LOCUS       NM_001330230            1182 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens interferon induced protein 35 (IFI35), transcript
            variant 2, mRNA.
ACCESSION   NM_001330230 XM_005257302
VERSION     NM_001330230.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1182)
  AUTHORS   De Masi,R., Orlando,S., Bagordo,F. and Grassi,T.
  TITLE     IFP35 Is a Relevant Factor in Innate Immunity, Multiple Sclerosis,
            and Other Chronic Inflammatory Diseases: A Review
  JOURNAL   Biology (Basel) 10 (12), 1325 (2021)
   PUBMED   34943240
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1182)
  AUTHORS   Jing,X., Yao,Y., Wu,D., Hong,H., Feng,X., Xu,N., Liu,Y. and
            Liang,H.
  TITLE     IFP35 family proteins promote neuroinflammation and multiple
            sclerosis
  JOURNAL   Proc Natl Acad Sci U S A 118 (32) (2021)
   PUBMED   34362845
  REMARK    GeneRIF: IFP35 family proteins promote neuroinflammation and
            multiple sclerosis.
REFERENCE   3  (bases 1 to 1182)
  AUTHORS   De Masi,R. and Orlando,S.
  TITLE     IFI35 as a biomolecular marker of neuroinflammation and treatment
            response in multiple sclerosis
  JOURNAL   Life Sci 259, 118233 (2020)
   PUBMED   32781067
  REMARK    GeneRIF: IFI35 as a biomolecular marker of neuroinflammation and
            treatment response in multiple sclerosis.
REFERENCE   4  (bases 1 to 1182)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1182)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1182)
  AUTHORS   Chen,J. and Naumovski,L.
  TITLE     Intracellular redistribution of interferon-inducible proteins Nmi
            and IFP 35 in apoptotic cells
  JOURNAL   J Interferon Cytokine Res 22 (2), 237-243 (2002)
   PUBMED   11911807
  REMARK    GeneRIF: Dissociation of the IFN-induced protein IFP35 from NMI is
            a newly defined specific cytoplasmic event occurring during
            apoptosis.
REFERENCE   7  (bases 1 to 1182)
  AUTHORS   Chen,J., Shpall,R.L., Meyerdierks,A., Hagemeier,M., Bottger,E.C.
            and Naumovski,L.
  TITLE     Interferon-inducible Myc/STAT-interacting protein Nmi associates
            with IFP 35 into a high molecular mass complex and inhibits
            proteasome-mediated degradation of IFP 35
  JOURNAL   J Biol Chem 275 (46), 36278-36284 (2000)
   PUBMED   10950963
REFERENCE   8  (bases 1 to 1182)
  AUTHORS   Zhou,X., Liao,J., Meyerdierks,A., Feng,L., Naumovski,L.,
            Bottger,E.C. and Omary,M.B.
  TITLE     Interferon-alpha induces nmi-IFP35 heterodimeric complex formation
            that is affected by the phosphorylation of IFP35
  JOURNAL   J Biol Chem 275 (28), 21364-21371 (2000)
   PUBMED   10779520
REFERENCE   9  (bases 1 to 1182)
  AUTHORS   Wang,X., Johansen,L.M., Tae,H.J. and Taparowsky,E.J.
  TITLE     IFP 35 forms complexes with B-ATF, a member of the AP1 family of
            transcription factors
  JOURNAL   Biochem Biophys Res Commun 229 (1), 316-322 (1996)
   PUBMED   8954125
REFERENCE   10 (bases 1 to 1182)
  AUTHORS   Bange,F.C., Vogel,U., Flohr,T., Kiekenbeck,M., Denecke,B. and
            Bottger,E.C.
