LOCUS       NM_016545               4201 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens immediate early response 5 (IER5), mRNA.
ACCESSION   NM_016545
VERSION     NM_016545.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4201)
  AUTHORS   Doi,K., Takeuchi,H. and Sakurai,H.
  TITLE     PP2A-B55 and its adapter proteins IER2 and IER5 regulate the
            activity of RB family proteins and the expression of cell
            cycle-related genes
  JOURNAL   FEBS J 290 (3), 745-762 (2023)
   PUBMED   36047562
  REMARK    GeneRIF: PP2A-B55 and its adapter proteins IER2 and IER5 regulate
            the activity of RB family proteins and the expression of cell
            cycle-related genes.
REFERENCE   2  (bases 1 to 4201)
  AUTHORS   Pan,L., Lemieux,M.E., Thomas,T., Rogers,J.M., Lipper,C.H., Lee,W.,
            Johnson,C., Sholl,L.M., South,A.P., Marto,J.A., Adelmant,G.O.,
            Blacklow,S.C. and Aster,J.C.
  TITLE     IER5, a DNA damage response gene, is required for Notch-mediated
            induction of squamous cell differentiation
  JOURNAL   Elife 9, e58081 (2020)
   PUBMED   32936072
  REMARK    GeneRIF: IER5, a DNA damage response gene, is required for
            Notch-mediated induction of squamous cell differentiation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4201)
  AUTHORS   Zheng,J.J., He,Y., Liu,Y., Li,F.S., Cui,Z., Du,X.M., Wang,C.P. and
            Wu,Y.M.
  TITLE     Novel role of PAF1 in attenuating radiosensitivity in cervical
            cancer by inhibiting IER5 transcription
  JOURNAL   Radiat Oncol 15 (1), 131 (2020)
   PUBMED   32471508
  REMARK    GeneRIF: Novel role of PAF1 in attenuating radiosensitivity in
            cervical cancer by inhibiting IER5 transcription.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4201)
  AUTHORS   Yamano,S., Kimura,M., Chen,Y., Imamoto,N. and Ohki,R.
  TITLE     Nuclear import of IER5 is mediated by a classical bipartite nuclear
            localization signal and is required for HSF1 full activation
  JOURNAL   Exp Cell Res 386 (1), 111686 (2020)
   PUBMED   31669744
  REMARK    GeneRIF: Nuclear localization signal at amino acids 217-244
            mediates complex formation with importin-alpha and importin-beta.
            NLS is essential for HSF1 dephosphorylation and full activation by
            IER5.
REFERENCE   5  (bases 1 to 4201)
  AUTHORS   Ueda,T., Kohama,Y. and Sakurai,H.
  TITLE     IER family proteins are regulators of protein phosphatase PP2A and
            modulate the phosphorylation status of CDC25A
  JOURNAL   Cell Signal 55, 81-89 (2019)
   PUBMED   30599213
  REMARK    GeneRIF: The results suggest that IER2, IER5, and IER5L proteins
            are target protein-specific regulators of PP2A (protein phosphatase
            2A) activity and modulate cell proliferation through CDC25A (cell
            division cycle 25A protein) activity.
REFERENCE   6  (bases 1 to 4201)
  AUTHORS   Nakamura,S., Nagata,Y., Tan,L., Takemura,T., Shibata,K., Fujie,M.,
            Fujisawa,S., Tanaka,Y., Toda,M., Makita,R., Tsunekawa,K.,
            Yamada,M., Yamaoka,M., Yamashita,J., Ohnishi,K. and Yamashita,M.
  TITLE     Transcriptional repression of Cdc25B by IER5 inhibits the
            proliferation of leukemic progenitor cells through NF-YB and p300
            in acute myeloid leukemia
  JOURNAL   PLoS One 6 (11), e28011 (2011)
   PUBMED   22132193
  REMARK    GeneRIF: Transcriptional repression mediated by IER5 regulates
            Cdc25B expression levels via the release of NF-YB and p300 in acute
            myeloid leukemia.
REFERENCE   7  (bases 1 to 4201)
  AUTHORS   Ding,K.K., Shang,Z.F., Hao,C., Xu,Q.Z., Shen,J.J., Yang,C.J.,
            Xie,Y.H., Qiao,C., Wang,Y., Xu,L.L. and Zhou,P.K.
