LOCUS       NM_006332                988 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens IFI30 lysosomal thiol reductase (IFI30), mRNA.
ACCESSION   NM_006332
VERSION     NM_006332.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 988)
  AUTHORS   Wen,X., Lei,L., Wang,F. and Wang,Y.
  TITLE     Comprehensive analysis of the role of interferon gamma-inducible
            protein 30 on immune infiltration and prognosis in clear cell renal
            cell carcinoma
  JOURNAL   Biomol Biomed 24 (2), 411-422 (2024)
   PUBMED   37991414
  REMARK    GeneRIF: Comprehensive analysis of the role of interferon
            gamma-inducible protein 30 on immune infiltration and prognosis in
            clear cell renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 988)
  AUTHORS   Yang,J., Yang,S., Cai,J., Chen,H., Sun,L., Wang,J., Hou,G., Gu,S.,
            Ma,J. and Ge,J.
  TITLE     A Transcription Factor ZNF384, Regulated by LINC00265, Activates
            the Expression of IFI30 to Stimulate Malignant Progression in
            Glioma
  JOURNAL   ACS Chem Neurosci 15 (2), 290-299 (2024)
   PUBMED   38141017
  REMARK    GeneRIF: A Transcription Factor ZNF384, Regulated by LINC00265,
            Activates the Expression of IFI30 to Stimulate Malignant
            Progression in Glioma.
REFERENCE   3  (bases 1 to 988)
  AUTHORS   Ye,J., Xu,W. and Chen,T.
  TITLE     [Knockdown of interferon-gamma inducible protein 30 (IFI30)
            inhibits the proliferation, invasion and migration of human glioma
            U251 cells by activating STAT1 and promotes their apoptosis]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 40 (1), 33-42 (2024)
   PUBMED   38246175
  REMARK    GeneRIF: [Knockdown of interferon-gamma inducible protein 30
            (IFI30) inhibits the proliferation, invasion and migration of human
            glioma U251 cells by activating STAT1 and promotes their
            apoptosis].
REFERENCE   4  (bases 1 to 988)
  AUTHORS   Chen,Y., Xu,H., Yu,P., Wang,Q., Li,S., Ji,F., Wu,C. and Lan,Q.
  TITLE     Interferon-gamma inducible protein 30 promotes the
            epithelial-mesenchymal transition-like phenotype and
            chemoresistance by activating EGFR/AKT/GSK3beta/beta-catenin
            pathway in glioma
  JOURNAL   CNS Neurosci Ther 29 (12), 4124-4138 (2023)
   PUBMED   37408388
  REMARK    GeneRIF: Interferon-gamma inducible protein 30 promotes the
            epithelial-mesenchymal transition-like phenotype and
            chemoresistance by activating EGFR/AKT/GSK3beta/beta-catenin
            pathway in glioma.
REFERENCE   5  (bases 1 to 988)
  AUTHORS   Kubo,Y., Yasui,K., Izumida,M., Hayashi,H. and Matsuyama,T.
  TITLE     IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral
            Activity of gamma-Interferon and IDO1 Restricts Retrovirus
            Infection by Autophagy Enhancement
  JOURNAL   Cells 11 (14), 2240 (2022)
   PUBMED   35883685
  REMARK    GeneRIF: IDO1, FAT10, IFI6, and GILT Are Involved in the
            Antiretroviral Activity of gamma-Interferon and IDO1 Restricts
            Retrovirus Infection by Autophagy Enhancement.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 988)
  AUTHORS   Phan,U.T., Arunachalam,B. and Cresswell,P.
  TITLE     Gamma-interferon-inducible lysosomal thiol reductase (GILT).
            Maturation, activity, and mechanism of action
  JOURNAL   J Biol Chem 275 (34), 25907-25914 (2000)
   PUBMED   10852914
REFERENCE   7  (bases 1 to 988)
  AUTHORS   Arunachalam,B., Phan,U.T., Geuze,H.J. and Cresswell,P.
  TITLE     Enzymatic reduction of disulfide bonds in lysosomes:
            characterization of a gamma-interferon-inducible lysosomal thiol
            reductase (GILT)
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 745-750 (2000)
   PUBMED   10639150
REFERENCE   8  (bases 1 to 988)
  AUTHORS   Luster,A.D., Weinshank,R.L., Feinman,R. and Ravetch,J.V.
  TITLE     Molecular and biochemical characterization of a novel
            gamma-interferon-inducible protein
  JOURNAL   J Biol Chem 263 (24), 12036-12043 (1988)
   PUBMED   3136170
REFERENCE   9  (bases 1 to 988)
  AUTHORS   Csanyi,E.
  TITLE     [Endre Kotai; 1914-1976]
  JOURNAL   Magy Traumatol Orthop Helyreallito Seb 20 (1), 1 (1977)
   PUBMED   16170
REFERENCE   10 (bases 1 to 988)
  AUTHORS   Sabin,N.M.
  TITLE     Letters to the editors
  JOURNAL   J Wis Dent Assoc 52 (1), 9 (1976)
   PUBMED   1069150
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC021136.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006332.4.
