LOCUS       NM_032036                451 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens interferon alpha inducible protein 27 like 2
            (IFI27L2), mRNA.
ACCESSION   NM_032036
VERSION     NM_032036.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 451)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 451)
  AUTHORS   Gytz,H., Hansen,M.F., Skovbjerg,S., Kristensen,A.C., Horlyck,S.,
            Jensen,M.B., Fredborg,M., Markert,L.D., McMillan,N.A.,
            Christensen,E.I. and Martensen,P.M.
  TITLE     Apoptotic properties of the type 1 interferon induced family of
            human mitochondrial membrane ISG12 proteins
  JOURNAL   Biol Cell 109 (2), 94-112 (2017)
   PUBMED   27673746
REFERENCE   3  (bases 1 to 451)
  AUTHORS   Namciu,S.J., Friedman,R.D., Marsden,M.D., Sarausad,L.M.,
            Jasoni,C.L. and Fournier,R.E.
  TITLE     Sequence organization and matrix attachment regions of the human
            serine protease inhibitor gene cluster at 14q32.1
  JOURNAL   Mamm Genome 15 (3), 162-178 (2004)
   PUBMED   15014966
REFERENCE   4  (bases 1 to 451)
  AUTHORS   Parker,N. and Porter,A.C.
  TITLE     Identification of a novel gene family that includes the
            interferon-inducible human genes 6-16 and ISG12
  JOURNAL   BMC Genomics 5 (1), 8 (2004)
   PUBMED   14728724
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE737110.1 and BC032626.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032036.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ962754.1, CD108025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238609.4/ ENSP00000238609.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BE737110.1         19-51
            34-451              BC032626.1         9-426
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..451
                     /gene="IFI27L2"
                     /gene_synonym="FAM14A; ISG12B; TLH29"
                     /note="interferon alpha inducible protein 27 like 2"
                     /db_xref="GeneID:83982"
                     /db_xref="HGNC:HGNC:19753"
                     /db_xref="MIM:611319"
     exon            1..47
                     /gene="IFI27L2"
                     /gene_synonym="FAM14A; ISG12B; TLH29"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..433
                     /gene="IFI27L2"
                     /gene_synonym="FAM14A; ISG12B; TLH29"
                     /note="family with sequence similarity 14, member A;
                     ISG12(b) protein; interferon alpha-inducible protein
                     27-like protein 2; pIFI27-like protein;
                     interferon-stimulated gene 12b protein"
                     /codon_start=1
                     /product="interferon alpha-inducible protein 27-like
                     protein 2 precursor"
                     /protein_id="NP_114425.1"
                     /db_xref="CCDS:CCDS9920.1"
                     /db_xref="GeneID:83982"
                     /db_xref="HGNC:HGNC:19753"
                     /db_xref="MIM:611319"
                     /translation="MMKRAAAAAVGGALAVGAVPVVLSAMGFTGAGIAASSIAAKMMS
                     AAAIANGGGVSAGSLVATLQSVGAAGLSTSSNILLASVGSVLGACLGNSPSSSLPAEP
                     EAKEDEARENVPQGEPPKPPLKSEKHEE"
     exon            48..77
                     /gene="IFI27L2"
                     /gene_synonym="FAM14A; ISG12B; TLH29"
                     /inference="alignment:Splign:2.1.0"
     exon            78..239
                     /gene="IFI27L2"
                     /gene_synonym="FAM14A; ISG12B; TLH29"
                     /inference="alignment:Splign:2.1.0"
     exon            240..451
                     /gene="IFI27L2"
                     /gene_synonym="FAM14A; ISG12B; TLH29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      429..434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFI27L2"
                     /gene_synonym="FAM14A; ISG12B; TLH29"
                     /note="hexamer: AATAAA"
     polyA_site      451
                     /gene="IFI27L2"
                     /gene_synonym="FAM14A; ISG12B; TLH29"
                     /note="major polyA site"
ORIGIN      
        1 gtcatttcct gggccaagtt gggacccgga cggcctcacc atgatgaaac gggcagctgc
       61 tgctgcagtg ggaggagccc tggcagtggg ggctgtgccc gtggtgctca gtgccatggg
      121 cttcactggg gcaggaatcg ccgcgtcctc catagcagcc aagatgatgt ccgcagcagc
      181 cattgccaac gggggtggtg tttctgcggg gagcctggtg gctactctgc agtccgtggg
      241 ggcagctgga ctctccacat catccaacat cctcctggcc tctgttgggt cagtgttggg
      301 ggcctgcttg gggaattcac cttcttcttc tctcccagct gaacccgagg ctaaagaaga
      361 tgaggcaaga gaaaatgtac cccaaggtga acctccaaaa cccccactca agtcagagaa
      421 acatgaggaa taaaggtcac atgcagatgc a
//
