LOCUS       NM_001193457            2673 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens intermediate filament family orphan 1 (IFFO1),
            transcript variant 5, mRNA.
ACCESSION   NM_001193457
VERSION     NM_001193457.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2673)
  AUTHORS   Yu,H., Liu,P. and Chen,T.
  TITLE     CircIFFO1 suppresses tumor growth and metastasis of cutaneous
            squamous cell carcinoma by targeting the miR-424-5p/NFIB axis
  JOURNAL   Arch Dermatol Res 315 (9), 2585-2596 (2023)
   PUBMED   37405427
  REMARK    GeneRIF: CircIFFO1 suppresses tumor growth and metastasis of
            cutaneous squamous cell carcinoma by targeting the miR-424-5p/NFIB
            axis.
REFERENCE   2  (bases 1 to 2673)
  AUTHORS   Zhang,Y., Qiu,J.G., Jia,X.Y., Ke,Y., Zhang,M.K., Stieg,D.,
            Liu,W.J., Liu,L.Z., Wang,L. and Jiang,B.H.
  TITLE     METTL3-mediated N6-methyladenosine modification and HDAC5/YY1
            promote IFFO1 downregulation in tumor development and
            chemo-resistance
  JOURNAL   Cancer Lett 553, 215971 (2023)
   PUBMED   36257380
  REMARK    GeneRIF: METTL3-mediated N6-methyladenosine modification and
            HDAC5/YY1 promote IFFO1 downregulation in tumor development and
            chemo-resistance.
REFERENCE   3  (bases 1 to 2673)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2673)
  AUTHORS   Li,W., Bai,X., Li,J., Zhao,Y., Liu,J., Zhao,H., Liu,L., Ding,M.,
            Wang,Q., Shi,F.Y., Hou,M., Ji,J., Gao,G., Guo,R., Sun,Y., Liu,Y.
            and Xu,D.
  TITLE     The nucleoskeleton protein IFFO1 immobilizes broken DNA and
            suppresses chromosome translocation during tumorigenesis
  JOURNAL   Nat Cell Biol 21 (10), 1273-1285 (2019)
   PUBMED   31548606
  REMARK    GeneRIF: The lamin A/C-IFFO1-constituted nucleoskeleton prevents
            chromosome translocation by immobilizing broken DNA ends during
            tumorigenesis.
REFERENCE   5  (bases 1 to 2673)
  AUTHORS   Tureci,O., Sahin,U., Koslowski,M., Buss,B., Bell,C., Ballweber,P.,
            Zwick,C., Eberle,T., Zuber,M., Villena-Heinsen,C., Seitz,G. and
            Pfreundschuh,M.
  TITLE     A novel tumour associated leucine zipper protein targeting to sites
            of gene transcription and splicing
  JOURNAL   Oncogene 21 (24), 3879-3888 (2002)
   PUBMED   12032826
REFERENCE   6  (bases 1 to 2673)
  AUTHORS   Steinert,P.M. and Roop,D.R.
  TITLE     Molecular and cellular biology of intermediate filaments
  JOURNAL   Annu Rev Biochem 57, 593-625 (1988)
   PUBMED   3052284
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA744744.1, DA969856.1,
            AK298905.1, AL080214.1, AI423929.1 and BC063004.1.
            
            On Apr 20, 2020 this sequence version replaced NM_001193457.1.
            
            Summary: This gene is a member of the intermediate filament family.
