LOCUS       NM_001376587            2883 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens interferon gamma inducible protein 16 (IFI16),
            transcript variant 4, mRNA.
ACCESSION   NM_001376587
VERSION     NM_001376587.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2883)
  AUTHORS   Sutter,S.O., Tobler,K., Seyffert,M., Lkharrazi,A., Zollig,J.,
            Schraner,E.M., Vogt,B., Buning,H. and Fraefel,C.
  TITLE     Interferon-gamma inducible factor 16 (IFI16) restricts
            adeno-associated virus type 2 (AAV2) transduction in an
            immune-modulatory independent way
  JOURNAL   J Virol 98 (7), e0011024 (2024)
   PUBMED   38837381
  REMARK    GeneRIF: Interferon-gamma inducible factor 16 (IFI16) restricts
            adeno-associated virus type 2 (AAV2) transduction in an
            immune-modulatory independent way.
REFERENCE   2  (bases 1 to 2883)
  AUTHORS   Shi,X., Wei,M., Feng,Y., Yang,Y., Zhang,X., Chen,H., Xing,Y.,
            Wang,K., Wang,W., Wang,L., Wang,A. and Zhang,G.
  TITLE     IFI16 Positively Regulates RIG-I-Mediated Type I Interferon
            Production in a STING-Independent Manner
  JOURNAL   DNA Cell Biol 43 (4), 197-205 (2024)
   PUBMED   38466944
  REMARK    GeneRIF: IFI16 Positively Regulates RIG-I-Mediated Type I
            Interferon Production in a STING-Independent Manner.
REFERENCE   3  (bases 1 to 2883)
  AUTHORS   Randle,R.K., Amara,V.R. and Popik,W.
  TITLE     IFI16 Is Indispensable for Promoting HIF-1alpha-Mediated APOL1
            Expression in Human Podocytes under Hypoxic Conditions
  JOURNAL   Int J Mol Sci 25 (6), 3324 (2024)
   PUBMED   38542298
  REMARK    GeneRIF: IFI16 Is Indispensable for Promoting HIF-1alpha-Mediated
            APOL1 Expression in Human Podocytes under Hypoxic Conditions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2883)
  AUTHORS   Azumi,Y., Koma,Y.I., Tsukamoto,S., Kitamura,Y., Ishihara,N.,
            Yamanaka,K., Nakanishi,T., Miyako,S., Urakami,S., Tanigawa,K.,
            Kodama,T., Nishio,M., Shigeoka,M., Kakeji,Y. and Yokozaki,H.
  TITLE     IFI16 Induced by Direct Interaction between Esophageal Squamous
            Cell Carcinomas and Macrophages Promotes Tumor Progression via
            Secretion of IL-1alpha
  JOURNAL   Cells 12 (22), 2603 (2023)
   PUBMED   37998338
  REMARK    GeneRIF: IFI16 Induced by Direct Interaction between Esophageal
            Squamous Cell Carcinomas and Macrophages Promotes Tumor Progression
            via Secretion of IL-1alpha.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2883)
  AUTHORS   Fan,Z., Chen,R., Yin,W., Xie,X., Wang,S. and Hao,C.
  TITLE     Effects of AIM2 and IFI16 on Infectious Diseases and Inflammation
  JOURNAL   Viral Immunol 36 (7), 438-448 (2023)
   PUBMED   37585649
  REMARK    GeneRIF: Effects of AIM2 and IFI16 on Infectious Diseases and
            Inflammation.
            Review article
REFERENCE   6  (bases 1 to 2883)
  AUTHORS   Johnstone,R.W., Kershaw,M.H. and Trapani,J.A.
  TITLE     Isotypic variants of the interferon-inducible transcriptional
            repressor IFI 16 arise through differential mRNA splicing
  JOURNAL   Biochemistry 37 (34), 11924-11931 (1998)
   PUBMED   9718316
REFERENCE   7  (bases 1 to 2883)
  AUTHORS   Dawson,M.J. and Trapani,J.A.