  TITLE     Induced expression of the IER5 gene by gamma-ray irradiation and
            its involvement in cell cycle checkpoint control and survival
  JOURNAL   Radiat Environ Biophys 48 (2), 205-213 (2009)
   PUBMED   19238419
  REMARK    GeneRIF: the early radiation-induced expression of IER5 affects
            radiosensitivity via disturbing radiation-induced cell cycle
            checkpoints
REFERENCE   8  (bases 1 to 4201)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   9  (bases 1 to 4201)
  AUTHORS   Cirelli,C. and Tononi,G.
  TITLE     Gene expression in the brain across the sleep-waking cycle
  JOURNAL   Brain Res 885 (2), 303-321 (2000)
   PUBMED   11102586
  REMARK    GeneRIF: Studies in rat found higher mRNA levels after waking and
            sleep deprivation for immediate early genes/transcription factors
            such as IER5
REFERENCE   10 (bases 1 to 4201)
  AUTHORS   Williams,M., Lyu,M.S., Yang,Y.L., Lin,E.P., Dunbrack,R., Birren,B.,
            Cunningham,J. and Hunter,K.
  TITLE     Ier5, a novel member of the slow-kinetics immediate-early genes
  JOURNAL   Genomics 55 (3), 327-334 (1999)
   PUBMED   10049588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI696140.1, AF178984.1, AL356267.27 and AA235294.1.
            
            On May 17, 2019 this sequence version replaced NM_016545.4.
            
            Summary: This gene encodes a protein that is similar to other
            immediate early response proteins. In the mouse, a similar gene may
            play an important role in mediating the cellular response to
            mitogenic signals. Studies in rats found the expression of a
            similar gene to be increased after waking and sleep deprivation.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DRR138524.717372.1, BC000128.2
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367577.7/ ENSP00000356549.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AI696140.1         199-259
            62-807              AF178984.1         1-746
            808-808             AL356267.27        92707-92707
            809-2139            AF178984.1         748-2078
            2140-2144           AA235294.1         9-13                c
            2145-4201           AL356267.27        94044-96100
FEATURES             Location/Qualifiers
     source          1..4201
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..4201
                     /gene="IER5"
                     /gene_synonym="SBBI48"
                     /note="immediate early response 5"
                     /db_xref="GeneID:51278"
                     /db_xref="HGNC:HGNC:5393"
                     /db_xref="MIM:607177"
     exon            1..4201
                     /gene="IER5"
                     /gene_synonym="SBBI48"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1187
                     /gene="IER5"
                     /gene_synonym="SBBI48"
                     /codon_start=1
                     /product="immediate early response gene 5 protein"
                     /protein_id="NP_057629.2"
                     /db_xref="CCDS:CCDS1343.1"
                     /db_xref="GeneID:51278"
                     /db_xref="HGNC:HGNC:5393"
                     /db_xref="MIM:607177"
                     /translation="MEFKLEAHRIVSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSAR
                     QVYLSDPCPGLYLAGPAGTPAPPPQQQPGEPAAGPPAGWGEPPPPAARASWPETEPQP
