LOCUS       NM_001130080             652 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens interferon alpha inducible protein 27 (IFI27),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001130080
VERSION     NM_001130080.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 652)
  AUTHORS   Oguz,A.K., Oygur,C.S., Tasir,S., Ozdag,H. and Akar,M.N.
  TITLE     Behcet syndrome: The disturbed balance between anti- (CLEC12A, CLC)
            and proinflammatory (IFI27) gene expressions
  JOURNAL   Immun Inflamm Dis 11 (4), e836 (2023)
   PUBMED   37102643
  REMARK    GeneRIF: Behcet syndrome: The disturbed balance between anti-
            (CLEC12A, CLC) and proinflammatory (IFI27) gene expressions.
REFERENCE   2  (bases 1 to 652)
  AUTHORS   Jiang,C., He,C., Kan,J., Guan,H., Zhou,T. and Yang,Y.
  TITLE     Integrative bulk and single-cell transcriptome profiling analysis
            reveals IFI27 as a novel interferon-stimulated gene in dengue
  JOURNAL   J Med Virol 95 (4), e28706 (2023)
   PUBMED   36971141
  REMARK    GeneRIF: Integrative bulk and single-cell transcriptome profiling
            analysis reveals IFI27 as a novel interferon-stimulated gene in
            dengue.
REFERENCE   3  (bases 1 to 652)
  AUTHORS   Shojaei,M., Shamshirian,A., Monkman,J., Grice,L., Tran,M.,
            Tan,C.W., Teo,S.M., Rodrigues Rossi,G., McCulloch,T.R., Nalos,M.,
            Raei,M., Razavi,A., Ghasemian,R., Gheibi,M., Roozbeh,F., Sly,P.D.,
            Spann,K.M., Chew,K.Y., Zhu,Y., Xia,Y., Wells,T.J., Senegaglia,A.C.,
            Kuniyoshi,C.L., Franck,C.L., Dos Santos,A.F.R., de Noronha,L.,
            Motamen,S., Valadan,R., Amjadi,O., Gogna,R., Madan,E.,
            Alizadeh-Navaei,R., Lamperti,L., Zuniga,F., Nova-Lamperti,E.,
            Labarca,G., Knippenberg,B., Herwanto,V., Wang,Y., Phu,A., Chew,T.,
            Kwan,T., Kim,K., Teoh,S., Pelaia,T.M., Kuan,W.S., Jee,Y.,
            Iredell,J., O'Byrne,K., Fraser,J.F., Davis,M.J., Belz,G.T.,
            Warkiani,M.E., Gallo,C.S., Souza-Fonseca-Guimaraes,F., Nguyen,Q.,
            Mclean,A., Kulasinghe,A., Short,K.R. and Tang,B.
  TITLE     IFI27 transcription is an early predictor for COVID-19 outcomes, a
            multi-cohort observational study
  JOURNAL   Front Immunol 13, 1060438 (2023)
   PUBMED   36685600
  REMARK    GeneRIF: IFI27 transcription is an early predictor for COVID-19
            outcomes, a multi-cohort observational study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 652)
  AUTHORS   Saini,J., Thapa,U., Bandyopadhyay,B., Vrati,S. and Banerjee,A.
  TITLE     Knockdown of NEAT1 restricts dengue virus replication by augmenting
            interferon alpha-inducible protein 27 via the RIG-I pathway
  JOURNAL   J Gen Virol 104 (1) (2023)
   PUBMED   36748518
  REMARK    GeneRIF: Knockdown of NEAT1 restricts dengue virus replication by
            augmenting interferon alpha-inducible protein 27 via the RIG-I
            pathway.
REFERENCE   5  (bases 1 to 652)
  AUTHORS   Guo,M., Cao,W., Chen,S., Tian,R., Xue,B., Wang,L., Liu,Q., Deng,R.,
            Wang,X., Wang,Z., Zhang,Y., Yang,D., Zuo,C., Li,G., Tang,S. and
            Zhu,H.
  TITLE     TRIM21 Regulates Virus-Induced Cell Pyroptosis through
            Polyubiquitination of ISG12a
  JOURNAL   J Immunol 209 (10), 1987-1998 (2022)
   PUBMED   36426955
REFERENCE   6  (bases 1 to 652)
  AUTHORS   Izmailova,E., Bertley,F.M., Huang,Q., Makori,N., Miller,C.J.,
            Young,R.A. and Aldovini,A.
  TITLE     HIV-1 Tat reprograms immature dendritic cells to express
            chemoattractants for activated T cells and macrophages
  JOURNAL   Nat Med 9 (2), 191-197 (2003)
   PUBMED   12539042
REFERENCE   7  (bases 1 to 652)
  AUTHORS   Martensen,P.M., Sogaard,T.M., Gjermandsen,I.M., Buttenschon,H.N.,
            Rossing,A.B., Bonnevie-Nielsen,V., Rosada,C., Simonsen,J.L. and
            Justesen,J.
