LOCUS       NM_203434               2710 bp    mRNA    linear   PRI 24-APR-2024
DEFINITION  Homo sapiens immediate early response 5 like (IER5L), mRNA.
ACCESSION   NM_203434 XM_372145
VERSION     NM_203434.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2710)
  AUTHORS   Wang,N., Tan,X., Cao,S. and Liu,M.
  TITLE     Predictive value of immediate early response 5 like (IER5L) in the
            prognosis and immune checkpoint blockade therapy of non-small cell
            lung cancer patients
  JOURNAL   Pathol Res Pract 256, 155270 (2024)
   PUBMED   38552564
  REMARK    GeneRIF: Predictive value of immediate early response 5 like
            (IER5L) in the prognosis and immune checkpoint blockade therapy of
            non-small cell lung cancer patients.
REFERENCE   2  (bases 1 to 2710)
  AUTHORS   Doi,K., Takeuchi,H. and Sakurai,H.
  TITLE     PP2A-B55 and its adapter proteins IER2 and IER5 regulate the
            activity of RB family proteins and the expression of cell
            cycle-related genes
  JOURNAL   FEBS J 290 (3), 745-762 (2023)
   PUBMED   36047562
REFERENCE   3  (bases 1 to 2710)
  AUTHORS   Ueda,T., Kohama,Y. and Sakurai,H.
  TITLE     IER family proteins are regulators of protein phosphatase PP2A and
            modulate the phosphorylation status of CDC25A
  JOURNAL   Cell Signal 55, 81-89 (2019)
   PUBMED   30599213
  REMARK    GeneRIF: The results suggest that IER2, IER5, and IER5L proteins
            are target protein-specific regulators of PP2A (protein phosphatase
            2A) activity and modulate cell proliferation through CDC25A (cell
            division cycle 25A protein) activity.
REFERENCE   4  (bases 1 to 2710)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM763373.1, BX458317.2, AL158151.16, BQ574938.1, CN293040.1 and
            BU676697.1.
            
            On May 17, 2019 this sequence version replaced NM_203434.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DRR138511.42761.1, ERR279842.132.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372491.4/ ENSP00000361569.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               BM763373.1         1-466
            467-709             BX458317.2         434-676
            710-710             AL158151.16        85033-85033         c
            711-868             BX458317.2         677-834
            869-961             AL158151.16        84782-84874         c
            962-1604            BQ574938.1         15-657              c
            1605-2105           CN293040.1         51-551
            2106-2183           BU676697.1         546-623             c
            2184-2710           BU676697.1         15-541              c
FEATURES             Location/Qualifiers
     source          1..2710
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..2710
                     /gene="IER5L"
                     /gene_synonym="bA247A12.2"
                     /note="immediate early response 5 like"
                     /db_xref="GeneID:389792"
                     /db_xref="HGNC:HGNC:23679"
     exon            1..2710
                     /gene="IER5L"
                     /gene_synonym="bA247A12.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1424
                     /gene="IER5L"
                     /gene_synonym="bA247A12.2"
                     /codon_start=1
                     /product="immediate early response gene 5-like protein"
                     /protein_id="NP_982258.2"
                     /db_xref="CCDS:CCDS43888.1"
                     /db_xref="GeneID:389792"
                     /db_xref="HGNC:HGNC:23679"
                     /translation="MECALDAQSLISISLRKIHSSRTQRGGIKLHKNLLVSYVLRNAR
                     QLYLSERYAELYRRQQQQQQQQPPHHQHQHLAYAAPGMPASAADFGPLQLGGGGDAEA
                     REPAARHQLHQLHQLHQLHLQQQLHQHQHPAPRGCAAAAAAGAPAGGAGALSELPGCA
                     ALQPPHGAPHRGQPLEPLQPGPAPLPLPLPPPAPAALCPRDPRAPAACSAPPGAAPPA
                     AAASPPASPAPASSPGFYRGAYPTPSDFGLHCSSQTTVLDLDTHVVTTVENGYLHQDC
                     CASAHCPCCGQGAPGPGLASAAGCKRKYYPGQEEEEDDEEDAGGLGAEPPGGAPFAPC
                     KRARFEDFCPDSSPDASNISNLISIFGSGFSGLVSRQPDSSEQPPPLNGQLCAKQALA
