacaact gggatatctg agaagtatag
      781 gacatactct attagagacg ggaaagatgg caaatacctg ccgtttattc tgtgtgactc
      841 actggggctg agtgagaaag aaggcggcct gtgcagggat gacatattct atatcttgaa
      901 cggtaacatt cgtgatagat accagtttaa tcccatggaa tcaatcaaat taaatcatca
      961 tgactacatt gattccccat cgctgaagga cagaattcat tgtgtggcat ttgtatttga
     1021 tgccagctct attcaatact tctcctctca gatgatagta aagatcaaaa gaattcgaag
     1081 ggagttggta aacgctggtg tggtacatgt ggctttgctc actcatgtgg atagcatgga
     1141 tttgattaca aaaggtgacc ttatagaaat agagagatgt gagcctgtga ggtccaagct
     1201 agaggaagtc caaagaaaac ttggatttgc tctttctgac atctcggtgg ttagcaatta
     1261 ttcctctgag tgggagctgg accctgtaaa ggatgttcta attctttctg ctctgagacg
     1321 aatgctatgg gctgcagatg acttcttaga ggatttgcct tttgagcaaa tagggaatct
     1381 aagggaggaa attatcaact gtgcacaagg aaaaaaatag atatgtgaaa ggttcacgta
     1441 aatttcctca catcacagaa gattaaaatt cagaaaggag aaaacacaga ccaaagagaa
     1501 gtatctaaga ccaaagggat gtgttttatt aatgtctagg atgaagaaat gcatagaaca
     1561 ttgtagtact tgtaaataac tagaaataac atgatttagt cataattgtg aaaaataata
     1621 ataatttttc ttggatttat gttctgtatc tgtgaaaaaa taaatttctt ataaaactcg
     1681 gg
//