  TITLE     IFP 35 is an interferon-induced leucine zipper protein that
            undergoes interferon-regulated cellular redistribution
  JOURNAL   J Biol Chem 269 (2), 1091-1098 (1994)
   PUBMED   8288566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC055866.19 and AA827287.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001330230.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279826.5750.1,
                                           SRR1163657.562757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000415816.7/ ENSP00000394579.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AC055866.19        191075-191259
            186-284             AC055866.19        196470-196568
            285-432             AC055866.19        197338-197485
            433-539             AC055866.19        197558-197664
            540-726             AC055866.19        197767-197953
            727-833             AC055866.19        198067-198173
            834-1150            AC055866.19        198399-198715
            1151-1182           AA827287.1         15-46               c
FEATURES             Location/Qualifiers
     source          1..1182
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..1182
                     /gene="IFI35"
                     /gene_synonym="IFP35"
                     /note="interferon induced protein 35"
                     /db_xref="GeneID:3430"
                     /db_xref="HGNC:HGNC:5399"
                     /db_xref="MIM:600735"
     exon            1..185
                     /gene="IFI35"
                     /gene_synonym="IFP35"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1025
                     /gene="IFI35"
                     /gene_synonym="IFP35"
                     /note="isoform 2 is encoded by transcript variant 2;
                     interferon-induced 35 kDa protein; IFP 35; ifi-35"
                     /codon_start=1
                     /product="interferon-induced 35 kDa protein isoform 2"
                     /protein_id="NP_001317159.1"
                     /db_xref="CCDS:CCDS82134.1"
                     /db_xref="GeneID:3430"
                     /db_xref="HGNC:HGNC:5399"
                     /db_xref="MIM:600735"
                     /translation="MSAPLDAALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPFS
                     VPKIPLVFRGHTQQDPEVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTI
                     NMEECRLRVQVQPLELPMVTTIQMSSQLSGRRVLVTGFPASLRLSEEELLDKLEIFFG
                     KTRNGGGDVDVRELLPGSVMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGE
                     IQKAEIRSQPVPRSVLVLNIPDILDGPELHDVLEIHFQKPTRGGGEVEALTVVPQGQQ
                     GLAVFTSESG"
     exon            186..284
                     /gene="IFI35"
                     /gene_synonym="IFP35"
                     /inference="alignment:Splign:2.1.0"
     exon            285..432
                     /gene="IFI35"
                     /gene_synonym="IFP35"
                     /inference="alignment:Splign:2.1.0"
     exon            433..539
                     /gene="IFI35"
                     /gene_synonym="IFP35"
                     /inference="alignment:Splign:2.1.0"
     exon            540..726
                     /gene="IFI35"
                     /gene_synonym="IFP35"
                     /inference="alignment:Splign:2.1.0"
     exon            727..833
                     /gene="IFI35"
                     /gene_synonym="IFP35"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1182
                     /gene="IFI35"
                     /gene_synonym="IFP35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1161..1166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFI35"
                     /gene_synonym="IFP35"
                     /note="hexamer: AGTAAA"
     polyA_site      1182
                     /gene="IFI35"
                     /gene_synonym="IFP35"
                     /note="major polyA site"
ORIGIN      
        1 caaacagcct gcgagcagag cctcctgagg tgtatttcgg gtcttgctgg ggctgagaga
       61 gaccacagcc ctttgggggg tacaaacaag agttcagttg ctgtgaattc tgccactgtg
      121 cccagctctg aagcctcagc tcttgccaaa cagacccgag acccatgtca gccccactgg
      181 atgccgccct ccacgccctt caggaggagc aggccagact caagatgagg ctgtgggacc
      241 tgcagcagct gagaaaggag ctcggggact cccccaaaga caaggtccca ttttcagtgc
      301 ccaagatccc cctggtattc cgaggacaca cccagcagga cccggaagtg cctaagtctt
      361 tagtttccaa tttgcggatc cactgccctc tgcttgcggg ctctgctctg atcacctttg
      421 atgaccccaa agtggctgag caggtgctgc aacaaaagga gcacacgatc aacatggagg
      481 agtgccggct gcgggtgcag gtccagccct tggagctgcc catggtcacc accatccaga
      541 tgtccagcca gttgagtggc cggagggtgt tggtcactgg atttcctgcc agcctcaggc
      601 tgagtgagga ggagctgctg gacaagctag agatcttctt tggcaagact aggaacggag
      661 gtggcgatgt ggacgttcgg gagctactgc cagggagtgt catgctgggg tttgctaggg
      721 atggagtggc tcagcgtctg tgccaaatcg gccagttcac agtgccactg ggtgggcagc
      781 aagtccctct gagagtctct ccgtatgtga acggggagat ccagaaggct gagatcaggt
      841 cgcagccagt tccccgctcg gtactggtgc tcaacattcc tgatatcttg gatggcccgg
      901 agctgcatga cgtcctggag atccacttcc agaagcccac ccgcgggggc ggggaggtag
      961 aggccctgac agtcgtaccc caaggacagc agggcctagc agtcttcacc tctgagtcag
     1021 gctaggggcc tccccttctc atcctcccca cccccccgcc aaggttctca cactggcctg
     1081 ggcttgggtg cccatatagg aggtctgtat gttcaccaac agtgcggagg ggtcacacat
     1141 tgcaaaacac tgcccagaac agtaaaaaga gcctgcatgc ca
//