                     ERSSVSDAPRVGDEVPVATVTGVGDVFQGGEADATEAAWSRVEGPRQAAAREAEGTAG
                     GWGVFPEVSRAARRPCGCPLGGEDPPGTPAATPRAACCCAPQPAEDEPPAPPAVCPRK
                     RCAAGVGGGPAGCPAPGSTPLKKPRRNLEQPPSGGEDDDAEEMETGNVANLISIFGSS
                     FSGLLRKSPGGGREEEEGEESGPEAAEPGQICCDKPVLRDMNPWSTAIVAF"
     regulatory      2121..2126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IER5"
                     /gene_synonym="SBBI48"
                     /note="hexamer: ATTAAA"
     polyA_site      2139
                     /gene="IER5"
                     /gene_synonym="SBBI48"
                     /note="major polyA site"
     regulatory      3302..3307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IER5"
                     /gene_synonym="SBBI48"
                     /note="hexamer: ATTAAA"
     polyA_site      3320
                     /gene="IER5"
                     /gene_synonym="SBBI48"
     regulatory      4121..4126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IER5"
                     /gene_synonym="SBBI48"
                     /note="hexamer: TATAAA"
     polyA_site      4146
                     /gene="IER5"
                     /gene_synonym="SBBI48"
     regulatory      4164..4169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IER5"
                     /gene_synonym="SBBI48"
                     /note="hexamer: AAGAAA"
     polyA_site      4201
                     /gene="IER5"
                     /gene_synonym="SBBI48"
ORIGIN      
        1 gtttagcgac cggacccgaa acggggaagt tgtcttgttt ggagaggtta gtagagcagc
       61 gcgcgcgtca ccagagtcgt ttctcttcgg agtcttaggt gatcgagggt gtgcccaggg
      121 ggcggacttg tttgcgcctc ccgttccctc ccaatttcca aacgtgtcac cccggcgccg
      181 acggccctgt gcaggggaag cagatggagt tcaagctgga ggctcatcgc atcgtcagca
      241 tctctctggg caagatctac aactcgcggg tccagcgcgg cggcatcaag ctgcataaga
      301 acctcctggt ctcgctggtg ctgcgcagcg cccgccaagt ctacctgagc gacccgtgcc
      361 ccggcctcta cctggccggt cccgctggga ccccggcgcc gccaccgcag cagcagcccg
      421 gggagccggc ggccgggcca cccgccggct ggggagagcc gcccccgccc gccgctcgtg
      481 cctcttggcc ggagaccgag ccgcagccgg agcgctcctc cgtctcagac gcgccgcggg
      541 taggggacga ggtgccggtg gccacggtga ctggagtcgg ggacgttttt cagggcggag
      601 aggcggacgc gacggaagct gcctggagcc gcgtggaggg gccgcgccag gcggcggcca
      661 gagaagccga gggtaccgcc ggaggctggg gcgtcttccc cgaggtatct cgtgccgcgc
      721 gccgcccctg cggctgcccc ctaggcgggg aggacccgcc gggtacaccg gccgcgaccc
      781 cccgcgctgc ctgctgctgc gcgccgcaac cagcggagga cgagcccccc gcgccgcccg
      841 cggtgtgccc caggaagcgc tgcgcggcgg gggtgggcgg cggcccagcg ggctgcccgg
      901 cgcccggctc gaccccgctc aagaagcccc gccggaactt agagcagccg ccgagtggag
      961 gagaggacga cgacgcggag gagatggaga ccgggaacgt ggctaacctc atcagcatct
     1021 tcggttccag tttctcggga ctcctacgga aaagccccgg gggcggcaga gaggaagagg
     1081 agggagagga gagcggtccg gaagccgccg agcccgggca gatctgctgc gataagccgg
     1141 tgctgagaga catgaacccc tggagcacag ccatcgtggc cttctgagcc cttggccccc
     1201 ctgcggggag gaggtggagc agcgggcgtc cccgaagtga gggccaggcc cttcccggct
     1261 gcgaggacgc ccagagaccg cgggcgctga gcgcgttggg cagactggtt gcctctgggc
     1321 atcgcaaact gcccccgggc gcatctggct tatctggaga cctgggagct tgaggctcat
     1381 tggaagagga cgatcgttaa cttttgtgtt tgtgtatgtc tgtgtatgta agtttgtctt
     1441 gtggcattaa gactattttg ctcttctgga atgcaccact ccttccccag ggtttaagag