  TITLE     The interferon alpha induced protein ISG12 is localized to the
            nuclear membrane
  JOURNAL   Eur J Biochem 268 (22), 5947-5954 (2001)
   PUBMED   11722583
REFERENCE   8  (bases 1 to 652)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 652)
  AUTHORS   Taules,M., Rius,E., Talaya,D., Lopez-Girona,A., Bachs,O. and
            Agell,N.
  TITLE     Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4)
            activity and nuclear accumulation of cyclin D1-Cdk4 during G1
  JOURNAL   J Biol Chem 273 (50), 33279-33286 (1998)
   PUBMED   9837900
REFERENCE   10 (bases 1 to 652)
  AUTHORS   Rasmussen,U.B., Wolf,C., Mattei,M.G., Chenard,M.P., Bellocq,J.P.,
            Chambon,P., Rio,M.C. and Basset,P.
  TITLE     Identification of a new interferon-alpha-inducible gene (p27) on
            human chromosome 14q32 and its expression in breast carcinoma
  JOURNAL   Cancer Res 53 (17), 4096-4101 (1993)
   PUBMED   8358738
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BN000227.1.
            
            On Oct 30, 2018 this sequence version replaced NM_001130080.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). This variant represents an allele commonly found in the human
            population and corresponds to the allele present in the GRC
            reference assembly. Variants 1, 3, 5, 11 and 12 encode the same
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB113159.1, BX647330.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621160.5/ ENSP00000483498.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-652               BN000227.1         1-652
FEATURES             Location/Qualifiers
     source          1..652
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..652
                     /gene="IFI27"
                     /gene_synonym="FAM14D; ISG12; ISG12A; P27"
                     /note="interferon alpha inducible protein 27"
                     /db_xref="GeneID:3429"
                     /db_xref="HGNC:HGNC:5397"
                     /db_xref="MIM:600009"
     exon            1..62
                     /gene="IFI27"
                     /gene_synonym="FAM14D; ISG12; ISG12A; P27"
                     /inference="alignment:Splign:2.1.0"
     exon            63..211
                     /gene="IFI27"
                     /gene_synonym="FAM14D; ISG12; ISG12A; P27"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..489
                     /gene="IFI27"
                     /gene_synonym="FAM14D; ISG12; ISG12A; P27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     2310061N23Rik; interferon alpha-inducible protein 27,
                     mitochondrial; ISG12(a); interferon-stimulated gene 12a
                     protein; interferon alpha-induced 11.5 kDa protein"
                     /codon_start=1
                     /product="interferon alpha-inducible protein 27,
                     mitochondrial isoform 1"
                     /protein_id="NP_001123552.1"
                     /db_xref="GeneID:3429"
                     /db_xref="HGNC:HGNC:5397"
                     /db_xref="MIM:600009"
                     /translation="MEASALTSSAVTSVAKVVRVASGSAVVLPLARIATVVIGGVVAM
                     AAVPMVLSAMGFTAAGIASSSIAAKMMSAAAIANGGGVASGSLVATLQSLGATGLSGL
                     TKFILGSIGSAIAAVIARFY"
     exon            212..241
                     /gene="IFI27"
                     /gene_synonym="FAM14D; ISG12; ISG12A; P27"
                     /inference="alignment:Splign:2.1.0"
     exon            242..403
                     /gene="IFI27"
                     /gene_synonym="FAM14D; ISG12; ISG12A; P27"
                     /inference="alignment:Splign:2.1.0"
     exon            404..652
                     /gene="IFI27"
                     /gene_synonym="FAM14D; ISG12; ISG12A; P27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      632..637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFI27"
                     /gene_synonym="FAM14D; ISG12; ISG12A; P27"
                     /note="hexamer: AATAAA"
     polyA_site      652
                     /gene="IFI27"
                     /gene_synonym="FAM14D; ISG12; ISG12A; P27"
                     /note="major polyA site"
ORIGIN      
        1 aacacatcca agcttaagac ggtgaggtca gcttcacatt ctcaggaact ctccttcttt
       61 gggtctggct gaagttgagg atctcttact ctctaggcca cggaattaac ccgagcaggc
      121 atggaggcct ctgctctcac ctcatcagca gtgaccagtg tggccaaagt ggtcagggtg
      181 gcctctggct ctgccgtagt tttgcccctg gccaggattg ctacagttgt gattggagga
      241 gttgtggcca tggcggctgt gcccatggtg ctcagtgcca tgggcttcac tgcggcggga
      301 atcgcctcgt cctccatagc agccaagatg atgtccgcgg cggccattgc caatgggggt
      361 ggagttgcct cgggcagcct tgtggctact ctgcagtcac tgggagcaac tggactctcc
      421 ggattgacca agttcatcct gggctccatt gggtctgcca ttgcggctgt cattgcgagg
      481 ttctactagc tccctgcccc tcgccctgca gagaagagaa ccatgccagg ggagaaggca
      541 cccagccatc ctgacccagc gaggagccaa ctatcccaaa tatacctggg gtgaaatata
      601 ccaaattctg catctccaga ggaaaataag aaataaagat gaattgttgc aa
//