            
            Summary: The protein encoded by this gene is a lysosomal thiol
            reductase that at low pH can reduce protein disulfide bonds. The
            enzyme is expressed constitutively in antigen-presenting cells and
            induced by gamma-interferon in other cell types. This enzyme has an
            important role in MHC class II-restricted antigen processing.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031020.1, SRR5189658.213581.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407280.4/ ENSP00000384886.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-988               BC021136.1         3-990
FEATURES             Location/Qualifiers
     source          1..988
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..988
                     /gene="IFI30"
                     /gene_synonym="GILT; IFI-30; IP-30; IP30"
                     /note="IFI30 lysosomal thiol reductase"
                     /db_xref="GeneID:10437"
                     /db_xref="HGNC:HGNC:5398"
                     /db_xref="MIM:604664"
     exon            1..161
                     /gene="IFI30"
                     /gene_synonym="GILT; IFI-30; IP-30; IP30"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..782
                     /gene="IFI30"
                     /gene_synonym="GILT; IFI-30; IP-30; IP30"
                     /note="gamma-interferon-inducible lysosomal thiol
                     reductase; interferon gamma-inducible protein 30
                     preproprotein; gamma-interferon-inducible protein IP-30;
                     legumaturain; interferon, gamma-inducible protein 30"
                     /codon_start=1
                     /product="gamma-interferon-inducible lysosomal thiol
                     reductase preproprotein"
                     /protein_id="NP_006323.2"
                     /db_xref="CCDS:CCDS46015.1"
                     /db_xref="GeneID:10437"
                     /db_xref="HGNC:HGNC:5398"
                     /db_xref="MIM:604664"
                     /translation="MTLSPLLLFLPPLLLLLDVPTAAVQASPLQALDFFGNGPPVNYK
                     TGNLYLRGPLKKSNAPLVNVTLYYEALCGGCRAFLIRELFPTWLLVMEILNVTLVPYG
                     NAQEQNVSGRWEFKCQHGEEECKFNKVEACVLDELDMELAFLTIVCMEEFEDMERSLP
                     LCLQLYAPGLSPDTIMECAMGDRGMQLMHANAQRTDALQPPHEYVPWVTVNGKPLEDQ
                     TQLLTLVCQLYQGKKPDVCPSSTSSLRSVCFK"
     exon            162..344
                     /gene="IFI30"
                     /gene_synonym="GILT; IFI-30; IP-30; IP30"
                     /inference="alignment:Splign:2.1.0"
     exon            345..419
                     /gene="IFI30"
                     /gene_synonym="GILT; IFI-30; IP-30; IP30"
                     /inference="alignment:Splign:2.1.0"
     exon            420..512
                     /gene="IFI30"
                     /gene_synonym="GILT; IFI-30; IP-30; IP30"
                     /inference="alignment:Splign:2.1.0"
     exon            513..665
                     /gene="IFI30"
                     /gene_synonym="GILT; IFI-30; IP-30; IP30"
                     /inference="alignment:Splign:2.1.0"
     exon            666..719
                     /gene="IFI30"
                     /gene_synonym="GILT; IFI-30; IP-30; IP30"
                     /inference="alignment:Splign:2.1.0"
     exon            720..988
                     /gene="IFI30"
                     /gene_synonym="GILT; IFI-30; IP-30; IP30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      968..973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFI30"
                     /gene_synonym="GILT; IFI-30; IP-30; IP30"
                     /note="hexamer: AGTAAA"
     polyA_site      988
                     /gene="IFI30"
                     /gene_synonym="GILT; IFI-30; IP-30; IP30"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcgcca cacctttgcc cctgctgcga tgaccctgtc gccacttctg ctgttcctgc
       61 caccgctgct gctgctgctg gacgtcccca cggcggcggt gcaggcgtcc cctctgcaag
      121 cgttagactt ctttgggaat gggccaccag ttaactacaa gacaggcaat ctatacctgc
      181 gggggcccct gaagaagtcc aatgcaccgc ttgtcaatgt gaccctctac tatgaagcac
      241 tgtgcggtgg ctgccgagcc ttcctgatcc gggagctctt cccaacatgg ctgttggtca
      301 tggagatcct caatgtcacg ctggtgccct acggaaacgc acaggaacaa aatgtcagtg
      361 gcaggtggga gttcaagtgc cagcatggag aagaggagtg caaattcaac aaggtggagg
      421 cctgcgtgtt ggatgaactt gacatggagc tagccttcct gaccattgtc tgcatggaag
      481 agtttgagga catggagaga agtctgccac tatgcctgca gctctacgcc ccagggctgt
      541 cgccagacac tatcatggag tgtgcaatgg gggaccgcgg catgcagctc atgcacgcca
      601 acgcccagcg gacagatgct ctccagccac cacacgagta tgtgccctgg gtcaccgtca
      661 atgggaaacc cttggaagat cagacccagc tccttaccct tgtctgccag ttgtaccagg
      721 gcaagaagcc ggatgtctgc ccttcctcaa ccagctccct caggagtgtt tgcttcaagt
      781 gatggccggt gagctgcgga gagctcatgg aaggcgagtg ggaacccggc tgcctgcctt
      841 tttttctgat ccagaccctc ggcacctgct acttaccaac tggaaaattt tatgcatccc
      901 atgaagccca gatacacaaa attccacccc atgatcaaga atcctgctcc actaagaatg
      961 gtgctaaagt aaaactagtt taataagc
//