            Intermediate filaments are proteins which are primordial components
            of the cytoskeleton and nuclear envelope. The proteins encoded by
            the members of this gene family are evolutionarily and structurally
            related but have limited sequence homology, with the exception of
            the central rod domain. Multiple alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (5) uses two alternate in-frame
            splice sites in the central coding region, compared to variant 2,
            resulting in an isoform (5) that is longer than isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK298905.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000619571.5/ ENSP00000482285.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-422               DA744744.1         61-482
            423-751             DA969856.1         1-329
            752-1941            AK298905.1         2-1191
            1942-2273           AL080214.1         532-863
            2274-2634           AI423929.1         42-402              c
            2635-2673           BC063004.1         1923-1961
FEATURES             Location/Qualifiers
     source          1..2673
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..2673
                     /gene="IFFO1"
                     /gene_synonym="HOM-TES-103; IFFO"
                     /note="intermediate filament family orphan 1"
                     /db_xref="GeneID:25900"
                     /db_xref="HGNC:HGNC:24970"
                     /db_xref="MIM:610495"
     exon            1..786
                     /gene="IFFO1"
                     /gene_synonym="HOM-TES-103; IFFO"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1729
                     /gene="IFFO1"
                     /gene_synonym="HOM-TES-103; IFFO"
                     /note="isoform 5 is encoded by transcript variant 5;
                     intermediate filament-like MGC:2625; NHEJ factor IFFO1;
                     non-homologous end joining factor IFFO1"
                     /codon_start=1
                     /product="non-homologous end joining factor IFFO1 isoform
                     5"
                     /protein_id="NP_001180386.1"
                     /db_xref="CCDS:CCDS73425.1"
                     /db_xref="GeneID:25900"
                     /db_xref="HGNC:HGNC:24970"
                     /db_xref="MIM:610495"
                     /translation="MNPLFGPNLFLLQQEQQGLAGPLGDSLGGDHFAGGGDLPPAPLS
                     PAGPAAYSPPGPGPAPPAAMALRNDLGSNINVLKTLNLRFRCFLAKVHELERRNRLLE
                     KQLQQALEEGKQGRRGLGRRDQAVQTGFVSPIRPLGLQLGARPAAVCSPSARVLGSPA
                     RSPAGPLAPSAASLSSSSTSTSTTYSSSARFMPGTIWSFSHARRLGPGLEPTLVQGPG
                     LSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNEL
                     QEEAQEADACQEELALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRI
                     DITAKLCDVAQQRNCEDMIQMFQKKLSLHLSPIKVPSMGGRKRERKAAVEEDTSLSES
                     EGPRQPDGDEEESTALSINEEMQRMLNQLREYDFEDDCDSLTWEETEETLLLWEDFSG
                     YAMAAAEAQGEQQEDSLEKVIKDTESLFKTREKEYQETIDQIELELATAKNDMNRHLH
                     EYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPPPPPSEAEDSDRDVSS
                     DSSMR"
     exon            787..847
                     /gene="IFFO1"
                     /gene_synonym="HOM-TES-103; IFFO"
                     /inference="alignment:Splign:2.1.0"
     exon            848..943
                     /gene="IFFO1"
                     /gene_synonym="HOM-TES-103; IFFO"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1084
                     /gene="IFFO1"
                     /gene_synonym="HOM-TES-103; IFFO"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1093
                     /gene="IFFO1"
                     /gene_synonym="HOM-TES-103; IFFO"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1275
                     /gene="IFFO1"
                     /gene_synonym="HOM-TES-103; IFFO"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1396
                     /gene="IFFO1"
                     /gene_synonym="HOM-TES-103; IFFO"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1492