  TITLE     IFI 16 gene encodes a nuclear protein whose expression is induced
            by interferons in human myeloid leukaemia cell lines
  JOURNAL   J Cell Biochem 57 (1), 39-51 (1995)
   PUBMED   7536752
REFERENCE   8  (bases 1 to 2883)
  AUTHORS   Dawson,M.J., Trapani,J.A., Briggs,R.C., Nicholl,J.K.,
            Sutherland,G.R. and Baker,E.
  TITLE     The closely linked genes encoding the myeloid nuclear
            differentiation antigen (MNDA) and IFI16 exhibit contrasting
            haemopoietic expression
  JOURNAL   Immunogenetics 41 (1), 40-43 (1995)
   PUBMED   7806273
REFERENCE   9  (bases 1 to 2883)
  AUTHORS   Trapani,J.A., Dawson,M., Apostolidis,V.A. and Browne,K.A.
  TITLE     Genomic organization of IFI16, an interferon-inducible gene whose
            expression is associated with human myeloid cell differentiation:
            correlation of predicted protein domains with exon organization
  JOURNAL   Immunogenetics 40 (6), 415-424 (1994)
   PUBMED   7959953
REFERENCE   10 (bases 1 to 2883)
  AUTHORS   Trapani,J.A., Browne,K.A., Dawson,M.J., Ramsay,R.G., Eddy,R.L.,
            Show,T.B., White,P.C. and Dupont,B.
  TITLE     A novel gene constitutively expressed in human lymphoid cells is
            inducible with interferon-gamma in myeloid cells
  JOURNAL   Immunogenetics 36 (6), 369-376 (1992)
   PUBMED   1526658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359753.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of the HIN-200 (hematopoietic
            interferon-inducible nuclear antigens with 200 amino acid repeats)
            family of cytokines. The encoded protein contains domains involved
            in DNA binding, transcriptional regulation, and protein-protein
            interactions. The protein localizes to the nucleoplasm and
            nucleoli, and interacts with p53 and retinoblastoma-1. It modulates
            p53 function, and inhibits cell growth in the Ras/Raf signaling
            pathway. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Apr 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.17027.1,
                                           DRR138524.139542.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000295809.12/
                                                ENSP00000295809.7
            RefSeq Select criteria           :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AL359753.9         106775-107029
            256-540             AL359753.9         111529-111813
            541-656             AL359753.9         112740-112855
            657-824             AL359753.9         113401-113568
            825-1247            AL359753.9         115097-115519
            1248-1436           AL359753.9         117209-117397
            1437-1604           AL359753.9         129392-129559
            1605-1772           AL359753.9         142165-142332
            1773-1940           AL359753.9         146300-146467
            1941-2360           AL359753.9         148547-148966
            2361-2552           AL359753.9         150401-150592
            2553-2883           AL359753.9         151689-152019
FEATURES             Location/Qualifiers
     source          1..2883
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..2883
                     /gene="IFI16"
                     /gene_synonym="IFNGIP1; PYHIN2"
                     /note="interferon gamma inducible protein 16"
                     /db_xref="GeneID:3428"
                     /db_xref="HGNC:HGNC:5395"
                     /db_xref="MIM:147586"
     exon            1..255
                     /gene="IFI16"
                     /gene_synonym="IFNGIP1; PYHIN2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..540
                     /gene="IFI16"