     1501 attgggggca gacagggact ttcctctgcc ggctgcgtgg agaaggaagc ggctaaaagg
     1561 tttgggccgg ggagttcccc attcgttctc cggggaggga gggactttac acctacccct
     1621 caccggaaag ctagacccgc ttcagggcca ggagtggcgt ttccgcacag gatttcctaa
     1681 gacgagaggg atttagccaa gagcacagac ttggattcct tctgtccctc cccacctttc
     1741 tctcccaatg aagaaacgtt tatatcctgt gattactcta ggaaaggggc gtattaacgg
     1801 tcctttgctt ccccgcaggg gagaaaaagc ttgacgaact tcacagaaga gttcaagctt
     1861 ggaaataatg gagtttatag agaaaagata tatttttaaa agctctaggt cagaagtact
     1921 acacagtgct tttaaaaagt gtttaatgag agtttacaga cagaagcccg aagtggaaag
     1981 accttatggt tttgtagata tggtgactcc agtctttgtt gtataaaggt tgggggagct
     2041 gataaggttt ttgtacagta ttttctcctt cgttgtattg atttttgtat aaaaatgtaa
     2101 cttctacgtg tctaacacgt attaaatatt ttgaagcaac gtaactgcct gcttgtctgt
     2161 aataacctgc ctgggttggg agggaagtgg gaggagggaa accagggcct gagctagaaa
     2221 attgaaggtg tggttcttag tatcagtcat tcgcagactg aggacattgt ttactgactc
     2281 cactaagtat caagagagac acgtttaatt tttcctccta gatcagagga ctgctattag
     2341 atactaatat cggcgacctg tcaggttcta gaaacctgcc actacaactg ccttttctaa
     2401 ggtcagttta gaccaatttg tcacccaata tgtgggtgtc taatactaag taatttaacc
     2461 aacttttgaa gccccgctta tccacaaaaa tgtttttcag caaaactttg tttcctgtta
     2521 agctattaat acgggtcatc ttttagcttt gtaattgaaa aaaaaaaagt ttagatagta
     2581 gtttacctta aaagcccatt cgaactgaca taggaagatg aaagagactg acttgtccaa
     2641 attgtcaggt ccacctctgc atcacagtgg atgtcaggat gtaaattttc agtttttctc
     2701 ttacatctag aaagtaaata tattgctgag agggaaattg tttgcatcaa accagataag
     2761 gaaggagggc taggcaaatt tagttctcat ttagcaaaac ttcctgattt gttttgttac
     2821 ttaaatggtg acatcagtgt ttggtcatgg tagacactta ggtgatgata gccaaaacat
     2881 ccatcgattt tactaaaatc actgccatta agagagtttt ttgtctcttc atgttcaatg
     2941 tttgaaaggt attcagtaat ctatttcaga agcaaatcaa ttagggaatg gtgtttatta
     3001 aaatacggta cagttgccag gactttaaaa gatggtactg gtttctaaca acttacgagt
     3061 atatagggta tttaaaagat gggagagatt gaagaaagac aaaggtttaa aggtcatagc
     3121 cttcgagcat aagaggcata tgaatggtgt cttggcctta actcccaatt atacgaactt
     3181 ctgttttagc tgaataggcc agtgcctcgt gccttgatat ttcggcaaat ctattagtgg
     3241 ttccttaagc atagggaact ttgtacttta tgctctgtcg ccataataat gtatttatag
     3301 aattaaacat tctcaaatta gggtcttgtt aaactgactt tttctttcag aaagtagcta
     3361 cttaaattct gttacagcta caaaagatcc atcaagtgct gactgcttaa actgaagaag
     3421 gtgtccaggg ccttaattct gcaaacattt cctgttgtta gaaagtatga tgcttgaaca
     3481 gcgatctcag tgtattttat gttttaaagg gggtaacgtt tggtgtgttt aagagagctg
     3541 atgtgttttg gatgagacta aagttgatcc ttggttttac attaagatga acctgggtcc
     3601 atgtgtctgc ttaaagaatg taaattggca tacttgatag gaggataaag ctttgtagga
     3661 attagaaaag atcattctct tttttgttgc agaagcagta tagtatagta gttagagcat
     3721 gggccctgga gccaggctgc ttggtgtctt cctttattta tttatttatt taattataaa
     3781 aagtaaatat aaagtgagct atgttgacca ggttcgtctt gaactcctgg cctcaagcaa
     3841 tcctcctgcc tcagcctccc aaagtgctgg gattacaggc atgagccacc acaacctggc
     3901 ctgcttgggt ttttctatct tggctctgcc acctagctgt gggtccttgg acaagttact
     3961 tcatctctct gtgcctcagg tttttcaaat gtaaaattgg gataattgga tctgtctcat
     4021 agggttgtga aaattaatga gttaatgctc ttagaagagt acctcatatg taataagcac
     4081 gcaactgtta attattgtta atgtagaagt taattctgtg tataaatcag atacactgtg
     4141 gtcaaagatt tgtgtgtatt tgtaagaaaa gaggagaatg gagaatctat ttttaagtgg
     4201 t
//
