LOCUS       NM_001136265            6179 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens intermediate filament family orphan 2 (IFFO2), mRNA.
ACCESSION   NM_001136265 XM_001714732 XM_001721924 XM_001722365
VERSION     NM_001136265.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6179)
  AUTHORS   Kottyan,L.C., Davis,B.P., Sherrill,J.D., Liu,K., Rochman,M.,
            Kaufman,K., Weirauch,M.T., Vaughn,S., Lazaro,S., Rupert,A.M.,
            Kohram,M., Stucke,E.M., Kemme,K.A., Magnusen,A., He,H.,
            Dexheimer,P., Chehade,M., Wood,R.A., Pesek,R.D., Vickery,B.P.,
            Fleischer,D.M., Lindbad,R., Sampson,H.A., Mukkada,V.A.,
            Putnam,P.E., Abonia,J.P., Martin,L.J., Harley,J.B. and
            Rothenberg,M.E.
  TITLE     Genome-wide association analysis of eosinophilic esophagitis
            provides insight into the tissue specificity of this allergic
            disease
  JOURNAL   Nat Genet 46 (8), 895-900 (2014)
   PUBMED   25017104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL080251.23.
            
            On Nov 22, 2018 this sequence version replaced NM_001136265.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.468881.1,
                                           SRR1163655.439449.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000455833.7/ ENSP00000387941.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               AL080251.23        72155-72498         c
            345-1009            AL080251.23        71490-72154         c
            1010-1070           AL080251.23        36883-36943         c
            1071-1166           AL080251.23        35500-35595         c
            1167-1307           AL080251.23        34184-34324         c
            1308-1447           AL080251.23        32725-32864         c
            1448-1568           AL080251.23        27785-27905         c
            1569-1661           AL080251.23        27206-27298         c
            1662-1792           AL080251.23        26164-26294         c
            1793-6179           AL080251.23        20102-24488         c
FEATURES             Location/Qualifiers
     source          1..6179
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..6179
                     /gene="IFFO2"
                     /note="intermediate filament family orphan 2"
                     /db_xref="GeneID:126917"
                     /db_xref="HGNC:HGNC:27006"
     exon            1..1009
                     /gene="IFFO2"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..1898
                     /gene="IFFO2"
                     /codon_start=1
                     /product="intermediate filament family orphan 2"
                     /protein_id="NP_001129737.1"
                     /db_xref="CCDS:CCDS44076.1"
                     /db_xref="GeneID:126917"
                     /db_xref="HGNC:HGNC:27006"
                     /translation="MVNSLLFGEMALAFGCPPGGGGGGCPGGGGGGGGAGPGPSPVTA
                     ALRDDLGSNIHLLKGLNVRFRCFLAKVHELERRNRLLEKQLEQQQSERERRLRYKTFS
                     REQAVQTGPELLRPPAPGGGHGLSSGAAAGANANAVALGGLPPGGGSHPQHYGRLPGT
