LOCUS       NM_206949                647 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens interferon alpha inducible protein 27 like 1
            (IFI27L1), transcript variant 2, mRNA.
ACCESSION   NM_206949
VERSION     NM_206949.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 647)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 647)
  AUTHORS   Gytz,H., Hansen,M.F., Skovbjerg,S., Kristensen,A.C., Horlyck,S.,
            Jensen,M.B., Fredborg,M., Markert,L.D., McMillan,N.A.,
            Christensen,E.I. and Martensen,P.M.
  TITLE     Apoptotic properties of the type 1 interferon induced family of
            human mitochondrial membrane ISG12 proteins
  JOURNAL   Biol Cell 109 (2), 94-112 (2017)
   PUBMED   27673746
REFERENCE   3  (bases 1 to 647)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 647)
  AUTHORS   Polasek,O., Marusic,A., Rotim,K., Hayward,C., Vitart,V.,
            Huffman,J., Campbell,S., Jankovic,S., Boban,M., Biloglav,Z.,
            Kolcic,I., Krzelj,V., Terzic,J., Matec,L., Tometic,G., Nonkovic,D.,
            Nincevic,J., Pehlic,M., Zedelj,J., Velagic,V., Juricic,D.,
            Kirac,I., Belak Kovacevic,S., Wright,A.F., Campbell,H. and Rudan,I.
  TITLE     Genome-wide association study of anthropometric traits in Korcula
            Island, Croatia
  JOURNAL   Croat Med J 50 (1), 7-16 (2009)
   PUBMED   19260139
REFERENCE   5  (bases 1 to 647)
  AUTHORS   Namciu,S.J., Friedman,R.D., Marsden,M.D., Sarausad,L.M.,
            Jasoni,C.L. and Fournier,R.E.
  TITLE     Sequence organization and matrix attachment regions of the human
            serine protease inhibitor gene cluster at 14q32.1
  JOURNAL   Mamm Genome 15 (3), 162-178 (2004)
   PUBMED   15014966
REFERENCE   6  (bases 1 to 647)
  AUTHORS   Parker,N. and Porter,A.C.
  TITLE     Identification of a novel gene family that includes the
            interferon-inducible human genes 6-16 and ISG12
  JOURNAL   BMC Genomics 5 (1), 8 (2004)
   PUBMED   14728724
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA693965.1, BN000225.1 and BU739372.1.
            
            On Nov 22, 2018 this sequence version replaced NM_206949.2.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR compared to variant 1. Both variants 1 and 2 encode
            the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BN000225.1, BG495263.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000555523.6/ ENSP00000451851.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               DA693965.1         10-149
            141-627             BN000225.1         186-672
            628-647             BU739372.1         23-42               c
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..647
                     /gene="IFI27L1"
                     /gene_synonym="FAM14B; ISG12C"
                     /note="interferon alpha inducible protein 27 like 1"
                     /db_xref="GeneID:122509"
                     /db_xref="HGNC:HGNC:19754"
                     /db_xref="MIM:611320"
     exon            1..140
                     /gene="IFI27L1"
                     /gene_synonym="FAM14B; ISG12C"
                     /inference="alignment:Splign:2.1.0"
     exon            141..219
                     /gene="IFI27L1"
                     /gene_synonym="FAM14B; ISG12C"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..506
                     /gene="IFI27L1"
                     /gene_synonym="FAM14B; ISG12C"
                     /note="family with sequence similarity 14, member B;
                     ISG12(c) protein; interferon alpha-inducible protein
                     27-like protein 1; interferon-stimulated gene 12c protein"
                     /codon_start=1
                     /product="interferon alpha-inducible protein 27-like
                     protein 1 precursor"
                     /protein_id="NP_996832.1"
                     /db_xref="CCDS:CCDS9919.1"
                     /db_xref="GeneID:122509"
                     /db_xref="HGNC:HGNC:19754"
                     /db_xref="MIM:611320"
                     /translation="MGKESGWDSGRAAVAAVVGGVVAVGTVLVALSAMGFTSVGIAAS
                     SIAAKMMSTAAIANGGGVAAGSLVAILQSVGAAGLSVTSKVIGGFAGTALGAWLGSPP
                     SS"
     exon            220..252
                     /gene="IFI27L1"
                     /gene_synonym="FAM14B; ISG12C"
                     /inference="alignment:Splign:2.1.0"
     exon            253..414
                     /gene="IFI27L1"
                     /gene_synonym="FAM14B; ISG12C"
                     /inference="alignment:Splign:2.1.0"
     exon            415..647
                     /gene="IFI27L1"
                     /gene_synonym="FAM14B; ISG12C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      626..631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFI27L1"
                     /gene_synonym="FAM14B; ISG12C"
                     /note="hexamer: AATAAA"
     polyA_site      647
                     /gene="IFI27L1"
                     /gene_synonym="FAM14B; ISG12C"
                     /note="major polyA site"
ORIGIN      
        1 agtgccggcg ggagagctgg cttggggcgc tggcacctcc tcttacagct ttactcctgc
       61 cagcttggga aaaggccgga gaaggtgaaa ttctgtgtgc tccctccggc gagagacttt
      121 gtcagctccc gcacagtaac gtggaagtcc aagaatccga gtggaggctc accgaggcga
      181 aggggccaac catgggaaag gagagtggat gggactcagg cagggctgct gtagcagctg
      241 tggtcggagg agttgtggct gtggggactg tgctcgtggc gctcagtgcc atgggcttca
      301 cctcagtagg aatcgccgca tcctccatag cagccaagat gatgtctaca gcagccattg
      361 ccaacggggg cggagttgct gctggcagtc tggtggctat tctgcagtca gtgggggcag
      421 ctggactctc tgtgacatct aaagttatcg ggggctttgc tgggacagct cttggggcct
      481 ggctgggttc acccccttcc agctgaacac cacactgagg cagggagttg gctctcttgg
      541 tggagatgac tttcctgggc ctctggatga caatcttcca aaggacaagt ctcctactcc
      601 caaaactatt taaggaagca tgaaaaataa agatgctggt tatcttc
//