                     /gene="IFFO1"
                     /gene_synonym="HOM-TES-103; IFFO"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1623
                     /gene="IFFO1"
                     /gene_synonym="HOM-TES-103; IFFO"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..2673
                     /gene="IFFO1"
                     /gene_synonym="HOM-TES-103; IFFO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2657..2662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFFO1"
                     /gene_synonym="HOM-TES-103; IFFO"
                     /note="hexamer: AATGAA"
     polyA_site      2673
                     /gene="IFFO1"
                     /gene_synonym="HOM-TES-103; IFFO"
                     /note="major polyA site"
ORIGIN      
        1 agaaggcgca gccatgaatc cgttattcgg ccccaacctc ttcctcctgc agcaggagca
       61 gcagggcctg gccgggccac tgggggactc actgggaggc gaccacttcg ccgggggagg
      121 agacttgccc ccggcgcctc tctcgccggc cggccctgct gcctactcgc cgcccgggcc
      181 gggcccggcc ccgcctgccg ccatggccct ccgcaatgac ctgggctcca acatcaacgt
      241 gctcaagacc ctgaacctcc ggttccgctg cttcctggcc aaggtgcatg agctggagcg
      301 ccggaaccgg ctgttggaga agcaactgca gcaagcgctg gaggagggta agcagggccg
      361 gcggggcctg ggtcgtcgcg accaggcagt gcagaccggc ttcgtcagcc ccatccggcc
      421 cctggggctg cagctgggcg cccggccggc cgctgtctgc agcccttcgg cgcgcgtgct
      481 gggctcgccc gcgcgctccc cggccggccc cctcgcgccc tccgcggcca gcctctcgtc
      541 gtcctccacc tccacctcca ccacctattc ctcgtcggcc cgcttcatgc ccggcaccat
      601 ctggtcgttc tcgcacgccc gccggctcgg gccgggactg gagcccactc tggtgcaagg
      661 gcctggcttg tcgtgggtgc acccggatgg ggtgggcgtc cagatcgaca ccatcacgcc
      721 cgagatccgc gctctctaca acgtgctggc caaagtgaag cgggagcggg acgagtacaa
      781 gcggaggtgg gaagaggagt acacggtgcg gatccagctg caagaccgtg taaatgagct
      841 ccaggaggaa gcccaggagg ctgatgcctg ccaggaggag ctggcactga aggtggaaca
      901 gttgaaggct gagctggtgg tcttcaaggg gctcatgagt aacaacctgt cggagctgga
      961 caccaagatc caggagaaag ccatgaaggt ggatatggac atctgccgcc gcatcgacat
     1021 caccgccaag ctctgcgatg tggctcagca gcgcaactgc gaggacatga tccagatgtt
     1081 ccagaagaag ctgtctctgc acttgtctcc cattaaggtc ccatccatgg gggggcggaa
     1141 gcgggagcgc aaggctgccg tcgaggagga cacctccctg tcggagagtg aggggccccg
     1201 ccagcccgat ggggatgagg aggagagcac agccctcagc atcaacgagg agatgcagcg
     1261 catgctcaac cagctgaggg agtatgattt tgaggacgac tgtgacagcc tgacttggga
     1321 ggagactgag gagaccctgc tgctttggga ggatttctca ggctatgcca tggcagctgc
     1381 agaggcccag ggagagcagc aggaagatag cctggagaag gtgattaaag atacggagtc
     1441 cctgttcaaa acccgggaga aggagtatca ggagaccatt gaccagatag agctggagtt
     1501 ggccacggcc aagaacgaca tgaaccggca cctgcacgag tacatggaga tgtgcagcat
     1561 gaagcgcggc ctggacgtgc agatggagac ctgccgccgg ctcatcaccc agtctggaga
     1621 ccgaaagtct cctgctttca ctgcggtccc gcttagcgac ccgccgccgc cgccaagcga
     1681 ggctgaggac tccgatcgcg atgtctcatc tgacagctcc atgagataga gacctgcctc
     1741 ccccttgcac ccgaggccct cgcagcaggg agctcagcga ggcagagggt ggggctgcac
     1801 agaggggaac atcagctgca gctctgcacc aggccggtcc ctggggactg gggcgctcct
     1861 ccctcaggct ttctccctca gtcttggctt ctccagggct ctggggtgtc tggagctagg
     1921 cttggcccta ccattctggg gccatttcca ccacagttgg ggctctcctg ccttcacgcg
     1981 tgggtgtctg ctacttcccc atctttaaaa tgctgccaga gcgattgcgg cccctcacct
     2041 tgtccacgta tcaggaatgt gaatgtggga cctttcctcc atccctgttg tccggagcca
     2101 gctcactgtc ttccacactg gtgctaactg gcccaggcac tggagtggaa tagaatgcag
     2161 ctggaggcta cgcatggcct ctgcagcaca cgcagctgga gagggcttct gtccctgtca
     2221 gcggcagagg gcgttggggc tggccggggc accttgtccc tgctatggtc cacgtgctca
     2281 cgctgtccac ctgccaggtg gagtgtatgt ggctgtggcc ctccctcgtg gaggtgccgt
     2341 gctttaaaga ggccttagtg cccgggatgg gcacagtgtt ttgaagggag gtgggagctc
     2401 ttgctctcct ggtcactgca gaatgacaga gaaggtgaag ctccatgcat gtgtgcgcgg
     2461 gtgtatgtgc gctcagggtc tctgtttaag tatcagctaa agatgtgctt cctccgtgtc
     2521 tgtcatacac tgagaccaac aggctacagt gtccctgatt cttggaaaag cctggagaag
     2581 ctggggagat gcggttcaca atgcctcggt ataggaggct gtgttgagct gacattcaaa
     2641 tggattcttt aataataatg aaactggcga gta
//