                     IWSYTQVRRTGGGGVETVQGPGVSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDE
                     YKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEEMNEKIERLKAELVVFKGLMSDPM
                     TDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNSEDVSKIFQVVPKKKERKVASD
                     DDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFDFDDDCDSLTWEENEDTLLL
                     WEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQETIGQIELELATAKSDMN
                     RHLHEYMEMCSMKRGLDVQMETCRRLIKGSADRNSPSPSSVASSDSGSTDEIQDEFER
                     EADVEPMVS"
     exon            1010..1070
                     /gene="IFFO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1166
                     /gene="IFFO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1307
                     /gene="IFFO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1447
                     /gene="IFFO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1568
                     /gene="IFFO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1661
                     /gene="IFFO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1792
                     /gene="IFFO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..6179
                     /gene="IFFO2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6154..6159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFFO2"
                     /note="hexamer: AATAAA"
     polyA_site      6179
                     /gene="IFFO2"
                     /note="major polyA site"
ORIGIN      
        1 agtgccggcc gagagtcctc tgcgtgcggc tgccgcggcc cctccacagc gtctctgaca
       61 gcccgggcgg tgagacccgc gacccttctg gccccgcgca gataccgcgg cctccaccgc
      121 gtcccgagga gcggccgagt gccctctctc gcctcggcgc ccgcatccgg ggccatccgt
      181 cctgccgtct ctgcggaggc cgcatctggc gcgcatctgg aaccgcccgg ccggccgcgc
      241 tggagcccgc gcccaccctg gcccggccgc gccgggagcc ctgcccggag ctggagccgc
      301 acctggagcc gcgggcccgg ggccctgagc cgcgcagccg gcgcatggtg aactcgctgc
      361 tgttcgggga gatggccttg gccttcggct gcccgccggg cggcggcggc gggggctgcc
      421 ctggcggggg cggcggcggc ggcggggcag ggccgggtcc gtcgccggtg acggcggcgc
      481 tgcgggacga cctgggctcc aacatccacc tcttgaaggg gctcaacgtg cgcttccgct
      541 gcttcctggc taaggtgcac gagctggagc ggcgcaaccg gctgctggag aagcagctgg
      601 agcagcagca gagcgagcgc gagcggcggc tgcgctacaa gaccttctcc cgcgagcagg
      661 ccgtgcagac cgggcccgag ttgctgcggc ccccggcgcc cggcggcggg cacggcctca
      721 gcagtggcgc ggcggccggc gccaacgcca atgccgtggc cctgggcggc ctgccccccg
      781 gcggcggctc gcacccgcag cactacggcc gcctgcccgg gaccatctgg agctacacgc
      841 aggtgcggcg cacgggcggc ggcggcgtgg agaccgtgca gggccccggc gtgtcgtggg
      901 tgcaccccga cggcgtgggc gtgcagatcg acaccatcac gccggagatc cgcgcgctct
      961 acaacgtgct ggccaaggtg aagcgcgagc gcgacgagta taagcggagg tgggaggagg
     1021 agctcgccaa gcgcatgaac cttcagacca tggtggacac gctgcaggag gcagcacagg
     1081 aggctgatgc catccaggag gagatgaatg agaagatcga gcggctcaag gccgagctgg
     1141 tggtgtttaa ggggcttatg agtgacccca tgacagacct ggacacaaag atccaagaaa