                     /gene_synonym="IFNGIP1; PYHIN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..2633
                     /gene="IFI16"
                     /gene_synonym="IFNGIP1; PYHIN2"
                     /note="isoform 3 is encoded by transcript variant 4;
                     interferon-gamma induced protein IFI 16;
                     interferon-inducible myeloid differentiation
                     transcriptional activator"
                     /codon_start=1
                     /product="gamma-interferon-inducible protein 16 isoform 3"
                     /protein_id="NP_001363516.1"
                     /db_xref="CCDS:CCDS91079.1"
                     /db_xref="GeneID:3428"
                     /db_xref="HGNC:HGNC:5395"
                     /db_xref="MIM:147586"
                     /translation="MGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYD
                     KIQIADLMEEKFRGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRKKEV
                     DATSPAPSTSSTVKTEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMS
                     TAMGRSPSPKTSLSAPPNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEY
                     ETPEMEKKIMFHATVATQTQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEE
                     STVSEAGPNQTFEVPNKIINRAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIY
                     EIQDDRGKMDVVGTGQCHNIPCEEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKT
                     NPRNNDPKSMKLPQEQRQLPYPSEASTTFPESHLRTPQMPPTTPSSSFFTKKSEDTIS
                     KMNDFMRMQILKEGSHFPGPFMTSIGPAESHPHTPQMPPSTPSSSFLTTKSEDTISKM
                     NDFMRMQILKEGSHFPGPFMTSIGPAESHPHTPQMPPSTPSSSFLTTLKPRLKTEPEE
                     VSIEDSAQSDLKEVMVLNATESFVYEPKEQKKMFHATVATENEVFRVKVFNIDLKEKF
                     TPKKIIAIANYVCRNGFLEVYPFTLVADVNADRNMEIPKGLIRSASVTPKINQLCSQT
                     KGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEEGDKLKLTCFEL
                     APKSGNTGELRSVIHSHIKVIKTRKNKKDILNPDSSMETSPDFFF"
     exon            541..656
                     /gene="IFI16"
                     /gene_synonym="IFNGIP1; PYHIN2"
                     /inference="alignment:Splign:2.1.0"
     exon            657..824
                     /gene="IFI16"
                     /gene_synonym="IFNGIP1; PYHIN2"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1247
                     /gene="IFI16"
                     /gene_synonym="IFNGIP1; PYHIN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1436
                     /gene="IFI16"
                     /gene_synonym="IFNGIP1; PYHIN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1604
                     /gene="IFI16"
                     /gene_synonym="IFNGIP1; PYHIN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1772
                     /gene="IFI16"
                     /gene_synonym="IFNGIP1; PYHIN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1940
                     /gene="IFI16"
                     /gene_synonym="IFNGIP1; PYHIN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2360
                     /gene="IFI16"
                     /gene_synonym="IFNGIP1; PYHIN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2552
                     /gene="IFI16"
                     /gene_synonym="IFNGIP1; PYHIN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2883
                     /gene="IFI16"
                     /gene_synonym="IFNGIP1; PYHIN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2859..2864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFI16"
                     /gene_synonym="IFNGIP1; PYHIN2"
                     /note="hexamer: AATAAA"
     polyA_site      2883
                     /gene="IFI16"