                     SLGAWTRAIVAF"
     regulatory      1581..1586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IER5L"
                     /gene_synonym="bA247A12.2"
                     /note="hexamer: AATAAA"
     polyA_site      1604
                     /gene="IER5L"
                     /gene_synonym="bA247A12.2"
                     /note="major polyA site"
     regulatory      2690..2695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IER5L"
                     /gene_synonym="bA247A12.2"
                     /note="hexamer: AATAAA"
     polyA_site      2710
                     /gene="IER5L"
                     /gene_synonym="bA247A12.2"
                     /note="major polyA site"
ORIGIN      
        1 actcattgct ttggcgccgt ctggggagcg cgagcccgcg ggtggcgcgc ggcgcatggt
       61 ggcggctcct ttcggagcgc agccgaacct ctgacccgga ctccgttacc cctgcccggc
      121 gcgccccggc ggccggctgg aggcagaaac agcagaagcg ttaacagcag cagcggcggc
      181 ggctgctccg ccgccgtctc cgcgggagca tggagtgcgc cctggacgcc cagagcctga
      241 tcagcatctc cctgcgcaag atccacagct cccgaaccca gcgcggcggc atcaagctgc
      301 acaagaacct cctggtgtcc tacgtgctcc gcaacgcgcg ccagctctac ctgagcgagc
      361 gctacgccga gctctaccgg cgccagcagc agcagcaaca gcagcagccg ccccaccacc
      421 agcaccagca cctagcgtac gcggcgccgg gcatgccggc cagcgcggcc gacttcggcc
      481 cgctccaact tggcggcggc ggggacgcgg aggcgcgcga gccggccgcc cggcaccagc
      541 tgcaccagct ccaccagctc caccagctgc acctccagca gcagctgcac cagcaccagc
      601 acccggcgcc caggggctgc gcggcggcgg cggcggccgg agcgcccgcg ggcggcgcgg
      661 gggcgctctc ggagctgccc gggtgcgccg cgctccagcc gccgcacggc gcgccccacc
      721 gcgggcagcc cttggagcct ctgcagccgg gtcctgcgcc gctgccgctg ccgctgccgc
      781 cgcccgcgcc cgctgcgctc tgcccgcggg accctcgcgc cccggccgcc tgctccgcgc
      841 ccccaggggc cgcccctccg gccgccgccg cttctccgcc cgcctccccg gcccccgcct
      901 cctcccccgg cttctaccgg ggcgcatacc ctaccccttc ggacttcggc ttgcactgca
      961 gcagccagac caccgtgctg gacctagaca ctcacgtggt gaccacggtg gagaacggct
     1021 acttgcacca ggactgctgc gcctccgccc actgcccctg ctgtggccag ggcgctccgg
     1081 gaccgggcct ggcgtccgcc gccggctgca agcgcaagta ttaccctggc caggaggagg
     1141 aggaagacga cgaggaggat gcgggcgggc tgggggccga gccccccggg ggcgccccgt
     1201 tcgccccctg caagcgcgcc cgcttcgagg acttctgccc ggactcgtcc ccggacgcgt
     1261 ccaacatctc aaacttgatc tccatctttg gctccggctt ctcggggctg gtgagccgac
     1321 agccggactc ctcggagcag ccgccgccgc tcaacgggca gctgtgcgcc aagcaggcgc
     1381 tcgccagcct cggcgcctgg actcgagcca ttgtcgcctt ctagggaccc ccgagggcac
     1441 agggacccgg ggccccgcgg ggctggggcc agacaaagac tcggcaaagg ggcgagagga
     1501 gggaacgagc gggcgccggg ccactcgggg ctgagctggg ggcgagcggg ggcaggcggc
     1561 tgatgtttta taaattgtaa aataaaaaaa aaagaaatct aaaatcttgg actttatttt
     1621 tgcagagaga aaaagcgcct atttaagtat gctttgtgtt tctcctactc ctttttttct
     1681 ttttattgta gtgattgcag tggtgtttag cgaggagcct accacgtgag ggagggctgc
     1741 tgcccggagg aggtgccggg cagccggggg cgaggcaggg cgccctggcc gccggggcgc
     1801 gccgggggcg cagctcagga gggcgccgga cctgggaagc cgattccaat cagttgtcag
     1861 acccgggaag cccgacgttc cgctctcccg agtccctctg tggggtgagg aatgggtctt
     1921 gtgaaattct gagcaaaaac aaaggcaaac tctatctccg aaagggacgt ttgggtcaca
     1981 tttcctctct gggggcggac tccaaagttc tcaaaatgag aaggcagaaa tgaaaacact
     2041 tcaacttttt ttttcttttc ttcccggggc gggtgtcttg aacccctctt ctccccgccc
     2101 ctctggctcc gttctcctcc cctcctccac ccgtctcccg gactcggggg tggcgcctga
     2161 caccccgaca ctctcggaca ctgggtaagg ggtggggggc gggcacggcg gactacattt
     2221 cccatcatgc ctagcactgc ggtcctcact aaacaaaaaa ggaagtcaat tccttcacct
     2281 ggatccccgg cggccccggg ggagggaggg gccgggaccg ccgactgcgt tggagacttt
     2341 gcactaagtt cctggtcagc tgtggtgttt gtgtgtgtgc ttctaagttg cactgccttg
     2401 gttcagcctt cggttgcatt tcatgaaacc agcattgttc gagcctgtga gaaccccgtc
     2461 ctgtgtcttc agctcgatag atttgtttaa tttaaaagcc ttttgttgta aaaaggtggg
     2521 gttcgtctgc agcccctctg gttctctgcc atcagcaccg tgtggactcc aaaacgagtt
     2581 gccaatcctt cctttctcgg cccttttccc tcattaccct gtatttttgt gcatactgaa
     2641 ttgtatatca ccgggtaaaa ctgttcagat tgtttaaatt tataatctta ataaaaagtc
     2701 gattacagaa
//