     1201 aggccatgaa ggtggacatg gacatctgcc gccgaatcga tatcacggcc aagctgtgcg
     1261 atgtcgcaca gcagcggaac tcagaagacg tgtccaagat cttccaggtg gtccccaaaa
     1321 agaaagagcg taaggtggct tccgatgatg acatctctga gcaggacggg gaggtgaacc
     1381 ggttctcgga cgatgaggtc ggctccatga acatcaccga tgagatgaag cgcatgttta
     1441 accagctgcg ggagaccttt gactttgacg acgactgtga cagcctgacg tgggaagaga
     1501 atgaagacac gctgctgctc tgggaggatt tcaccaactg caatccgacc atcgacctgc
     1561 agggcgagca agaggaaaac ttgggcaact tgatccatga gaccgaatcc ttcttcaaga
     1621 cgagagacaa ggagtaccag gaaacgatag gtcagatcga gctcgagctg gccacagcca
     1681 aaagtgacat gaaccgacac ctgcacgagt acatggagat gtgcagcatg aagcgaggcc
     1741 tggacgtgca gatggagacc tgccgccggc tcatcaaagg ctccgcagac aggaattcac
     1801 cgtcccccag ctccgtggcc agcagcgact caggaagtac agatgagatc caggatgagt
     1861 tcgagcgcga ggcggatgtg gagcccatgg tcagctgatg actgaggccc tgcgagcctg
     1921 gtggtcttgg tgatggggcc ctgccacctc tcctcatggg gccaggaagg cccctcggag
     1981 tggggttcga agccacacca cacagacttt ctctgccctc ccttctctgg aggccctgag
     2041 ggactgctgc ttccttcctt ccttccacac caccaacggg tgccccgtct ccatccccca
     2101 cccacccaag gaatggtgct gtcaatttct attgttctcc acattacaaa tgcagacttc
     2161 tgtgcggact ttgcagtgtt aactgtgcct tctcccttaa gctgagccac tttgagctcc
     2221 aaagaattat tcctagcagg tgtttttata cagaactcta agctgagggc cgggccaacc
     2281 ggccgtggtg taatgtggtt tctgccgtcc gtcccacctg ctcctctgat tggccatggg
     2341 ctatgccctc ccttcctcct gagccagccc agactcggcc tggagcttgg ggtgctctgc
     2401 caacccccag gaaggagccg cttgcctctg tgagctttct aggcctgggt agggaccacc
     2461 ccaattttct cactccctga aggagagaaa ggtggaagga agggaaggag gacacatttt
     2521 aattttttgg ggggatcgag tggcaaagtt gaagggacaa ggcactgtga ggggaaggca
     2581 gagcctcact gtgtttaaac tactatgcaa aaaacaaaac aaacaacaaa agcagcttgc
     2641 cttatatcat tgtggaaggc aggacctctc ctgggctcct ggcttccccc tggagctggg
     2701 agagaggccg gggttagggt gatctgtgtg gcagcactga ctgggtagtg tgggtttggc
     2761 cgaggttggt catgaggctg gggttcccgc aaggcactgg cctccctgac cgcttgcttc
     2821 cttccggacc tctgggttca gggcgggggc ggagggatcc ttgatttccc tgataacttg
     2881 atgttcttcc ctccctcgcc agccaacaat agaggcttag agatctgtaa tttctctgtg
     2941 agaaagtctg aaggggccag gcctggtctc tgctcccttc tacccgcctt gggttaggac
     3001 tgtccggcag ttgcctgctt ttggctgctg gcaggagaga agcagggtgg gctgctggca
     3061 gtgcaggagc tggagtgagg gccatcctct ttctgctcct cgacacacgc aagccgctct
     3121 cagcagttcc ctcgactggc cagtcggggt attgatctga gccagcatcc cccaagactt
     3181 gaatggcttg agtgggactg cgttgaaggg cactgtgtgg cccccttcca aatctcagct
     3241 tggagccagc tgagcaggct ttgctttatt attatttttt aagcctactg cagtgggtct
     3301 gttgccaatt ttaatttttt attgtcccag gagctccctc tagtggtcaa ggtagcaaaa
     3361 tgtgcccaag gactagaact tgggtccctc tgccttgcct ggaggcagaa ggagggggct
     3421 ctgggtttga ctgggattgt ggtccccagg ggtccgtggc ctttaaggct cttctctctt
     3481 ttctgtttcc cccacctgtg ttacagtctt aaaaatactg tacataaaag atatatgtag
     3541 agagagagag agagcgtgag aatgtgttag tgactatgtg tgatgtaatt tatcacgatt
     3601 tggtggcctt cgtcatgagt tttttccttt gttttctttt gctgggggca cctcccacgg
     3661 gtcccctgtg gcagtctggc tgtgacactt ccatagtcag catctcttgt tagccaaaca