                     /gene_synonym="IFNGIP1; PYHIN2"
                     /note="major polyA site"
ORIGIN      
        1 attttctctg gggcaatagc agaataggag caagccagca ctagtcagct aactaagtga
       61 ctcaaccaag gccttttttc cttgttatct ttgcagatac ttcattttct tagcgtttct
      121 ggagattaca acatcctgcg gttccgtttc tgggaacttt actgatttat ctcccccctc
      181 acacaaataa gcattgattc ctgcatttct gaagatctca agatctggac tactgttgaa
      241 aaaatttcca gtgaggctca cttatgtctg taaagatggg aaaaaaatac aagaacattg
      301 ttctactaaa aggattagag gtcatcaatg attatcattt tagaatggtt aagtccttac
      361 tgagcaacga tttaaaactt aatttaaaaa tgagagaaga gtatgacaaa attcagattg
      421 ctgacttgat ggaagaaaag ttccgaggtg atgctggttt gggcaaacta ataaaaattt
      481 tcgaagatat accaacgctt gaagacctgg ctgaaactct taaaaaagaa aagttaaaag
      541 taaaaggacc agccctatca agaaagagga agaaggaagt ggatgctact tcacctgcac
      601 cctccacaag cagcactgtc aaaactgaag gagcagaggc aactcctgga gctcagaaaa
      661 gaaaaaaatc aaccaaagaa aaggctggac ccaaagggag taaggtgtcc gaggaacaga
      721 ctcagcctcc ctctcctgca ggagccggca tgtccacagc catgggccgt tccccatctc
      781 ccaagacctc attgtcagct ccacccaaca gttcttcaac tgagaacccg aaaacagtgg
      841 ccaaatgtca ggtaactccc agaagaaatg ttctccaaaa acgcccagtg atagtgaagg
      901 tactgagtac aacaaagcca tttgaatatg agaccccaga aatggagaaa aaaataatgt
      961 ttcatgctac agtggctaca cagacacagt tcttccatgt gaaggtttta aacaccagct
     1021 tgaaggagaa attcaatgga aagaaaatca tcatcatatc agattatttg gaatatgata
     1081 gtctcctaga ggtcaatgaa gaatctactg tatctgaagc tggtcctaac caaacgtttg
     1141 aggttccaaa taaaatcatc aacagagcaa aggaaactct gaagattgat attcttcaca
     1201 aacaagcttc aggaaatatt gtatatgggg tatttatgct acataagaaa acagtaaatc
     1261 agaagaccac aatctacgaa attcaggatg atagaggaaa aatggatgta gtggggacag
     1321 gacaatgtca caatatcccc tgtgaagaag gagataagct ccaacttttc tgctttcgac
     1381 ttagaaaaaa gaaccagatg tcaaaactga tttcagaaat gcatagtttt atccagataa
     1441 agaaaaaaac aaacccgaga aacaatgacc ccaagagcat gaagctaccc caggaacagc
     1501 gtcagcttcc atatccttca gaggccagca caaccttccc tgagagccat cttcggactc
     1561 ctcagatgcc accaacaact ccatccagca gtttcttcac caagaaaagt gaagacacaa
     1621 tctccaaaat gaatgacttc atgaggatgc agatactgaa ggaagggagt cattttccag
     1681 gaccgttcat gaccagcata ggcccagctg agagccatcc ccacactcct cagatgcctc
     1741 catcaacacc aagcagcagt ttcttaacca cgaaaagtga agacacaatc tccaaaatga
     1801 atgacttcat gaggatgcag atactgaagg aagggagtca ttttccagga ccgttcatga
     1861 ccagcatagg cccagctgag agccatcccc acactcctca gatgcctcca tcaacaccaa
     1921 gcagcagttt cttaaccacg ttgaaaccaa gactgaagac tgaacctgaa gaagtttcca
     1981 tagaagacag tgcccagagt gacctcaaag aagtgatggt gctgaacgca acagaatcat
     2041 ttgtatatga gcccaaagag cagaagaaaa tgtttcatgc cacagtggca actgagaatg
     2101 aagtcttccg agtgaaggtt tttaatattg acctaaagga gaagttcacc ccaaagaaga
     2161 tcattgccat agcaaattat gtttgccgca atgggttcct ggaggtatat cctttcacac
     2221 ttgtggctga tgtgaatgct gaccgaaaca tggagatccc aaaaggattg attagaagtg
     2281 ccagcgtaac tcctaaaatc aatcagcttt gctcacaaac taaaggaagt tttgtgaatg
     2341 gggtgtttga ggtacataag aaaaatgtaa ggggtgaatt cacttattat gaaatacaag
     2401 ataatacagg gaagatggaa gtggtggtgc atggacgact gaccacaatc aactgtgagg
     2461 aaggagataa actgaaactc acctgctttg aattggcacc gaaaagtggg aataccgggg
     2521 agttgagatc tgtaattcat agtcacatca aggtcatcaa gaccaggaaa aacaagaaag
     2581 acatactcaa tcctgattca agtatggaaa cttcaccaga ctttttcttc taaaatctgg
     2641 atgtcattga cgataatgtt tatggagata aggtctaagt gcctaaaaaa atgtacatat
     2701 acctggttga aatacaacac tatacataca caccaccata tatactagct gttaatccta
     2761 tggaatgggg tattgggagt gcttttttaa tttttcatag ttttttttta ataaaatggc
     2821 atattttgca tctacaactt ctataatttg aaaaaataaa taaacattat cttttttgtg
     2881 aaa
//