     3721 gttccctttg acaggtactt ggagggacaa tggttttgga agagagacgg cccttctctc
     3781 tcctcactca cccttgttct aaaggttaca gggttcaaac atacctgatt cttgttgtta
     3841 ttgttgttga atttttattt taaccaaagg ttatcagagc cagttgggct tggacctcag
     3901 ctgctaaaaa gattttccgt ttcctcgagg gcaggaaaac atccaccctc gtgggtctcc
     3961 tccgtccagg gccgagggag gcattggaca atgtggtatg ggagtttcgt gggcagcgtg
     4021 gaagccggcc ctgggttgtt ccccaaggtg gtgggagggt gacagatata tctttagact
     4081 taagactgta aggcagcagt gttagcatgg gagtaactaa ggttactgtg gttatcggtg
     4141 tccggcggta ttatttttac tttcctcctt gtatacatag gtcatttgtc tttgaggact
     4201 agggtactct agggagtttg aaaactgcag gagccagaaa gagatcctgg cctgagagtc
     4261 ccttctggct ggcttttaat atctgctctc ctcttgggag tgaggacttg gggcaggtgg
     4321 gtaggagagg gaaagccaga gtgtgatggg cctgcctcct gggctggttc ctgggtccgg
     4381 cctgcctgcc tgcctgcctg cctctccacc acatgctttt ttcagttaat gtcagtgggc
     4441 cctgcttgtc ccctcaccat gagcccacag cttgccaaga aagaccccaa cgctcgctgg
     4501 ggcagcacca gtcctagctg ggacgaattg gtccatcctt tgtaaagctg taaatactta
     4561 attttgactt tctatttcta agcccagtgt catattgaca ctggtatttt agaattttct
     4621 cagatgggct ctcctgcgct gccctctgtc tcctgttttt gggggtttta tacaaacaga
     4681 ggattgggga gggataggaa gactagcatc cttttggctc cctggttggt tgtgaaatac
     4741 acacacacac acacacacac acacacacac tcgcactcct ctgagactcc gaacagagaa
     4801 aaaaattatt ggcaaatcaa cacatttttc tttctcgtct tgagaaaatg tcttgaggtc
     4861 cctgaagggc caaatccatc gtggactaac tctgtgggta gagctcagat gacctaggga
     4921 gaattaaacc acttaagctt ggagtgggag gagagggggt ggggtggggg agaatataag
     4981 atgtaactta agctaaatgt aatctattta taaagcaaga gactctcatc tatttttatg
     5041 aaaggaaggg ttttttaatc tagggtaggc agttgtggta gcccagcatt ttcctgtgga
     5101 cgagacatgg tgcatgttgt tgctggattg aatggaaccc attcctgtcc cccggcctcg
     5161 tcttctgtcc tcacttttgg tcatccacac ccatgagcag cttcagcaga gtgtaggtcc
     5221 cacttcaccc cattctcctc tcctctgacc cctcagctcc ttggaagtct tggggtgggg
     5281 atctgagggg gtgggtgggc tgcaggaaat tcagaaatgt ggtgggtggg ggaagggaca
     5341 aggcgcatta gggagggaac aagctgggct ctggggatag gctctgatta attagttact
     5401 ctgactctgg tctgccgaga tccatttcca acccagttgc gttgggagag ggttgggagg
     5461 cagcagagca tgggtgacag tgggagcaca cgacttcctt ggagcctggg cctttgcggg
     5521 tcccaggtgg tcaggcagct ggagcagaag tggaaatggc ttaagatgct catagcccag
     5581 ccccggctgt gtctactcca ggccaagcct gggctgcagt ccttgctatg ttccccccag
     5641 ggccctgggg ggagggatca gggtgctggg ggtttcctag gacaggggtc ttcccccttg
     5701 agacaccaag ctctggctct agaagagctc tctcctggag tggggagtct ggaggggact
     5761 gggtgggtgc aggtaaagcc agattctctc tggaagggaa ttttctatga atggatgatt
     5821 tccaggctca gggtgggctg tgtgttagtt ctgagcaaat ccctcaccaa gacccttccc
     5881 tcccaagccc tcaaagaaat gaggcaaagc ccttccctgc aagacccctt gtggatgttt
     5941 ttgcatctac ctgattttta gccccaccca gggagacttt ataccccatg atcctgcccc
     6001 accgttgctg ttgtctgcca gctgggtcta gcatcacagg gaaggggggg atttatactc
     6061 atggaaagac tactgatcct accggaaacc aacctgttta ctgtactgtt gtaaatatca
     6121 tgccctttat atcctgtata ttggcttctt ttaaataaag tgaaatgtct tagaactga
//
